DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and Sspo

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001007017.1	Gene:	Sspo / 474348	RGDID:	1549716	Length:	5141	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	117/626 - (18%)
Similarity:	179/626 - (28%)	Gaps:	264/626 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  2435 DIKVVGNPKP----------KLQWFHNGHEIKPD----ASHIAIVENPDNSSSLIIEKTAPGDSG 2485
            ::.|.|.|.|          .|||       :.|    :..:.:|...|.|||:||.
  Rat   263 EVSVKGQPVPVGESQLLHGMSLQW-------QGDWLVLSGGLGVVVRLDRSSSIIIS-------- 312

  Fly  2486 LYEVIAQNPEGSTASKAKLYVAPKADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPMPEV 2550
                :.....|.|.....||.....|:        ||        :.|..|.:.|....|.
  Rat   313 ----VDHEFWGRTQGLCGLYNGRPEDD--------FV--------EPGGGLAMLAATFGNS---- 353

  Fly  2551 IWSKDGVT--LTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDS-SACNANVRKVY 2612
             |...|..  ......:...|:|...| |:...||.........|.:.|.||. |.|:..|
  Rat   354 -WRLPGYEPGCLDTVEVARGCEGLLEG-TLTGLEAGKLQAQAQDLCHQLLEDPFSQCHGQV---- 412

  Fly  2613 KPP-------VF------TQKISDQQQV------FGNNAKIPVTVSGVPYPDLEWY---FQDKPI 2655
             ||       :|      |.....::||      |.|.|:    .....:..:.|.   |.::..
  Rat   413 -PPDEYHETCLFAYCVGATAGSGPEEQVKAVCATFANYAQ----ACARQHIYVHWRKPGFCERLC 472

  Fly  2656 PKSEKYSIKNDGDHHMLIVNNC-------EKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSR 2713
            |..:.||.         .:::|       .:|::|  .|      ||:...|
  Rat   473 PGGQLYSD---------CISSCPPSCSAVAQGEEG--SC------GKECVSG------------- 507

  Fly  2714 SEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIK 2778
                        |:...|:......|.   |......:...|:..|.|              |:|
  Rat   508 ------------CECPTGLFWDGALCV---PAAHCPCYYRRQRYAPGD--------------TVK 543

  Fly  2779 ---NVTEYDVGRYSC----------------------RIFNPYGDDICHAELFYDSLDSQ----- 2813
               |......||:.|                      |.|:..|:..|...|..||:..|
  Rat   544 QQCNPCVCQDGRWHCAQAPCPAECAVGGDGHYCTFDGRSFSFRGNPGCQYSLVQDSVKGQLLVVL 608

  Fly  2814 -------------------QKPLEDQYTDFKKYKKSGA----------PPPLSEGPIISRMTDRG 2849
                               :..::.:|        |||          |...:||..:|..:...
  Rat   609 EHGACETGSCLHALSAFLGKTHIQLRY--------SGAVLVDGQDVDLPWIGAEGFNVSHASSTF 665

  Fly  2850 LLLSW----------NPSVPLT--PRYPITYQIE---------MMD---LPEGDWRTLRTGVRSC 2890
            |||.|          :|:|.:|  ||:  .||::         ..|   .|.||..|..|...|
  Rat   666 LLLRWPGAWVLWGVADPAVYITLDPRH--AYQVQGLCGTFTWKQQDDFLTPAGDIETSVTAFAS- 727

  Fly  2891 ACDIRNLEPFRDYRFRVRVENKFGVSDPSPYT--QTYRQKL 2929
                         :|:|..:.:..:.|.:|.:  .||.|:|
  Rat   728 -------------KFQVSGDGRCPLVDNTPLSSCSTYSQRL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352	18/84 (21%)
		I-set	2519..2608	CDD:254352	20/91 (22%)
		I-set	2615..2696	CDD:254352	18/109 (17%)
		I-set	2717..2805	CDD:254352	17/112 (15%)
		FN3	2834..2925	CDD:238020	25/116 (22%)
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Sspo	NP_001007017.1	VWD	192..341	CDD:214566	22/112 (20%)
		C8	393..468	CDD:285899	17/83 (20%)
		TIL	472..527	CDD:280072	14/99 (14%)
		VWD	556..716	CDD:214566	30/169 (18%)
		C8	769..826	CDD:285899
		TIL	830..883	CDD:280072
		VWD	1019..1168	CDD:278521
		C8	1206..1276	CDD:285899
		TIL	1280..1336	CDD:280072
		LDLa	1381..1416	CDD:238060
		LDLa	1421..1455	CDD:238060
		LDLa	1457..1491	CDD:238060
		LDLa	1497..1528	CDD:197566
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1533..1567
		Ldl_recept_a	1568..1604	CDD:278486
		TSP1	1702..1753	CDD:214559
		TSP1	1758..1812	CDD:214559
		TIL	1822..1873	CDD:280072
		TSP1	1917..1970	CDD:214559
		FA58C	2070..2226	CDD:214572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2087..2109
		FA58C	<2111..2225	CDD:238014
		LDLa	2236..2270	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2262..2335
		LDLa	2392..2426	CDD:238060
		LDLa	2449..2483	CDD:238060
		TSP1	2490..2538	CDD:214559
		TSP1	2543..2595	CDD:214559
		TIL	2618..2660	CDD:280072
		TSP1	2703..2752	CDD:214559
		TSP1	2760..2813	CDD:214559
		TSP_1	2819..2867	CDD:278517
		TIL	2871..2930	CDD:280072
		VWC_out	2932..2979	CDD:214565
		TSP1	2972..3023	CDD:214559
		TIL	3075..3127	CDD:280072
		TSP1	3240..3292	CDD:214559
		TIL	3300..3350	CDD:280072
		TSP1	3396..3439	CDD:214559
		TSP1	3460..3504	CDD:214559
		TIL	3514..3570	CDD:280072
		TSP1	3633..3677	CDD:214559
		TSP1	3810..3862	CDD:214559
		TSP1	3879..3927	CDD:214559
		TSP1	3945..3998	CDD:214559
		TSP1	4003..4055	CDD:214559
		TIL	4058..4113	CDD:280072
		TSP1	4158..4208	CDD:214559
		TSP1	4252..4303	CDD:214559
		TSP1	4367..4418	CDD:214559
		TIL	4422..4477	CDD:280072
		TSP1	4611..4659	CDD:214559
		TIL	4673..4719	CDD:280072
		TSP1	4763..4812	CDD:214559
		TIL	4814..4868	CDD:280072
		TIL	4920..4978	CDD:280072
		VWC	4980..5035	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900