DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and Obsl1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_017452317.1 Gene:Obsl1 / 363259 RGDID:1306073 Length:1897 Species:Rattus norvegicus


Alignment Length:2207 Identity:467/2207 - (21%)
Similarity:817/2207 - (37%) Gaps:495/2207 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1123 PAFLVSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDKDYLGFYELVIA 1187
            |.||...:...::..........::|:|.|.|.:.|..:::: .::|:....|....|   |:::
  Rat    12 PCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVLWEKGGQQLV-ASERLSFPEDGAEHG---LLLS 72

  Fly  1188 DVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQILP-----AGE-KPVF------Q 1240
            ....||||.|.|:|.|..|||...|..|.:|...|.........|     .|| .|||      |
  Rat    73 GALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPQSSECPPPPPGTGEGAPVFLTGPQSQ 137

  Fly  1241 WKRNGEEFD--------PEERFKVLFGEDED-------------------------SLALVFQHV 1272
            |...|.|..        ||.:   |:.|.:.                         ||.|.....
  Rat   138 WVLRGAEVVLTCQVGGLPEPK---LYWEKDGMALDEVWDSSHYTLEPDRGASDGGASLTLRILAA 199

  Fly  1273 KPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTL-VIEHREAN-----ASIGGSAI 1331
            :..|:|:|.|.|:.:.|:....|.|.|....:...::|::|.: |||..:..     .:.|..|.
  Rat   200 RLPDSGVYVCHARNAHGHAQAGALLQVHQPHENPPQDPDEPPVRVIEPLKCAPKTFWVNEGKHAK 264

  Fly  1332 LELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNV--DTVDAGVYTIEAINELGQ 1394
            ......|.|:|.::|..:|..: :.||.:.||.|.:. ..|:|.:  ...|.|:|...|.|..||
  Rat   265 FRCYVMGKPEPEIEWHLEGRPL-LPDRRRLMYRDRDG-GFVLKVLYCQAKDRGLYVCAARNSAGQ 327

  Fly  1395 DESSINLVVKAPPK--IKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAESNVKISSS 1457
            ..|::.|.||.|..  .:.:.|:.......:.:|.:|.....||.....:.:.:......:|...
  Rat   328 TLSAVQLHVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEG 392

  Fly  1458 SIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEKENV 1522
            ::.:      :.:..:|....|.|..:....:...:   :.|||..  |:|....:....|.||.
  Rat   393 TVRR------LVIHRLKADDDGVYLCEMRGRVRTVA---NVTVKGP--ILKRLPRKLDVLEGENA 446

  Fly  1523 QMTVRIDAYPEAKL--TWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHG 1585
            .:.|...   ||.:  .|..|..|:..|    ..||.|:.:.|.:.|.||.|||:.|...    |
  Rat   447 VLLVETQ---EAGVQGCWSRDGEELPAT----CQSSCGHMHALVLPGVTREDAGEVTFSL----G 500

  Fly  1586 SATSSTQLLIKC---APEFTHKLKNITVAEGDSNVELVVGVDAYPRPHAKWYIDGIEIDEKRND- 1646
            ::.::|.|.:||   :|.....|  :.:.:|..|..|:......|.|... :|..:|..|..:: 
  Rat   501 NSRTTTLLRVKCVKHSPPGPPVL--VEMFKGQKNTVLLTWKPPEPPPETS-FIYRLERQEVGSED 562

  Fly  1647 ----FRHVEEGNDFKLIMNQVATNMQGNYTCKI--MNDYGKL-------EDNCVVTVNCKPKVKR 1698
                | .:|:....::..:.|.|  :|:|..:|  ::::|:.       ..:.|.|.    ::..
  Rat   563 WIQCF-SIEKAGAVEVPGDCVPT--EGDYRFRICTVSEHGRSPHVVFNGSAHLVPTA----RLVS 620

  Fly  1699 GLKNVEVQEGKS--FTLEVEVYSEPEAKIKWFKDGHEIYED---ARIKISRDTQRIE----NYYL 1754
            ||::|:|.:|:.  |:|::....:.    .||.:|..:..|   .:::......|||    .:.|
  Rat   621 GLEDVQVYDGEDAVFSLDLSTIIQG----SWFLNGELLKNDEAEGQVEPGALRYRIEQKGLQHRL 681

  Fly  1755 TLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVH 1819
            .|...:.:|.|.    ...||      |. .|..|.|||::::....|     .|::..:.... 
  Rat   682 ILQTVKHQDNGA----LVGFI------CP-GVQDSAALSIQESPVHIL-----SPQDKVLLTFT- 729

