DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and sls

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001261304.1	Gene:	sls / 44013	FlyBaseID:	FBgn0086906	Length:	18468	Species:	Drosophila melanogaster

Alignment Length:	4914	Identity:	993/4914 - (20%)
Similarity:	1635/4914 - (33%)	Gaps:	1488/4914 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DEKQIHLSLKAPEANSFLPIDIKPHG-PEAHLTWFNEISSHINQDVTLQEHNADDLKVDA----- 401
            ||.:...:.:.....:...:.|:|.| |...|.....:..:|..:........::.:||.
  Fly   155 DEGEYTCTARNQYGEAICSVYIQPEGAPMPALQPIQNLEKNIYSNGYSYTSIEEEFRVDTFEYRL 219

  Fly   402 -------------SQIASESELILHLPQ-RAEAHDPNLSVRP--------SDVAENYFLSKETKE 444
                         |....:|:|...|.: :..|..|.:|.:|        ||......:....|.
  Fly   220 LREVSFREAITRRSGYEQDSQLSQELDRNQGPAQAPQISQKPRSSKLIEGSDAVFTARVGSNPKP 284

  Fly   445 RLQ--HEQQELLKLEQEAIELYKKQQSSKSVSSKT-----------ESVE--ITSSQVKSSSEVR 494
            ||.  |..|.|:..::..|. |....::..|.:.|           |:::  :.||.|.:.....
  Fly   285 RLTWFHNGQRLVASQKYEIS-YSSGVATLRVKNATARDGGHYTLLAENLQGCVVSSAVLAVEPAA 348

  Fly   495 KVVSPPPPPQAQVKEVTPVKVVSSPPP------PKEITPAKV------ATPPPQPQVVTSPVKEV 547
            :....|.|.....:::...|.:  ||.      .:|||..::      .|..|.|:|..
  Fly   349 ETAYEPKPVDVMAEQLEAGKAL--PPAFVKAFGDREITEGRMTRFDCRVTGNPYPEVFW------ 405

  Fly   548 APPPQPRAVASPAKEVTPSQSEPVKAPSPIKEVRKEVPPSASHSKEVEALVATEIRESLTETRST 612
                     ....::|....|..:.           |..|.|||     |:.|.:    |...:.
  Fly   406 ---------LINGRQVRDDASHKIL-----------VNESGSHS-----LMITNV----TRLDAG 441

  Fly   613 VVESGQSSEIREEIVVTEESSLEGKQVVALE----------REPSPCSIPKIQVYRPVECENPVV 667
            .|:....::..|..:..:.:.||.:||||.:          ||..|.::....:..|    .|.:
  Fly   442 AVQCLARNKAGEVAIEAQLNVLEKEQVVAPQFVQRFSTMTVREGEPITMSANAIGTP----QPRI 502

  Fly   668 TKHKP-IELKDIVGYSESLRDGDTA-----PAGGSPGRQQGYSANITDHASLTIWNNRLANIAGD 726
            |..|. :::.........:..|.|.     ......|..|..:.||....:    |.....:...
  Fly   503 TWQKDGVQISSTAERFVGIDGGATCLEIPRVTANDAGWYQCTAQNIAGSTA----NRARLYVEVP 563

  Fly   727 RSGANQHLQQSGPPPP-----PIPPNFTRMPGFFQPLPLIAYETTIEILIVKARPPSPP------ 780
            |...|...::...|.|     |.|     :||     |.|.|...:|    :|:|...|
  Fly   564 REQPNYEQRRLNLPRPTKVIEPEP-----IPG-----PEIIYLRHVE----RAKPHLRPGEEDRV 614

  Fly   781 -PPPPPTIKRVLVHTESLEQ------KTQNFFEGIYDAASSDTSLRNAKQKIRSIKST-VLK--- 834
             |||     :.::..::::|      ..:...|.:.|.........|.:....|.::| |.|
  Fly   615 YPPP-----QFIIPLQNVQQTEGGRVHMEARIEPVGDPTMVVEWYLNGRPLAASARATSVFKFGF 674

  Fly   835 ---------SKDSTNY---AQDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVN----IFELEGD 883
                     ..||..|   ..:....|::|..|     .|.:||..|...:..|    |.:|| |
  Fly   675 IALDLLSIMGHDSGEYMCRVTNASGVAESRAIL-----SVVQRPSIEQSSQNPNSLQYINQLE-D 733

  Fly   884 Y-----TESI------ADDFREPSAD-----------FEARGQSVGG----MDDYYSGYSRASTR 922
            |     ||||      |..|..|..|           |||:...|..    ::.|..|....::.
  Fly   734 YSRYQRTESIDEQLNQAPQFIRPLRDLGEFEEGKNVHFEAQVTPVNDPSMRVEWYKDGLPITASS 798

