DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and camk1a

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_021332939.1	Gene:	camk1a / 555945	ZFINID:	ZDB-GENE-131120-147	Length:	394	Species:	Danio rerio

Alignment Length:	359	Identity:	98/359 - (27%)
Similarity:	183/359 - (50%)	Gaps:	19/359 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  3176 RSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYA-----AKIMYGRPELRPFMLNELEMMN 3235
            :.|....::.||..:.||.|.....:.|.|:.:....|     .|.:.|:..   .:.||:.:::
Zfish    11 KKKTTDIKENYDFKEVLGTGAFSEVFLAEEKKTQRLVAIKCIPKKALEGKEN---SIENEIAVLH 72

  Fly  3236 TFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEM 3300
            ...|:|::...|.:::...:.|:|:|.:||||. |.::.:.:|||||.:..|||.|..::::|:|
Zfish    73 RIKHENIVSLEDIFESQSHLYLVMQLVSGGELF-DRIVEKGFYTERDASKLIRQILDAVKYLHDM 136

  Fly  3301 GVGHMGLTIKDLL-ISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHD 3364
            |:.|..|..::|| .|:.....|.:||||||:..:..::.:...|.|.:|:|||:.::..:.:.|
Zfish   137 GIVHRDLKPENLLYYSMEEDSNIMISDFGLSKIEDSGSVMSTACGTPGYVAPEVLAQKPYSKAVD 201

  Fly  3365 MWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERM 3429
            .|::|:|:|:||.|:.||...:|.:...:|.:..::|....|..|||..:||||.|:...|..|.
Zfish   202 CWSIGVISYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFISHLMEKDPSLRY 266

  Fly  3430 DVKTALKHPWF---FMLDRPVYDHDYQIGTDRLRNY-YDHFRDWYANASCKNYFRRRRLSGCFQH 3490
            ..:.||.|||.   ..||:.:::   .:.....:|: ...::..:...:...:.||.:||...:.
Zfish   267 TCEQALLHPWISGDTALDKNIHE---SVSAQIKKNFAKSKWKQAFNATAVVRHMRRLQLSTSLEG 328

  Fly  3491 PSKM--VYPPGHVYTPENTPEPLPEPRIRAKREE 3522
            ||::  ..|..|:..|....:...|.....:.||
Zfish   329 PSQITSTSPYRHLLLPAKELDQRDEEEEEEEEEE 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011	81/263 (31%)
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
camk1a	XP_021332939.1	STKc_CaMKI	17..276	CDD:270985	80/262 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910