| Sequence 1: | NP_001097440.1 | Gene: | Unc-89 / 3346201 | FlyBaseID: | FBgn0053519 | Length: | 4218 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001316727.1 | Gene: | PLEKHG1 / 57480 | HGNCID: | 20884 | Length: | 1444 | Species: | Homo sapiens |
| Alignment Length: | 1580 | Identity: | 306/1580 - (19%) |
|---|---|---|---|
| Similarity: | 548/1580 - (34%) | Gaps: | 495/1580 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 17 QSLATDEIS-----VSRGDLVELISSKASE---------KSRCFVRMFDSGDSPKE-GWVPIDIL 66
Fly 67 EFNPTMSS-------SNGKESGD--------AEFR-----------------KL----TILRELV 95
Fly 96 ETEEEFSRDLLHVVEKYIKGI-DKPVVPRSVRDNKDIIFCNFLQIAEFHNNVLKEGLKCYSNQPN 159
Fly 160 MVAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSPDAK---KYFQELSKQLGDDKSLAEHLKLPIQ 221
Fly 222 RINDYQLLF--------KDFIKYSLSLKE---------NVKDLERALELMLSVPSRAYDNRFLSS 269
Fly 270 IEGCRG-NIYKLGRLLLHAWCNVVDKEGKAHDRYCFLFKSRILVTKVRKISENRSVFIL------ 327
Fly 328 -QNIVKLPLCNIELKADEKQIHLSLKAPEANSFLPIDIKPHGPEAHLTWFNEISSHINQDVTL-- 389
Fly 390 -------QEHNADDLKVDASQIASESELILHLPQRAEAHDPNLSVRPSDVAENYFLSKETKERLQ 447
Fly 448 HEQQELLKLEQEAIELYKKQQSSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQVKEVTP 512
Fly 513 VKVVSSPPPPKEITPAKVATPPPQPQVVT-----SPVKEVAPPPQPRAVASPAKEVTPSQSEPVK 572
Fly 573 APSPIKEVRKEVPPSASHSKEVEALVATEIRESLTETRSTVVESGQSSEIREEIVVTEESSLEGK 637
Fly 638 QVV---ALEREPSPCSIPKIQVYRPVECENPVVTKHKPIELKDIVGYSESLRDGDTAPAGGSPGR 699
Fly 700 QQ----GYSANIT----DHASLTIWNNRLANIAGDRSGANQHLQQSGPPPPPIPPNFTRMPGFFQ 756
Fly 757 PLPLIAYETTIEILIVK---------------ARPPSPPPPPPPTIKRVLVHTE-SLEQKTQNFF 805
Fly 806 EGIYDAASSDTSLRNAKQKIRSIKSTV-LKSKDSTNYAQDTVQKAKARDFLHI---FTPPVKKRP 866
Fly 867 IYEIVEEPVNIFELEGDYTESIADD------FREPSADFEARGQSVGG-----MDDYYSGYSRAS 920
Fly 921 TRRYETKTRDY-------------DRGTSYDSTVERSQYGISSRRDRSSVDKVEARSSLLATGRT 972
Fly 973 ESRAASRAESRAE----------------SRAS--------YSVAESRAGIRSSSRLQEDRPLRS 1013
Fly 1014 VDKPV--VVKM----------------LKSVQVE-PGETAHFEIQFKDQPGLVTWLKDNKPL--- 1056
Fly 1057 ----EDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASE-----------TTTVSAQL 1106
Fly 1107 AVGQAPGHD---------ETKTNTEPAFL------VSLKDAEMIENTLFRFMVKIIGDPKPRVKF 1156
Fly 1157 YKD-------EKEI---------LETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYSCKATNKH 1205
Fly 1206 GEANCEA---IATTVEDKNPFGA--LSGQILPAGEKPVF--------------QWKRNGEEFDPE 1251
Fly 1252 E--RFKVLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLN--REPEK 1312
Fly 1313 PTLVIEHREANASIGGSAIL 1332 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Unc-89 | NP_001097440.1 | RhoGEF | 90..260 | CDD:238091 | 49/190 (26%) |
| PH_unc89 | 275..388 | CDD:270134 | 25/120 (21%) | ||
| Atrophin-1 | <493..690 | CDD:331285 | 36/204 (18%) | ||
| TonB_N | 502..>596 | CDD:318287 | 16/98 (16%) | ||
| I-set | 1017..1108 | CDD:333254 | 21/127 (17%) | ||
| I-set | 1123..1212 | CDD:254352 | 16/110 (15%) | ||
| I-set | <1236..1299 | CDD:333254 | 16/78 (21%) | ||
| I-set | 1313..1403 | CDD:254352 | 5/20 (25%) | ||
| Ig_3 | 1406..1487 | CDD:316449 | |||
| I-set | 1499..1595 | CDD:254352 | |||
| I-set | 1599..1690 | CDD:333254 | |||
| I-set | 1694..1786 | CDD:254352 | |||
| I-set | <1836..1903 | CDD:333254 | |||
| I-set | 1922..2005 | CDD:333254 | |||
| I-set | 2018..2108 | CDD:333254 | |||
| I-set | 2113..2214 | CDD:333254 | |||
| I-set | 2220..2302 | CDD:254352 | |||
| I-set | 2318..2408 | CDD:254352 | |||
| I-set | 2415..2506 | CDD:254352 | |||
| I-set | 2519..2608 | CDD:254352 | |||
| I-set | 2615..2696 | CDD:254352 | |||
| I-set | 2717..2805 | CDD:254352 | |||
| FN3 | 2834..2925 | CDD:238020 | |||
| I-set | <2996..3063 | CDD:333254 | |||
| I-set | 3067..3157 | CDD:333254 | |||
| PK_Unc-89_rpt1 | 3182..3440 | CDD:271011 | |||
| I-set | 3654..3744 | CDD:333254 | |||
| FN3 | 3748..3840 | CDD:238020 | |||
| STKc_Unc-89_rpt2 | 3893..4151 | CDD:271014 | |||
| PLEKHG1 | NP_001316727.1 | RhoGEF | 176..351 | CDD:279015 | 46/176 (26%) |
| PH_PLEKHG1_G2_G3 | 332..477 | CDD:270063 | 32/181 (18%) | ||
| PH | 381..474 | CDD:278594 | 25/123 (20%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||