DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and Camk1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_598687.1 Gene:Camk1 / 52163 MGIID:1098535 Length:374 Species:Mus musculus


Alignment Length:383 Identity:102/383 - (26%)
Similarity:170/383 - (44%) Gaps:78/383 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  3183 QDKYDIGDELGRG------------TQG------ITYHAVERSSGDNYAAKIMYGRPELRPFMLN 3229
            :|.||..|.||.|            ||.      |...|:|...|.                |.|
Mouse    17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGS----------------MEN 65

  Fly  3230 ELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGL 3294
            |:.:::...|.|::...|.|::...:.|||:|.:||||. |.::.:.:|||||.:..|.|.|..:
Mouse    66 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELF-DRIVEKGFYTERDASRLIFQVLDAV 129

  Fly  3295 EHMHEMGVGHMGLTIKDLLISVVGGDI-IKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEG 3358
            :::|::|:.|..|..::||...:..|. |.:||||||:..:..::.:...|.|.:|:|||:.::.
Mouse   130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKP 194

  Fly  3359 VNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLY 3423
            .:.:.|.|::|:|.|:||.|:.||...:|.:...:|.:..::|....|..|||..:|||..|:..
Mouse   195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEK 259

  Fly  3424 SPEERMDVKTALKHPWF---FMLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKNYFR----- 3480
            .||:|...:.||:|||.   ..||:.::           ::..:..:..:|.:..|..|.     
Mouse   260 DPEKRFTCEQALQHPWIAGDTALDKNIH-----------QSVSEQIKKNFAKSKWKQAFNATAVV 313

  Fly  3481 ---RRRLSGCFQHPSKMVYPPGHVYTP--------------------ENTPEPLPEPR 3515
               |:...|..|.........|.:.||                    |..|.|.|..|
Mouse   314 RHMRKLQLGTSQEGQGQTGSHGELLTPTAGGPAAGCCCRDCCVEPGSELPPAPPPSSR 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011 85/275 (31%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Camk1NP_598687.1 STKc_CaMKI_alpha 16..278 CDD:271069 86/277 (31%)
Autoinhibitory domain. /evidence=ECO:0000250 276..316 5/50 (10%)
Calmodulin-binding. /evidence=ECO:0000250 296..317 3/20 (15%)
Nuclear export signal. /evidence=ECO:0000250 315..321 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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