DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and hmcn1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_005160777.1	Gene:	hmcn1 / 559150	ZFINID:	ZDB-GENE-041014-322	Length:	5623	Species:	Danio rerio

Alignment Length:	4036	Identity:	854/4036 - (21%)
Similarity:	1396/4036 - (34%)	Gaps:	1158/4036 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 ELLKLEQEAIELYKK----------QQSSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQ 506
            |||.|......|.:.          ::|.:.|.:.|.:...:|.:|:.:..||..:|  ...:|.
Zfish  1011 ELLDLSGSVFSLTEDGSLHIHSPSGEESGEFVCTATNAAGYSSRKVQLTVYVRPKLS--GVGEAD 1073

  Fly   507 VKEVTPVKVVSSPPPPKEIT-PAKVATPPPQPQVVTSPVKEVAPPPQPRAVASP----------- 559
            :.:.:...:..|.....:|| |.:|.:.|| |.:..:..|::..|..||.:..|
Zfish  1074 IHDNSEKLLEMSVIVGDDITLPCEVESVPP-PIITWAKDKQLISPFSPRHIQLPSGSMRITDTRV 1137

  Fly   560 ---------AKEVTPSQSEPVKAPSPIKEVRKEVPPSAS-----------HSKEVEALVATEIRE 604
                     |..:..:.|:.||       :...||||.|           |:.::..:.......
Zfish  1138 TDSGMYLCVATNIAGNFSQTVK-------LSVLVPPSISAGPRAMKVQIGHAIDLPCVTQGVPEP 1195

  Fly   605 SLTETR-STVVESGQSSEIRE------EIVVTEES-------SLEGKQVVALEREPSPCSIPKIQ 655
            |::..: .||::.|....|.:      ::.:|:|.       ::.||:..|::..        :|
Zfish  1196 SVSWLKDGTVLQDGSRYRISDGALTLNQVALTDEGIYVCRAVNIAGKEETAIQLH--------VQ 1252

  Fly   656 VYRPVECENPVVTKHKPIELKDIVGYSESLRDGDTA---PAGGSP--------------GRQQGY 703
            |...||...|..  :.|::        |.:.:...|   ||.|:|              |.:.|.
Zfish  1253 VPPVVEVSEPPF--NSPLQ--------ERVANQQIAFPCPAKGTPEPVIKWFRNGHELTGNEPGV 1307

  Fly   704 SANITDHASLTIWNNRLANIA------------GDRSGANQHLQQSGPPPPPIPPNFTRMPGFFQ 756
            |  |.:..:|.|    ||:::            .|.....:..|.....||.|..|     |...
Zfish  1308 S--ILEDGTLLI----LASVSPLDNGEYTCMAVNDAGTTEKKYQLKVNVPPDIRDN-----GLLS 1361

  Fly   757 PLPLIAYETTIEILIVKARPPSPPPPPPPTIKRVLVHTESLEQKTQNFFEGIYDAASSDTSLRNA 821
            .:.::..:.|..:..|..       .|.|.|..              :.:|:....|||..:...
Zfish  1362 NVSVVINQPTNLVCDVTG-------TPVPVITW--------------YKDGVEVVPSSDVQILQK 1405

  Fly   822 KQKIRSIKSTVLKSKDSTNYAQDTVQKAKARD---FLHIFTPP-----VKKRPIYEIVEEPVNI- 877
            .:.::.:|:.|   :|:..|....:..|.:|:   :|.:..||     |..|.:..::.:.:.:
Zfish  1406 GKTLKLLKAAV---QDAGRYICKAINIAGSRERDFYLDVLVPPTIIGTVGSRDLSAVLNQEIVLE 1467

  Fly   878 FELEGD-------YTESIADDFREPSADFEARGQSV----GGMDDYYSGYSRASTRRYETKTRDY 931
            .:::||       |.:.......:|:.:...|||.:    ..:.| .:.|..::|.....:::|:
Zfish  1468 CKVKGDPFPTIQWYKDRKPVFLGDPNIEVLNRGQQLKIKSARLGD-QARYQCSATNAAGKQSKDF 1531

