DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and SIGLEC1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_075556.1 Gene:SIGLEC1 / 6614 HGNCID:11127 Length:1709 Species:Homo sapiens


Alignment Length:1807 Identity:374/1807 - (20%)
Similarity:614/1807 - (33%) Gaps:477/1807 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1231 LPAGEKPVFQWKRNGE------EFDP---EERFK---VLFGEDEDSLA-LVFQHVKPEDAGIYTC 1282
            :|.|...::.:..:|:      ..||   |.||:   ...|..|..:. |:.:.::|||:|.|..
Human    51 VPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNF 115

  Fly  1283 VAQTSTGNISCSAELSVQGAIQTLNREPEKPTL-----VIEHREANASIGGSAI-LELQCKGFPK 1341
            ..:.|..|    ....|:|.:.|:..||..||:     ::|..|.:.:.....: |:.|.:    
Human   116 RFEISEVN----RWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVR---- 172

  Fly  1342 PAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNVDTVDAGV----------YTIEAINELGQDE 1396
              :||:  |:    |......:..::.....:.:::|:...:          ..:...|...|.|
Human   173 --LQWQ--GQ----DPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSE 229

  Fly  1397 SSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVT-NNGKDVTAESNVKISSSSIG 1460
              |:|.||..||..||  :...:|..|        .|...|.:| .......|.|::|.....:.
Human   230 --IHLQVKYAPKGVKI--LLSPSGRNI--------LPGELVTLTCQVNSSYPAVSSIKWLKDGVR 282

  Fly  1461 KSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEK----EN 1521
            ...:..|:.:.:...|.||.|:.:|.|.:.        ::.|.|:.:..|.:|......    ||
Human   283 LQTKTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPILEN 339

  Fly  1522 VQMTVRIDAYPEA----KLTWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATN 1582
            ..:|:..:...||    :.:||          ..:.:..|.:::||::..|||.|.|.|..:..|
Human   340 QTVTLVCNTPNEAPSDLRYSWY----------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394

  Fly  1583 EHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVELVVGVDAYPRPHAKWYID--GIEIDEKRN 1645
            .|||..|....::...|..|..|  ....|..:.:..::.......|.|...:.  |..:.....
Human   395 VHGSERSGPVSVVVNHPPLTPVL--TAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG 457

  Fly  1646 DFRH------VEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKN-- 1702
            |..|      ....|..:|.:..:.....|.|.|...|..|    |...|::......|.|.:  
Human   458 DSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG----NATSTLDFHANAARLLISPA 518

  Fly  1703 VEVQEGKSFTLEVE--VYSEPEAKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAG 1765
            .||.||::.||...  :...|:|:..|:.:|..::|.            ....|.|..|.:.|||
Human   519 AEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG------------PGSSLLLPAASSTDAG 571

  Fly  1766 TYEMKATNFIGETTS-TCKVAVLTSEALSLEQTVT--------------KTLIATTEEPEEGAVP 1815
            :|..:|.:  |.:.| ....||||......:.|.|              :.|:....:.:..|..
Human   572 SYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634

  Fly  1816 EIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQSLDL 1880
            :::|.|              .|:||.:|.........|  .:|  ...:|...:..::|:.:..|
Human   635 QLLHKD--------------RVVATSLPSGGGCSTCGG--CSP--RMKVTKAPNLLRVEIHNPLL 681

  Fly  1881 VDAGEYKVVVQNKVGEKS----HQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVVFTA 1941
            .:.|.|.....|.:|..|    ..|:.::..||    |..|                        
Human   682 EEEGLYLCEASNALGNASTSATFNGQATVLAIA----PSHT------------------------ 718

  Fly  1942 DPAPEIVLLKDGQPVVETNNVKLKVDKKDA-----ENGLVQYTC---TLNILEAEIKDSGRYELK 1998
                    |::|.....|.||..:.....|     .||::....   |:.:|.....|:..|..:
Human   719 --------LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACR 775

  Fly  1999 VKNKYG-ELVTSGWIDVL---AKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTRGNENLCN 2059
            :..:.| :|.|...:.||   .:|::|.|.|..  .|....|...|.:.|...::...|...|..
Human   776 ILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMG--QGHMALFICTVDSRPLALLALFHGEHLLAT 838

  Fly  2060 HENCEV------IADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQ 2118
            ....:|      .|..:|:..:|..:.:...:.|.|...|||..|.:.......|   :..::..
Human   839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV---RGAWVQV 900

  Fly  2119 PESQSIHDYRPVSTKVLVH-GVPLPT-IEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIES 2181
            ..|..:.:.:.|.....|| |||..| ..|::|.:|:               :|.|       .:
Human   901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------------QEST-------SA 943

  Fly  2182 VLDIKSFRENDVGAYTCVATNEIGVT---KAPFKLAMLSLAPSFVKKLDNALDVLQGEPLVLECC 2243
            .|...:......|||.|.|......|   .||..| .:|.||..| .|...:|...|...:|.|.
Human   944 TLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL-HVSYAPRHV-TLTTLMDTGPGRLGLLLCR 1006

  Fly  2244 VDGSPLPTVQWLKDGDEVKPSESIKISTNPDG------------LVKLEINSCQPNDSGAYKLII 2296
            ||..| |....|..||.:..| :::....|:|            .::|||:.....|.|.|....
Human  1007 VDSDP-PAQLRLLHGDRLVAS-TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069

  Fly  2297 SNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQV-TGFPAP-EVKWYKDGM--- 2356
            ||..|:     |.|....:.|...::.....||..|:.:.|...| |..||. ...||:||.   
Human  1070 SNTLGQ-----ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL 1129

