DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and mybphb

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001093607.1	Gene:	mybphb / 321053	ZFINID:	ZDB-GENE-030131-9794	Length:	529	Species:	Danio rerio

Alignment Length:	769	Identity:	164/769 - (21%)
Similarity:	243/769 - (31%)	Gaps:	271/769 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2308 AVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEINFINSPNG 2372
            |.|.|.||..|   .|....     ||..........||||           |:|.     .|..
Zfish    12 AKAAKKEEPAP---APAPEP-----EPAPAPEPAPAEPAPE-----------PAPA-----EPAS 52

  Fly  2373 QIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAE--LQDASSIEGFPVKMD 2435
            ......:.| |.:|..       :|...|..:..|..|.|:.|   ||  ...|:..|..|.: :
Zfish    53 AEAAPAEGA-PAEAPA-------EGAPAEAAAPAEAPPAEAPP---AEPVAPPAADAEAPPAE-E 105

  Fly  2436 IKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLIIEKTAP---GDSGLYEVIAQNPEGS 2497
            ||....|.|.          :|.:..:.:.....|.:|:.|....|   |:|||        :|
Zfish   106 IKAPTPPPPP----------EPTSEPLELGVEDVNDTSVTISWRPPATIGNSGL--------DG- 151

  Fly  2498 TASKAKLYVAPKADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPN 2562
                   ||               |...::..||                    |.      ..|
Zfish   152 -------YV---------------VEVCKEGTAD--------------------WK------AAN 168

  Fly  2563 ERLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNAN---VRKVY-KPPVFTQKISD 2623
            |.|.::|  :::   ||.....|..|...:..||.|....|..|:   ||:|. :|.:...:...
Zfish   169 EELTVSC--RYV---IKNQTTGDRLNIRVVAMNPGGRSPPATLADTVLVREVVDRPKIRLPRFLR 228

  Fly  2624 QQQV--FGNNAKIPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYK 2686
            |:.|  .|....:.:...|.|.|.:.|....:|| .::|.:|:|.....:..:...|:.|.|||:
Zfish   229 QRYVKKVGEKINLVIPFGGKPQPVVSWTKDGQPI-DTKKVNIRNSDKDSIFFIRAAERVDSGVYE 292

  Fly  2687 CIASNREGKDITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWF 2751
            ........:|..|..|.|:      ....||..:|.:   |.:...||             :||.
Zfish   293 MCVKVDSFEDKAQLTLQII------ELPGPPASVKIV---DTWGFNVA-------------LEWT 335

  Fly  2752 KNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKP 2816
            :      |.|        ||...:|
Zfish   336 E------PKD--------NGNTTIT---------------------------------------- 346

  Fly  2817 LEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYPITYQIEMMDLPEGDWR 2881
                                                              .|.|:..|...|||.
Zfish   347 --------------------------------------------------GYTIQKADKKTGDWF 361

  Fly  2882 TLRTGVRSCACDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDF 2946
            |:..........|.:|.....|.|||..|||.|:|..:..|:|           :.|....|.|:
Zfish   362 TVLEHYHRLNATISDLIMGNTYIFRVFTENKCGISQEATTTKT-----------SATIQKTGIDY 415

  Fly  2947 RPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDM 3011
            :|   |.:.:        || .::||:|....||.|..| .:||:|:..|.|:||||:.:..:.|
Zfish   416 KP---PVYKE--------HD-FSEAPKFTTPMQDRSTTV-GYNTKLLCAVRGFPKPKIEWLKNQM 467

  Fly  3012 LIESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAE 3065
            :|....:|.| ....|..:|.|.|..:.|.|.|...|.||||||....:||:.:
Zfish   468 IIGDDPKFRQ-INNQGICSLEIRKPGNFDGGVYSCRAKNEHGEAVVTCKLEVKQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352	16/89 (18%)
		I-set	2415..2506	CDD:254352	20/95 (21%)
		I-set	2519..2608	CDD:254352	17/91 (19%)
		I-set	2615..2696	CDD:254352	17/82 (21%)
		I-set	2717..2805	CDD:254352	12/87 (14%)
		FN3	2834..2925	CDD:238020	19/90 (21%)
		I-set	<2996..3063	CDD:333254	25/66 (38%)
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
mybphb	NP_001093607.1	FN3	124..205	CDD:238020	26/142 (18%)
		I-set	224..310	CDD:254352	20/86 (23%)
		Ig	238..310	CDD:299845	17/72 (24%)
		FN3	314..402	CDD:238020	31/207 (15%)
		I-set	429..518	CDD:254352	34/90 (38%)
		Ig	447..513	CDD:143165	25/66 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000