DRSC/TRiP Functional Genomics Resources

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Protein Alignment Obsc and mylkb

DIOPT Version :10

Sequence 1:NP_001097440.1 Gene:Obsc / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_009300538.1 Gene:mylkb / 492576 ZFINID:ZDB-GENE-041111-150 Length:966 Species:Danio rerio


Alignment Length:1376 Identity:277/1376 - (20%)
Similarity:447/1376 - (32%) Gaps:478/1376 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2436 IKVVGNPKPKLQWFHNGHEIKPD----ASHIAIVENPDNSSSLIIEKTAP--GDSGLYEVIAQNP 2494
            :|....|||       |.|||..    ....:::...|.||...:..|.|  |.|....|:::. 
Zfish     8 LKPSSGPKP-------GSEIKTSTPAKVDFRSLLNKKDGSSKAPVATTPPSRGPSDFRSVLSKK- 64

  Fly  2495 EGSTASKAKLYVAPKADETATEEAPQFVSALRD--VNADEGQELVLSAPFISNPMPEVIWSKDGV 2557
              ..|...|   ..:.::.:|:.||:.....:.  ||...|..:...:....|            
Zfish    65 --QAAESVK---TEEKEQNSTKPAPKTPQKEKQSGVNGVNGGAVDKKSTLKEN------------ 112

  Fly  2558 TLTPNERLLMTCDGKHIGLTIK--PAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQK 2620
            |.|..|:.....|...||...|  |.:....|..|      ...|....|...:...|||||.|.
Zfish   113 TTTTTEKKDSKTDAGTIGKKEKSSPEKKTSDGQIT------ESNDKKVVNGGEKDAGKPPVFKQP 171

  Fly  2621 ISDQQQVFGNNAKIPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVY 2685
            :||...|.|...::...|:......:.|....|.:..|:...:.::|:...|.::.....|:|.|
Zfish   172 LSDITVVDGERLRLECQVTSDLQAAITWILDGKTVKPSKFIVLSHEGEKCSLTIDKALPEDEGRY 236

  Fly  2686 KCIASNREGK----------DITQGRLDIVN--------------EIKKH----SRSEPPVFLKK 2722
            .|.|.|..||          |.:....|..|              .|||.    .:..||.||..
Zfish   237 TCRAENAHGKAECSCVVTVDDPSDPSADKKNRKSSSATPTTENEARIKKKPAPTKQGSPPQFLHF 301

  Fly  2723 IGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFL-IDIEPNGLLRLTIKNVTEYDVG 2786
            .||..|..|...:......|.|.....|.|..:.:.|.:..: |:...|. .:|||....:...|
Zfish   302 PGDQKIRAGEKVELLGNFGGSPPITCTWLKFKKPIQPGNGGISIETTENS-SQLTIAASDQDHCG 365

  Fly  2787 RYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLL 2851
            .|:..:.|.:|  :..|.|....:|.                    |.|.:..|..|.:....|.
Zfish   366 CYTLELQNKFG--LKQASLNLTIVDK--------------------PDPPAGIPAASDIRRSSLT 408

  Fly  2852 LSWNPSVPLTPRYP-----ITYQIEMMDLPEGDWRTLRTGVRSCACDIRNLEPFRDYRFRVRVEN 2911
            |||     ..|.|.     .:|.:|:.:..:..|..| |...|.:..::||...|.|:||||..|
Zfish   409 LSW-----YGPTYDGGSIVQSYNLEIWNSVDNTWNDL-TSCNSTSFHVQNLLSDRQYKFRVRAVN 467

  Fly  2912 KFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQAPQFLL 2976
            .:||.:||                            .|:.|                        
Zfish   468 VYGVGEPS----------------------------AESGP------------------------ 480

  Fly  2977 REQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQATLFINKMLDRDV 3041
                                                ||.|..                       
Zfish   481 ------------------------------------IEVGAE----------------------- 486

  Fly  3042 GWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGIPLPEVHWFKDWKP 3106
                                |:.|     |:.:|                               
Zfish   487 --------------------EVTE-----KKEEE------------------------------- 495

  Fly  3107 IVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTVHIEENEDQYIYKTYGR 3171
                                                     .:..:|:...||.|.:|       
Zfish   496 -----------------------------------------EVGAAVSDDDEEKEPEY------- 512

  Fly  3172 HPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIM--YGRPELRPFMLNELEMM 3234
            ...|..|....:|.|||.|.||.|..|..:..||:||...:|.|.:  :.:.| :..:..|:.:|
Zfish   513 RDVVIKKDCSVKDFYDIEDRLGTGKFGQVFKLVEKSSKKVWAGKFIKAFSQKE-KENVRQEIGIM 576

  Fly  3235 NTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDY-YTERDIAHYIRQTLWGLEHMH 3298
            |:.:|..|::..||::....:.::||:.:||||. :.::..|: .|||::..|:.|.:.|::.:|
Zfish   577 NSLHHPKLVQCMDAFEGKSDMVMVMEMISGGELF-ERIVDEDFELTEREVIKYMLQIIDGVQFIH 640

