DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and MYLK

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens


Alignment Length:2310 Identity:493/2310 - (21%)
Similarity:802/2310 - (34%) Gaps:694/2310 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1701 KNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDARIKIS---RDTQRIENYYLTLNLARTE 1762
            :|:.::||.:...|..|...||.::.|.::|..|....|..:.   |.|     :.|.::....|
Human    50 RNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGT-----FSLVIHAVHEE 109

  Fly  1763 DAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQ-TVTKTLIATTEEPEEGAVPEIVHVDVFQQH 1826
            |.|.|..:|||..|....|.::.|..|.|..|.| .|:|||......|.....|.|         
Human   110 DRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSI--------- 165

  Fly  1827 SYESVPLKY-----EVIA------------TGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLE 1874
             :...|.|:     .|:.            ||.|:|:..|.....|:.|....:::.......||
Human   166 -WGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 229

  Fly  1875 VQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGI---------------AEYRKP---ILTQGPG 1921
            :..::..|.|.|..:|.|..|:.|...|||:.|:               ::.||.   ::::...
Human   230 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESK 294

  Fly  1922 LKDIKVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILE 1986
            |..::.....|.|.        :|:    :.|.|....|:......:...|      :|      
Human   295 LDSLEAAAKSKNCS--------SPQ----RGGSPPWAANSQPQPPRESKLE------SC------ 335

  Fly  1987 AEIKDSGRY--ELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQANPKPKVS 2049
               |||.|.  :..|..|....:|.....|..:|...||....  |...   |....|.|:|...
Human   336 ---KDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLS--PSGE---ERKRPAPPRPATF 392

  Fly  2050 WTR----GNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLV 2110
            .||    |::::                       ||...:.:..:     ||:....|      
Human   393 PTRQPGLGSQDV-----------------------VSKAANRRIPM-----EGQRDSAF------ 423

  Fly  2111 EKPTFIVQPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKG 2175
              |.|..:|:||.:.:.:.|..:..|.|:|.|.:.||.:..|:.    .:.|..::|        
Human   424 --PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVR----RQEGSIEVY-------- 474

  Fly  2176 TDQIESVLDIKSFRENDVGAYTCVATNEIGVTKAPF-----KLAMLSLAPSFVKKLDNALDVLQG 2235
            .|.....|.:...|..|.|.|:|.|:|..|.....:     :||::.:||||...|.:.. |::|
Human   475 EDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCA-VIEG 538

  Fly  2236 EPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIISNPH 2300
            :..||:|.|.|:|:|.:.||.:|..::.:.    ||...|:.:|.|....|.|.|.|..:..|..
Human   539 QDFVLQCSVRGTPVPRITWLLNGQPIQYAR----STCEAGVAELHIQDALPEDHGTYTCLAENAL 599

  Fly  2301 GEKVALCAVAVKPEEMQ------------------PKFLKPITSQTVVVGEPLKLEAQVTGFPAP 2347
            |:  ..|:..|...|.:                  |.||:.::...|:.|..:.:..||:|.|.|
Human   600 GQ--VSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPP 662

  Fly  2348 EVKWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEI--EGVSKVEIVP 2410
            ||.|..:|..::.|.:.:| .....|..|.|....|.|.|.|.|...|..||:  :.|..|:...
Human   663 EVIWLHNGNEIQESEDFHF-EQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPH 726

  Fly  2411 KESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLI 2475
            ..::|.|:::.:..::..|..|.:...:.|:|.|.:.|..:|..:..|..|..:::|.| ..:|:
Human   727 DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNED-VFTLV 790

  Fly  2476 IEKTAPGDSGLYEVIAQNPEGSTASKAKLYV-------APKADETA------------------- 2514
            ::|..|..:|.||::.:|..|..:.:..|.:       .|:..|.|                   
Human   791 LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDR 855

  Fly  2515 -------------------------------------TEEA--PQFVSAL--RD----------V 2528
                                                 ||||  .|.|..|  ||          :
Human   856 YGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTL 920

  Fly  2529 NADEGQEL-VLSAPFISNPMPEV----------------------IWSKDGVTLTPNERLL---- 2566
            :.|:.:|: .....|.:|...:|                      :.:|.|.:.||....:    
Human   921 SEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPK 985

  Fly  2567 -MTCDGKHI--GLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQQVF 2628
             .|.|.:.:  |....|||...|...| |.|..:.......||......| ||...|.::..:..
Human   986 PATPDFRSVLGGKKKLPAENGSSSAET-LNAKAVESSKPLSNAQPSGPLK-PVGNAKPAETLKPM 1048

  Fly  2629 GNNAKIPVTVS--GVPYPDLEWYFQDKPIPKSE-KYSIKNDGDHHMLIVNNCEKGDQGVYKCIAS 2690
            | |||...|:.  |...||...    |...|.| |..:|||        .||::|..|...    
Human  1049 G-NAKPAETLKPMGNAKPDENL----KSASKEELKKDVKND--------VNCKRGHAGTTD---- 1096

  Fly  2691 NREGKDITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQ 2755
                           ||.:..|:...|.|.:|:.|..:.||.........:..|...:.|..|. 
Human  1097 ---------------NEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNG- 1145

  Fly  2756 KLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQ 2820
            |...:.:|:|..:...|..::|:.....|.|.|.|...|..|...|..::..|...:.:.....:
Human  1146 KTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1210

  Fly  2821 YTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYPITYQIEMMDLPEGD------ 2879
            ..  .:..||..||.|.        |:....:...|:....|:..:..||  :..||..      
Human  1211 MK--SRRPKSSLPPVLG--------TESDATVKKKPAPKTPPKAAMPPQI--IQFPEDQKVRAGE 1263

