DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and RGD1563354

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_006235524.1	Gene:	RGD1563354 / 311592	RGDID:	1563354	Length:	1198	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	205/1166 - (17%)
Similarity:	355/1166 - (30%)	Gaps:	419/1166 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DEKQIHLSLKA-----------PEANSFLPIDIKPHGPEA----------H------------LT 374
            :|:.:|::||.           |...||..:...|...||          |            :.
  Rat   134 EEQSVHMTLKCLSSDLREVDKKPIPESFYSLIFTPEWLEAINNDFEGRPLHNCLVASENGITPVP 198

  Fly   375 WFNEISSHINQD----VTLQEHNADDLKVDASQIASESELILHLPQRA----------EAHDPN- 424
            |....|.....|    |.:...:.|...::...::|..|     |.:|          ::.|.:
  Rat   199 WTRITSPEFVDDKPPIVKVPSSDGDSCPLEGLHLSSPQE-----PYQASDFGSKGSVTQSWDKDK 258

  Fly   425 -----------LSVRPSDVAENYF-LSKETKERLQHEQQELLKLEQEAIELYKKQQSSKSVSSKT 477
                       :.|.|:...:..| :..|..:.|:.:...||...||.        ...|..||.
  Rat   259 GKLSGDKYPGLIKVEPARSGQMAFKIDSEASQGLEGDYVALLGFPQEF--------RGPSPDSKV 315

  Fly   478 ESVEITSSQVKSSSEVRKVVSPP---PP---PQAQVKEVTPV----------------------K 514
                :|.|:.|.:..:.:|  ||   ||   |..:.....|.                      .
  Rat   316 ----VTRSRTKGTPLLGRV--PPLSGPPEALPLGRWPSAKPAGSGEKLCSGGSRKKARHKAFGNS 374

  Fly   515 VVSSPPPPKEITPAKVATPPPQPQVVTSPVKEVAPPP------QPRAVASPAKEVTPSQSEPVKA 573
            .|..|..|....|.|:..      ..:..|:::...|      :|..:.....::.|.   |.:|
  Rat   375 AVQQPQQPHASVPEKLLA------CTSGLVEDIEEEPAASKMQRPLGMPEAMVQLRPG---PRQA 430

  Fly   574 PSPIKEVRKEVPPSASHSKEVEALVATEIRESLTETRSTVVESGQSSEIRE---EIVVTEESSLE 635
            .||:......|.|:                 |.|.|..|....|.:|:..:   :.:....|...
  Rat   431 FSPLLSSAGPVAPA-----------------SETNTEETTPGHGGASKPEDCLSKNISGHGSPAP 478

  Fly   636 GKQVVALEREPSPCSIP-KIQVYRPVE--CENPVVTKHKPIELKDIVGYSESLRDGDTAPAGGSP 697
            |.|...|:.:.:|...| |.|:.:|.:  |         |:......|.....:||.|.|.....
  Rat   479 GLQFSYLKEQRAPLGNPEKGQLTKPWKALC---------PLNSLQPCGAKAPGKDGTTLPTTSGS 534

  Fly   698 GRQQGYSANI-TDHASL----------------------TIWNNRLANIAGDRSGANQHL----- 734
            |...|..... .|.|.|                      .:.::|:|.:.|.|....:.|
  Rat   535 GTLSGEPPGFRRDSAGLPGGGLRLEECSRPKPRIVTLGVKLLHSRIACLPGGRDKVGRPLLLVST 599

  Fly   735 -QQSGPPPPPIPPNFTRMPGFFQPLPLIAYETTIEILIVKARPPSPPPP------------PPPT 786
             :::...|.........:..:...:|.:..:....::::.|| ..||.|            ||.:
  Rat   600 AEEAWEAPWCTASEVAELLSYLCSVPRLEDKAKGLLVVIDAR-KGPPRPGLVIALQSIQALPPAS 663

