DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and DSCAML1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:2003 Identity:385/2003 - (19%)
Similarity:624/2003 - (31%) Gaps:700/2003 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1978 YTCTLNILEAEIKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQA 2042
            |.||......:|:..   .::||            .|..:|....:.|.:.:.|:...|:.|:.:
Human   101 YFCTAENAAGKIRSP---NIRV
K------------AVFREPYTVRVEDQRSMRGNVAVFKCLIPS 150

  Fly  2043 NPK---PKVSWTRGNENLCNHENCEV-------IADVDAD----KYRLVFQSVSPCEDGKYTITA 2093
            :.:   ..|||.:...::.......:       |:||..:    .||.:.:.       ||:...
Human   151 SVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKH-------KYSGET 208

  Fly  2094 TNSEG---------RAAVDFNLAVLVEK-PTFIVQPESQSIHDYRPVSTKVLVHGVPLPTIEWFK 2148
            ..|.|         |||....|....|. ||.:....||.:.....|.......|.|:|.|.|.|
Human   209 RQSNGARLSV
TGLARAADPLCLPDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK 273

  Fly  2149 DDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVTKAPFKL 2213
            |.:|:       |...:.     ||:.|.     |.|...|..|.|.|.|..||..|..:|...|
Human   274 DGRPL-------PADSRW-----TKRITG-----LTISDLRTEDSGTYICEVTNTFGSAEATGIL 321

  Fly  2214 AML-----SLAPSFVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNP 2273
            .::     :|.|   |||...:    |..::|.|.:.|||..|::|.::.:.|.|.|:|.|.   
Human   322 MV
IDPLHVTLTP---KKLKTGI----GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIR--- 376

  Fly  2274 DGLVK--LEINSCQPNDSGAYKLIISNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLK 2336
             ||..  |.|.|.|.:.||||:...:...........:|:  |:..|:.:...:.:.|..||...
Human   377 -GLSNETLLITSAQKSHSGAYQCFAT
RKAQTAQDFAIIAL--EDGTPRIVSSFSEKVVNPGEQFS 438

  Fly  2337 LEAQVTGFPAPEVKW-------YKDG------MLLRPSPEINFINSPNGQIGLIIDAAQPLDAGV 2388
            |.....|.|.|.|.|       .:||      ..:.....|:.:|....||         .|.||
Human   439 LMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI---------RDGGV 494

  Fly  2389 YKCLIANKGGEIEGVSKVEIVPKESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGH 2453
            |:|...|..|..|..:::.:    ..|..:..:::.:::.|....::.:|:|.|...::|:.:. 
Human   495 YRCTARNLVGSAEYQARINV
----RGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA- 554

  Fly  2454 EIKPDASHIAIVENPDNSSSLIIEKTAPG-DSGLY--EVIAQNPEGSTASKAKLYVAPKADETAT 2515
            .:.||.....:.||    .:|.:.....| |.|.|  .|:.| |:.|.:.  .::||.|      
Human   555 LLLPDNHRQVVFEN----GTLKLTDVQKGMDEGEYLCSVLIQ-PQLSISQ--SVHVAVK------ 606

  Fly  2516 EEAPQFVSALRDVNADEGQELVLSAPFISNPMP-EVIWSKDGVTLTPNERLLMTCDGKHI--GLT 2577
              .|..:.......|..||.|.:.....|..|| .:.|.|||..:.....  :|.:.|..  .|.
Human   607 --VPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSG--VTIESKEFMSSLQ 667

  Fly  2578 IKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQQVFGNNAKIPVTVSGVP 2642
            |.......:|||||:.:|.....|......||   .||.|..:.::|..::|....:..:|.|.|
Human   668 ISSVSLKHNGNYTCIASNAAATVSRERQLIVR---VPPRFVVQPNNQDGIYGKAGVLNCSVDGYP 729

  Fly  2643 YPDLEWYF--------QDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQ 2699
            .|.:.|..        |..|:|.:.:..|..:..   |::.:..:.|.|.|.|.|||..|.||::
Human   730 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSS---LLIRHVLEEDIGYYLCQASNGVGTDISK 791

  Fly  2700 GRLDIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSD--R 2762
            . :.:..:|.....|.|...:       ..:|...:....|.|.....:.|.|.|..:.|..  |
Human   792 S-MFLTVKIPAMITSHPNTTI-------AIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMR 848

  Fly  2763 FLIDIEPNG---LLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDF 2824
            :.|..:.||   :..|.:|.....|...:||...|.||:|....:|      :.|:|.:      
Human   849 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL------TVQEPPD------ 901

  Fly  2825 KKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYP----IT-YQIEMMDLPEGDWRTLR 2884
                    ||.|.    |..:..|.:.|.|      |.|:.    || :.||..:  :.|....:
Human   902 --------PPELE----IREVKARSMNLRW------TQRFDGNSIITGFDIEYKN--KSDSWDFK 946

  Fly  2885 TGVRSCA-----CDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGT 2944
            ...|:.:     .:|.:|.|...|..|:...||.|.|:||.......::..||.|      |...
Human   947 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGP------PMDV 1005

  Fly  2945 DFRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFD 3009
            ..:|.||......:           :||     ::::..||          :.||          
Human  1006 TLQPVTSQSIQVTW-----------KAP-----KKELQNGV----------IRGY---------- 1034

  Fly  3010 DMLIESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPD 3074
                :.|.| :.|...|||.::                                           
Human  1035 ----QIGYR-ENSPGSNGQYSI------------------------------------------- 1051