  Fly   923 RYET------------KTRDYDRGTSYDSTVERSQYGISSRRDRSSVDKVEARSSLLATGRTESR 975
            |...            ..|..|.||.....|.|                         .|...|:
  Fly   799 RITAIFNFGYVSLNILHLRAEDAGTYTVRAVNR-------------------------IGEAISQ 838

  Fly   976 AASRAESRAESRASYSVAESRAGIRSSSRL------QEDRPLRSVDKPVVVKMLKS-----VQVE 1029
            ::.|..||::..|...:.|.:..|.....|      |:.|.::...:.:.....|:     :.:.
  Fly   839 SSIRVHSRSQVTADLGIPEQQRYIEKVEELEDYRKSQQRRHVQEAAEAIAPPQFKTPIQNQLDLR 903

  Fly  1030 PGETAHFEIQFK---DQPGLVTWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTI 1091
            ....||||.:.:   |....|.||||.:|||  .:.||| |........|.||..:..||||||.
  Fly   904 EHAHAHFEARLEPVGDSTMRVEWLKDGQPLE--ASSRIT-TYHNFGYVALTIKQLTIYDAGTYTC 965

  Fly  1092 RAQSASETTTVSAQLAV---------GQAPG------------------HDETKTNTEPAFLVSL 1129
            ||.:|....|..|||.|         .|.||                  .:||.....|.||..|
  Fly   966 RAYNAMGQDTTVAQLTVISKNEIVSESQHPGGLQKIQHLEDSSRYGRREEEETYITQAPRFLGPL 1030

  Fly  1130 K-DAEMIENTLFRFMVKIIGDPKPR----VKFYKDEKEILETNDRIQIIRDKDYLGFYELVIADV 1189
            | ..:::|.....|..::  :|:..    :::|.:.:.|...| |||...|   .|:..|.|:.|
  Fly  1031 KGTTKILEGQRAHFEARV--EPQSDLGLVIEWYHNGRSITAAN-RIQTYYD---FGYVALDISQV 1089

  Fly  1190 QKTDAGTYSCKATNKHGEANCEA------------------------------------------ 1212
            :..|||.|...|.||.|||..:|
  Fly  1090 RAEDAGVYLVVARNKLGEAQQQATMIVETRSSIDTSSMHRGLYEKTQNLENKPFVEPQYDIEEIS 1154

  Fly  1213 -----IATTVEDKNPFG-----ALSGQILPAGEKPV-FQWKRNGEEFDPEERFKVLFGEDEDSLA 1266
                 ..|.:.|..|..     .|..::.|.|:..: .:|..||.......||:..:  |...:|
  Fly  1155 KSKPVFVTPLSDPKPIHDGKNIHLECRLEPMGDPTMRVEWFHNGRPVTVGSRFRTYY--DFGFVA 1217

  Fly  1267 LVFQHVKPEDAGIYTCVAQTSTGNISCSAELSV----QGAIQTLNREPEKPTLVIE------HRE 1321
            |........|:|.||..|....|....||.:.|    ....:|.|.:..:...::|      |:|
  Fly  1218 LDIIKATAADSGEYTVRATNHLGTAHTSACVRVIDHTDVVTETQNEQSLEQIQLLEDSRRRHHQE 1282

  Fly  1322 ANASI-----------------GGSAILE--LQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEE 1367
            .:.:|                 |.:..||  ||..|.|...::|..:|:.::...|.:..|| .:
  Fly  1283 EDITIMQAPQFTRGLHNIETIEGTNVHLECRLQPVGDPSMRIEWFVNGKPVKTGHRFRPAYE-FD 1346

  Fly  1368 SMSLVIKNVDTVDAGVYTIEAINELG--------------------QDESS-------------- 1398
            .::|.:.....:|:||||.:|.|:||                    |:||.
  Fly  1347 YVALDLLGCYAIDSGVYTCQARNQLGEAVTSCSVRIIAKNDLILETQNESGLQKIQYLEDSTRHR 1411

  Fly  1399 ----INLVVKAPPKI----KKITDITCSAGETIKMEIEVEGFPQPTVQVT--NNGKDVTAESNVK 1453
                ::.||...|:.    |.:|: |...|.. ..|.::|....|.::|.  .||:.:|
  Fly  1412 RSEFVDEVVNIRPRFLTHPKSLTN-TREGGHA-HFECKIEPVTDPNLKVEWFKNGRPIT------ 1468

  Fly  1454 ISSSSIGKSLEK------VVVEVKEIKLSQAGNYSIKATNDL--SQTSEYWSCTVKSKPVIVKNF 1510
                 :|.....      |.:::..:....:|.|:.:|.|.:  .:|.....|....:.|.|...
  Fly  1469 -----VGHRFRPIHDFGYVALDIVHLIAEDSGVYTCRAVNLIGSDETQVELQCRSGEQIVTVTQN 1528

