DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and capslb

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_001017776.2 Gene:capslb / 550473 ZFINID:ZDB-GENE-050417-298 Length:209 Species:Danio rerio


Alignment Length:254 Identity:49/254 - (19%)
Similarity:87/254 - (34%) Gaps:71/254 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   949 SSRRDRSSVDKVEARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSSRLQEDRPLRS 1013
            :||.:|..:  :.|:..|...    |....|...:..||....:    .|:..:.|:.:|...|:
Zfish     4 TSRHNREMM--INAKKQLAEC----SDPIERLRLQCLSRGCAGI----KGLGRTFRIMDDDNNRT 58

  Fly  1014 VDKPVVVKMLK--SVQVEPGETAHFEIQF-KDQPGLVTWLKDNKPLEDRLADRITQT-AAPMNSY 1074
            :|....:|.|.  .|.:|..|..:...|| :|..|.:.:            |....| ..||::.
Zfish    59 LDLKEFIKGLNDYGVLMEKEEAINLFQQFDRDGSGQIDF------------DEFLITLRPPMSNA 111

  Fly  1075 RLDI-----KNCSETDAGTYTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDAEM 1134
            |.::     |...:|..|..|:......                :|..|   .|.:|    :.|.
Zfish   112 RKEVVLQAFKKLDKTGDGVITVEDLKGV----------------YDVRK---HPKYL----NGEW 153

  Fly  1135 IENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDKDYLGFYELVIADVQKTD 1193
            .|:.:||..:.....|..     ||.|           :..::::.:|..|.|.:. ||
Zfish   154 TEDQIFRKFLDSFDSPDD-----KDGK-----------VTKEEFMNYYSGVSASID-TD 195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254 18/99 (18%)
I-set 1123..1212 CDD:254352 15/71 (21%)
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
capslbNP_001017776.2 EF-hand_7 44..101 CDD:290234 14/68 (21%)
EFh 46..101 CDD:238008 14/66 (21%)
EFh 79..136 CDD:298682 14/68 (21%)
EF-hand_7 82..140 CDD:290234 13/85 (15%)
EF-hand_7 118..185 CDD:290234 16/105 (15%)
EFh 119..182 CDD:298682 16/101 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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