  Fly  3299 EMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSH 3363
            :.|:.|:.|..::::.....|..||:.||||:|::.......:.:|.||||:|||:|.|.:::..
Zfish   641 KQGIVHLDLKPENIMCINKTGSKIKLIDFGLARRLEDSGSLKVLFGTPEFVAPEVINYEAISYPT 705

  Fly  3364 DMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEER 3428
            |||::|:|.|:|:.|.:||:|.:|.|||..:....|||:||.:..|||..:|||||||.      
Zfish   706 DMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFEDEAFDEISDQAKDFISRLLK------ 764

  Fly  3429 MDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKNYFRRRRLSGCFQHPSK 3493
                                                  :|..|..:|         :.||:|.  
Zfish   765 --------------------------------------KDMRARLTC---------AQCFEHS-- 780

  Fly  3494 MVYPPGHVYTPENTPEPLPEPRIRAKR--EEVVSKYLHPDYELGLIQSESHYQYGPDTYLLQLRD 3556
                    :..::|      ..:.||:  :|.:.||:                         || 
Zfish   781 --------WLKQDT------KNMEAKQLSKERMKKYI-------------------------LR- 805

  Fly  3557 VNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDERTRSRISMYAANES 3621
                   |.:.|..:                 .:|...||              |.:.|...   
Zfish   806 -------RRWQKTGN-----------------AVRAISRF--------------SSMGMLGG--- 829

  Fly  3622 YSIRRLRTELGPRLDEYTE----ADAMIETQREGY---PPFFREKPQTIAITENQPSHIHCFAVG 3679
                     :||:....||    |..:...:.|.:   .|.|....|.:.:.|...:...|...|
Zfish   830 ---------IGPKKSSPTEEEPPAPFLESVEDENHTPAAPSFASVIQDVEVVEGSAARFDCKIEG 885

  Fly  3680 DPKPCVQWFKNDMVLTESKRIKISVDEDGRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVV 3744
            .|.|.|.|:|:|..:.|::..:|..:|||...|........|...|...|.|.:|:......::|
Zfish   886 CPDPEVVWYKDDQPIKETRHFQIDYEEDGHCSLVISEVCPDDDAKYTCKAVNGLGEASCTAELMV 950

