DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and triob

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_009290354.2 Gene:triob / 368847 ZFINID:ZDB-GENE-030616-399 Length:3023 Species:Danio rerio


Alignment Length:3117 Identity:565/3117 - (18%)
Similarity:955/3117 - (30%) Gaps:1225/3117 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   917 SRASTRRYETKTRDYDRGTSYDSTVERSQYGISSRRDRSSVDK-VEARSSLLATGRTESRAASRA 980
            :||..:|:|    |::.       |.::.|        ::.|| :||...|..||..:.....:|
Zfish   582 ARALQKRHE----DFEE-------VAQNTY--------TNADKLLEAAEQLAQTGECDPEEIYQA 627

  Fly   981 ESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPG 1045
            ..:.|.|           |:...|..|.|           |:|..:.|.      |....|:   
Zfish   628 AHQLEDR-----------IQDFVRRVEQR-----------KVLLDMSVA------FHTHSKE--- 661

  Fly  1046 LVTWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASETTTVSAQLAVGQ 1110
            |.|||::   |:..|.|.:  .|..:.:.:..||...:....|..:......|...:..||. ..
Zfish   662 LWTWLEE---LQKELLDDV--YAESVEAVQELIKRFGQQQQTTLQVTVNVIKEGEDLIQQLR-DS 720

  Fly  1111 APGHDETKTNTEPAFLVS----LKDAEMIENTLF-----------------RFMVKIIGDPKPRV 1154
            |...::|..|:..|.:.|    |.:|:.....||                 |..:.:|.|.:...
Zfish   721 AISSNKTPHNSSMAHIESVLQQLDEAQAQMEELFQERKIKLELFLQLRIFERDAIDVISDLESWN 785

  Fly  1155 KFYKDEKEILETND------RIQIIRDK----DYLGFY------ELV--IADVQKTDAGTYSCKA 1201
            :....:....:|.|      |:|...||    :.|.|:      ||:  :.:||.:..       
Zfish   786 EELSQQMNEFDTEDLTLAEQRLQHHADKALTMNNLTFHVIHQGQELLQYVTEVQASGV------- 843

  Fly  1202 TNKHGEANCEA---IATTVEDKNPFGALSGQILPAGE--------------------KPVFQWKR 1243
                 |..|:.   :||.|:|...|.....|.|.|..                    |.|..|.|
Zfish   844 -----ELLCDRDVDMATRVQDLLDFLHEKQQELDAAAEQHRRHLEQCVQLRHLQAEVKQVLGWIR 903

  Fly  1244 NGEEFDPEERFKVLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNR 1308
            |||                                     :..:.|.|:.|   |:|.|.| |.|
Zfish   904 NGE-------------------------------------SMLNAGLITAS---SLQEAEQ-LQR 927

  Fly  1309 EPEKPTLVIEHREANASIGGSAILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVI 1373
            |.|:    .:|                       |::..|. ..:||..:.:.:           
Zfish   928 EHEQ----FQH-----------------------AIEKTHQ-SALQVQQKAEAL----------- 953

  Fly  1374 KNVDTVDAGVYTIEAINELGQDESS--INLVVKAPPKIK---------KITDITCSAGETIKMEI 1427
                 :.|..|.::.|.:..:..:|  ..|::|...::|         |.::..||..|:::.|.
Zfish   954 -----LQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEY 1013

  Fly  1428 EVEGFPQPTVQVTNNGKDVTAESNVKISSSS--------IGKSLEKVVVEVKEIKLSQA-GNYSI 1483
            :.|       :....|.|       |:..:|        :.|.||:....:|...|::. .:..:
Zfish  1014 KRE-------EDWCGGTD-------KLGPNSESDHVTPMVSKHLEQKEAFLKACTLARRNADVFL 1064

  Fly  1484 KATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEK-------------ENVQMTVRIDAYPEAK 1535
            |..:..|.........||:....|||..:|.:..|.             :..|..|..:...:..
Zfish  1065 KYLHRNSVNMPGMLAHVKAPEQQVKNILNELLQRENRVLHFWTMRKRRLDQCQQYVVFERSAKQA 1129

  Fly  1536 LTWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPE 1600
            |.|.|                               |.|::.:......||....||.|:|...|
Zfish  1130 LEWIH-------------------------------DTGEFYLSTHTSTGSTIHHTQELLKEHEE 1163