  Fly   932 D---------RGTSYDS----------TVERSQYGI---------------SSRR----DRSSVD 958
            :         :|.:..|          |:|....|:               |||:    ||....
Zfish  1532 NLSIFVPPSIKGGNVSSEVTVLLGNLVTLECEVRGVPLPAVTWYKNGEVILSSRQAQYVDRGQFL 1596

  Fly   959 KVEARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKML 1023
            |: .|:.:...|:...|..|.| ..||     .|.|....:..|.....|.|   .|..||:.
Zfish  1597 KI-LRAQVSDAGQYTCRVTSVA-GTAE-----KVVELDVYVPPSITAGSDGP---TDMKVVLN-- 1649

  Fly  1024 KSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGT 1088
            ||:.:|.....|       .|..:|||||..|:..|.:.|:..     ...:::|.|..::|||.
Zfish  1650 KSLILECEAEGH-------PPPSLTWLKDGSPVAVRESLRVLD-----QGRKIEILNALQSDAGR 1702

  Fly  1089 YTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDAEMIENTLFRFMVKIIGDPKPR 1153
            |...|.|.:....:...::|...|..|.....|         ||.:|.|.:........|.|.|.
Zfish  1703 YVCVATSVAGEKEIKYDVSVLVPPVVDGASDTT---------DATVILNNILELECYATGRPTPT 1758

  Fly  1154 VKFYKD-------EKEILETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCE 1211
            :.:.||       |...:.:|.|             .|||:..|.:|...:.|.|||:.||...|
Zfish  1759 ITWLKDGVPVKHGEGVRITSNGR-------------RLVISRAQVSDTALFHCVATNEAGEQERE 1810

  Fly  1212 -----AIATTVEDKNP-------FGALSGQILPAG-EKPVFQWKRNGEEFDPEERFKVLFGEDED 1263
                 .:...:....|       ..::|.|.:.:| ..|...|.::|...|..:.|..|     :
Zfish  1811 FKVSVHVPPAIRSTGPAERSVVLHTSISLQCVVSGIPPPSTTWLKDGRPVDTTQEFLKL-----E 1870

  Fly  1264 SLALVFQHVKP---EDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANAS 1325
            |...|. |:|.   ||||.|||||..:.|.......|||.          |.|::.......|.:
Zfish  1871 SAGRVL-HIKKARLEDAGKYTCVATNAAGEAQQHIRLSVH----------EPPSIQYAGEMLNET 1924

  Fly  1326 IGGSAILELQCK--GFPKPAVQWKHDGEV------IQVDDRHKFMYEDEESMSLVIKNVDTVDAG 1382
            |.....::|:||  |.|.|||.|..||..      :.:..|...:..|...:|         |||
Zfish  1925 ILAGFQIQLKCKATGSPLPAVTWYKDGRPLTSAAGVNILSRGHVLEIDRAQVS---------DAG 1980

  Fly  1383 VYTIEAINELGQDESSINLVVKAPPKI-KKITDITCSAGETIKMEIEVEGFPQPT---------- 1436
            .|...|||..|..|.:.:|.|..||.| .|...:|....:.:::|.|..|.|.|:
Zfish  1981 FYKCVAINVAGSTELTYSLQVYVPPTISSKGGMVTVVVNDPVRLECEASGVPVPSLTWLKEGSPV 2045

  Fly  1437 ------VQVTNNGKDVT--------------------------AESNVKISSSSIGKSLEKVVVE 1469
                  :||.:.|:.::                          .|..|.:..:.:|:.:...|:.
Zfish  2046 SSFSDGIQVLSGGRVLSFISAQVSDAGHYTCVAVNAGGEQHREYELRVYVPPNIMGEEVNNTVLM 2110

