DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and kalrn

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_031748495.1 Gene:kalrn / 548783 XenbaseID:XB-GENE-1014006 Length:2062 Species:Xenopus tropicalis


Alignment Length:3020 Identity:534/3020 - (17%)
Similarity:910/3020 - (30%) Gaps:1197/3020 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1304 QTLNREPEKPTLVIEHREANASIGGSAILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEES 1368
            :.|.||.|:..:.||..                  |...::|..|. ..:||..:.:.:      
 Frog    20 EQLQREHEQFQMAIESL------------------FHASSLQKTHQ-SALQVQQKAEAL------ 59

  Fly  1369 MSLVIKNVDTVDAGVYTIEAINELGQDESS--INLVVKAPPKIK---------KITDITCSAGET 1422
                      :.||.|..:||.|..:..:.  ..|::|...::|         |.::..||..|:
 Frog    60 ----------LQAGHYDADAIRECAEKVAMHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLES 114

  Fly  1423 IKMEIEVEGFPQPTVQVTNNGKDVTAESNVKISSSS--------IGKSLEKVVVEVKEIKLSQAG 1479
            ::.|...:       :....|.|       |:..|:        |.|.||:     ||..|.   
 Frog   115 LEQEYRRD-------EDWCRGHD-------KLGPSTESDHVMPLISKHLEQ-----KEAFLK--- 157

  Fly  1480 NYSIKATNDLSQTSEYWSCTV--KSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLTWYHDE 1542
                             :||:  ::..|.:|     |||  :.||.|.   ...|..::    .|
 Frog   158 -----------------ACTLARRNAEVFLK-----YIH--RNNVSMP---GVAPHTRV----PE 191

  Fly  1543 TEIKITDSKYTVSSDG--NAYTLKITGATRVD---------------------AGKYTVKATNEH 1584
            .::|...|:.....:.  :.:|||   ..|:|                     ||::.:......
 Frog   192 QQVKAILSELLQRENRVLHFWTLK---KRRLDQCQQYIVFERSAKQALDWIQEAGEHYLSTRISP 253

  Fly  1585 GSATSSTQLLIKCAPEF------THKLKNITVAEGDSNVELVVGVDAYPRPHAKWYIDGIEIDEK 1643
            |.....||.|:|...||      |.:...:.:...||.||             |.::...|:.:.
 Frog   254 GECIEETQELLKEYEEFRIPAKQTKEKVRLLIQLADSFVE-------------KGHVHATELKKW 305

  Fly  1644 RNDF-RHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQE 1707
            .... :|..|   |.|.|        |.|.|.:....|                      :..::
 Frog   306 VTTVNKHYRE---FALRM--------GKYHCGLQRALG----------------------ICTED 337

  Fly  1708 GKSFTLEV--EVYSEPEAKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDA---GTY 1767
            .|...|::  .:.::||.|::  ..|||:.|:.| |.:|..:     ::...|.:||.|   ..:
 Frog   338 TKDLELDIVPAILTDPEVKLR--DAGHELNEEKR-KSARKKE-----FIMAELLQTEKAYVRDLH 394

  Fly  1768 EMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEI--VHVDVFQQHSYES 1830
            |...| ::.|.||            .:|:....  |...|....|.:.||  .|.::|.:...  
 Frog   395 ECMET-YLWEMTS------------GVEEIPPG--IVNKEHIIFGNIQEIYDFHNNIFLKELE-- 442

  Fly  1831 VPLKYEVIATGIPKPEAIWYHDGKPITPDK-HTAITVDGDHYKLEVQSLDLVDAGEYKVVVQNKV 1894
               |||.:...:......|        .|| |..:|...:  |.:...|.|..||.:...:|.:.
 Frog   443 ---KYEQLPEDVGHCFVTW--------ADKFHMYVTYCKN--KPDSSQLILEHAGSFFDEIQQRH 494

  Fly  1895 GEKSHQGELSLSG--------IAEYR---KPILT---QGPGLKDIKVNKGDKVCEPVVFTADPAP 1945
            |..:     |:|.        |.:|:   |.:||   :|.|    ::..|.:|...|...|:.|.
 Frog   495 GLAN-----SISSYLIKPVQRITKYQLLLKELLTCCEEGKG----EIKDGLEVMLSVPKRANDAM 550

  Fly  1946 EIVLLKDGQPVVETNNVKLKVD-----------KKDAENGLVQYTCTLNILEAEIKDS-GRYELK 1998
            .:.:|:.....::.....:..|           :|..:..|..:..:| :...||||| |..:..
 Frog   551 HVSMLEGFDENLDVQGELILQDSFQVWDPKSLIRKGRDRHLFLFEISL-VFSKEIKDSTGHTKYV 614

