DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and Siglec1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_017447235.1 Gene:Siglec1 / 311426 RGDID:1311953 Length:1708 Species:Rattus norvegicus


Alignment Length:1865 Identity:393/1865 - (21%)
Similarity:647/1865 - (34%) Gaps:473/1865 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1017 PVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNC 1081
            |.:......|.|..|.||.:...:..:..:|....|.|.:::|...|...|.      .:|.|.|
  Rat    40 PCIFSFPADVSVPNGITAIWYYDYSGKRQVVIHSGDPKLVDERFRGRAELTG------NMDHKVC 98

  Fly  1082 S-------ETDAGTYTIRAQ-------SASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDA 1132
            :       ..|:|||..|.:       |....|||:.            ||..:.|...:..:..
  Rat    99 NLLLKDLKLEDSGTYNFRFEISDGNRWSDVRGTTVTV------------TKDPSPPTITIPHELR 151

  Fly  1133 EMIE-----NTLFRFMVKIIGDPKPRVKFYKDEKEIL-------ETNDRIQIIRDKDYLGFYE-- 1183
            |.:|     :|.:..:               .||::.       .|...|...:..:..|.|.  
  Rat   152 EGVEVNVNCSTPYLCL---------------QEKQVSLHWQGQDPTRSVISNFQSLEPTGVYHQT 201

  Fly  1184 -LVIADVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQILPAGEKPVFQWKRNGEE 1247
             |.:|...:....|..|:.          ::||....|..:  |..|..|.|.:.:.  ..:|..
  Rat   202 TLHMAPSWQDHRRTLRCQL----------SLATHSSQKEVY--LQVQHAPKGVEILL--SSSGRN 252

  Fly  1248 FDP----------EERFKVLFGED--EDSLALVFQ-HVKP------EDAGIYTCVAQTSTGNISC 1293
            ..|          ...:..:...|  :|.:.|..: ||..      .|:|:|||.|..:.|::: 
  Rat   253 ILPGNLVTLTCRVNSSYPAVSSVDWVKDGVNLTAKGHVLQLSSATWNDSGVYTCQATNNVGSLA- 316

  Fly  1294 SAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKGFPKPAVQ-----WKHDGEVI 1353
            |..||:...:..:...|..|.|..|            .:.|.| ..||.|.|     |.      
  Rat   317 SPPLSLHVFMAEVKINPAGPILENE------------TVTLLC-STPKEAPQELRYSWY------ 362

  Fly  1354 QVDDRHKFMYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESS-INLVVKAPPKIKKITD-IT 1416
                ::..:.||..:.:|.:..|...|.|.|..|..|..|.:.|. :::||:.||....:|. :.
  Rat   363 ----KNNILLEDAHAPTLHLPAVTRADTGFYFCEVQNTQGSERSGPVSVVVRYPPLTPDLTTFLE 423

  Fly  1417 CSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAES-----NVKISSSSIGKSLEKVVVEVKEIKLS 1476
            ..||........|...|..||.:::.|..:.:.|     |.:.|.||...|   |.:|:::::.:
  Rat   424 TQAGLVGIFHCSVISEPLATVVLSHGGLTLASSSGENDFNPRFSISSAPNS---VRLEIRDLQPA 485

  Fly  1477 QAGNYSIKATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLTWYHD 1541
            .:|.|:..|||.|.::............:::.. ..|.:.|:...:.....::..|:.:.:||.:
  Rat   486 DSGEYTCSATNSLGKSMSSLDFHANVARLLISP-SKEVVEGQAVTLSCRSGLNPAPDTRFSWYLN 549

  Fly  1542 ETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKA-TNEHGSATSSTQLLIKCAP----EF 1601
            .          .:..:|::....:..|:..|:|.|..:| ...|.|..|...:|....|    .|
  Rat   550 G----------ALLLEGSSSNFLLPAASSTDSGSYYCRARAGPHTSGPSLPTVLTVFYPPRKLTF 604