  Fly  1820 VDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQSLDLVDAG 1884
                   :.|.|.|..|:.....|   |.||.||:.:...:...:.:||..::|.:....:.|:|
  Rat   730 -------TSERVVLTCELSRVDFP---ATWYKDGQKVEESESLVVKMDGRKHRLILPEAQVRDSG 784

  Fly  1885 EYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPV--VFTADPAPEI 1947
            |:               |....||:.:.. :..|.|.:         .:.:|.  ||......|.
  Rat   785 EF---------------ECRTEGISAFFS-VTVQDPPV---------HIVDPQEHVFVHAITSES 824

  Fly  1948 VLL--------------KDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILEAEIKDSGRYELK 1998
            |:|              ||||.|.|:..:.|  :|:...:.||       :..|:..|.|.::..
  Rat   825 VMLTCEVDREDAAVHWYKDGQEVEESAVIVL--EKEGPRHRLV-------LPAAQPSDGGEFQCV 880

  Fly  1999 VKNK---YGELVT--SGWIDV-LAKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTRGNENL 2057
            |.::   :...:|  |.||.. ..|..::.:...:.:....:|       .|..:|.||:..|.:
  Rat   881 VGDERAYFTVTITDVSSWIVYPNGKVYVAAVRLERVVLTCELC-------RPWAEVRWTKDGEEV 938

  Fly  2058 CNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQPESQ 2122
            .  |:..::.:.:....|||..||...:.|:| :...:.|   :..|.:.| .|.|..|:.|:.:
  Rat   939 L--ESPALLLEKEDTIRRLVLPSVQLEDSGEY-LCEIHDE---SASFTITV-TEPPVRIIYPQDE 996

  Fly  2123 SIHDYRPVSTKVLVHGVPLP----TIEWFKDDKPINYEAINKPGKDKLYAKEDTKK---GTDQIE 2180
                       |.:|.|.|.    |.|..:.|.|:.:.      ||.|.. |:|:.   .:|...
  Rat   997 -----------VTLHAVSLECVVLTCELSRVDAPVRWY------KDGLEV-EETEALVLQSDGPR 1043

  Fly  2181 SVLDIKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNALDVLQGEPLVLECCVD 2245
            ..|.:.:.:..|.|.:.|    :.|...|.|.:.:.:.....|..:..:||:..|.|..:|...:
  Rat  1044 RRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPVARSLDLQFGAPGHVELRCE 1104

  Fly  2246 GSPLPT-VQWLKDGDEVKPSESIKISTNPDGLVK-LEINSCQPNDSGAYKLIISNPHGEKVALCA 2308
            .:|..: |:|.|||.||:.|:::::..  :|..: |.:...||.|:|.|   :.....|.|..  
  Rat  1105 VAPAGSQVRWYKDGLEVEVSDALQLGA--EGPARTLTLPHAQPEDAGEY---VCETRDEAVTF-- 1162

  Fly  2309 VAVKPEEMQPKFLKPITSQT---VVVGEPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEINFINSP 2370
             .|...|:..:||.|.....   ||.|||:.|..:::...| .|.|..:|..::....:. :.:.
  Rat  1163 -NVSLAELPVQFLAPEAVPNPLCVVPGEPVMLSCELSRASA-HVSWSHNGNPVKQGEGLE-LRAE 1224

  Fly  2371 NGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEI-VPKESKPVFVAELQDASSIEGFPVKM 2434
            ..:..|.|.||.....|||.|    :.|...|...:.. |.....||.|...:.|.:........
  Rat  1225 GPRRILCIQAADLAHTGVYTC----QSGTAPGAPSLSFNVQVAEPPVRVVAPEAAQTRVRSTPGG 1285

  Fly  2435 DIKVV---GNPKPKLQWFHNGHEIKPDASHIAI-VENPDNSSSLIIEKTAPGDSGLYEVIAQNPE 2495
            |:::|   ..|...::|:.:|..:   ||...: :|.......|.:.....||:|.|...|    
  Rat  1286 DLELVVHLSRPGGPVRWYKDGERL---ASQGRVQLEQAGERQVLRVRGARRGDAGEYLCDA---- 1343

  Fly  2496 GSTASKAKLYVAPKADETATEEAP--QFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVT 2558
               :..:::::      .:.||.|  :.||.|..:...||.:...... :|.|..||.|.::|..
  Rat  1344 ---SQDSRIFI------VSVEEPPPVKLVSELTPLTVHEGDDATFQCE-VSPPDAEVTWLRNGAI 1398