  Fly  1470 VKEIKL-------------------------------------------SQAGNYSIKATNDLSQ 1491
            .:.::|                                           ...|.|:.:|||...:
Zfish  2111 GQSVQLHCQSDAIPPPALSWRKDGRPLYRKPGLSVSEDGSFLKIISAQVQDTGRYTCEATNVAGK 2175

  Fly  1492 TSEYWSCTVKSKPVIVKNFESEYIHGEKENVQMTV----------RIDAYPEAKLTWYHDETEIK 1546
            |.::::..|...|         .|.|..|...:||          .....|...|.|..|.:|:|
Zfish  2176 TEKHYNLNVWVPP---------SIRGSDEVSSLTVIEGGLITLVCESSGIPPPSLIWKKDGSELK 2231

  Fly  1547 ITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVA 1611
             .||:..|.|.|.  .|:|:.|.:.||..||..|::..|||.....|.:...|..:...::....
Zfish  2232 -GDSRVRVLSGGR--QLQISSAEKADASSYTCLASSAAGSAIKEYNLQVYVRPSISSSAQDEETV 2293

  Fly  1612 EGDSNVELVVGVDAYPRPHAKWYIDGIEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIM 1676
            ....::.|....|..|||...|..||..:...|. .:.:.||...:::..|||..  |.|||..:
Zfish  2294 TRGGDITLRCEADGVPRPAVSWMKDGRPLSTGRK-AQILNEGRLLRILEAQVADT--GRYTCIAI 2355

  Fly  1677 NDYGKLEDNCVVTVNCKPKV---KRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDA 1738
            |..|:.:....|.|:..|.:   ....:|:.|.......|..|....|...|.|.|||..|...:
Zfish  2356 NVAGQADRKYDVNVHVPPTIIGQTHMPENISVVVKNPVVLTCEASGMPPPAITWLKDGQPISTSS 2420

  Fly  1739 RIKISRDTQRIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLI 1803
            .:::....:.     |.|..|.:.|||.|....:|..||......:.||...::..|.||
Zfish  2421 SVRVISGGRG-----LRLMHAASSDAGRYTCIVSNSAGEERKNFDLYVLVPPSIVNEGTV----- 2475

  Fly  1804 ATTEEPEEGAVPEIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDG 1868
                  |:..|.|           .::..|..||  ||.|.||..|..||:|:..|....:..:|
Zfish  2476 ------EDVKVKE-----------RQNAILACEV--TGNPVPEITWLKDGQPLASDTRLQVMSNG 2521

  Fly  1869 DHYKLEVQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGP--GLKDIKVNKGD 1931
            ..  |::.:..:.|.|.|..:..|..|::|....|::.    ....|...||  ..:::.|....
Zfish  2522 RF--LQISASQVADTGRYSCLASNSAGDRSRHFNLNVL----VSPTIAGSGPEGSAEEVTVTLNS 2580

  Fly  1932 K---VCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILEAEIKDSG 1993
            .   |||...:   |...|..||||.|...:.||::....:           ||.||.|:.:|:|
Zfish  2581 PTSLVCEAQSY---PPAIITWLKDGTPFESSRNVRVLPGGR-----------TLQILNAKEEDAG 2631

  Fly  1994 RYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGD-------------TICFEALVQANPK 2045
            ||.....|:.||.:.:..:.|...|.|: .||   :||:             |:..|...||.|.
Zfish  2632 RYTCVATNEAGETLKNYEVKVFVPPVIN-KND---IPGESLAPKEVKIKVNNTLTLECEAQAIPT 2692

  Fly  2046 PKVSWTRGNENLCNHENCEVIADVDADKYRLV-FQSVSPCEDGKYTITATNSEGRAAVDFNLAVL 2109
            |.:.|.:..:.|....:..:.|:     .|:| .:.....:.|:||..|||..|....||::.:.
Zfish  2693 PTLVWYKDGQILKADGHLTITAN-----GRIVQIKHTQVSDTGRYTCVATNIAGEDEKDFDVNIQ 2752