  Fly  1511 ES--EYIHGEKENVQMTVR--ID---------------------------------AYPEAKLTW 1538
            |:  |.||..::..:.|.|  ||                                 :.|..::.|
  Fly  1529 EAGLEQIHYLEDRSRYTRREEIDESTKQAPVFTTSLKNVEIKENQRAHFECRLIPVSDPSMRVEW 1593

  Fly  1539 YHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKC------ 1597
            ||:...:| :.|::|.:::.....|.|......|||.||.:|.|..|.|.:|...::..
  Fly  1594 YHNNLPLK-SGSRFTETNNFGFVALDIMSTLPEDAGTYTCRAYNAVGEAITSAVAVVHTKKSIYL 1657

  Fly  1598 --------------------------------APEFTHKLKNITVAEGDS---NVELVVGVDAYP 1627
                                            ||.||..::::.|||..:   ...|:...|  |
  Fly  1658 ESQHETALPRLQHLEDGSKRQRISVQDEFVSQAPVFTMPVRDVRVAENQAVHFEARLIPVGD--P 1720

  Fly  1628 RPHAKWYIDGIEIDEKR-----NDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCV 1687
            :...:|..:|..|:...     :||.:|      .|.|..|.....|.|||:.:|:.|:...:..
  Fly  1721 KLTVEWLRNGQPIEASNRTTTMHDFGYV------ALNMKYVNPEDSGTYTCRAVNELGQAVTSAS 1779

  Fly  1688 VTVNCKPKVKRGLKNVEVQ--------------------------------------------EG 1708
            :.|..|..::     :|.|                                            ||
  Fly  1780 LIVQSKTSIQ-----LETQHEAAMHKIHQLEDHSRYQRREEEEYTVTTAPVFVTKLIGPSNLVEG 1839

  Fly  1709 KS--FTLEVEVYSEPEAKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTYEMKA 1771
            :|  :...:|.|.:|..|::||.:|..:....|.:.:.|........||:   ..||:|.|..:.
  Fly  1840 QSAHYECRIEPYPDPNLKVEWFHNGKPLSTGHRFRTTYDFGFAALDILTV---YAEDSGEYTCRV 1901

  Fly  1772 TNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVHVD---VFQQHSYES--- 1830
            ||.:||..:          ::.|..|...::|..|:..|  |:.:|.|::   .||:.:.|.
  Fly  1902 TNNLGEAIN----------SIVLNVTSRSSIIHETQHEE--ALTKIQHLEDTSRFQRKTDEEQFH 1954

  Fly  1831 --------------------VPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEV 1875
                                |.|:..:|....|..:..||.:|:||........|.|.....|::
  Fly  1955 AERPQFGRPLRNAKVNEGAPVHLEATLIPVNDPTMKVEWYCNGRPIQTGHRFKTTYDFGFVALDI 2019

  Fly  1876 QSLDLVDAGEYKVVVQNKVGEK--------SHQGELSLSGIAEYR----KPILTQGPGLKDIKVN 1928
            ......|.|.|....:|.:||.        :....|.|..:...|    :.:.|..|..|.:...
  Fly  2020 LYAHAEDTGTYMCKAKNAIGEAVTTCAVNVTANKTLDLDTLDAQRLEKIRQLETYAPPPKPVVEE 2084

  Fly  1929 KGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTC------------- 1980
            ||.|   |:..|  |...:..||:|    |..:::.:|:..:..|..:::.|
  Fly  2085 KGQK---PIFLT--PLSNLEHLKEG----EHAHLECRVEPINDPNLKIEWFCNGKQLPTGHRYRT 2140

  Fly  1981 -------TLNILEAEIKDSGRYELKVKNKYGELVTSGWIDVL----------------------- 2015
                   .|:||....:|:|.|..|..|:.||.|.:..:.||
  Fly  2141 THDFGYVALDILYVYGEDTGTYICKATNQLGEAVNTCNVRVLNRRSMILDTQHPDALEKIQKLES 2205

  Fly  2016 ----AKPEISGL------------NDTKCLPGDTICFEALVQA--NPKPKVSWTRGNENLCNHEN 2062
                |:.|:...            ..|:...|.|..|||.|..  :|..::.:....:.|
  Fly  2206 KVPNARTEVGDAPISPPHFTAELRGSTEIYEGQTAHFEAQVAPVHDPNLRIEFYHNGKPL----- 2265

  Fly  2063 CEVIADVDADKYRLVFQ--------SVSPCED-GKYTITATNSEGRAAVDFNLAVL--------- 2109
                  ..|.::.:.|.        :.:..|| |:|::.|.|:.|:|....||.|:
  Fly  2266 ------PSASRFHITFDFGYVSLDITHAVAEDAGEYSVRAVNALGQAVSSTNLRVIPRGTIISDT 2324

