DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and MAG

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_002352.1 Gene:MAG / 4099 HGNCID:6783 Length:626 Species:Homo sapiens


Alignment Length:594 Identity:126/594 - (21%)
Similarity:225/594 - (37%) Gaps:126/594 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  2060 HENCE----VIADVDADKYRLVFQSVSPCEDGKYTITA--------TNSEGRAAVDFNLAVLVEK 2112
            ||:.:    ::.|:......|:..:|||...|||....        |.|| .:.:|     :|..
Human    82 HESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSE-HSVLD-----IVNT 140

  Fly  2113 PTFIVQPESQSIHDYRPVSTKVLVH-GVP------LPTIEWFKDDKPINYEAINKP---GKDKLY 2167
            |..:|.||..:       .|:|.|. .||      .|.:.|      :.:|.:.:|   |:    
Human   141 PNIVVPPEVVA-------GTEVEVSCMVPDNCPELRPELSW------LGHEGLGEPAVLGR---- 188

  Fly  2168 AKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNALDV 2232
            .:||  :||....|:|.....||.:.....|.|:......:.....:|....|..:.:::::::.
Human   189 LRED--EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEA 251

  Fly  2233 LQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIIS 2297
            ::|..:.|.|..|.:|.|.:.|::||..::  |::..|      :.||:....|.:.|.|..:..
Human   252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLR--EAVAES------LLLELEEVTPAEDGVYACLAE 308

  Fly  2298 NPHGE--KVALCAVAVKPEEMQPKFLKPITSQTVVV--GEPLKLEAQVTGFPAPEVKWYKDGMLL 2358
            |.:|:  :....:|...|       .||..:.|:|.  ||.:.:.......|.|.:..:|:..:|
Human   309 NAYGQDNRTVGLSVMYAP-------WKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366

  Fly  2359 RPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAELQD 2423
              |..|.     ..::.|.:.|..|.|.|.|.|:..|:.|:......:.:   |..||.:.|...
Human   367 --STVIY-----ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV---EFAPVLLLESHC 421

  Fly  2424 ASSIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLIIEKTAPGDS---- 2484
            |::.:  .|:....|..||:|.:.:......:..:.|....|.:..:...|....|..|.:    
Human   422 AAARD--TVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPP 484

  Fly  2485 -------GLY-----EVIAQ----------NPEGSTASKAKL-----YVAPKADETATEEAPQFV 2522
                   .||     |:..|          .|.|:..:.|.|     |:.....:....|:|.| 
Human   485 RVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSF- 548

  Fly  2523 SALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSG 2587
                  :|.:...::.|:.|..:..||...|:.  .|....|||        ||..:|.|...|.
Human   549 ------SAGDNPPVLFSSDFRISGAPEKYESER--RLGSERRLL--------GLRGEPPELDLSY 597

  Fly  2588 NYTCLLANP 2596
            :::.|...|
Human   598 SHSDLGKRP 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254 14/59 (24%)
I-set 2113..2214 CDD:333254 24/110 (22%)
I-set 2220..2302 CDD:254352 18/81 (22%)
I-set 2318..2408 CDD:254352 21/91 (23%)
I-set 2415..2506 CDD:254352 22/121 (18%)
I-set 2519..2608 CDD:254352 19/78 (24%)
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
MAGNP_002352.1 Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250|UniProtKB:P07722 20..325 60/275 (22%)
Ig_Siglec_N 22..139 CDD:143189 14/62 (23%)
Ganglioside GT1b binding. /evidence=ECO:0000250|UniProtKB:P20917 65..67
Ganglioside GT1b binding. /evidence=ECO:0000250|UniProtKB:P20917 124..128 0/3 (0%)
Ig 141..223 CDD:325142 24/100 (24%)
Ig_3 239..309 CDD:316449 17/77 (22%)
IG_like 333..409 CDD:214653 19/82 (23%)
Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250|UniProtKB:P20917 577..626 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..608 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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