DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and sestd1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_878301.2	Gene:	sestd1 / 360133	ZFINID:	ZDB-GENE-030801-1	Length:	714	Species:	Danio rerio

Alignment Length:	850	Identity:	156/850 - (18%)
Similarity:	271/850 - (31%)	Gaps:	308/850 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1282 CVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQ----------C 1336
            |..|||...:|.:.:..:  .|.:...:....|::::.|::..:|..:.:|.||          |
Zfish    34 CTEQTSMEELSTTLDYLL--GIPSEKCKARGFTVIVDGRKSQWNIVKTVVLMLQNVIPAEVSLVC 96

  Fly  1337 KGFP-----KPAVQ---WKHDG----EVIQVDDRHKFMY------EDEESMSLVIKNVDTVDAGV 1383
            ...|     |....   ||...    |||.|.......|      .||...||:..::|.|:..:
Zfish    97 VVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTDEFGGSLLYDHLDWVNKRL 161

  Fly  1384 ----YTIEAI-----------NELG----QDESS-INLVVKAPPKIKKITDITCSAGETIKMEIE 1428
                :|.|:.           ||.|    :|.|| .|::....|      :.....|..:..|::
Zfish   162 VFEKFTKESTSLLDELIVINENEKGSQAEKDRSSESNILPSFDP------ETVLQTGHELLSELQ 220

  Fly  1429 VEGF---------------------PQPTVQVTNNGKDVTAESNVKISSSSIGKSLEKVVVEVKE 1472
            ...|                     .||.|...   .|...|...|.......:|....:.|: :
Zfish   221 QRRFNGSEGGGGGGTAWSPMDDELLAQPQVMKL---LDSLREQYTKYQEVCRQRSKRSQLEEI-Q 281

  Fly  1473 IKLSQAGNY-----------------SIKATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGE-- 1518
            .|:.|..|:                 ||:|:..|.|                |:.|.|..|.|
Zfish   282 TKVMQVVNWLEGPGTDQLRTQWGIGDSIRASQALQQ----------------KHEEIESQHSEWF 330

  Fly  1519 ----KENVQMTVRIDAYPEAKLTWYHDETEIK-----ITDSKYTVSSDGNAYTLKITGATRVDAG 1574
                :.|.|:...:.|..|      .|..|:|     ::|..|
Zfish   331 AVYVELNQQIAALLSAGDE------EDLMELKGLQQQLSDVCY---------------------- 367

  Fly  1575 KYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVELVVGV---DAYPRPHAKWYID 1636
                    ...|.....|.:::.|.||     ::|..:....::.::|:   |..|       .|
Zfish   368 --------RQASQLEFRQNVLQSAYEF-----HMTAQDLSQQLDGLLGMLCADVAP-------AD 412

  Fly  1637 GIEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGK-LEDNCVVTVNCKPKVKRGL 1700
            |..|.:   ..:|:||.      :..|.:.:|      .:.:.|: |.|
Zfish   413 GAAIQQ---TLKHLEEK------LKSVESALQ------TLREKGQALLD---------------- 446

  Fly  1701 KNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDARIKISR-----DTQRIENYYLTLNLAR 1760
               ::....||:...||..|.:..|...   |.:.||.:::..|     |.:|::...:......
Zfish   447 ---QMSNQTSFSYGKEVGVENKENIDHI---HSVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKC 505

  Fly  1761 TEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVH---VDV 1822
            .|||.    :|..::||                |...:.||.|...::.:|..|....|   |||
Zfish   506 EEDAS----QAVEWLGE----------------LLDALLKTHIRLGDDSQETKVLLEKHKKFVDV 550

  Fly  1823 FQQ-HSYESVPLKYEVI----------ATG--IPKPEAIWYHDGKPITPDKHTAITVDGDHYKLE 1874
            .|. :.|....|:..|:          ::|  :|:...:|          |...:|.|...::||
Zfish   551 AQSTYDYGRQLLQATVVLCQSLRCTTRSSGDTLPRLNRVW----------KQFTVTSDERQHRLE 605

  Fly  1875 VQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVVF 1939
            :       |..:....:..|.|.....|| |..:..|.: :.|.|.||.       |::..||:|
Zfish   606 M-------ASAFHTAAEKIVRESPELAEL-LVDVEAYEE-VETLGKGLL-------DRLTVPVIF 654

  Fly  1940 ----------TADPAPEIVLLKDGQPVVETNNV-------KLKVDKKDAENGLVQYTCTLNILEA 1987
                      ..|.|.....:::...:||....       :|:.::::.|..          ||.
Zfish   655 PDGSEQFFGSPGDMASSAESIRERMKLVEEKRFLQEEAEQRLEEEEEEEEAA----------LEV 709

  Fly  1988 EIKDS 1992
            |.::|
Zfish   710 EPRES 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254	5/16 (31%)
		I-set	1313..1403	CDD:254352	31/137 (23%)
		Ig_3	1406..1487	CDD:316449	18/118 (15%)
		I-set	1499..1595	CDD:254352	16/106 (15%)
		I-set	1599..1690	CDD:333254	17/94 (18%)
		I-set	1694..1786	CDD:254352	18/96 (19%)
		I-set	<1836..1903	CDD:333254	12/78 (15%)
		I-set	1922..2005	CDD:333254	14/87 (16%)
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
sestd1	NP_878301.2	CRAL_TRIO_2	28..147	CDD:290435	24/114 (21%)
		Spectrin 1	275..381		25/158 (16%)
		SPEC	276..447	CDD:295325	43/269 (16%)
		SPEC	383..607	CDD:295325	58/309 (19%)
		Spectrin 2	384..497		29/161 (18%)
		Spectrin 3	503..605		26/131 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..714		5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900