  Fly  2110 -----VEKPTFIVQPESQSIHD----------YRPVSTKVLVH-------------------GVP 2140
                 :||   |.:.||.:.|.          .|||.|:.|.:                   |.|
  Fly  2325 QHPEGLEK---IRKLESTAPHQRQEPETPGTRQRPVFTQPLQNIDRINEHQTAHFEARLIPVGDP 2386

  Fly  2141 LPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIE---SVLDIKSFRENDVGAYTCVATN 2202
            ...:||::::|.|                ||:.:.|.|.:   ..|||...|:.|.|.|.|.|.|
  Fly  2387 NLKVEWYRNEKII----------------EDSSRITKQHDFGFVSLDISHIRKEDEGVYMCRAVN 2435

  Fly  2203 EIG--VTKA---------------------------------PFKLAMLSLAPSFVKKLDNALDV 2232
            .:|  ||.|                                 |.:...|...|.|.:.|....::
  Fly  2436 PLGEAVTTASMRVVSEASIQMDTQHPDSISRIHQLEKPLAPRPTEPERLFEKPIFTQLLTGPSEL 2500

  Fly  2233 LQGEPLVLECCV--DGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLI 2295
            .:|.....|..|  .|.|....:|..:|.|::....:: :|:..|.|.|:|.:..|.|:|.|...
  Fly  2501 WEGTHAHFEARVVPVGDPSLKFEWFINGVELQMGSRLR-TTHDFGFVTLDITAVVPEDAGVYMCR 2564

  Fly  2296 ISNPHGEKVALCAVAVK-----------PEEMQ------------PKFLKPITSQTVVV------ 2331
            ..|..||.|:..|:.||           ||..:            |:.....|.|...|
  Fly  2565 AYNAAGEAVSSTAMKVKTKSNIDGQPLIPESWEAIRLKEAAMNRVPEMFVDSTPQQAPVFTTHLQ 2629

  Fly  2332 -------GEPLKLEAQV--TGFPAPEVKWYKDGMLLRPSPEI----NFINSPNGQIGLIIDAAQP 2383
                   |:.:.|||||  ...|...::|:|:|:.|.....|    :|     |.:.|.|:..:.
  Fly  2630 SYDKLHEGQHVLLEAQVEPRADPNLRIEWFKNGISLTTGSRIRSTFDF-----GLVTLSINGLRA 2689

  Fly  2384 LDAGVYKCLIANKGGEIEGVSKVEI-----------------------VPKESK----------P 2415
            .|:.:|.|...|:.||....|.::|                       .|||.:          |
  Fly  2690 DDSAIYTCKATNQVGEAVSTSSLKIEDRHWLQAESLHPDSLPRIGELEAPKEGRPEAPEPTYETP 2754

  Fly  2416 VFVAELQDASSIEGFPVKMDIKV--VGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLIIEK 2478
            ||:..|.:....|...|:.:..|  ..:|...::||:||..::..|...:|.:  ....:|.:..
  Fly  2755 VFITHLNNIECKESDNVRFECNVEPARDPTMSIEWFYNGQPLQAAAKFKSIYD--FGYCALDLTN 2817

  Fly  2479 TAPGDSGLYEVIAQNPEGSTASKAKLYVA-----------PKAD-------ETATEEAPQFVSAL 2525
            :...:||:|...|.|.:||..:...|...           |:.:       ||..|.|.::.|..
  Fly  2818 SYAENSGVYTCKATNSKGSATTSGTLKCTGGKTMFLDTQHPQGEAGLEAVQETEEELANRYTSKT 2882

  Fly  2526 -----------------RDVNADEGQELVLSAPFISNPMPEVI--WSKDGVTLTPNERLLMTCDG 2571
                             .:.:..|.|.:.|.|.......|.:.  |..:|..|....|..||.:.
  Fly  2883 TKPETQYPPPVWTKPLQAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKMLNHGSRFKMTSEF 2947

  Fly  2572 KHIGLTIKPAEAADSGNYTCLLANPLGEDSSA----CNA-------------------------N 2607
            ..:.:.:....|.|.|.|||...|..||..::    |::                         :
  Fly  2948 GFVTMDMIEVYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIESTQHPKGAEGLEQIQDLEDS 3012

  Fly  2608 VRK---------VYKPPVFTQK---ISDQQQVFGNNAKIPVTVSGVPYPD----LEWYFQDKPIP 2656
            :||         :..||.||.:   |:|    .|.........:.:|..|    :||::..|.:.
  Fly  3013 LRKDGSKPEQPDLGIPPRFTTEFVNIAD----IGEGELAHFEANLIPVGDQSMVIEWFYNGKVLE 3073

  Fly  2657 KSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEPPVFLK 2721
            .|.:...........|.|...:..|.|.|.|.|:|:.|.......|:.|::    .|.:.|.|..
  Fly  3074 ASHRVRTIYAFGTVALEVLGTKIEDTGTYTCRATNKHGTAEISCNLECVDK----PRGQKPRFTS 3134