  Fly  2110 VEKPTFIVQPES-----QSIHDY---RPVSTKVLVHGVPLPTIEWFKDDKPI--NYEAINKPGKD 2164
            | .|:|....:|     ..:.|.   .|:|.....:.||.|.:.|:||...:  |.:.:..||
Zfish  2753 V-PPSFRGFGDSGPGNNGEVKDVILNNPISLYCETNAVPPPVLTWYKDGHLLTSNDKVLILPG-- 2814

  Fly  2165 KLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNA 2229
                           ..||.|...:.:|.|.|||||.||.|.....:.:.:| |.|| ::..|..
Zfish  2815 ---------------GRVLQIPRAQVDDTGRYTCVAVNEAGEDSIQYDVRVL-LPPS-IRGADGE 2862

  Fly  2230 L----DVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSG 2290
            |    .||..:.::|||.|||||.|.:.|:||...:....:.::.:|..   .|:|.:.|..|:|
Zfish  2863 LPDEVTVLVNKTMLLECQVDGSPTPKISWVKDSQPLTQDNTHRLLSNGR---TLQILNAQVTDTG 2924

  Fly  2291 AYKLIISNPHG--EK-------VALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPA 2346
            .|..:..|..|  ||       |:...|.::.|.:           |||:...:.|..:.||.|.
Zfish  2925 RYVCVAQNLAGTAEKSFNLHVHVSPTIVGIREENV-----------TVVLNNFVSLNCEATGLPP 2978

  Fly  2347 PEVKWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEG--------- 2402
            |.::|:||...::.|  .|.:..|.|:. |.|..|:..|.|.|.|:..|..||.:.
Zfish  2979 PTLRWFKDRRPVQAS--TNALIMPGGRT-LQILKAKMSDGGKYSCVAVNPAGEAQKLIYLTVYVP 3040

  Fly  2403 ------------VSKVEI------------VP-------KESKPVF-----------------VA 2419
                        |..|::            ||       |..:|:.                 ..
Zfish  3041 PSIRHNSGDLPVVLNVQVGKSVMLECESNAVPPPVITWYKNGRPIAETANLRILADGQMLQLKET 3105

  Fly  2420 ELQD-------ASSIEG-----------FPVKMD-------IKVVGN-----------PKPKLQW 2448
            |:.|       |:::.|           .|.::|       ::.:.|           |.|.|.|
Zfish  3106 EVSDTGQYVCKATNVAGQVDKNFHLNIHVPPRLDGPAEERVVETISNPVTFACDATGIPPPSLTW 3170

  Fly  2449 FHNGHEIKPDAS---HIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKL--YVAP 2508
            ..||..|:...|   ||.     ...|.|.|.::...|||.|..:|.|.||.......|  :|.|
Zfish  3171 LKNGRVIENSESLEMHIL-----SGGSKLQISRSQLSDSGTYTCVASNVEGKAQKNYHLVIHVPP 3230

  Fly  2509 KADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTL--TPNERLLMTCDG 2571
               .....|.|..:|.|    .::..:||..|.  ..|.||:.|.|||:|:  |..:.:.::.||
Zfish  3231 ---NIIGSELPSEMSVL----LNDSVQLVCRAE--GTPTPEIQWLKDGMTISRTAQKNIKISPDG 3286

  Fly  2572 KHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFT---QKISDQQQVFGNNAK 2633
            .  .||:.....:|||.|||:..|..||:....|.|   ||.||:..   ....:...|..::..
Zfish  3287 S--TLTVTAVHTSDSGKYTCVATNQAGEEDRIFNLN---VYVPPLIQGNGPAAKELTTVLDSSIN 3346

  Fly  2634 IPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDIT 2698
            |....||.|.|.|.|.....|:|.|.:..:.:.|  .:|.:...:..|.|.|.|:||||.|.|..
Zfish  3347 IECVASGSPPPQLNWLKNGLPLPVSSQIRLLSAG--QVLRIARAQVSDGGSYTCVASNRAGVDNR 3409

