DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and dapk1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_001093460.1 Gene:dapk1 / 558314 ZFINID:ZDB-GENE-060526-177 Length:1439 Species:Danio rerio


Alignment Length:1002 Identity:228/1002 - (22%)
Similarity:365/1002 - (36%) Gaps:268/1002 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  3179 QLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGRPE-------LRPFMLNELEMMNT 3236
            |...:|.|:||.|||.|...:......:|:|..||||.:..|..       .:..:..|:.::..
Zfish     6 QENVEDYYEIGGELGSGQFAVVKKCRHKSTGVEYAAKFIKKRRSKSSRRGVSKDDIEREVSILKE 70

  Fly  3237 FNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMG 3301
            ..|.|:|..:|.::....|.||:||.|||||. |.|..::..:|.:...:::|.|.|:.::|...
Zfish    71 IQHPNVITLHDVFENKHEVILILELVAGGELF-DFLAEKESLSEEEATEFLKQILDGVSYLHSKR 134

  Fly  3302 VGHMGLTIKDLLI--SVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHD 3364
            :.|..|..:::::  ..|....||:.||||:.||:..|.....:|.||||:|||||.|.:....|
Zfish   135 ISHFDLKPENIMLLNRNVPHPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYEPLGLEAD 199

  Fly  3365 MWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERM 3429
            ||::|:|||:||.|.:||||.:.:|||..:....::|.::.::|.|...:|||:|||:..|::||
Zfish   200 MWSIGVITYILLSGASPFLGENKQETLANVSAVDYEFDEDYFSHTSALAKDFIARLLIKDPKKRM 264

  Fly  3430 DVKTALKHPWFFMLD--RPVYDHDYQIGTDRLRNYYDHFRDW--------YANASCKNYFRRRRL 3484
            .:..:|:|||....|  :.:...:..:..::.:.:... |.|        ..|...:::..|..:
Zfish   265 TILDSLQHPWIKPKDTQQALSRKESAVNMEKFKKFAAR-RKWKQSVRLISLCNRLSRSFLSRSNM 328

  Fly  3485 SGC----------------------------------------FQHPSKMVYPP----------- 3498
            |..                                        ...|:|...||           
Zfish   329 SVARSDDTLDEEDSFVMKAIIHAINDDNVPGLKHLLGSLTSYDINQPNKHGTPPLLIAAGCGNVQ 393

  Fly  3499 -----------------------------GHVYTPENTPEPLPEPRIRAKREE----VVSKYLHP 3530
                                         |||.|.....|......|:.|..|    |.::|.:.
Zfish   394 IIDVLMKKGAEIQAFDKTGASAIYYAARHGHVGTLRFLHEKKCPLDIQDKSGETALHVAARYGNV 458

  Fly  3531 DYELGLIQSESHYQYGPDTYLLQLRDVNFPVRL---REYMKVA-------------HRRSPSFAL 3579
            |    ::|........||  ||. |:...|:..   ..|..||             :|...|..|
Zfish   459 D----VVQYLCSIHANPD--LLD-REQETPLHCAAWHGYSAVARALCEAGCDVNARNREGESPLL 516

  Fly  3580 NDSVDWSLPVIRERRRFTDIMD------EEIDDERTRSRISMYAANESYSIRRLRTELGP-RLDE 3637
            ..|.          |.|.||::      .::|.......|:::.|     :||.:.|:.. .|..
Zfish   517 TASA----------RGFKDIVECLLEHGADMDSADKDGHIALHLA-----VRRCQVEVVKCLLSH 566

  Fly  3638 YTEADAMIETQREGYPPFFREKPQTIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKI 3702
            :...|   ...|.|                |.|.||.|.....|           |:|:....|.
Zfish   567 HCYVD---HQDRHG----------------NTPLHIACKDANMP-----------VVTQLCAAKA 601