  Fly  2722 KIGDCD-IYEGMVAKF--TACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEY 2783
            .|...: :.:|..|.|  |......|:.:|||:.|.:.:..|:| :..:...|.:.|.|..:.::
  Fly  3135 HIQPLEGLKDGQSAHFECTLIPVNDPDLKVEWYHNGKLMRHSNR-IKTVSDFGYVVLDISYLQDH 3198

  Fly  2784 DVGRYSCRIFNPYGDDICHAEL--------FYDSL--DSQQKPLEDQYTDFKKYKKSGAPPPLSE 2838
            |.|.|.||.:|.||:|.....|        |||||  ||.|:..|.:....::...|.  |.::|
  Fly  3199 DSGEYVCRAWNKYGEDFTRTTLNCGGRGGVFYDSLQPDSLQRIRELECPQGQQADTSA--PLVAE 3261

  Fly  2839 GP-IISRMTDRGLLLSWNPS------VPLT-PRYPITYQIEMMDLPEGD-WRTLRT-GVRSCACD 2893
            .| .|:::.|...|:....:      .|:| |...:.:......||.|. :||... |:  ...|
  Fly  3262 PPKFITQIVDVTKLVEGQSAHFEARLTPITDPDLVVEWYFNGKKLPHGHRFRTFHDFGI--VILD 3324

  Fly  2894 IRNLEPFRDYRFRVRVENKFG--VSDPSPYTQTYRQKLVPDPPKTYTYLPPGTD----------- 2945
            |..........:..|..||:|  |:..|....: :..|:.|     :.||.|.:
  Fly  3325 ILYCYEENSGVYEARARNKYGEDVTRASLKCAS-KSSLILD-----SQLPRGMEGGLEKIANLEY 3383

  Fly  2946 ----FRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNT--ELMWFVYGYPKPKM 3004
                .|.||:             .:...:||.|.:..::|....:..|.  |........||.|:
  Fly  3384 SMVRTREETT-------------EETKGKAPVFTVPLENIENLREGENAHFEARITPADDPKLKV 3435

  Fly  3005 TYYFDDMLIESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEA----------RQRV 3059
            .:|::...:::|.|| :::...|...|.|:.:...|.|.|...|.||:|||          ::.:
  Fly  3436 EWYWNGRPLKAGSRF-RTFCDFGFVILEISPVYPEDSGEYSCRAINEYGEAVTTATMKIQGKRSI 3499

  Fly  3060 RLE-------------IAE-------------------HPRFLKRPDETFIMARKNGRIEAKL-- 3090
            .:|             |||                   .|.|:..|.:..|........|.:|
  Fly  3500 IMESQLPKGMEGTIDRIAELEGLGSRSTEFVPDDDTGKPPEFITSPFDMVIGENALAHFECRLQP 3564

  Fly  3091 VGIPLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTV 3155
            :..|...|.||.:.|.:...||||..: |....:|.|.....:|.|||:..|.|..|..:.|..:
  Fly  3565 INDPSMRVDWFHNGKALWAGSRIKTIN-DFGFVILEIAGCYQRDSGLYTCKATNKHGEATVSCKL 3628

  Fly  3156 HIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGR 3220
            .::           ||...|...||        ......||:.:  ..:|.:         |:.|
  Fly  3629 QVK-----------GRQGIVMEPQL--------PSNFRTGTESL--QKLEET---------MHKR 3663

  Fly  3221 PELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGG--------ELVRDNLLRRDY 3277
            .||    :.|.|..|.......|:..            :::..||        |.|.|..:|.::
  Fly  3664 EEL----VTEDEQPNPPKFTEEIKDN------------LDVPEGGPIHFDCRVEPVGDPTMRIEW 3712

  Fly  3278 YTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFG-------------- 3328
            :                .:.|.|..|.....:.|.....:..|.|...|.|
  Fly  3713 F----------------YNGHVMATGSRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTAT 3761

  Fly  3329 LSRKI---NRHNL---STLDYGM-------------PEFVSPEVVNKEGVNFSHDMWTVGLITYV 3374
            .|.|:   .:||:   |.|..||             ||  :|:||.:.   |....:|..:.:
  Fly  3762 TSAKVTCKGKHNIVYESQLPEGMTSEKLKELERGRIPE--APKVVEEV---FGPPKFTTQITS-- 3819

  Fly  3375 LLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPW 3439
                    :.:|:.|.:.        |:.::                    |.:.|  .:|:..|
  Fly  3820 --------VTVDEAEAVR--------FECQV--------------------EPKTD--PSLRVEW 3846

  Fly  3440 FFMLDRPV-----YDHDYQIGTDRLRNYYDHFRD--WYANASCKNY--FRRRRLSGCFQHPSKMV 3495
             :...:|:     |.:.:.:|...|...|.:..|  .|...:..||  .|.|....|.:.|:
  Fly  3847 -YRNGKPLPSGHRYRNIFDMGFVSLDILYVYGEDSGEYVCRAINNYGEDRTRATVSCKKLPT--- 3907