  Fly  1602 THKLKNITVAEGDSNVE-LVVGVDAYPRPHAKWYIDGIEIDEKRNDFRHV--------------- 1650
            |.:|...|..:||.... |:..||:.|....:....|           ||               
  Rat   605 TARLDLDTSGDGDGRRGILLCQVDSDPPAQLQLLHKG-----------HVVATSLPSMCGSCSRR 658

  Fly  1651 ----EEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEGKSF 1711
                ...|..::.:.:.....:|.|.|:..|..|  ..:...:.|.|..|.....:..:.||...
  Rat   659 MKVSRASNSLQVEIQKPVLEDEGMYLCEASNTLG--NSSVSASFNAKATVVVITPSDTLLEGTEA 721

  Fly  1712 TLEVEVYSE---PEAKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTYEMKATN 1773
            :|...|..|   ..|...||::| .::....:    :|.|::      .|||| ||..|      
  Rat   722 SLTCNVTQEVAVSPANFSWFRNG-VLWTQGPL----ETVRLQ------PLART-DAAVY------ 768

  Fly  1774 FIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVHVDVFQQH------SYESVP 1832
                   .|:  :||.:...|...|..::....:.|:..|:     :||.|.|      :.:|.|
  Rat   769 -------ACR--LLTDDGAQLSAPVVLSVQYAPDPPKLSAL-----LDVGQGHMAVFICTVDSYP 819

  Fly  1833 LKY-------EVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQSLDLVDAGEYKVVV 1890
            |.:       .::||.: :|:.:.:  |:  ...|.||     :..:|||:.|.|.|:|.|....
  Rat   820 LAHLSLFRGERLLATSL-EPQRLSH--GR--IQAKATA-----NSLQLEVRELGLEDSGNYHCEA 874

  Fly  1891 QNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKV---CEPVVFTADP-APEIVLLK 1951
            .|.:|..:......:.|......|    .|.|::     |..|   |:  |.|..| .......:
  Rat   875 TNVLGSANSSLFFQVRGAWVQVSP----SPELRE-----GQAVVLSCQ--VPTGVPEGTSYRWFQ 928

  Fly  1952 DGQPVVETNNVKLKVDKKDAENGLVQ---YTCTLNILEAEIKDSGRYELKV-------------- 1999
            ||:|:.|:.:..|::    |...|.|   |.|     :|:..|:....|..              
  Rat   929 DGRPLQESTSSILRI----AAISLRQAGAYHC-----QAQAPDTAAASLAAPVSLHVSYTPRHVT 984

  Fly  2000 --------KNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICF-EALVQANPKPKVSWTRGNE 2055
                    ..:||.||.|...|   .|.:..|.....|...|:.. |.|..:||:..|:      
  Rat   985 LSALLSTGPGRYGHLVCSAQSD---PPALLRLFHQNRLVASTLQGPEELASSNPRLHVA------ 1040

  Fly  2056 NLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAA--VDFNL-AVLVEK-PTFI 2116
                         |.:::.||..|.....:.|.||..|||:.|:|:  .||:. ||.|.. |...
  Rat  1041 -------------VSSNELRLEIQFTELEDGGTYTCEATNTLGQASATADFDAQAVRVAVWPNAT 1092

  Fly  2117 VQPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIES 2181
            || |.|.::               |..:.|......::|               ...||..|:..
  Rat  1093 VQ-EGQQVN---------------LSCLAWSTHQDSLSY---------------TWYKGGQQLLG 1126

  Fly  2182 V--LDIKSFRENDVGAYTCVATNEIG---------------VTKAPFKLAMLSLAPSFVKKLDNA 2229
            |  :.:.|...:|..:|.|    .:|               |..||..|.:..|..|        
  Rat  1127 VRSISLPSVTVSDATSYRC----GVGLPGHTPHLSRPVTLDVLYAPRSLQLTYLLES-------- 1179