  Fly  2357 ------------------------------LLRP-------SPE----INFINSPNGQIGLI--- 2377
                                          |.||       :|.    ...:.|..||:.|:   
Human  1130 DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCT 1194

  Fly  2378 IDA---------------------------------AQPLDAGVYKCLIANKGGE--------IE 2401
            :|:                                 .||.|.|.|.|...:..|:        :|
Human  1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259

  Fly  2402 GVSKVEIVPKESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPKL-QWFHNGHEIKPDASHIAIV 2465
            || :|.:.|:.:.|            ||.|:.:.........|.| .|:|||..::         
Human  1260 GV-RVILAPEAAVP------------EGAPITVTCADPAAHAPTLYTWYHNGRWLQ--------- 1302

  Fly  2466 ENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASK-AKLYVAPKADETATEEAPQ--FVSALRD 2527
            |.|..|.|.::...|  .:|.|...||:.:|:.:|: |.|.|.         .|||  .:|:.||
Human  1303 EGPAASLSFLVATRA--HAGAYSCQAQDAQGTRSSRPAALQVL---------YAPQDAVLSSFRD 1356

  Fly  2528 VNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKH---------------IGLT 2577
            ..|  ....|:.....|.|..|:..|.||       ::|.|..|.|               :.|.
Human  1357 SRA--RSMAVIQCTVDSEPPAELALSHDG-------KVLATSSGVHSLASGTGHVQVARNALRLQ 1412

  Fly  2578 IKPAEAADSGNYTCLLANPLGEDSSACNANV---RKVYKPPVFTQKISDQQQVFGNNAKIPVTVS 2639
            ::...|.|. .|.|...|.||..|:.....|   |.|.:|.:...:        |....:...:.
Human  1413 VQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--------GAALNLSCRLL 1468

  Fly  2640 GVPYP----DLEWYFQDK-----PIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGK 2695
            |.|.|    ...|::.|:     |:|              .|...:..:...|:|.|:|....|.
Human  1469 GGPGPVGNSTFAWFWNDRRLHAEPVP--------------TLAFTHVARAQAGMYHCLAELPTGA 1519

  Fly  2696 DITQG-RLDIVNEIKKHSRS---EPPVFLKKIGDCDIYEGMVAKFT------ACATGYP-----E 2745
            ..:.. .|.::...|..:..   ||...|:.|.||.:....:|..|      ..|:..|     |
Human  1520 AASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584

  Fly  2746 PEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYG 2797
            |.:.               :...||. ||:.|:.:...|.|.|.|...|..|
Human  1585 PHIH---------------VLASPNA-LRVDIEALRPSDQGEYICSASNVLG 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254 16/75 (21%)
I-set 1313..1403 CDD:254352 16/105 (15%)
Ig_3 1406..1487 CDD:316449 18/81 (22%)
I-set 1499..1595 CDD:254352 25/103 (24%)
I-set 1599..1690 CDD:333254 17/98 (17%)
I-set 1694..1786 CDD:254352 23/96 (24%)
I-set <1836..1903 CDD:333254 15/70 (21%)
I-set 1922..2005 CDD:333254 13/91 (14%)
I-set 2018..2108 CDD:333254 20/95 (21%)
I-set 2113..2214 CDD:333254 22/105 (21%)
I-set 2220..2302 CDD:254352 25/93 (27%)
I-set 2318..2408 CDD:254352 32/179 (18%)
I-set 2415..2506 CDD:254352 23/92 (25%)
I-set 2519..2608 CDD:254352 26/105 (25%)
I-set 2615..2696 CDD:254352 14/89 (16%)
I-set 2717..2805 CDD:254352 21/92 (23%)
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
SIGLEC1NP_075556.1 Ig 21..136 CDD:299845 21/88 (24%)
IG_like 26..135 CDD:214653 20/87 (23%)
Sialic acid binding. /evidence=ECO:0000250 122..126 1/7 (14%)
C2-set_2 142..228 CDD:285423 12/97 (12%)
Ig_2 245..323 CDD:290606 17/93 (18%)
IG_like 247..323 CDD:214653 17/91 (19%)
Ig 336..408 CDD:299845 21/81 (26%)
IG_like 338..408 CDD:214653 21/79 (27%)
Ig 430..503 CDD:143165 13/76 (17%)
IG_like 431..503 CDD:214653 13/75 (17%)
Ig_2 514..594 CDD:290606 25/93 (27%)
IG 516..594 CDD:214652 24/91 (26%)
IG_like 624..703 CDD:214653 17/96 (18%)
IG_like 715..792 CDD:214653 17/108 (16%)
ig 715..788 CDD:278476 17/104 (16%)
Ig 809..893 CDD:299845 16/83 (19%)
I-set 898..980 CDD:254352 23/104 (22%)
Ig_2 900..980 CDD:290606 23/102 (23%)
Ig 1003..1080 CDD:143165 23/83 (28%)
Ig_2 1093..1168 CDD:290606 15/74 (20%)
IG_like 1093..1168 CDD:214653 15/74 (20%)
I-set 1186..1256 CDD:254352 11/69 (16%)
Ig_2 1263..1342 CDD:290606 25/101 (25%)
IG_like 1271..1342 CDD:214653 23/93 (25%)
Ig 1363..1442 CDD:299845 20/86 (23%)
IG_like 1455..1529 CDD:214653 15/95 (16%)
Ig 1457..1518 CDD:299845 13/82 (16%)
Ig <1552..1630 CDD:299845 19/85 (22%)
IG 1552..1627 CDD:214652 19/85 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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