  Fly  3703 SVD---EDGRSILRFEPALHFDVGVYKVVARNKVGQTVAR--CRIVVATLPDAPDSPEISANSG- 3761
            ::|   :.||:      .||        :|.:..|..|.|  |      |..|  :.|...|.| 
Zfish   602 NLDIPNKFGRT------PLH--------LAASNGGLEVVRHLC------LSGA--NTEAITNDGK 644

  Fly  3762 -TEILLRWKQPRDDGHSTVLCYSLQYKLSNCDAWTTVADNIDHEFYLLHDLQPNTNYQFRLASKN 3825
             .|.|...:|..   |..||...|:            .||  |:...:..|:|....|.||..| 
Zfish   645 TAEDLATAEQQE---HVAVLLAKLK------------KDN--HKSIYIQQLRPTQTLQHRLKLK- 691

  Fly  3826 RIGWSEMGIPVSASTVGGDAPKIHITKAM--KHLQQLTEN-GHQVVPEEERVHTDYHCEREPPNW 3887
            ..|.|..|    .||: .::.|..|.::.  :...:||.. .|...|...:...........|..
Zfish   692 LFGHSGAG----KSTL-VESLKCGILRSFFRRRRTRLTNPVRHPASPVTSKPAVSVSISNLYPGC 751

  Fly  3888 VTDSSVSDKYSFISEIARG---EFSTIVKGIQKSTDTVVVAKILEVTDENEDNVVAEFDNFKTLR 3949
            ...|..|....|...:.:|   .||.:...:..:.||  ..|.:::.:.|.:.|    .:|....
Zfish   752 ENVSVRSRSMMFEPSLTKGVLEVFSPVHNALSTADDT--ATKAIDIQNANVNGV----GDFSIWE 810

  Fly  3950 HERIPALFSAYK--PLNVPIAIFVMEKLQGADVLTYFSSRHEYSEQMVATVVTQLLDALQYLHWR 4012
            ....|..:.:|.  ..|...||.          |..||....|..|:  ..||..|:.|:     
Zfish   811 FSGNPVYYCSYDYFAANDATAIH----------LVLFSLEEPYETQL--NQVTFWLNCLK----- 858

  Fly  4013 GYCHLNIQPDNVVM-ASVRS-IQVKLV 4037
               .|.:..||:.. ..:|: ::|.||
Zfish   859 ---ALTLPEDNIAFGGKIRNPLRVVLV 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011 92/266 (35%)
I-set 3654..3744 CDD:333254 19/94 (20%)
FN3 3748..3840 CDD:238020 23/93 (25%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014 32/152 (21%)
dapk1NP_001093460.1 STKc_DAPK1 7..275 CDD:271096 92/268 (34%)
S_TKc 13..275 CDD:214567 91/262 (35%)
Ank_2 <337..409 CDD:289560 4/71 (6%)
ANK 373..497 CDD:238125 25/130 (19%)
ANK repeat 378..409 CDD:293786 2/30 (7%)
Ank_4 379..432 CDD:290365 6/52 (12%)
ANK repeat 412..442 CDD:293786 6/29 (21%)
Ank_2 416..508 CDD:289560 21/98 (21%)
ANK 439..564 CDD:238125 30/146 (21%)
ANK repeat 444..475 CDD:293786 8/36 (22%)
ANK repeat 477..508 CDD:293786 4/30 (13%)
ANK 505..629 CDD:238125 36/182 (20%)
ANK repeat 510..541 CDD:293786 8/40 (20%)
Ank_4 513..564 CDD:290365 13/65 (20%)
ANK repeat 543..574 CDD:293786 7/38 (18%)
Ank_2 548..635 CDD:289560 29/143 (20%)
ANK repeat 576..607 CDD:293786 11/57 (19%)
ANK 604..>671 CDD:238125 24/105 (23%)
ANK repeat 609..638 CDD:293786 11/50 (22%)
Ank_4 610..662 CDD:290365 19/76 (25%)
Death_DAPK1 1310..1399 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.