  Fly  3745 ATLPDAPDSPE 3755
            ..:.:.....|
Zfish   951 EFMQEEEGDAE 961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ObscNP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Not5 <477..>652 CDD:444384
Ig 1017..1108 CDD:472250
Ig strand B 1034..1038 CDD:409353
Ig strand C 1046..1050 CDD:409353
Ig strand E 1074..1078 CDD:409353
Ig strand F 1088..1093 CDD:409353
Ig strand G 1101..1104 CDD:409353
I-set 1123..1212 CDD:400151
Ig strand B 1140..1144 CDD:409353
Ig strand C 1153..1157 CDD:409353
Ig strand E 1182..1186 CDD:409353
Ig strand F 1196..1201 CDD:409353
Ig strand G 1209..1212 CDD:409353
Ig <1236..1299 CDD:472250
Ig strand C 1238..1242 CDD:409353
Ig strand E 1259..1269 CDD:409353
Ig strand F 1279..1284 CDD:409353
Ig strand G 1292..1295 CDD:409353
I-set 1313..1403 CDD:400151
Ig strand B 1330..1334 CDD:409353
Ig strand C 1343..1347 CDD:409353
Ig strand E 1369..1373 CDD:409353
Ig strand F 1383..1388 CDD:409353
Ig strand G 1396..1399 CDD:409353
Ig_3 1406..1487 CDD:464046
I-set 1499..1595 CDD:400151
Ig strand B 1522..1526 CDD:409353
Ig strand C 1535..1539 CDD:409353
Ig strand E 1561..1565 CDD:409353
Ig strand F 1575..1580 CDD:409353
Ig strand G 1588..1591 CDD:409353
Ig 1599..1690 CDD:472250
Ig strand B 1617..1621 CDD:409353
Ig strand C 1630..1634 CDD:409353
Ig strand E 1656..1660 CDD:409353
Ig strand F 1670..1675 CDD:409353
Ig strand G 1683..1686 CDD:409353
I-set 1694..1786 CDD:400151
Ig strand B 1711..1715 CDD:409353
Ig strand C 1724..1728 CDD:409353
Ig strand E 1752..1756 CDD:409353
Ig strand F 1766..1771 CDD:409353
Ig strand G 1779..1782 CDD:409353
Ig <1836..1903 CDD:472250
Ig strand C 1846..1850 CDD:409353
Ig strand E 1871..1875 CDD:409353
Ig strand F 1885..1890 CDD:409353
Ig 1922..2005 CDD:472250
Ig strand B 1933..1937 CDD:409353
Ig strand C 1946..1950 CDD:409353
Ig strand E 1971..1984 CDD:409353
Ig strand F 1994..1999 CDD:409353
Ig 2018..2108 CDD:472250
Ig strand B 2034..2038 CDD:409353
Ig strand C 2047..2051 CDD:409353
Ig strand E 2074..2078 CDD:409353
Ig strand F 2088..2093 CDD:409353
Ig strand G 2101..2104 CDD:409353
Ig 2113..2214 CDD:472250
Ig strand B 2130..2134 CDD:409353
Ig strand C 2143..2147 CDD:409353
Ig strand E 2176..2185 CDD:409353
Ig strand F 2195..2200 CDD:409353
I-set 2220..2302 CDD:400151
Ig strand B 2238..2242 CDD:409353
Ig strand C 2251..2255 CDD:409353
Ig strand E 2277..2281 CDD:409353
Ig strand F 2291..2296 CDD:409353
Ig strand G 2304..2307 CDD:409353
I-set 2318..2408 CDD:400151
Ig strand B 2335..2339 CDD:409353
Ig strand C 2348..2352 CDD:409353
Ig strand E 2374..2378 CDD:409353
Ig strand F 2388..2393 CDD:409353
Ig 2415..2506 CDD:472250 18/75 (24%)
Ig strand B 2432..2436 CDD:409353 277/1376 (20%)
Ig strand C 2445..2449 CDD:409353 0/3 (0%)
Ig strand E 2472..2476 CDD:409353 1/3 (33%)
Ig strand F 2486..2491 CDD:409353 1/4 (25%)
Ig strand G 2499..2502 CDD:409353 1/2 (50%)
I-set 2519..2608 CDD:400151 17/92 (18%)
Ig strand B 2536..2540 CDD:409353 0/3 (0%)
Ig strand C 2549..2553 CDD:409353 0/3 (0%)
Ig strand E 2574..2578 CDD:409353 2/3 (67%)
Ig strand F 2588..2593 CDD:409353 1/4 (25%)
I-set 2615..2696 CDD:400151 22/90 (24%)
Ig strand B 2632..2636 CDD:409353 0/3 (0%)
Ig strand C 2645..2649 CDD:409353 0/3 (0%)
Ig strand E 2670..2674 CDD:409353 1/3 (33%)
Ig strand F 2684..2689 CDD:409353 2/4 (50%)
Ig strand G 2697..2700 CDD:409353 0/2 (0%)
I-set 2717..2805 CDD:400151 22/88 (25%)
Ig strand B 2734..2738 CDD:409353 0/3 (0%)
Ig strand C 2747..2751 CDD:409353 0/3 (0%)
Ig strand E 2773..2777 CDD:409353 1/3 (33%)
Ig strand F 2787..2792 CDD:409353 1/4 (25%)
Ig strand G 2800..2803 CDD:409353 0/2 (0%)
FN3 2834..2925 CDD:238020 28/95 (29%)
Ig <2996..3063 CDD:472250 3/66 (5%)
Ig strand C 3003..3007 CDD:409353 0/3 (0%)
Ig strand E 3029..3033 CDD:409353 0/3 (0%)
Ig strand F 3043..3048 CDD:409353 0/4 (0%)
Ig strand G 3056..3059 CDD:409353 0/2 (0%)
Ig 3067..3157 CDD:472250 3/89 (3%)
Ig strand B 3085..3088 CDD:409353 0/2 (0%)
Ig strand C 3097..3101 CDD:409353 0/3 (0%)
Ig strand E 3123..3127 CDD:409353 0/3 (0%)
Ig strand F 3137..3142 CDD:409353 0/4 (0%)
Ig strand G 3150..3153 CDD:409353 0/2 (0%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 88/260 (34%)
Ig 3654..3744 CDD:472250 23/89 (26%)
Ig strand B 3671..3675 CDD:409353 0/3 (0%)
Ig strand C 3684..3688 CDD:409353 1/3 (33%)
Ig strand E 3710..3714 CDD:409353 1/3 (33%)
Ig strand F 3724..3729 CDD:409353 1/4 (25%)
Ig strand G 3737..3740 CDD:409353 0/2 (0%)
FN3 3748..3840 CDD:238020 1/8 (13%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014
mylkbXP_009300538.1 I-set 166..255 CDD:400151 22/88 (25%)
Ig strand B 183..187 CDD:409570 0/3 (0%)
Ig strand C 196..200 CDD:409570 0/3 (0%)
Ig strand E 218..225 CDD:409570 2/6 (33%)
Ig strand F 235..240 CDD:409570 2/4 (50%)
Ig strand G 248..251 CDD:409570 0/2 (0%)
Ig 295..394 CDD:472250 27/121 (22%)
Ig strand B 313..317 CDD:409353 0/3 (0%)
Ig strand C 326..330 CDD:409353 0/3 (0%)
Ig strand E 352..356 CDD:409353 1/3 (33%)
Ig strand F 366..371 CDD:409353 1/4 (25%)
Ig strand G 379..382 CDD:409353 1/2 (50%)
FN3 390..475 CDD:238020 27/90 (30%)
Protein Kinases, catalytic domain 524..782 CDD:473864 94/322 (29%)
Ig 866..950 CDD:472250 21/83 (25%)
Ig strand B 877..881 CDD:409353 0/3 (0%)
Ig strand C 890..894 CDD:409353 1/3 (33%)
Ig strand E 916..920 CDD:409353 1/3 (33%)
Ig strand F 930..935 CDD:409353 1/4 (25%)
Ig strand G 943..946 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

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