  Fly  1999 VKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTRGNENLCNHENC 2063
            .|||   |:|            |.|..|:.:.||. |..||          |:            
 Frog   615 FKNK---LLT------------SELGVTEHVEGDP-CKFAL----------WS------------ 641

  Fly  2064 EVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQPESQSIHDYR 2128
                            ..:|..|.|..:.|::                     ::.:.:.|.:.|
 Frog   642 ----------------GRTPSSDNKTVLKASS---------------------IEVKQEWIKNIR 669

  Fly  2129 PVSTKVLVHGVPLPTIEWFKD--DKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFREN 2191
            .|..:.::|         .|.  .:||  :....|.|.:..:|.|..:..|....    .|.:.:
 Frog   670 EVIQERMIH---------LKGALKEPI--QPPKTPAKQRNNSKRDVLEDADSQGD----GSSQPD 719

  Fly  2192 DVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLK 2256
            .:...:..:.|.:...|......:.::...|:...:|.|.:..|:              ||:.|:
 Frog   720 TISIASRTSQNTMDSDKLSGGCELTTVLQDFIALHNNELSIQVGQ--------------TVELLE 770

  Fly  2257 DGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIISNPHGEKVALCAVAVKPE-EMQPKF 2320
                 :||:.       .|...:......|...|   |:.|:      |||....:.. ||:..|
 Frog   771 -----RPSDR-------PGWCLVRTTDRSPPQEG---LVPSS------ALCISHSRSSVEMECFF 814

  Fly  2321 LKPITSQTVVVGEPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLD 2385
                                                             |:|:....:.||:   
 Frog   815 -------------------------------------------------PSGKDSFSVSAAE--- 827

  Fly  2386 AGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPK----- 2445
                      .||:.|.               ||.||..:|:.        .:..:|.||     
 Frog   828 ----------NGGKSES---------------VANLQPQASLN--------SIHSSPGPKRSTNT 859

  Fly  2446 -LQWFHNGHEIKPDASHIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPK 2509
             .:|.         .|.:..:.:....|::..:|...|.:          .||          |:
 Frog   860 LKKWL---------TSPVRRLNSGKGESNIKKQKKRDGRN----------LGS----------PR 895

  Fly  2510 A-DETATEEAPQFVSALR------DVNADEGQELVLSAP---FISNPMPE----VIWSKDGVTLT 2560
            | |||    .||..||..      |..||:.....|..|   |.::|.|:    ::..:......
 Frog   896 AGDET----TPQGDSADEKGKKGWDEEADDESHTPLPPPMKIFDNDPTPDDKSSLLVVRQSSAEV 956

  Fly  2561 PNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQ 2625
            |:...|:|.    |...::.....|.|:|           ..|.|.|                  
 Frog   957 PSAAELVTA----IENLVRNKMTIDGGSY-----------RGAQNIN------------------ 988

  Fly  2626 QVFGNNAKIPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIAS 2690
            :.|.|....|                 .|.|::.:                             .
 Frog   989 EGFVNEGLAP-----------------SPAPRNHE-----------------------------E 1007

  Fly  2691 NREGKDITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPE----PEVEWF 2751
            .::.|.: :||:.::||:.:..:.    :::.:|  .:.|..:.|..  ..|.||    .:...|
 Frog  1008 EQKAKAL-RGRMFVLNELVQTEKD----YVRDLG--FMVETYIPKME--ERGTPEDMNGKDKIVF 1063

  Fly  2752 KNDQKLFP--SDRFLID-----IEPNGLLRLTIKN--------------------VTEYDVGRYS 2789
            .|..:::.  .|.:|.:     :||..|.:|.||:                    |.|||.    
 Frog  1064 GNIHQIYDWHKDFYLAELEKCLLEPERLAQLFIKHERRLHMYVVYCQNKPRSEFVVAEYDA---- 1124

  Fly  2790 CRIFNPYGDDIC-HAELFYDSLDSQQKPLE--DQY----TDFKKYKKSGAPPPLSEGPIISRMTD 2847
                  |.:|:. .....:...|...||::  .:|    .||.||.:..                
 Frog  1125 ------YFEDLMQEVNPRFTVSDFLIKPIQRITKYQLLLKDFLKYSQKA---------------- 1167

  Fly  2848 RGLLLSWNPSVPLTPRYPITYQIEMMDLPEGDWRTLRTGVRSCACDIRNLEPFRDYRFRVRVENK 2912
             ||..|           .|...:|:|.|           |.....|:.||...:.:..::..:.|
 Frog  1168 -GLECS-----------EIEKAVELMCL-----------VPKRCNDMMNLGRLQGFEGKLTAQGK 1209

