DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and otk2

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	80/335 - (23%)
Similarity:	132/335 - (39%)	Gaps:	90/335 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1906 SGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKD 1970
            |.|..:||...|    |:.:::.:.|..      |::|..|.:|.:|       :.|.|..|
  Fly    68 SVILRWRKDSKT----LRQVELGRMDST------TSEPQLETMLRED-------SRVALSKD--- 112

  Fly  1971 AENGLVQYTCTLNILEAEIKDSGRYELKV--------KNKYGELVTSGWIDVLAKP-----EISG 2022
              :|.:|:|..|      ..|:|:|:.::        .:..|.|:....:..:.:|     |:..
  Fly   113 --SGALQFTSVL------ASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTSKNLELGT 169

  Fly  2023 LNDTKCLPGDTICFEALVQANPKPKVSWTRGNENLCNHENCEVIADVDADKYRLVFQSVSPCEDG 2087
            |:...|          ..|..|.|:|.|.|..:       ..:..:|......|:|..||..:.|
  Fly   170 LSKVHC----------KAQGTPAPQVKWMRETQ-------LPLPVNVTDQNGTLIFNQVSNEQRG 217

  Fly  2088 KYTITATNSEGR--AAVDFNLAVLVEKPTFIVQPESQSIHDYRPVST----KVLVH----GVPLP 2142
            :||..|:||:|:  |.|..|:.|   .|.|.|.||.       |:..    ..::|    |.|.|
  Fly   218 QYTCIASNSQGQITATVSINVVV---APKFSVPPEG-------PIEVAEAGTAVIHCQAIGEPKP 272

  Fly  2143 TIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVT 2207
            ||:|   ||.:.|...|....::....|:   ||      |:|::.|..|.|.|.|...:..|:.
  Fly   273 TIQW---DKDLTYLNENNTDPERFSLMEN---GT------LEIRNVRPEDEGRYGCTIGSSAGLK 325

  Fly  2208 KAPFKLAMLS 2217
            :....|.:.|
  Fly   326 REDVLLVLKS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254	17/90 (19%)
		I-set	2018..2108	CDD:333254	25/96 (26%)
		I-set	2113..2214	CDD:333254	28/108 (26%)
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
otk2	NP_612571.1	IG_like	41..132	CDD:214653	22/91 (24%)
		I-set	155..238	CDD:254352	24/99 (24%)
		IGc2	175..228	CDD:197706	18/69 (26%)
		IG_like	250..331	CDD:214653	23/99 (23%)
		IGc2	258..323	CDD:197706	21/76 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900