  Fly  1601 FTHKLKNITVAEGDSNVELVVGV-DAY-PRPHA------KWYIDGIEIDEKRNDFRHVEEGNDFK 1657
            |     .||..:....|:|::.: |.: .:.||      ||.   ..:|::   :|      ||.
Zfish  1164 F-----QITAKQTKERVKLLIQLADGFCEKGHAHASEIQKWV---ASVDKR---YR------DFS 1211

  Fly  1658 LIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPE 1722
            |.|::..                          :|..|. .||.....:..|...|::...|.|.
Zfish  1212 LRMDKYR--------------------------SCLEKA-LGLSTDSNKASKDLQLDIIPASAPG 1249

  Fly  1723 AKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVL 1787
            |::|.....||:.|:.|    :..:|.|  ::...|.:||.|...:::          .|....|
Zfish  1250 AEVKLRDVNHELNEEKR----KSARRKE--FIMAELIQTEKAYVRDLR----------ECMDTYL 1298

  Fly  1788 TSEALSLEQTVTKTLIATTEEPEEGAVPEIV---HV------DVFQQHSYESVPL----KYEVIA 1839
            ...:..:|           |.|     |.||   |:      |:::.|  .::.|    |||.:.
Zfish  1299 WEMSSGVE-----------EIP-----PGIVNKEHIIFGNMQDLYEFH--HNIFLKELEKYEQLP 1345

  Fly  1840 TGIPKPEAIW---------YHDGKPITPDKHTAITVDGDHYKLEVQSLDLVDAGEYKVVVQNKVG 1895
            ..:......|         |...||                  :...|.|..||.|...:|.:  
Zfish  1346 EDVGHCFVTWADKFQMYVNYCKNKP------------------DSTQLILEHAGPYFDEIQQR-- 1390

  Fly  1896 EKSHQGELSLSG--------IAEYR---KPILT---QGPGLKDIKVNKGDKVCEPVVFTADPAPE 1946
               |:...|:|.        |.:|:   |.:||   :|.|    ::..|.:|...|...|:.|..
Zfish  1391 ---HRLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKG----EIKDGLEVMLSVPKRANDAMH 1448

  Fly  1947 IVLLKDGQPVVETNNVKLKVD-----------KKDAENGLVQYTCTLNILEAEIKDS-GRYELKV 1999
            :.:|:.....:|:....:..:           :|..|..|..:..:| |...::||| ||.:...
Zfish  1449 LSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSL-IFSKDVKDSNGRSKYLY 1512

  Fly  2000 KNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQANPKP------KVSWTRGNENLC 2058
            |:|   |:|            |.|..|:.:.||...|...|...|..      |.|.....::..
Zfish  1513 KSK---LMT------------SELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASCIENKQDWI 1562

  Fly  2059 NHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQPESQS 2123
            .|.. |||.:   ....|......|....|.|.|....:.|...|     |..:.....||::.|
Zfish  1563 KHVR-EVIQE---RTIHLRGALKEPIHIPKATATKHKGKRRDGED-----LDSQGDASSQPDTIS 1618

  Fly  2124 IHDYRPVST------------KVLVH------GVPL-----PTIEWFK--DDKP---INYEAINK 2160
            |......:|            .|::|      |..|     .|:|..:  .|||   :.......
Zfish  1619 IASRTSQNTLDSDKLSGGSELTVVIHDFMASNGAELTVRRGQTVELLERPQDKPDWCLVRTTDRS 1683

  Fly  2161 PGKDKLYAKE----DTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVT-------------- 2207
            |.::.|....    |..:.:.::|.:     |...|.   ..|::||.|::              
Zfish  1684 PAQEGLVPSAMLCIDHSRSSMEMEGI-----FNHKDT---LSVSSNEGGISGSATLQPSHLQSSP 1740

  Fly  2208 -------------KAPFKLAMLSLAPSFVKKL----------------------DNALDVLQGEP 2237
                         .:|.:......|...||||                      |::....|.|.
Zfish  1741 GPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSRDVRKNADGGSQKDSDDSAATPQDET 1805

  Fly  2238 LV--------------------LECC--------VDGSPLPTVQWL-------KDGDEVK----- 2262
            :.                    ::.|        .|..|||....:       :|..|.|     
Zfish  1806 IEERMRNEGLSSGTLSKSSSSGMQSCGEEEGEEGPDSVPLPPPMAIQQHSLLHQDSQEDKAARLS 1870

  Fly  2263 --PSES-----IKISTNPDGLVKLEIN------------------SCQPNDSGAYKLIISNPHGE 2302
              ||.|     .::.:..:.|||.::|                  ||.|:|:..  |..|:|..|
Zfish  1871 GRPSSSETPSAAELVSAIEELVKSKMNLEDRPSSLPVEHRDSTSPSCNPSDNSL--LSSSSPIDE 1933