  Fly  2880 -----------------WRTLRTGVRS------------------------CACDIRNLEPFRDY 2903
                             |...|..::.                        |.|           
Human  1264 SVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGC----------- 1317

  Fly  2904 RFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGL 2968
             :.:.||||.| |..:....|...|  |||       |.||          |...||        
Human  1318 -YTLLVENKLG-SRQAQVNLTVVDK--PDP-------PAGT----------PCASDI-------- 1353

  Fly  2969 AQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQATLFI 3033
                             :..:..|.|:...|               .||...|||:         
Human  1354 -----------------RSSSLTLSWYGSSY---------------DGGSAVQSYS--------- 1377

  Fly  3034 NKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGIPLPEV 3098
                                       :||.:...                              
Human  1378 ---------------------------IEIWDSAN------------------------------ 1385

  Fly  3099 HWFKDWKPIVD--SSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTVHI---- 3157
               |.||.:..  |:...:....||      |:.      .:.:.|.|:.|:...|....:    
Human  1386 ---KTWKELATCRSTSFNVQDLLPD------HEY------KFRVRAINVYGTSEPSQESELTTVG 1435

  Fly  3158 ---------------EENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERS 3207
                           :|.|.:..|:|.    .:.::| :..|.|||.:.||.|..|..:..||:.
Human  1436 EKPEEPKDEVEVSDDDEKEPEVDYRTV----TINTEQ-KVSDFYDIEERLGSGKFGQVFRLVEKK 1495

  Fly  3208 SGDNYAAKIM--YGRPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRD 3270
            :...:|.|..  |...| :..:..|:.:||..:|..|::..||::...::.:::|:.:||||. :
Human  1496 TRKVWAGKFFKAYSAKE-KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELF-E 1558

  Fly  3271 NLLRRDY-YTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKI- 3333
            .::..|: .|||:...|:||...|:|::|:.|:.|:.|..::::.....|..||:.||||:|:: 
Human  1559 RIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLE 1623

  Fly  3334 NRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGR 3398
            |..:|..| :|.||||:|||:|.|.:.::.|||::|:|.|:|:.|.:||:|.:|.|||..:....
Human  1624 NAGSLKVL-FGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSAT 1687

  Fly  3399 WDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYY 3463
            |||.||.:..||||.:||||.||....:.|:|....|:||| .|.|....:.. ::..||:    
Human  1688 WDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW-LMKDTKNMEAK-KLSKDRM---- 1746

  Fly  3464 DHFRDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKYL 3528
                        |.|..||:    :|.....|...|                 |.....::|   
Human  1747 ------------KKYMARRK----WQKTGNAVRAIG-----------------RLSSMAMIS--- 1775

  Fly  3529 HPDYELGLIQSESHYQYGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRER 3593
                  ||...:|                             ...||:..||             
Human  1776 ------GLSGRKS-----------------------------STGSPTSPLN------------- 1792

  Fly  3594 RRFTDIMDEEIDDERTRSRISMYAANESYSIRRLRTELGPRLDEYTEADAMIETQREGYP---PF 3655
                   .|:::.|...|:                              |.:|...|..|   |:
Human  1793 -------AEKLESEEDVSQ------------------------------AFLEAVAEEKPHVKPY 1820

  Fly  3656 FREKPQTIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKISVDEDGRSILRFEPALHF 3720
            |.:..:.:.:.|...:...|...|.|.|.|.|||:|..:.||:..:|..||||...|........
Human  1821 FSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD 1885

  Fly  3721 DVGVYKVVARNKVGQTVARCRIVVATLPDAPDSPE 3755
            |...|...|.|.:|:......::|.|:.:.....|
Human  1886 DDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGE 1920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352 23/87 (26%)
I-set <1836..1903 CDD:333254 17/78 (22%)
I-set 1922..2005 CDD:333254 15/84 (18%)
I-set 2018..2108 CDD:333254 16/93 (17%)
I-set 2113..2214 CDD:333254 25/105 (24%)
I-set 2220..2302 CDD:254352 26/81 (32%)
I-set 2318..2408 CDD:254352 29/91 (32%)
I-set 2415..2506 CDD:254352 22/90 (24%)
I-set 2519..2608 CDD:254352 26/130 (20%)
I-set 2615..2696 CDD:254352 22/83 (27%)
I-set 2717..2805 CDD:254352 21/87 (24%)
FN3 2834..2925 CDD:238020 19/137 (14%)
I-set <2996..3063 CDD:333254 6/66 (9%)
I-set 3067..3157 CDD:333254 11/91 (12%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 95/261 (36%)
I-set 3654..3744 CDD:333254 25/89 (28%)
FN3 3748..3840 CDD:238020 1/8 (13%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014
MYLKXP_024309300.1 I-set 43..133 CDD:254352 23/87 (26%)
I-set 171..260 CDD:254352 20/88 (23%)
23ISL 261..422 CDD:318761 35/220 (16%)
I-set 424..514 CDD:254352 25/101 (25%)
I-set 524..610 CDD:254352 29/92 (32%)
I-set 633..722 CDD:254352 28/89 (31%)
I-set 731..819 CDD:254352 21/88 (24%)
I-set 1108..1197 CDD:254352 21/89 (24%)
Ig8_hMLCK_like 1248..1345 CDD:143239 19/120 (16%)
FN3 1341..1433 CDD:238020 30/229 (13%)
STKc_MLCK1 1471..1729 CDD:271093 96/261 (37%)
I-set 1819..1909 CDD:254352 25/89 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 76 1.000 Domainoid score I9029
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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