DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and vwa10.2

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_685294.5	Gene:	vwa10.2 / 557188	ZFINID:	ZDB-GENE-090313-295	Length:	990	Species:	Danio rerio

Alignment Length:	843	Identity:	164/843 - (19%)
Similarity:	278/843 - (32%)	Gaps:	258/843 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   929 RDYDRGTSYDSTVERSQYGISSRRDRSSVDKVEARSSLLATGRTESR-------AASR---AESR 983
            ||:....:...|....|...||....|::..:...|::..|..:.:.       :|:|   .||.
Zfish    61 RDFTLPINNGLTSSAVQKACSSSASSSTLSSLSFYSAISMTYMSNAAIDGLFLLSAARHFDDESF 125

  Fly   984 AESR--ASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGL 1046
            :|.|  .:.:|:..:|..:..|.:.....|.::...:......|..||.|.:|.|.
Zfish   126 SEGRDLITSAVSSVKASAKQGSYISARITLGALCHTLQDFYSHSNWVELGNSAPFS--------- 181

  Fly  1047 VTWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASET----TTVSAQLA 1107
             |.:|...|| |.:||..|.|.          |.|:|.:. .|.:..::...|    :..|::..
Zfish   182 -TLIKPELPL-DNVADLSTPTC----------KACTEGNC-IYNLLPENKKLTSGYFSLYSSKKP 233

  Fly  1108 VGQAP--GHDETKTNTEPAFLVSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRI 1170
            .|:..  |..:..::.:|...::..|.......|           .|:..    :..|..|.|.:
Zfish   234 AGKCSHGGSADMTSSADPTGGINKDDIYSSHGFL-----------HPQAA----DLAIRATMDML 283

  Fly  1171 QIIR----DKDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQIL 1231
            :.||    .|.:     |.:..:.:|....:              .|.||       |::|..|
Zfish   284 EDIRMAIGSKPF-----LQLMGISQTSVLAF--------------VIDTT-------GSMSDDI- 321

  Fly  1232 PAGEKPVFQW--KRNGEEFDPEERFKVLFGEDEDSLALVFQHVKPEDAGIY----TCVAQTSTGN 1290
            .|.:...|..  .|.|...:|.|...|.| .|.|...|    .:.::|.|:    |.:.....|:
Zfish   322 EAAKSVSFSIIDSRRGTPQEPSEYILVPF-NDPDFGPL----TRTDNADIFKKRLTSLTAEGGGD 381

  Fly  1291 ISCSAELSVQGAIQTL-NREPEKPTLVIEHREANASIGGS---AILELQCKGFPKPAVQWKHDG- 1350
            .   .|:.:.|.:..| ...|.....|.....|..|..||   |::|.     .|..|.:...|
Zfish   382 F---PEMCLSGLLLALAGAPPSSDIFVFTDATAKDSELGSIVQAMIER-----TKSTVTFMLTGS 438

  Fly  1351 ----------EVIQVDDRHKF-----MYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESSIN 1400
                      :..|...|..|     :|.|...:|    ...|::....|:.....:..|.|:..
Zfish   439 FSYRRRRAVSQSQQFTSRSLFQSDIQLYRDLAHVS----GGQTIEVPKSTLSQATAVITDSSTSA 499

  Fly  1401 L-----VVKAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAESNVKIS-SSSI 1459
            |     ||::|...:..:.:..|:...:            ||.:|.:....|..|...:| |.|:
Zfish   500 LVTILQVVRSPAIAENFSIVLDSSLSNV------------TVYITGDSPFFTLYSPTGVSQSGSV 552

  Fly  1460 GKSLEKVVVEV---KEIKLS---QAGN----------YSIKATN-----------DLSQTSEYWS 1497
            ...|...::.|   |.||||   |.|.          ||:|.|.           :.||:|::
Zfish   553 ANGLLGSILTVGNLKRIKLSSENQKGEWRISINATSFYSLKVTAESSVNFLFNFVEQSQSSDF-- 615

  Fly  1498 CTVK-SKPVIVKNFE-----------------------SEYIHGEKENVQMT---VRIDAYPEAK 1535
             |.| ::|.|.:|..                       |..::|..:.|..|   |.||..||
Zfish   616 -TPKANRPFIGRNATLFVSVTGGDSVTVTDVLLVEASGSAVVNGTIKAVGTTDFLVNIDTIPE-- 677

  Fly  1536 LTW---------YHDETEIKITDSKYTVSSDGNAYTLKITGATRVD----------------AGK 1575
              |         ::|...:.....:......|:..|:|...::.::                .|.
Zfish   678 --WAFVVQLRGLFNDSLAVSRFQRQSPTQQQGSKLTIKAQPSSTIEPGIPLDLNFTLVNTATGGN 740

  Fly  1576 YTVKATNE---------------HGSATSSTQLLIKCAPEFTHKLKNITV-------AEGDSN 1616
            ||::|..:               .|||..:..|:   ||..|....::|:       |.||||
Zfish   741 YTIRARTDRNFNVSFPNSLIIGAEGSAQGTVTLI---APSGTDSGTDVTLTIEAEAPASGDSN 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254	21/94 (22%)
		I-set	1123..1212	CDD:254352	12/92 (13%)
		I-set	<1236..1299	CDD:333254	15/68 (22%)
		I-set	1313..1403	CDD:254352	21/113 (19%)
		Ig_3	1406..1487	CDD:316449	22/97 (23%)
		I-set	1499..1595	CDD:254352	27/162 (17%)
		I-set	1599..1690	CDD:333254	8/25 (32%)
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
vwa10.2	XP_685294.5	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900