  Fly  2303 KVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLE--------AQVTGFPA-------PE---- 2348
            .          :|.:..|||   .:..|:.|.::.|        |.|.|:.:       |:    
Zfish  1934 M----------DERKTGFLK---RRHYVLLELVETERDYVRDLGAVVEGYMSRMKEEGVPDDMKG 1985

  Fly  2349 ------------VKWYKDGML-----------------LRPSPEINFI-----NSPNGQ------ 2373
                        ..|:||..|                 :|....::..     |.|..:      
Zfish  1986 KDKIVFGNIHQIFDWHKDFFLAELEKCLEDPDRLAPLFVRQERRLHMYIVYCQNKPKSEHIVSEY 2050

  Fly  2374 -----------IG-------LIIDAAQPLDAGVYKCLI------ANKGG----EIE-GVSKVEIV 2409
                       :|       |:|...|.:..  |:.|:      ..|.|    ::| .|..:.:|
Zfish  2051 IDTYFEDLKQRLGHRLQITDLLIKPVQRIMK--YQLLLKDLLKFTKKAGLDTVDLEKAVEVMCVV 2113

  Fly  2410 PKESKPVFVAELQDASSIEGFPVKM----------------------------------DIKVVG 2440
            ||...     ::.:...::||..|:                                  .|.:..
Zfish  2114 PKRCN-----DMMNVGRLQGFDGKIVAQGRLLLQDTFMVSDQDGGLLSRLKERRIFLFEQIVIFS 2173

  Fly  2441 NPKPKLQWFH-NGHEIKPD--ASHIAIVENPDN----------------------SSSLIIEKT- 2479
            .|..|.:.|. .|:..|..  .|.:.:.|:|||                      ||:.::.:| 
Zfish  2174 EPLDKKKGFSMPGYLFKNSIKVSWLGLEESPDNDPCKFILTSRSSAGSLEHYVLHSSNRVVCQTW 2238

  Fly  2480 -----------------------------------APGDSGLYEVIAQNPEGSTASK-------- 2501
                                               .|..|||       |.||::|.        
Zfish  2239 IHQISSILENQRNFLNALTSPIEYQRNHVGSSGLAGPSSSGL-------PGGSSSSSMGPGCGSR 2296

  Fly  2502 ----------------AKLYVAPKADETATEEAPQFVSALRDVNADEGQELVLSAPF-------- 2542
                            .:.:.||..|:..:...|   ..::|:|.:..:..||.:|.        
Zfish  2297 SRASRIPQPSSRLPQPVQHHHAPAPDDRTSGTCP---PPIKDLNGEVPRMRVLESPLKELREEAQ 2358

  Fly  2543 ISNPMPEVIWSKDGVTLT-PNER----LLMTCDGKHIGLTIKPAEAADSGN--YTCLLANPLGED 2600
            ...|:|....:...:||| |..|    :|.:.:.::. .|..|:..|..|:  :.|:.|:|.|  
Zfish  2359 SGMPIPRATVAPLSLTLTKPRLRAPSPILPSLNPQNF-TTFAPSMPAQKGSAFWACMPASPTG-- 2420

  Fly  2601 SSACNANVRKVYKPPVFTQKISDQQQVFGNNAKIPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKN 2665
                        :|..:|    :|......|                 .||.:   :...:|.:.
Zfish  2421 ------------RPGSYT----EQSDTLSRN-----------------QFQTR---RHSAHSKEL 2449

  Fly  2666 DGDHHMLIVNNCEK-GDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIY 2729
            |.      ::.|.. .:|.::...::..|....:.....:|        ::..|.||: .:..:|
Zfish  2450 DR------ISTCSSTSEQSLHSTYSNGSESSSSSSVSTMLV--------TQDYVALKE-DEISVY 2499

  Fly  2730 EGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFN 2794
            :|.|.:..|             .|.|.:|                |..:..||..          
Zfish  2500 QGEVVQILA-------------SNQQNMF----------------LVFRAATEQG---------- 2525

  Fly  2795 PYGDDICHAELFYDSLDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVP 2859
                                                    |.:||              |     
Zfish  2526 ----------------------------------------PAAEG--------------W----- 2531

  Fly  2860 LTPRYPITY-QIEMMDLPEG------DWRTLRTGVRSCACDIRNLEPFRDY--RFRVRVENKFGV 2915
             .|.|.:.: .|.:.|.|:|      .|.|        |..||.....||.  |...:.||.|..
Zfish  2532 -IPGYVLGHTSIIIPDYPDGTLKKSTSWHT--------ALRIRRKSEKRDKEGRKESKAENGFRK 2587