  Fly   787 IKRVLVHTESLEQKTQNFFEGIYDAASSDTSLRNAKQKIRSIKSTVLKSKDSTNYAQDTVQKAKA 851
            |.:||:    |.:|....                 :..:||::..||.|..:.....|..|
  Rat   664 ISKVLL----LGEKASIL-----------------QLPVRSVQVEVLTSLKALRNHVDPNQ---- 703

  Fly   852 RDFLHIFTPPVKKRPIYEIVEEPVNIFELEGDYTESIADDFREPSA-------DFEARGQSVGGM 909
                   .|...:.|......|.|..|:    ..:....|..:.||       :|| :|:..||:
  Rat   704 -------LPEALEGPFPYHHSEWVQFFQ----KLDPFLTDLHQASALLQASIQEFE-KGEPPGGV 756

  Fly   910 DDYYSGYSRASTRRYETKTRD-------YDRGTSYDSTVERSQYGISSRRDRSSVDKVEARSSLL 967
            ::.....|: |....|:..||       .:.||:. :::::...|:::..|        .|..|:
  Rat   757 EEATRCLSK-SKELMESVLRDPGLLALQREGGTTL-ASLQQEASGLNANPD--------VRDHLM 811

  Fly   968 ATGRTESRAASRAESRAESRASYSVAESRAG--IRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEP 1030
                             |:.|.|::.:.:..  :.:|::|.....||             |::..
  Rat   812 -----------------EAAALYNLVDDQLHVLVTASNQLLRRLELR-------------VRLGH 846

  Fly  1031 GETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAPMN-------SYRLDIKNCSETDAGT 1088
            .|||..::.        .|::..       ..|..|..||:|       ....|.::.....|..
  Rat   847 LETAIHQVS--------DWMRGE-------GSRCLQALAPVNVCAGTVEKVHADFEDFFLQVAAQ 896

  Fly  1089 YTIRAQSASETTTVSAQLAVGQAPGHDETK-------TNTEPAFLVSL-----------KDAEMI 1135
            |    :...|.:...|||...: .|..||:       .:|:.||...|           .|.|.:
  Rat   897 Y----RQGLELSKQVAQLGTAE-EGAGETELPDLVAFASTQQAFQARLTHFYMAAERQRTDLETL 956

  Fly  1136 ENTLFRFMVKIIGDPKPRVKFYKDEKEIL-----------ETNDRIQIIRDKDYLG--------- 1180
            .: |.||..|:       .:|:.|.|::|           ...|:|. :|...||.
  Rat   957 LH-LHRFRRKM-------SRFHTDCKDLLTQLSLGKAVKASPGDQIH-LRLHCYLKRLASEFQTE 1012

  Fly  1181 ---FYELVIADVQKTDAGTYSC-KATNKHGE---------ANC------EAIATTVEDKNPFGAL 1226
               ..:|.:|.:.:...|.... :|..:|.:         |.|      .|.:..::...|  |.
  Rat  1013 KLLAMKLQVASLSQPGLGQELWEEAWERHQKIQNLLRKALAYCPCPEVPAAYSAHIDQSRP--AA 1075

  Fly  1227 SGQILP--AGEK-----------------------PVFQWKRN----------GEEFDPEE 1252
            .||.||  .|.|                       |..:..||          |:..||||
  Rat  1076 KGQGLPREVGSKWDRSLQDILAVDRVLKSQRSPRAPQGEQNRNMWAGLLSPEPGQSVDPEE 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134	14/81 (17%)
		Atrophin-1	<493..690	CDD:331285	42/236 (18%)
		TonB_N	502..>596	CDD:318287	18/124 (15%)
		I-set	1017..1108	CDD:333254	17/97 (18%)
		I-set	1123..1212	CDD:254352	25/138 (18%)
		I-set	<1236..1299	CDD:333254	9/50 (18%)
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
RGD1563354	XP_006235524.1	PHA03247	<303..570	CDD:223021	57/315 (18%)
RGD1563354	XP_006235524.1	Mating_C	1012..>1168	CDD:289506	24/127 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900