  Fly  2699 QGRLDIVNEIKKHSRSEPPVFLKKIGDCD---IYEGMVAKFTACATGYPEPEVEWFKNDQKLFPS 2760
            ...|.:.          .|..|...|..:   :.:|..|.|...|.|.|.|.:.|.:....: ..
Zfish  3410 HYTLQVY----------VPPSLDGAGSTEEVTVVKGSTASFICIADGTPSPVIIWLRTGASV-SK 3463

  Fly  2761 DRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDFK 2825
            |..:..:..|..::  |.||.....|||:|...|..||...|..|              :..|..
Zfish  3464 DAHISLLNQNSTMQ--IVNVLVNHTGRYTCTAHNQAGDASRHFSL--------------KVLDPP 3512

  Fly  2826 KYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYPITYQIEMMDLPEGD-WRTLRTG--V 2887
            :...||.|..:|  .:::.:.:   ||.....:||.   .:|:..:...||:.: .|.||.|  :
Zfish  3513 RINGSGVPAEVS--VVVNHVLE---LLCEADGIPLP---TLTWLKDGRPLPQTENIRLLRDGQML 3569

  Fly  2888 RSCACDIRNLEPFR----------DYRFRVRVE------NKFGVSDPSPYTQ---TYRQKLVPDP 2933
            |..:..:.|...:.          |..|.|||.      ...||.|.|....   |...|....|
Zfish  3570 RVASAQVENTGRYTCLASSPAGDDDKEFLVRVHVPPNIAGDRGVQDVSVLQNRQVTLECKSDAVP 3634

  Fly  2934 PKTYTYLPP-----------------------------------GTDFRPETSPYFPKDFDIERP 2963
            |.|.|:|..                                   .::...||..:|....::...
Zfish  3635 PPTLTWLKDDAPLKMSPRVRVLSSGRYLQINNAVLGDGAQYSCVASNVAGETRRHFKLSVNVPPT 3699

  Fly  2964 PHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQ 3028
            ..||          .|.:|..: :....|...|.|.|.|::|:.....:: :|......:..:|.
Zfish  3700 IKDG----------PQSVSVHI-NQPVVLECVVNGVPAPRITWRKQGSIL-AGNNPRYKFGEDGS 3752

  Fly  3029 ATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGI 3093
            ..:...::  .|.|.|..:|||:.|..|:||.|::...|...:.|....:.......:..:..||
Zfish  3753 LRILSAQV--TDTGRYLCMATNQAGTERKRVDLQVYVPPSIAEGPTNITVTVNVQTTLSCEATGI 3815

  Fly  3094 PLPEVHWFKDWKPI-VDSSRIKISSYDPDIYVLSIHDSI------IKDGGLYSISARNIAGSIST 3151
            |.|.|.|.|:.:.: .|.::        ::|.|....|:      ::|..||.....|.||..|.
Zfish  3816 PKPSVSWTKNTQALNTDQNQ--------NMYRLLSSGSLVVIAPSVEDTALYECVVSNEAGQESR 3872

  Fly  3152 SV--TVHIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAA 3214
            ::  |||:..:                           |.||                     |.
Zfish  3873 AIQLTVHVPPS---------------------------IADE---------------------AT 3889

  Fly  3215 KIMYGRPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGE---LVRDNLLRRD 3276
            :::..|  |.|.::.       .....:..|...:..|.     :.||..||   ::....|.
Zfish  3890 ELVVSR--LSPVVIG-------CTASGVPHPVLYWSKDG-----LRLAKDGEGFTILPSGPLE-- 3938

  Fly  3277 YYTERDIAH-----YIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRH 3336
             .|..|::|     .:.:...|..|.      |:.||:.:       ..:|:.....|...:|.|
Zfish  3939 -ITAADLSHSGRYSCVAKNAAGTAHR------HVQLTVHE-------SPVIQSHPSTLDVILNNH 3989