  Fly  3496 YPPGHVYTPENTPEPLPEPRIRAKREEVVSKYLHPDYELGLIQSESHYQ----YGPDTYLLQLRD 3556
                 :......|..:.......:.|..:.||          .||.|..    :.||    :.:.
  Fly  3908 -----ILLQNQVPRGMKRSDALTQMEATIKKY----------TSEVHLTEDDLFDPD----RKQP 3953

  Fly  3557 VNFPVRLREYMKVAHRRSPSFAL--------NDSVDW---SLPVIRERRRFTDIMD--------- 3601
            ..|..:::|.:.:.......|..        |..|:|   ..|:: .:.||..|.|
  Fly  3954 PRFVTQIKEQLTLTEMAVTKFECQLAPVGDPNMKVEWFFNGKPLL-HKNRFQPIYDFGYVAMNFG 4017

  Fly  3602 ---EEIDDERTRSRISMYAANESYSIRRLRTELG-----------PRLDEYTEADAM-----IET 3647
               .|...|......::|..:|:.:|.::..:.|           ..:|...|.:|.     .|.
  Fly  4018 WVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDSQLPAHMQSIDRIREMEASWQVVPDEV 4082

  Fly  3648 QREGYP---PFFREK--PQTIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKISVDED 3707
            ..:..|   |.|..|  |||  :.|..|:.......|.|:|.|.|..|...:....|.|::  .|
  Fly  4083 DPDAKPRTKPVFVSKLEPQT--VEEGDPARFCVRVTGHPRPRVMWLINGHTVVHGSRYKLT--ND 4143

  Fly  3708 GRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVATLPD-----APDSP------EISA--- 3758
            |...|.......:|.|..:|:|||.||:::|...:.|....|     ..:||      |::|
  Fly  4144 GMFHLDVPKTRQYDTGKVEVIARNSVGESIATTELKVVARSDDYRNVLKNSPRPWYDYELAAYQK 4208

  Fly  3759 ----NSGTEILLRWKQPRDDGHSTVL-----CYSLQYKLSNCDAWTTVADNIDHEFYLLHDLQPN 3814
                |...::....||...:..|..|     ....|||....|....|......::|  :.||..
  Fly  4209 ERQENELEKVFDERKQVLSEQSSHTLKGVEHLKPKQYKPPTPDWQQNVKAKKSEDYY--NKLQTL 4271

  Fly  3815 TNYQFRLASKNRIGWSEMGIP----VSASTVGGDAPKIHITKAMKHLQQLTENGHQVVPEEERVH 3875
            ...|....:..|....:..||    ||:|...|.|            |...||      .:|:..
  Fly  4272 ETEQLLKETNLRRDTHQYAIPGEKVVSSSQAKGMA------------QSYEEN------LQEKTS 4318

  Fly  3876 TDYHCEREPPNWVTDSSVSDKYSFISEIARGEFSTIVKGIQKSTDTVVVAKILEVTDENEDNVVA 3940
            |. ..:..||..:...|.|..:.  .|:...:...:.|.||..         ||:|.:.......
  Fly  4319 TT-EVQAAPPKGIAQPSESSVHG--REVHMNKQQQVQKEIQGD---------LEITRKITATETT 4371

  Fly  3941 EFDNFKTLRHERIPALFSAYKPLNVPIAIFVMEKLQGADVLTYFSSRHE-------------YSE 3992
            |.::..|:: ||:  :....||...|:   ..:|:|...|.....::.|             |.|
  Fly  4372 EVEHKGTIQ-ERV--VQGPVKPAKAPV---FTKKIQPCRVFENEQAKFEVEFEGEPNPTVKWYRE 4430

  Fly  3993 QMVATVVTQLLDALQYLHWRGYCHLNIQ----PDNVVMASVRSIQVKLVDFGSAK-KVNKLGMKV 4052
                :...|....||...:.|...|.|:    .|:.|.:.|...:     .|:|| ..|.:..:.
  Fly  4431 ----SFPIQNSPDLQIHTFSGKSILIIRQVFVEDSAVFSCVAENR-----GGTAKCSANLVVEER 4486

  Fly  4053 TPCGSLDFQPPEMINDEPIFPQSDIWSLGALTYL--LLSGCSPFRGADEYETKQNISFVRYRFEN 4115
            ...|....|||..:..    .||...:.|.|...  .::|..|.   |.|..|..   ::.:...
  Fly  4487 RRAGKGGIQPPSFVTT----IQSTTVATGQLARFDAKVTGTRPL---DVYWLKNG---MKIQPSI 4541