  Fly  2230 LDVLQGEPLVLE-CCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYK 2293
                ||..|.|. |.||..| |....|..|.::..|.:   ..:....::||:...:|:|.|.|.
  Rat  1180 ----QGRRLALVLCTVDSRP-PAQLTLSHGGQLLASST---EASVPNTLRLELQDPKPSDEGLYS 1236

  Fly  2294 LIISNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPAPEV-KWYKDGML 2357
            ....:|.|:  ...::|::.|.::.: :.|  |.||..|||:.:..:.....:|.: .|:.:|..
  Rat  1237 CSAQSPLGK--VNTSLALRLEGVRVR-MNP--SATVPEGEPVTVTCEDPAALSPALYAWFHNGHW 1296

  Fly  2358 LRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAELQ 2422
            |:..|..:          |.........||.|.|.:.:..|           .:.|:|   |.||
  Rat  1297 LQEGPASS----------LQFPVTTQAHAGAYFCQVHDTQG-----------TRSSRP---ASLQ 1337

  Fly  2423 ------DA------SSIEGFPVKMDIKVVGNPKPKLQWFHNG---------HEIKPDASHIAIVE 2466
                  ||      .|.....|.:...|...|..:|....|.         |...|..||   |:
  Rat  1338 ILYAPRDAVLSSFRDSRTRHMVVIQCTVDSEPPAELVLSRNSKVLAASRELHSSAPGISH---VQ 1399

  Fly  2467 NPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPKADETATEEAPQFVSALRDVNAD 2531
            ...|:..|.::.|..||...|...|:|..||.::..||          ..|....|:|...::..
  Rat  1400 AARNALRLQVQDTTFGDGNTYVCTARNTLGSISTTHKL----------LRETDIHVTAEPGLDVP 1454

  Fly  2532 EGQELVLSA--PFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLA 2594
            ||..|.||.  |..|.|:     .....|...|..||.:.....:..|  |...|.:|:|.|...
  Rat  1455 EGTALNLSCHLPGGSQPV-----GNSSFTWFWNRHLLHSAPVPTLSFT--PVVRAQAGSYHCRAE 1512

  Fly  2595 NPLGEDSSACNANVRKVYKP--PVFTQKISDQQQVFGNNAKIPVTVSGVPYPDLEWYFQDKPIPK 2657
            ...|..:|. ...:|.:|.|  |..|..:..|.   |:...:...|...|...|......:.:..
  Rat  1513 LSTGVTTSP-PVMLRVLYPPKTPTLTVFVEPQG---GHQGILDCRVDSEPLASLTLQLGSQLVAS 1573

  Fly  2658 SEKYS------IKNDGDHHMLIVNNCEKG--DQGVYKCIASNREG 2694
            ::.:|      |:.....:.|.::..|.|  :||.|.|.|||..|
  Rat  1574 NQPHSAPTQPHIRVTAPPNALRLDIEELGPNNQGEYVCTASNALG 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254 24/104 (23%)
I-set 1123..1212 CDD:254352 14/103 (14%)
I-set <1236..1299 CDD:333254 16/81 (20%)
I-set 1313..1403 CDD:254352 21/95 (22%)
Ig_3 1406..1487 CDD:316449 21/86 (24%)
I-set 1499..1595 CDD:254352 14/96 (15%)
I-set 1599..1690 CDD:333254 20/114 (18%)
I-set 1694..1786 CDD:254352 20/94 (21%)
I-set <1836..1903 CDD:333254 17/66 (26%)
I-set 1922..2005 CDD:333254 21/111 (19%)
I-set 2018..2108 CDD:333254 23/93 (25%)
I-set 2113..2214 CDD:333254 20/117 (17%)
I-set 2220..2302 CDD:254352 20/82 (24%)
I-set 2318..2408 CDD:254352 18/90 (20%)
I-set 2415..2506 CDD:254352 29/111 (26%)
I-set 2519..2608 CDD:254352 22/90 (24%)
I-set 2615..2696 CDD:254352 20/88 (23%)
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Siglec1XP_017447235.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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