  Fly  3337 -NLSTLDYGMPEFVSPEVV-NKEGVNFSHDMWTVGLITYVLLGGHN--PFLGIDDRETLTKIREG 3397
             .|.....|.|.   |.:. .|||:|    ::|.|       ||..  |..|:.    ::|.:
Zfish  3990 VTLPCRATGSPR---PTITWQKEGIN----IFTTG-------GGFTVLPNGGLQ----ISKAK-- 4034

  Fly  3398 RWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNY 3462
                       :.|.|        .|....:....|||                   |..:||
Zfish  4035 -----------VEDSG--------TYMCVAQNPAGTAL-------------------GKTKLR-- 4059

  Fly  3463 YDHFRDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKY 3527
                                           :..||  |.|.:          |||
Zfish  4060 -------------------------------VQVPP--VITSD----------IRA--------- 4072

  Fly  3528 LHPDYELGLIQSESHYQYGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRE 3592
                |.:.|..|.:          ||.....||             :||.:.:.........:|:
Zfish  4073 ----YTVALDVSVT----------LQCNSEGFP-------------TPSVSWHKDGQLLSESVRQ 4110

  Fly  3593 RRRFTDIMDEEIDDERTRSRISMYAANESYSIRRLRTELGPRLDEYTEADAMIETQREGYPPFFR 3657
            |...|..:...........|.:...||.:.|               :..|..:..|   .||..|
Zfish  4111 RVLSTGALQIAFAQPGDTGRYTCTVANVAGS---------------SSLDISLTVQ---IPPSIR 4157

  Fly  3658 EKPQTIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKISVDEDGRSILRFEPALHFDV 3722
            .....:::.||..:.:.|.|.|.|:|.:.|.|:|:.||:: ..:.::...|.  |..:.|...|.
Zfish  4158 VGESEVSVVENTQALLTCVADGVPQPTITWEKDDIPLTDT-TAEYTILPTGD--LLIDTAQPEDS 4219

  Fly  3723 GVYKVVARNKVGQTVARCRIVVATLPDAPD-SPEISANSGTEIL------------LRW------ 3768
            |.|..|..|.:||......:.:.|.|...: ..:::.|....:|            :.|
Zfish  4220 GSYTCVGTNSMGQDSRTISLSIHTHPAFTELLGDVALNKRERLLMVCGVTGIPPPKITWTFNNNI 4284

  Fly  3769 ---KQPRDDGHSTVLCYSLQYKLSNCDA--WTTVADN------------------IDHEFY--LL 3808
               :....:|||.::.    .::|..|:  :|.:|:|                  ||.:.:  .:
Zfish  4285 VPAQYDHYNGHSELVI----ERVSKDDSGTYTCMAENSVGSIKSLGFVYVKEPPIIDGDVHSNRI 4345

  Fly  3809 HDLQPNT--NYQFRLASKNRIGWSEMGIPVSASTVGGDAPKIHITKAMKHLQQLTENGHQVVPEE 3871
            ..|..|.  |.:.|......|.||:.||.|..|               ..::|| :||...:
Zfish  4346 EPLGGNAILNCEVRGDPLPTIQWSKKGINVQIS---------------NRIRQL-DNGSLAI--- 4391

  Fly  3872 ERVHTDYHCEREPPNWVTDSSVSDKYSFISEIARGEFSTIV---KGIQKSTDTVVVAKILEVTDE 3933
                                     |..:||.| |.:..:.   .|:.:.|.|:.:.:...:|.|
Zfish  4392 -------------------------YGTVSEDA-GNYMCVATNDAGVVERTVTLTLQRSPTITVE 4430

