DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and dscamb

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_009289749.1 Gene:dscamb / 386937 ZFINID:ZDB-GENE-031118-67 Length:2020 Species:Danio rerio


Alignment Length:1959 Identity:360/1959 - (18%)
Similarity:621/1959 - (31%) Gaps:679/1959 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1978 YTCTLNILEAEIKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQA 2042
            |.||......:|:..   :|.:|            .|..:|....:.|.:.:.|:|..|:.::.|
Zfish   100 YYCTAENPSGKIRSQ---DLHIK------------AVFREPYTVRVADQRVMRGNTAVFKCIIPA 149

  Fly  2043 N----------PKPKVSWTRGNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSE 2097
            :          .|..||...|:..|........|.||.::....:::..:     ::..|....:
Zfish   150 SVEEYVSVVSWEKDTVSLVSGSRYLITSTGALYILDVQSEDAVNIYRCTT-----RHRYTGETRQ 209

  Fly  2098 GRAAVDFNLAVLVEKPTFIVQPESQSIHDYRPV------STKVLV----------HGVPLPTIEW 2146
            ..:|     .:|:.:|.           |..||      ..:|:|          .|.|.|...|
Zfish   210 SNSA-----RLLLSEPV-----------DSAPVILDGFERKEVMVGHRVELPCKASGHPPPRYRW 258

  Fly  2147 FKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIG------ 2205
            .:|:.|:.        .|..|         .|..|.|.|::.|.:|.|:|.|...|..|      
Zfish   259 LRDNSPLE--------SDSRY---------HQSVSGLLIEATRPSDAGSYVCEVWNSFGNAKVVG 306

  Fly  2206 --VTKAPFKLAMLSLAPSFVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIK 2268
              |.|.|.| |::|     .:|:..::    |..:.|.|.|.||....:.|.::.:::....:::
Zfish   307 RLVVKQPLK-AVVS-----PRKVRGSV----GSQVSLFCSVTGSDEFDITWYRNAEKIYQGINVR 361

  Fly  2269 IS-TNPDGLVKLEINSCQPNDSGAYKLIISNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVG 2332
            |: .|.:.||   :.....:|.|||:....|  |:......|.|..|:..||.|...:.:.|...
Zfish   362 ITGINNENLV---MEGMAKSDGGAYQCFARN--GKMSTQDLVQVVLEDGTPKILSAFSEKVVSPN 421

  Fly  2333 EPLKLEAQVTGFPAPEVKWY--KDGMLLRPSPEINFINSPNGQI--GLIIDAAQPLDAGVYKCLI 2393
            ||:.|...|.|.|.|.|.|.  .|.::...:..::.|.:..|.:  .|.:...|..|.|||:|..
Zfish   422 EPISLVCHVKGTPLPTVTWTLDDDPVIKDSNHRMDRIITTEGHVLSYLNVSHTQVSDGGVYRCTC 486

  Fly  2394 ANKGGEIEGVSKVEIVPKESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPD 2458
            .|..|.:...:::.:    ..|..:..:::.::|.|....:..:::|.|...::|:.:.:.:..:
Zfish   487 NNSAGSVSYQARINV----RGPASIRPMKNVTAIAGRDTYIHCRIIGYPYYSIKWYKDSNLLPFN 547

  Fly  2459 ASHIAIVENPDNSSSLIIEKTAPGDSGLYE-VIAQNPEGSTASKAKLYVAPKADETATEEAPQFV 2522
            ....|.    :|:.:|.:......|.|.|. .:..:||........:          |.:.|..:
Zfish   548 HRQRAF----ENNGTLKLSNVQNSDEGEYTCYVLVDPEKQIHRSVHV----------TVKVPPLI 598

  Fly  2523 SALRDVNADEGQELVLSAPFISNPMP-EVIWSKDGVTLTPNERLLMTCDGKHI--GLTIKPAEAA 2584
            ......:|..||.:.:....||..:| .:.|.|||..:  |..|.:|.|....  .|.|......
Zfish   599 QHSDSQSASIGQRVFIPCVVISGDLPMSITWHKDGRPI--NASLGVTIDNIDFTSSLRISNLSEI 661