  Fly  3075 ETFIMARKNGRIEAKLVGIPLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYS 3139
                       :|.|..|                          |.::|.|              
Human  1052 -----------VEMKATG--------------------------DSEVYTL-------------- 1065

  Fly  3140 ISARNIAGSISTSVTVHIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAV 3204
                                                                             
Human  1066 ----------------------------------------------------------------- 1065

  Fly  3205 ERSSGDNYAAKIMYGRPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVR 3269
                 ||......||            .::..||                               
Human  1066 -----DNLKKFAQYG------------VVVQAFN------------------------------- 1082

  Fly  3270 DNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKIN 3334
                                         ..|.|..                        |.:||
Human  1083 -----------------------------RAGTGPS------------------------SSEIN 1094

  Fly  3335 RHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGR- 3398
            ...|..:....||       |...::.:.|   |.:|::     ..|     .|.||..:.:|. 
Human  1095 ATTLEDVPSQPPE-------NVRALSITSD---VAVISW-----SEP-----PRSTLNGVLKGYR 1139

  Fly  3399 ---WD-FKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRL 3459
               |. :.|..|..:.:          :.:..||::::                      |.::.
Human  1140 VIFWSLYVDGEWGEMQN----------ITTTRERVELR----------------------GMEKF 1172

  Fly  3460 RNY------YDHFRDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPE--PRI 3516
            .||      |....|...                    |.::|    :.|.|:.|.| |.  ..:
Human  1173 TNYSVQVLAYTQAGDGVR--------------------SSVLY----IQTKEDVPGP-PAGIKAV 1212

  Fly  3517 RAKREEVVSKYLHPDYELGLIQ--------------SESHYQYGPDTYLLQLRDVNFPVRLREYM 3567
            .:....||..:|.|....|:|:              :.|.|:..|:    ||           :.
Human  1213 PSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPE----QL-----------FY 1262

  Fly  3568 KVAH-RRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDERTRSRISMYAANESYSIRRLRTEL 3631
            ::|| .|...:.|     |...|....|                       .|.|..:       
Human  1263 RIAHLNRGQQYLL-----WVAAVTSAGR-----------------------GNSSEKV------- 1292

  Fly  3632 GPRLDEYTEADAMIETQREGYPPFFREKPQTIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTE 3696
              .::...:|.|.|.:           ...|:.....:...:.|.:||||.|.|:|.|:    :|
Human  1293 --TIEPAGKAPAKIIS-----------FGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKD----SE 1340

  Fly  3697 SKRIKISVD------EDGRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVATLPDAPDSPE 3755
            ...|.:|:|      .:|..:||...|  .|.|.|...|.|..|.......::|...||.| ...
Human  1341 DSAIPVSMDGHRLIHTNGTLLLRAVKA--EDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-RLT 1402

  Fly  3756 ISANSGTEILLRWKQPRDDGHSTVLCYSLQYKLSNCDAWTTVADNIDHEFYLLHDLQPNTNYQFR 3820
            :|..|.:.|.|.| .|.|:|.|::..:.|||.:.|.:.|..|..:.....:.|..|:..|.|:.:
Human  1403 VSKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVK 1466

  Fly  3821 LASKNRIGWSEMGIPVSASTVGGDA---------PKIHITKAMKHLQQLTENG 3864
            ||:||.:|...:...:.|.|.|.:.         ..|:.|.|..:||.....|
Human  1467 LAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGG 1519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254 6/26 (23%)
I-set 2018..2108 CDD:333254 21/112 (19%)
I-set 2113..2214 CDD:333254 28/100 (28%)
I-set 2220..2302 CDD:254352 27/83 (33%)
I-set 2318..2408 CDD:254352 24/102 (24%)
I-set 2415..2506 CDD:254352 19/93 (20%)
I-set 2519..2608 CDD:254352 23/91 (25%)
I-set 2615..2696 CDD:254352 22/88 (25%)
I-set 2717..2805 CDD:254352 20/92 (22%)
FN3 2834..2925 CDD:238020 25/100 (25%)
I-set <2996..3063 CDD:333254 8/66 (12%)
I-set 3067..3157 CDD:333254 6/89 (7%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 28/262 (11%)
I-set 3654..3744 CDD:333254 24/95 (25%)
FN3 3748..3840 CDD:238020 28/91 (31%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653 4/20 (20%)
IGc2 43..110 CDD:197706 3/8 (38%)
Ig 125..218 CDD:299845 17/99 (17%)
IG_like 137..209 CDD:214653 13/78 (17%)
I-set 245..323 CDD:254352 27/94 (29%)
IGc2 252..313 CDD:197706 22/77 (29%)
IGc2 340..401 CDD:197706 23/68 (34%)
I-set 420..514 CDD:254352 24/102 (24%)
Ig 420..510 CDD:299845 24/98 (24%)
IGc2 531..589 CDD:197706 14/62 (23%)
IG_like 619..698 CDD:214653 22/80 (28%)
Ig 627..693 CDD:143165 18/67 (27%)
I-set 702..797 CDD:254352 24/98 (24%)
Ig7_DSCAM 719..797 CDD:143211 20/81 (25%)
I-set 803..896 CDD:254352 23/105 (22%)
Ig 815..903 CDD:299845 23/107 (21%)
FN3 899..993 CDD:238020 27/119 (23%)
FN3 1000..1097 CDD:238020 34/403 (8%)
fn3 1105..1191 CDD:278470 21/157 (13%)
FN3 1203..1294 CDD:238020 23/143 (16%)
IGc2 1318..1382 CDD:197706 22/69 (32%)
FN3 1396..1486 CDD:238020 28/91 (31%)
FN3 1500..1572 CDD:238020 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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