  Fly  2916 SDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQD 2980
            |...|..:...:.|.|:    |.|     |..|                       |:|::   .
Zfish  2588 SRDGPANKVSVKLLNPN----YIY-----DAVP-----------------------PEFVV---P 2617

  Fly  2981 ISYGVKDH--NTELMWFVYGYPKPKMTYYF-DDMLIESGGRFDQSYTRNGQATLFINKMLDRDVG 3042
            ::..|.|.  :..|...:.|.||..:.:.. |...:.||||:..:::..|:.||.|:.....|.|
Zfish  2618 LAEAVCDRGDSVTLRCKICGQPKASVCWRGPDQSTLSSGGRYTLTHSETGEVTLRISTATLEDSG 2682

  Fly  3043 WYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGIPLPEVHWFKDWKPI 3107
            .|..:|:|:.|.......|                           :::|.....:.|       
Zfish  2683 TYTCIASNDVGSVTSSAYL---------------------------RVLGTSCDGILW------- 2713

  Fly  3108 VDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTVHIEENEDQYIYKTYGRH 3172
                                     ||                                      
Zfish  2714 -------------------------KD-------------------------------------- 2715

  Fly  3173 PYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGRPELRPFMLNELEMMNTF 3237
                    .::..|....|||||...:|....:|.|..:.|||::..:...|..::.||.::...
Zfish  2716 --------NFESLYTEVMELGRGRFAVTKWCEQRGSRRSVAAKLVNKKLMRREQVVQELGVLQCL 2772

  Fly  3238 NHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGV 3302
            .|.:|:...|.|:|..|..||:|:|..|.:: |.::.....||..::.|:|..|..|.::|...:
Zfish  2773 QHPHLVGLLDTYETPASYVLILEIADQGRIL-DYIVSWGNLTEEKVSLYLRDVLEALHYLHACRI 2836

  Fly  3303 GHMGLTIKDLLISVVGG-DIIKVSDFGLSRKINRHNLSTLDY-----GMPEFVSPEVVNKEGVNF 3361
            .|:.|..:::||..... .::|::|||     :..:||...|     |.|||.:||:|..|....
Zfish  2837 AHLDLKPENVLIEQTSAKPLVKLADFG-----DAAHLSNTPYIHPLLGSPEFSAPELVLGEPAAL 2896

  Fly  3362 SHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPE 3426
            :.|:|::|::.||:|.|.:|||.....||...|....:.|.::.:..:|...||||..||...|.
Zfish  2897 ASDLWSLGVLAYVMLSGASPFLDESVEETCLNICRIDFSFPEDYFHGVSQAARDFICMLLQGEPC 2961

  Fly  3427 ERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYD---HFRDWYANASCKNYFRRRRLS 3485
            .|...:..|...  |.|.........::.|.||.::.:   |..|....||.:.:.|.|.||
Zfish  2962 RRPSAQVCLHEE--FWLQPDTTSSAARLDTSRLISFIERRKHQNDLRPVASFQAFLRSRLLS 3021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254 19/90 (21%)
I-set 1123..1212 CDD:254352 23/127 (18%)
I-set <1236..1299 CDD:333254 10/62 (16%)
I-set 1313..1403 CDD:254352 10/91 (11%)
Ig_3 1406..1487 CDD:316449 17/98 (17%)
I-set 1499..1595 CDD:254352 18/108 (17%)
I-set 1599..1690 CDD:333254 17/98 (17%)
I-set 1694..1786 CDD:254352 20/91 (22%)
I-set <1836..1903 CDD:333254 12/75 (16%)
I-set 1922..2005 CDD:333254 19/94 (20%)
I-set 2018..2108 CDD:333254 21/95 (22%)
I-set 2113..2214 CDD:333254 25/159 (16%)
I-set 2220..2302 CDD:254352 29/168 (17%)
I-set 2318..2408 CDD:254352 27/177 (15%)
I-set 2415..2506 CDD:254352 25/209 (12%)
I-set 2519..2608 CDD:254352 22/103 (21%)
I-set 2615..2696 CDD:254352 10/81 (12%)
I-set 2717..2805 CDD:254352 13/87 (15%)
FN3 2834..2925 CDD:238020 23/99 (23%)
I-set <2996..3063 CDD:333254 19/67 (28%)
I-set 3067..3157 CDD:333254 4/89 (4%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 77/263 (29%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
triobXP_009290354.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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