  Fly  2913 FGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQAPQFLLR 2977
                                                                   |.|...|.:.
 Frog  1210 -------------------------------------------------------LLQQDTFYVI 1219

  Fly  2978 EQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQAT------------ 3030
            ||:  .||:...           |.:..:.|:.::|.|      ...|.|.:|            
 Frog  1220 EQE--SGVQSRT-----------KERRVFLFEQIVIFS------ELLRKGSSTPGYMFKRGIKMN 1265

  Fly  3031 -LFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHP-RFLKRPDETFIMARKNGRIEAKLVGI 3093
             |.:.:.:|.|                          | :|..|..||                 
 Frog  1266 YLILEENIDND--------------------------PCKFAIRSRET----------------- 1287

  Fly  3094 PLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTVHIE 3158
                            |.|:.:.:.:.|     |..:.::|.|....:.|:...::.:.:....:
 Frog  1288 ----------------SERVILQAANAD-----IKQAWVQDIGQVLETQRDFLNALQSPIEYQRK 1331

  Fly  3159 ENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDE----LGRGTQGITYHAVERSSGDNYAAKIMYG 3219
            |:.........||.|   |..:|......:|.|    :....|.:....:..|:|.  |...||.
 Frog  1332 ESNAAMNKPQIGRGP---SPTVRPLSSTPVGCEKDVTIPVRNQSLPARKIPTSNGS--AGYEMYP 1391

  Fly  3220 RPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIA 3284
            |.|......:||...|..|               |:.::                :|||      
 Frog  1392 RAEKCDPNQSELSGCNGTN---------------SMVVV----------------QDYY------ 1419

  Fly  3285 HYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFV 3349
                                   .:|:..|.|..|:::::      ..||:.|:           
 Frog  1420 -----------------------ALKENEICVYHGELVQI------LAINQQNM----------- 1444

  Fly  3350 SPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGR 3414
                                .:.:.....|:|            ..|| | ....:..|||....
 Frog  1445 --------------------FLVFRPSNDHSP------------AAEG-W-IPGSVLGHISKPSA 1475

  Fly  3415 DFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKNYF 3479
            :...|          .:||:..  |..:..|.      :.||:             :|..||   
 Frog  1476 ENSDR----------SIKTSCS--WHTLRMRK------RDGTE-------------SNGPCK--- 1506

  Fly  3480 RRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKYLHPDYELGLIQSESHYQ 3544
            |:..|....:.|:.                         ..||.....|.|...:.::......:
 Frog  1507 RQEGLGSMAKDPNN-------------------------SSEESECDDLDPSASMEIMNPNFIQE 1546

  Fly  3545 YGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDERT 3609
            ..|: :|:.|.||                  ...|.|:|.                         
 Frog  1547 VAPE-FLVSLVDV------------------MCVLGDTVT------------------------- 1567

  Fly  3610 RSRISMYAANESYSIRRLRTELGPRLDEYTEADAMIETQREGYPPFFREKPQTIAITENQPSHIH 3674
                                                                           :.
 Frog  1568 ---------------------------------------------------------------LQ 1569

  Fly  3675 CFAVGDPKPCVQWFKNDMVLTE--SKRIKISVDEDGRSILRFEPALHFDVGVYKVVARNKVGQTV 3737
            |...|.|||.|.|...|..:.:  |....:|..|.|...|:....:..|.|:|..||.|::|.|.
 Frog  1570 CKVCGRPKPSVTWKGPDQSILDGNSNTYSMSTSESGDIKLKICHVMPQDSGIYTCVASNELGATS 1634

  Fly  3738 ARCRIVVATLPDAPDSPEISANSGTEILLRWKQPRDDGHSTVLCYSLQYKLSNCDAW-TTVADNI 3801
            ....|.|..:|.||..|.....|.|.::|||..|...|:.|:..|:::||......| .:||..:
 Frog  1635 TSATIKVQGVPGAPSQPLAQERSSTSVILRWLPPTSTGNCTISGYTVEYKEEGAQLWQQSVASTL 1699

  Fly  3802 DHEFYLLHDLQPNTNYQFRLASKNRIGW---SEMGIPVSASTVGGDAPKIHITKAMKHLQQLTEN 3863
            | .:.:|.||.|...||||:::.|..|.   ||...||.                          
 Frog  1700 D-TYLVLEDLCPGARYQFRVSASNPWGISLPSEPSEPVR-------------------------- 1737

  Fly  3864 GHQVVPEEERVHTDYHCEREPPNWVTDSSVSDKYSFISEIARGEFSTIVKGIQKSTDTVVVAKIL 3928
                :||     ||.:......:|  ..:....|:.:.||.||.||.:.|..:|.:...|.||.:
 Frog  1738 ----LPE-----TDTNSNGSTISW--KGNFEQVYTELHEIGRGRFSIVKKCAKKQSRKDVAAKFI 1791