  Fly  2585 DSGNYTCLLANPLGEDSSACNANVRKVYK-PPVFTQKISDQQQVFGNNAKIPVTVSGVPYPDLEW 2648
            .:|:|||:..|    :::|...:::.:.| ||.|..:..||..::|.:..:..:..|.|.|.:.|
Zfish   662 HNGSYTCIARN----EAAAVEHSIQLIVKVPPHFEVQPKDQDGIYGKSVTLNCSAKGNPIPTIVW 722

  Fly  2649 -YFQDKPIPKSEKYSIKNDG------DHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRL---- 2702
             :.:...:|:.:..:: |.|      ::..|::.:..:.|.|.|.|..||..|.||::...    
Zfish   723 NHSKGAGVPQFQPIAL-NSGSRVQLLENGSLLIKHVLEEDAGFYLCKVSNDVGADISKSMYLTVK 786

  Fly  2703 --DIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPS-DRFL 2764
              .::......:|:|              :|.:.:.:..|.|....:|.|.|....:.|. .|::
Zfish   787 IPAMITSYPNTTRAE--------------QGHMTEMSCTAHGEKPIKVRWEKESHIINPDMSRYV 837

  Fly  2765 IDIEPNG---LLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDFKK 2826
            :.::..|   :..|.|.:....|.|.:||...|.||:|....:|..     |.:|          
Zfish   838 VTVKEVGDEVISTLQILHTVREDSGFFSCIAINSYGEDKGIIQLIV-----QDRP---------- 887

  Fly  2827 YKKSGAPPPLSEGPIISRMTDRGLLLSW----NPSVPLTPRYPITYQIEMMDLPEGDW----RTL 2883
                  .||..|   |..:.||.:.|.|    :.:.|:| .|.|.|:.:     ...|    .|.
Zfish   888 ------DPPEVE---IREVKDRTIALRWTMGFDGNSPIT-GYDINYKNK-----SASWASSQMTK 937

  Fly  2884 RTGVRSCACDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRP 2948
            ....:.....|..|.|...|..|:..:|:.|.|.||                  ..|...||   
Zfish   938 DVSPQLNQATIIELHPASTYNIRMFAKNQIGESRPS------------------NELTITTD--- 981

  Fly  2949 ETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLI 3013
                        |.|| ||   |||.:..|...|.|:|                           
Zfish   982 ------------EAPP-DG---APQDVQLEAISSQGIK--------------------------- 1003

  Fly  3014 ESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFI 3078
                                                                             
Zfish  1004 ----------------------------------------------------------------- 1003

  Fly  3079 MARKNGRIEAKLVGIPLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISAR 3143
                                   ..|||             |..::         ..||      
Zfish  1004 -----------------------VTWKP-------------PHKHL---------QNGL------ 1017

  Fly  3144 NIAGSISTSVTVHIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSS 3208
                                           :||.|:.|:       |.|.|             
Zfish  1018 -------------------------------IRSYQVCYR-------EFGTG------------- 1031

  Fly  3209 GDNYAAKIMYGRPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLL 3273
                      |.|:           .||.|          .||...:.         .|..|||.
Zfish  1032 ----------GSPQ-----------YNTIN----------VDTTGDIE---------TLTLDNLK 1056

  Fly  3274 RRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNL 3338
            :   ||:.::.         ::..:..|   ||.|.:::.|:                     .|
Zfish  1057 K---YTQYEVR---------VQAANRAG---MGPTSEEITIT---------------------TL 1085

  Fly  3339 STLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKD 3403
            ..:....||.|.......|.::.|........:..:|||                       ::.
Zfish  1086 EDVPSRPPENVVTTATTPETISLSWSALPKEALNGMLLG-----------------------YRV 1127

  Fly  3404 EIWTHISDDGRDFISRLLLYSPE---ERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDH 3465
            ..|.::.|.....|..:....|.   ||::..|                 :|.|.........|.
Zfish  1128 IFWANLPDGELGEIRNITTTKPSLELERLEKYT-----------------NYSIQVLAFTRAGDG 1175

  Fly  3466 FRDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKYLHP 3530
            .|                        |:.:|    ..|.|:.|.|....:..|....||.....|
Zfish  1176 VR------------------------SEQIY----TRTKEDVPGPPAGVKAAASTSSVVFVSWLP 1212