  Fly  2559 LTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISD 2623
            :||..:|.|...|....|.|:..:..|:|..|   |.....|:|| ..:||:.  ..:|.:::.|
  Rat  1399 VTPGPQLEMVHSGSSRTLIIRGCQLKDAGTVT---ARAGATDTSA-RLHVRET--ELLFLRRLQD 1457

  Fly  2624 QQQVFGNNAKIPVTVSGVPYPD-LEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKC 2687
            .:...|.:..:.|....|..|. :.|....:|:|...:.:...||..|.|.::.....|||.|.|
  Rat  1458 VRAEEGQDVYLEVETGRVGAPGAVRWLRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGC 1522

  Fly  2688 IASNREGKDITQGRLDI-VNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKF-----TACATGYPEP 2746
            .:.:    |.|..||.: ..::::         |:.:.|..::||..|.|     ....||    
  Rat  1523 ESHH----DRTLARLSVRPRQLRE---------LRPLEDVTVHEGGSATFQLELSQEGVTG---- 1570

  Fly  2747 EVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYG--DDICHAELFYDS 2809
              ||.:...:|.|..:..|..|                 ||..|.:.:..|  |..| .....|:
  Rat  1571 --EWAQGGVRLHPGPKCHIHSE-----------------GRTHCLVLSGLGLADSGC-ISFTADT 1615

  Fly  2810 LDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYPITYQIEMMD 2874
            |                             ...:|:|.|        .||:|    |....:.::
  Rat  1616 L-----------------------------RCAARLTVR--------EVPVT----IVQGPQDLE 1639

  Fly  2875 LPEGDWRTLRTGVRSCACDI--------RNLEPFRDYRFRVRVEN-------------------- 2911
            :.|||..|....:.....|:        .:|.|      |:|:::                    
  Rat  1640 VTEGDTATFECELSQTLADVIWEKDGQALSLSP------RLRLQSLGTRRLLLLRRCSSSDAGTY 1698

  Fly  2912 --KFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQAPQF 2974
              ..|.:...|...|.|::.|                                   ..|.:....
  Rat  1699 CCAVGTARSGPARLTVREREV-----------------------------------SVLGELRSL 1728

  Fly  2975 LLREQD---ISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQA-TLFINK 3035
            ..||.|   ....|.:..|...|.:.|            ..:..|||.  ...:.|:. .|.:::
  Rat  1729 SAREGDSATFECTVSESETTGRWELGG------------RALRPGGRV--RIRQEGKKHILVLSE 1779

  Fly  3036 MLDRDVG--WYEAVATNEHGEARQRVRLEIAEHPRFLKR--PDETFIMARKNGRIEAKLVGIPLP 3096
            :...|.|  .::|      |.|:...|||:...|..:.|  |.|..::..:...:|. .|..|..
  Rat  1780 LRTEDTGEVCFQA------GPAQSLARLEVEALPLQMCRRPPREKTVLVDRRAVLEV-TVSRPGG 1837

  Fly  3097 EVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTVHIE 3158
            .|.|.::...:...|:.::.|:. ..:.|.|||...:|.|.||..    ||..|....:.:|
  Rat  1838 HVCWMREGVELCPGSKYEMRSHG-TTHSLVIHDVRPEDQGTYSCQ----AGQDSADTQLLVE 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352 23/88 (26%)
I-set <1236..1299 CDD:333254 22/101 (22%)
I-set 1313..1403 CDD:254352 27/97 (28%)
Ig_3 1406..1487 CDD:316449 10/82 (12%)
I-set 1499..1595 CDD:254352 29/97 (30%)
I-set 1599..1690 CDD:333254 19/104 (18%)
I-set 1694..1786 CDD:254352 21/100 (21%)
I-set <1836..1903 CDD:333254 13/66 (20%)
I-set 1922..2005 CDD:333254 20/101 (20%)
I-set 2018..2108 CDD:333254 16/89 (18%)
I-set 2113..2214 CDD:333254 24/107 (22%)
I-set 2220..2302 CDD:254352 22/83 (27%)
I-set 2318..2408 CDD:254352 23/92 (25%)
I-set 2415..2506 CDD:254352 18/94 (19%)
I-set 2519..2608 CDD:254352 26/90 (29%)
I-set 2615..2696 CDD:254352 18/81 (22%)
I-set 2717..2805 CDD:254352 20/94 (21%)
FN3 2834..2925 CDD:238020 18/120 (15%)
I-set <2996..3063 CDD:333254 13/69 (19%)
I-set 3067..3157 CDD:333254 22/91 (24%)
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Obsl1XP_017452317.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10221
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100287
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.900

Return to query results.
Submit another query.