DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and STK33

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_001275990.1 Gene:STK33 / 65975 HGNCID:14568 Length:514 Species:Homo sapiens


Alignment Length:448 Identity:101/448 - (22%)
Similarity:200/448 - (44%) Gaps:74/448 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  3108 VDSSRIKISSYDPDIYV--LSIHDSIIKDGGLYSI---SARNIAGSIST-----SVTVHIEENED 3162
            |.||:.::    |.:.|  :|...||.....|.|:   ..:||...|::     |.|.::|....
Human    27 VCSSKTRV----PPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKAS 87

  Fly  3163 QYIYK----TYGRHPYVRSKQ-LRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIM----Y 3218
            |..:.    |.|:.|::|.:. ...::.|..|..||:|:.||...|.::.:...:|.|.:    .
Human    88 QQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKA 152

  Fly  3219 GRPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDI 3283
            |...:: .:..|:.::.:..|:::|.....::|.:.:.|:|||...||| ::.|.|:.:::|.:.
Human   153 GSSAVK-LLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGEL-KEILDRKGHFSENET 215

  Fly  3284 AHYIRQTLWGLEHMHEMGVGHMGLTIKDLLI--SVV--GGDI---IKVSDFGLSRKINRHNLSTL 3341
            ...|:.....:.::|...:.|..|.::::::  |::  ..:|   |||:||||:.|....:.:.|
Human   216 RWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAML 280

  Fly  3342 D--YGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDE 3404
            .  .|.|.:::|||::....:...|:|::|::.|:||.|..|||...:.:....||:|...|::.
Human   281 QATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENA 345

  Fly  3405 IWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDHFRDW 3469
            :|..|||..:..:.:|:...|..|:..|..|.:.|.         ...::.:.|..|..:..::|
Human   346 VWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWL---------TGNKLSSVRPTNVLEMMKEW 401

  Fly  3470 YANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKY 3527
            ..|                               ||:..|...|.:.:...||.:..|
Human   402 KNN-------------------------------PESVEENTTEEKNKPSTEEKLKSY 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254 15/58 (26%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 68/270 (25%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
STK33NP_001275990.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..91 6/25 (24%)
STKc_STK33 114..381 CDD:270999 68/268 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 402..468 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..514
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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