  Fly  4116 LFKEVTPEATRFIMLLFKRHPTKRPYTED-----CL------EHRWLMSSDYMVR---KRERAIF 4166
            .||.:..::...::::       .|:.||     |:      |.|  ...|.:|:   |.|:...
  Fly  4542 KFKMLEEDSVHTLLII-------EPFAEDSGRYECVAVNAAGEAR--CDGDCIVQSPSKPEKPTT 4597

  Fly  4167 LGSRLKTFCDEYHDLKNASA-TSSKVL--NTVAGGPTPT 4202
            .||.......|  .||:.:. ..|||:  ..|.|.||||
  Fly  4598 PGSEKAPHIVE--QLKSQTVEEGSKVIFRCRVDGKPTPT 4634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134	8/45 (18%)
		Atrophin-1	<493..690	CDD:331285	38/219 (17%)
		TonB_N	502..>596	CDD:318287	18/105 (17%)
		I-set	1017..1108	CDD:333254	34/98 (35%)
		I-set	1123..1212	CDD:254352	29/93 (31%)
		I-set	<1236..1299	CDD:333254	16/63 (25%)
		I-set	1313..1403	CDD:254352	29/152 (19%)
		Ig_3	1406..1487	CDD:316449	17/92 (18%)
		I-set	1499..1595	CDD:254352	29/132 (22%)
		I-set	1599..1690	CDD:333254	24/98 (24%)
		I-set	1694..1786	CDD:254352	24/137 (18%)
		I-set	<1836..1903	CDD:333254	16/74 (22%)
		I-set	1922..2005	CDD:333254	22/102 (22%)
		I-set	2018..2108	CDD:333254	22/112 (20%)
		I-set	2113..2214	CDD:333254	34/167 (20%)
		I-set	2220..2302	CDD:254352	21/83 (25%)
		I-set	2318..2408	CDD:254352	27/108 (25%)
		I-set	2415..2506	CDD:254352	23/92 (25%)
		I-set	2519..2608	CDD:254352	22/136 (16%)
		I-set	2615..2696	CDD:254352	21/87 (24%)
		I-set	2717..2805	CDD:254352	26/90 (29%)
		FN3	2834..2925	CDD:238020	23/102 (23%)
		I-set	<2996..3063	CDD:333254	20/89 (22%)
		I-set	3067..3157	CDD:333254	26/91 (29%)
		PK_Unc-89_rpt1	3182..3440	CDD:271011	46/298 (15%)
		I-set	3654..3744	CDD:333254	28/91 (31%)
		FN3	3748..3840	CDD:238020	24/118 (20%)
		STKc_Unc-89_rpt2	3893..4151	CDD:271014	55/288 (19%)
sls	NP_001261304.1	I-set	87..174	CDD:254352	2/18 (11%)
		Ig	109..175	CDD:143165	2/19 (11%)
		Ig	254..334	CDD:299845	16/80 (20%)
		I-set	255..344	CDD:254352	19/89 (21%)
		I-set	372..462	CDD:254352	20/124 (16%)
		Ig	390..463	CDD:299845	16/107 (15%)
		Ig	471..561	CDD:299845	14/97 (14%)
		I-set	471..560	CDD:254352	14/96 (15%)
		I-set	618..709	CDD:254352	15/100 (15%)
		Ig	645..705	CDD:143165	10/59 (17%)
		DUF1136	715..741	CDD:284093	7/26 (27%)
		IG_like	762..843	CDD:214653	15/105 (14%)
		Ig	779..835	CDD:143165	10/80 (13%)
		I-set	890..982	CDD:254352	34/94 (36%)
		Ig	918..979	CDD:143165	26/63 (41%)
		DUF1136	988..1014	CDD:284093	3/25 (12%)
		I-set	1024..1116	CDD:254352	30/97 (31%)
		Ig	1058..1113	CDD:143165	21/58 (36%)
		I-set	1158..1250	CDD:254352	22/93 (24%)
		Ig	1178..1246	CDD:143165	17/69 (25%)
		DUF1136	1256..1282	CDD:284093	4/25 (16%)
		I-set	1291..1380	CDD:254352	22/89 (25%)
		IGc2	1304..1372	CDD:197706	20/68 (29%)
		DUF1136	1388..1414	CDD:284093	3/25 (12%)
		I-set	1424..1515	CDD:254352	19/103 (18%)
		Ig	1442..1513	CDD:143165	14/82 (17%)
		DUF1136	1522..1548	CDD:284093	7/25 (28%)
		I-set	1558..1645	CDD:254352	18/87 (21%)
		IGc2	1571..1639	CDD:197706	16/68 (24%)
		DUF1136	1655..1679	CDD:284093	0/23 (0%)
		I-set	1691..1782	CDD:254352	24/98 (24%)
		IGc2	1718..1772	CDD:197706	16/61 (26%)
		DUF1136	1788..1814	CDD:284093	2/30 (7%)
		I-set	1824..1916	CDD:254352	23/104 (22%)
		IGc2	1838..1906	CDD:197706	20/70 (29%)