  Fly  3531 DYEL-GLIQSE------------SHYQYGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDS 3582
            .::| |:|:..            |.::..||.|..:|.:                      ||.:
Zfish  1213 PHKLNGIIRKYIVFCSNPYPTVISEFEAAPDVYFRRLTN----------------------LNQN 1255

  Fly  3583 VDWSLPVI----RERRRFTDIMDEEIDDERTRSRISMYAANESYSIRRLRTELGPRLDEYTEADA 3643
            ..:|:.|:    ..|...::|:..| ...:..:||..::...:                      
Zfish  1256 WQYSIWVVAVTAAGRGNTSEIITVE-PQAKAPARILTFSGTVT---------------------- 1297

  Fly  3644 MIETQREGYPPFFREKPQTIAITENQPSHIHCFAVGDPKPCVQWFKND-----MVLTESKRIKIS 3703
                     .|:.|:    |.:.        |.|||||.|.::|.|.:     .|..:.:|   |
Zfish  1298 ---------TPWMRD----IVLP--------CKAVGDPPPTIKWLKGNNGTPAPVSIDGRR---S 1338

  Fly  3704 VDEDGRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVATLPDAPDSPEISANSGTEILLRW 3768
            ...:|..::|...|  .|.|.|:.||.|..|.......:.|...||.| ...::..:.|.|.|.|
Zfish  1339 AHNNGSFVIRTVKA--EDSGYYRCVASNNWGSDEIMLNLQVQVPPDQP-RLTVTKTTTTSITLFW 1400

  Fly  3769 KQPRDDGHSTVLCYSLQYKLSNCDAWTTVADNIDHEFYLLHDLQPNTNYQFRLASKNRIGWSEMG 3833
             .|.|:|.|::..|.|||...|.:.|.:.:.:.....|.|.:|:..|.|:|.|.::|.:|...:.
Zfish  1401 -IPGDNGGSSIRGYILQYSEDNSEEWGSYSISPSERSYRLENLKCGTWYKFTLTAQNAVGPGRIS 1464

  Fly  3834 IPVSASTVG 3842
            ..:.|.|.|
Zfish  1465 EIIEAKTHG 1473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254 6/26 (23%)
I-set 2018..2108 CDD:333254 16/99 (16%)
I-set 2113..2214 CDD:333254 29/124 (23%)
I-set 2220..2302 CDD:254352 17/82 (21%)
I-set 2318..2408 CDD:254352 25/93 (27%)
I-set 2415..2506 CDD:254352 14/91 (15%)
I-set 2519..2608 CDD:254352 23/91 (25%)
I-set 2615..2696 CDD:254352 20/87 (23%)
I-set 2717..2805 CDD:254352 19/91 (21%)
FN3 2834..2925 CDD:238020 25/98 (26%)
I-set <2996..3063 CDD:333254 0/66 (0%)
I-set 3067..3157 CDD:333254 6/89 (7%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 38/260 (15%)
I-set 3654..3744 CDD:333254 25/94 (27%)
FN3 3748..3840 CDD:238020 27/91 (30%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014
dscambXP_009289749.1 I-set 132..198 CDD:254352 13/65 (20%)
I-set 225..310 CDD:254352 23/101 (23%)
IGc2 239..300 CDD:197706 18/77 (23%)
IG_like 320..400 CDD:214653 19/88 (22%)
IGc2 328..391 CDD:197706 16/67 (24%)
IG_like 417..501 CDD:214653 22/83 (27%)
Ig 424..498 CDD:143165 19/73 (26%)
IG_like 511..592 CDD:214653 13/94 (14%)
IGc2 518..576 CDD:197706 10/61 (16%)
I-set 595..685 CDD:254352 23/95 (24%)
Ig 612..682 CDD:143165 19/75 (25%)
I-set 689..785 CDD:254352 22/96 (23%)
Ig7_DSCAM 706..785 CDD:143211 17/79 (22%)
IG_like 795..883 CDD:214653 22/101 (22%)
Ig 803..890 CDD:299845 22/107 (21%)
FN3 887..980 CDD:238020 27/135 (20%)
FN3 987..1084 CDD:238020 39/369 (11%)
FN3 1092..1185 CDD:238020 21/160 (13%)
FN3 1190..1279 CDD:238020 20/110 (18%)
IGc2 1302..1367 CDD:197706 23/81 (28%)
FN3 1398..1471 CDD:238020 22/73 (30%)
FN3 1485..1557 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.