  Fly  3934 NEDNVV 3939
            ..:.||
Zfish  4431 PVETVV 4436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285	44/242 (18%)
		TonB_N	502..>596	CDD:318287	24/125 (19%)
		I-set	1017..1108	CDD:333254	23/90 (26%)
		I-set	1123..1212	CDD:254352	24/100 (24%)
		I-set	<1236..1299	CDD:333254	21/65 (32%)
		I-set	1313..1403	CDD:254352	27/97 (28%)
		Ig_3	1406..1487	CDD:316449	21/166 (13%)
		I-set	1499..1595	CDD:254352	30/105 (29%)
		I-set	1599..1690	CDD:333254	22/90 (24%)
		I-set	1694..1786	CDD:254352	22/94 (23%)
		I-set	<1836..1903	CDD:333254	20/66 (30%)
		I-set	1922..2005	CDD:333254	23/85 (27%)
		I-set	2018..2108	CDD:333254	26/103 (25%)
		I-set	2113..2214	CDD:333254	28/110 (25%)
		I-set	2220..2302	CDD:254352	27/87 (31%)
		I-set	2318..2408	CDD:254352	27/110 (25%)
		I-set	2415..2506	CDD:254352	30/148 (20%)
		I-set	2519..2608	CDD:254352	29/90 (32%)
		I-set	2615..2696	CDD:254352	23/83 (28%)
		I-set	2717..2805	CDD:254352	24/90 (27%)
		FN3	2834..2925	CDD:238020	23/112 (21%)
		I-set	<2996..3063	CDD:333254	18/66 (27%)
		I-set	3067..3157	CDD:333254	22/98 (22%)
		PK_Unc-89_rpt1	3182..3440	CDD:271011	47/269 (17%)
		I-set	3654..3744	CDD:333254	24/89 (27%)
		FN3	3748..3840	CDD:238020	24/137 (18%)
		STKc_Unc-89_rpt2	3893..4151	CDD:271014	12/50 (24%)
hmcn1	XP_005160777.1	VWA_2	36..206	CDD:290253
		IG_like	443..510	CDD:214653
		I-set	514..600	CDD:254352
		ig	522..596	CDD:278476
		I-set	604..688	CDD:254352
		Ig	618..689	CDD:299845
		I-set	694..781	CDD:254352
		IGc2	708..771	CDD:197706
		I-set	785..876	CDD:254352
		Ig	789..876	CDD:299845
		IG	888..969	CDD:214652
		IGc2	895..959	CDD:197706
		I-set	973..1060	CDD:254352	10/48 (21%)
		Ig	990..1059	CDD:299845	10/47 (21%)
		IG	1084..1162	CDD:214652	17/85 (20%)
		Ig	1092..1159	CDD:143165	14/67 (21%)
		I-set	1166..1251	CDD:254352	14/92 (15%)
		IGc2	1179..1241	CDD:197706	8/61 (13%)
		I-set	1251..1348	CDD:254352	22/112 (20%)
		Ig	1254..1348	CDD:299845	20/109 (18%)
		I-set	1360..1441	CDD:254352	16/104 (15%)
		IGc2	1367..1431	CDD:197706	13/87 (15%)
		I-set	1450..1535	CDD:254352	13/85 (15%)
		IGc2	1461..1525	CDD:197706	10/64 (16%)
		IG_like	1547..1628	CDD:214653	19/87 (22%)
		Ig	1558..1625	CDD:143165	17/73 (23%)
		I-set	1641..1722	CDD:254352	25/97 (26%)
		Ig	1641..1718	CDD:299845	25/93 (27%)
		Ig	1725..1817	CDD:299845	27/113 (24%)
		IG	1738..1815	CDD:214652	22/89 (25%)
		Ig	1818..1908	CDD:299845	25/95 (26%)
		IG	1826..1908	CDD:214652	25/87 (29%)
		IG	1922..2001	CDD:214652	26/87 (30%)
		Ig	1927..2001	CDD:299845	24/82 (29%)
		IG	2014..2093	CDD:214652	10/78 (13%)
		IGc2	2019..2083	CDD:197706	8/63 (13%)
