DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and CFP

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_001138724.1 Gene:CFP / 5199 HGNCID:8864 Length:469 Species:Homo sapiens


Alignment Length:237 Identity:48/237 - (20%)
Similarity:68/237 - (28%) Gaps:89/237 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   614 VESGQSSEIREEIVVTEESSLEGK--------QVVALEREP--------------SPCSIPKIQV 656
            |...:.|::|....|.......||        |:.|.|.:.              .|||      
Human    91 VTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS------ 149

  Fly   657 YRPVECENPVVTKHKPIELKDIVGYSESLRDGDTAP--AGGSPGRQQGYSANITD-----HASLT 714
               |.|.....|:.:..              ...||  .|..||:.|...|..|.     |.:..
Human   150 ---VTCSKGTRTRRRAC--------------NHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWA 197

  Fly   715 IWNNRLANIAGDRSGANQHLQQ-----SGPPPPPIPPNFTRMPGFFQPLPLIAYE----TTIEIL 770
            .|.......|....|.::..:.     |.|.|...||.        :|.|.:|||    |.:   
Human   198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPG--------KPCPGLAYEQRRCTGL--- 251

  Fly   771 IVKARPPSP---------PPPPPPTIKRVLVHTESLEQKTQN 803
                 ||.|         |..|.|....:   .:::||:|.|
Human   252 -----PPCPVAGGWGPWGPVSPCPVTCGL---GQTMEQRTCN 285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285 15/97 (15%)
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
CFPNP_001138724.1 TSP_1 81..132 CDD:306574 9/40 (23%)
TSP_1 140..184 CDD:306574 12/66 (18%)
TSP1 196..255 CDD:214559 16/74 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..238 5/26 (19%)
TSP_1 261..312 CDD:306574 7/28 (25%)
Interaction with Compliment C3 beta chain. /evidence=ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604 351..359
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.