  Fly  3929 EVTDENEDNVVAEFDNFKTLRHERIPALFSAYKPLNVPIAIFVMEKLQGADVLTYFSSRHEYSEQ 3993
            ....:..:....|....:.|:|.:...:...::  :....|.:::.::...:|.|.....|..|:
 Frog  1792 SKKLKKREQAAHEATLLQHLQHPQYITIHDTFE--SDGAYILILDLMEDGRLLDYLMKHDELMEE 1854

  Fly  3994 MVATVVTQLLDALQYLHWRGYCHLNIQPDNVVM-ASVRSIQVKLVDFGSAKKVNKLGMKVTPCGS 4057
            .||..:..:::||||||.....||:|:|:|::: ..:...:||::|...|.::..........|:
 Frog  1855 KVAFYMRDIMEALQYLHSCRVAHLDIKPENLLIDLRIPVPRVKIIDLEDAVQITGHHYIHQLLGN 1919

  Fly  4058 LDFQPPEMINDEPIFPQSDIWSLGALTYLLLSGCSPFRGADEYETKQNISFVRYRF-ENLFKEVT 4121
            .:|..||:|...|:...:||||||.|||::|||.|||......||..||..|.:.| :..|..|:
 Frog  1920 PEFAAPELIQGSPVSLGTDIWSLGVLTYVMLSGVSPFLDESSEETCANICRVDFSFPQEYFSGVS 1984

  Fly  4122 PEATRFIMLLFKRHPTKRPYTEDCLEHRWL 4151
            ..|..||....:..|..||....||:|.||
 Frog  1985 QAAQDFIKATLQGDPRWRPTIATCLQHPWL 2014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352 14/91 (15%)
Ig_3 1406..1487 CDD:316449 17/97 (18%)
I-set 1499..1595 CDD:254352 23/120 (19%)
I-set 1599..1690 CDD:333254 18/97 (19%)
I-set 1694..1786 CDD:254352 21/96 (22%)
I-set <1836..1903 CDD:333254 13/67 (19%)
I-set 1922..2005 CDD:333254 19/94 (20%)
I-set 2018..2108 CDD:333254 13/89 (15%)
I-set 2113..2214 CDD:333254 15/102 (15%)
I-set 2220..2302 CDD:254352 14/81 (17%)
I-set 2318..2408 CDD:254352 8/89 (9%)
I-set 2415..2506 CDD:254352 15/96 (16%)
I-set 2519..2608 CDD:254352 21/101 (21%)
I-set 2615..2696 CDD:254352 5/80 (6%)
I-set 2717..2805 CDD:254352 22/119 (18%)
FN3 2834..2925 CDD:238020 12/90 (13%)
I-set <2996..3063 CDD:333254 10/79 (13%)
I-set 3067..3157 CDD:333254 12/90 (13%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 36/261 (14%)
I-set 3654..3744 CDD:333254 22/91 (24%)
FN3 3748..3840 CDD:238020 33/95 (35%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014 75/259 (29%)
kalrnXP_031748495.1 SPEC 3..222 CDD:238103 55/292 (19%)
SPEC 228..316 CDD:197544 18/103 (17%)
RhoGEF 377..547 CDD:238091 44/208 (21%)
PH1_Kalirin_Trio_like 554..676 CDD:270060 32/197 (16%)
SH3_Kalirin_1 742..801 CDD:212786 16/93 (17%)
SH3-RhoG_link 799..1019 CDD:406906 62/417 (15%)
RhoGEF 1020..1189 CDD:395496 40/225 (18%)
PH2_Kalirin_Trio_p63RhoGEF 1194..1328 CDD:270061 31/271 (11%)
SH3_Kalirin_2 1411..1469 CDD:212787 16/153 (10%)
I-set 1549..1641 CDD:400151 30/198 (15%)
Ig strand A' 1557..1560 CDD:409353 2/20 (10%)
Ig strand B 1564..1573 CDD:409353 3/96 (3%)
Ig strand C 1578..1584 CDD:409353 3/5 (60%)
Ig strand C' 1587..1589 CDD:409353 0/1 (0%)
Ig strand D 1597..1602 CDD:409353 1/4 (25%)
Ig strand E 1605..1613 CDD:409353 2/7 (29%)
Ig strand F 1621..1628 CDD:409353 3/6 (50%)
Ig strand G 1631..1641 CDD:409353 3/9 (33%)
FN3 1645..1734 CDD:238020 31/89 (35%)
PKc_like 1766..2013 CDD:419665 73/248 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I10898
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.