		Ig	2096..2186	CDD:299845	10/89 (11%)
		IG_like	2107..2184	CDD:214653	8/76 (11%)
		Ig	2187..2280	CDD:299845	29/104 (28%)
		I-set	2197..2277	CDD:254352	25/82 (30%)
		Ig	2292..2371	CDD:299845	22/81 (27%)
		IG	2292..2369	CDD:214652	21/79 (27%)
		I-set	2373..2463	CDD:254352	22/94 (23%)
		IGc2	2391..2453	CDD:197706	17/66 (26%)
		IG	2476..2556	CDD:214652	25/94 (27%)
		IGc2	2484..2546	CDD:197706	19/65 (29%)
		IG	2572..2652	CDD:214652	25/93 (27%)
		IGc2	2583..2642	CDD:197706	22/72 (31%)
		I-set	2670..2751	CDD:254352	20/85 (24%)
		IGc2	2678..2741	CDD:197706	17/67 (25%)
		IG	2774..2850	CDD:214652	24/92 (26%)
		IGc2	2777..2840	CDD:197706	23/79 (29%)
		I-set	2864..2945	CDD:254352	25/83 (30%)
		Ig	2864..2938	CDD:299845	23/76 (30%)
		Ig	2949..3039	CDD:299845	27/103 (26%)
		IG_like	2957..3037	CDD:214653	26/93 (28%)
		I-set	3051..3132	CDD:254352	10/80 (13%)
		IGc2	3059..3122	CDD:197706	7/62 (11%)
		I-set	3154..3226	CDD:254352	22/76 (29%)
		Ig	3154..3223	CDD:143165	21/73 (29%)
		Ig	3229..3323	CDD:299845	33/107 (31%)
		I-set	3238..3321	CDD:254352	30/93 (32%)
		IG	3335..3415	CDD:214652	24/81 (30%)
		Ig	3343..3415	CDD:299845	23/73 (32%)
Ig	3418..3508	CDD:299845	25/106 (24%)
IG	3428..3508	CDD:214652	22/96 (23%)
IG	3520..3601	CDD:214652	18/88 (20%)
Ig	<3533..3603	CDD:299845	18/72 (25%)
I-set	3614..3694	CDD:254352	12/79 (15%)
IGc2	3620..3684	CDD:197706	7/63 (11%)
Ig	3697..3787	CDD:299845	23/103 (22%)
IG_like	3704..3785	CDD:214653	21/84 (25%)
Ig	3788..3878	CDD:299845	20/97 (21%)
I-set	3789..3878	CDD:254352	20/96 (21%)
IG_like	3891..3969	CDD:214653	17/100 (17%)
Ig	3899..3968	CDD:299845	13/89 (15%)
IG_like	3979..4060	CDD:214653	27/171 (16%)
Ig	3990..4052	CDD:299845	18/100 (18%)
I-set	4064..4150	CDD:254352	23/148 (16%)
IGc2	4080..4140	CDD:197706	13/82 (16%)
Ig	4161..4241	CDD:299845	22/82 (27%)
IG_like	4161..4241	CDD:214653	22/82 (27%)
I-set	4245..4324	CDD:254352	12/82 (15%)
IGc2	4260..4320	CDD:197706	10/63 (16%)
Ig	4352..4420	CDD:299845	21/112 (19%)
I-set	4425..4511	CDD:254352	4/12 (33%)
Ig	4439..4512	CDD:299845
TSP1	4518..4569	CDD:214559
TSP1	4583..4626	CDD:214559
TSP1	4631..4683	CDD:214559
TSP1	4688..4740	CDD:214559
TSP1	4745..4797	CDD:214559
TSP1	4802..4854	CDD:214559
nidG2	4855..5070	CDD:238158
EGF_CA	5091..5130	CDD:214542
EGF_CA	5131..5174	CDD:284955
EGF_CA	5176..5213	CDD:214542
EGF_CA	5214..5251	CDD:214542
EGF_CA	5256..5297	CDD:284955
EGF_CA	5299..5338	CDD:214542
EGF_CA	5420..5459	CDD:214542
EGF_CA	5460..5496	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25562
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810