		DUF1136	1922..1948	CDD:284093	8/27 (30%)
		I-set	1958..2049	CDD:254352	18/90 (20%)
		Ig	1985..2044	CDD:143165	15/58 (26%)
		I-set	2089..2181	CDD:254352	21/97 (22%)
		IGc2	2103..2171	CDD:197706	13/71 (18%)
		DUF1136	2187..2213	CDD:284093	1/25 (4%)
		I-set	2222..2314	CDD:254352	21/102 (21%)
		IGc2	2236..2304	CDD:197706	16/78 (21%)
		DUF1136	2320..2346	CDD:284093	6/28 (21%)
		I-set	2356..2448	CDD:254352	28/107 (26%)
		Ig	2384..2445	CDD:143165	23/76 (30%)
		DUF1136	2454..2480	CDD:284093	1/25 (4%)
		I-set	2488..2580	CDD:254352	25/92 (27%)
		Ig	2516..2576	CDD:143165	18/60 (30%)
		I-set	2622..2714	CDD:254352	24/96 (25%)
		IGc2	2636..2704	CDD:197706	20/72 (28%)
		I-set	2754..2844	CDD:254352	22/91 (24%)
		Ig	2771..2840	CDD:143165	17/70 (24%)
		IGc2	2908..2974	CDD:197706	17/65 (26%)
		I-set	3029..3120	CDD:254352	21/94 (22%)
		Ig	3057..3116	CDD:143165	14/58 (24%)
		I-set	3130..3220	CDD:254352	26/90 (29%)
		Ig	3148..3219	CDD:143165	22/71 (31%)
		I-set	3263..3354	CDD:254352	21/92 (23%)
		I-set	3401..3493	CDD:254352	24/92 (26%)
		Ig	3429..3490	CDD:143165	19/61 (31%)
		I-set	3539..3630	CDD:254352	26/91 (29%)
		Ig	3556..3625	CDD:143165	21/69 (30%)
		I-set	3676..3767	CDD:254352	17/118 (14%)
IGc2	3690..3758	CDD:197706	14/83 (17%)
I-set	3811..3900	CDD:254352	19/129 (15%)
Ig	3828..3899	CDD:143165	16/101 (16%)
I-set	3954..4046	CDD:254352	16/92 (17%)
Ig	3963..4042	CDD:299845	13/79 (16%)
I-set	4092..4180	CDD:254352	28/91 (31%)
Ig	4102..4172	CDD:299845	22/73 (30%)
I-set	4394..4483	CDD:254352	20/100 (20%)
Ig	4411..4480	CDD:143165	15/77 (19%)
I-set	4497..4581	CDD:254352	18/102 (18%)
Ig	4519..4580	CDD:143165	13/75 (17%)
I-set	4604..4693	CDD:254352	12/33 (36%)
Ig	4621..4691	CDD:299845	7/14 (50%)
I-set	4702..4792	CDD:254352
Ig	4702..4791	CDD:299845
COG4372	4996..>5260	CDD:226809
I-set	6536..6622	CDD:254352
Ig	6554..6622	CDD:143165
Ig	6654..6725	CDD:143165
I-set	6743..6829	CDD:254352
Ig	6760..6829	CDD:299845
I-set	6841..6928	CDD:254352
Ig	6858..6927	CDD:143165
I-set	6942..7033	CDD:254352
IGc2	6957..7023	CDD:197706
I-set	7066..7157	CDD:254352
Ig	7084..7153	CDD:143165
IGc2	7224..7289	CDD:197706
Ehrlichia_rpt	14571..15030	CDD:118064
SH3_p47phox_like	16753..16807	CDD:212790
I-set	16841..16931	CDD:254352
Ig	16858..16931	CDD:299845
I-set	16965..17060	CDD:254352
IGc2	16978..17050	CDD:197706
I-set	17068..17152	CDD:254352
Ig_2	17078..17152	CDD:290606
IG_like	17170..17253	CDD:214653
Ig	17180..17250	CDD:143165
I-set	17260..17342	CDD:254352
IGc2	17274..17331	CDD:197706
I-set	17347..17432	CDD:254352
IGc2	17367..17423	CDD:197706
I-set	17437..17521	CDD:254352
Ig	<17468..17521	CDD:299845
I-set	17528..17611	CDD:254352
Ig	17553..17602	CDD:143165
I-set	17618..17708	CDD:254352
Ig	17635..17708	CDD:299845
FN3	17712..17791	CDD:238020
I-set	17813..17898	CDD:254352
Ig	17830..17894	CDD:143165
Ig	17922..17994	CDD:299845
FN3	17998..18090	CDD:238020
FN3	18098..18189	CDD:238020
FN3	18207..18298	CDD:238020
FN3	18307..18398	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9426
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4026at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820