DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and Ccdc141

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_003749542.2 Gene:Ccdc141 / 311134 RGDID:1593250 Length:1530 Species:Rattus norvegicus


Alignment Length:1807 Identity:339/1807 - (18%)
Similarity:627/1807 - (34%) Gaps:519/1807 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   869 EIVEEPVNIFELEGDYTESIADDFREPSADFEARGQSVGGMDDYYSGYSRASTRRYET---KTRD 930
            ::.|...|:.|:     .|..|:.|:...|.|.....:..::|...|..:.:.|..|.   ::..
  Rat    42 QLAEAQPNLLEI-----GSSQDETRKLLHDHELLLAKLKALEDRVWGLLQEADRTAEANKEQSEV 101

  Fly   931 YDR-----GTSYDSTV-----ERSQYGISSRRDRSSVD---KVEARSSLLATGRTESRAASRAES 982
            ||.     |.::.:.|     .|...|::|...:|:::   |::                 :||.
  Rat   102 YDAMAQTLGEAWATLVSMLERRRELLGLTSEFFQSALEFAIKID-----------------QAED 149

  Fly   983 RAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGLV 1047
            ..::...:..||:    ..|..|..||..:.:.:..:|.:.||.|:     ..|..:||      
  Rat   150 FLQNPHEFESAEA----LQSLLLLHDRHAKELLERSLVLLNKSQQL-----TDFIEKFK------ 199

  Fly  1048 TWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASETTTVSAQLAVGQAP 1112
               .|..|:...|......:...::|. |::..........:.  .|...|.:.| .||.:    
  Rat   200 ---CDGSPVNSELIQGAQSSCLKIDSL-LELLQDRRRQLDKHL--QQQRQELSQV-LQLCL---- 253

  Fly  1113 GHDETKTNTEPAFLVSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDKD 1177
             .|:.::.....|..:::|.:  |.:|...:              .|.||::..::.: .|:.|:
  Rat   254 -WDQQESQVSCWFQKTIRDLQ--EQSLGSSL--------------SDNKELIRKHEDL-TIKAKE 300

  Fly  1178 YLGFYELVIADVQKTDAGTYSCK--ATNKHGEANCEAIATTVEDKNPFGALSGQILPAGEKPVFQ 1240
                ::|.:..::....|....|  ...:|.:.:.:.:....|:   ||.|.     ...|   .
  Rat   301 ----WDLAMEKLKSQALGILLSKDLTEKEHLQLSNQKLNRLQEE---FGRLM-----VDRK---A 350

  Fly  1241 WKRNGEEF--DPEERFKVLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAI 1303
            |.....:|  ...|.|.|| |:.||.|.|    :|.|...:                        
  Rat   351 WLTMAHDFFTSANEAFDVL-GKVEDYLKL----LKSEGLSL------------------------ 386

  Fly  1304 QTLNREPEKPTLVIEHREANASIGGSAILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEES 1368
                     |.|..:|.|.:..|..|....||           |....:.|||.....:....|:
  Rat   387 ---------PALAAKHEELHREIKDSTAAALQ-----------KGRTLISQVDSCRAQVTGIHET 431

  Fly  1369 MSLVIKNVDTVDAGVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFP 1433
            |..:.|.||.:.   ....|..|....:.  .|.......::|:..........:...::|...|
  Rat   432 MGRIQKRVDRLS---QQCTAHQEFALKKQ--QLATSVDDYLRKVEMSVQEMRLVLATTLDVGSSP 491

  Fly  1434 QPTVQVTNNGKDVTAESNVKISSSSIGKSLEKVVVEVKEIKLSQAG--NYSIKATND----LSQT 1492
            ..:.::.|  |.:..:...|.::.:: ::..|:..|..|::|::..  .:.:|...:    ||::
  Rat   492 SESEKILN--KYLELDIQAKETAHAL-EAAAKITTEKNELELNEVALLPFKVKRLEEELSTLSRS 553

  Fly  1493 SEYWSCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLT---WYHDETEIKITDSKYTV 1554
            ..|.|..:::           ||...|.:.::..::.:..|..||   | .||.:..:|....:.
  Rat   554 VSYRSQVLQT-----------YIAFRKSSEEVEEQLQSLKEFYLTESPW-EDEDDAVVTCQSNSA 606

  Fly  1555 SSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVEL 1619
            ......: ||.:..|:    ..:::..|....|..:..|.:|   :..|.::|:...:.:...||
  Rat   607 ERKWQLF-LKKSFLTQ----DLSLEFLNLISMAKENEILNVK---KEMHIVENVMEKQTNGREEL 663

  Fly  1620 VVGVDAYPRPHAKWYIDGIE---IDEKRNDFRH--VEEGNDFKL----IMNQVATNMQGNYTCKI 1675
                   .|....|::..:|   :.|:...|:.  .:..::.||    :|...|.::.||  .:.
  Rat   664 -------SRLRMAWHLKAMEGKPVKERWETFKEKLKKTTHNVKLLHEVLMPVSALDLGGN--LQS 719

  Fly  1676 MNDYGKLEDNCVVTVNCKPK-------VKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHE 1733
            |:|..:.      .:..:|:       |::.:|..||..|:...|        :.|.:..||...
  Rat   720 MSDLRRR------WIAMQPQLQQLHEDVQQIMKEWEVLSGQGVPL--------KEKAEQLKDLIH 770

  Fly  1734 IYEDARIKISRDTQRIENY----YLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSL 1794
            :::       |..:||:.|    |.|:...:.::..|:.:|.           :...|.::.:.|
  Rat   771 LHQ-------RQRERIQEYEEILYKTVQFHQVKEELTHLIKP-----------RELELLAQPMEL 817

  Fly  1795 EQTVTKTLIATTEEPEEGAVPEIVHVDVFQQHSYE-SVPLKYEVIATGIPKPEAIWYHDGKPITP 1858
            |.: .:.|:.........|     |||    |.:. ::.|..::|:: :.:|..           
  Rat   818 EGS-KEVLMQLGRSQGRRA-----HVD----HLHRLALSLGVDIISS-VQRPNC----------- 860

  Fly  1859 DKHTAITVDGDHYKLEVQSLDLVD----AGEYKVVVQNKVGEKSHQGELSLSGIAEY---RKPIL 1916
               :.|:......:||...||..|    |.||:.|               |:...||   |:.|.
  Rat   861 ---SNISAKSLQQQLEALELDSRDWSAKAKEYEQV---------------LACSLEYCTTREEIN 907

  Fly  1917 TQGPGLKDIKVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCT 1981
            ......||||                              .:.||:|....||:.::.      .
  Rat   908 ELKESFKDIK------------------------------KKFNNLKFNYSKKNEKSR------N 936

  Fly  1982 LNILEAEIKDSGRYELKVK--NKYGELVTSGWID-VLAKPE------ISGLNDTKCLPGDTICFE 2037
            |..|:.:|:....|..|::  .|..|.|.....| ||:.|.      :..:.|.|....|   |:
  Rat   937 LKTLQYQIQQVETYADKIQALRKKMEKVNKKISDSVLSYPSNKANTLVEAMEDLKKHVDD---FD 998

  Fly  2038 ALVQANPKPKVSWTRGNENLCNH-----ENCEV-IADVDADKYRLVFQSVSPCEDGKYTITATNS 2096
            .:        |:..:.|.:|..|     |.|.. ..|..|...|:          |||::   ..
  Rat   999 KV--------VTDYKMNLDLTEHLQEVIEECNFWYEDASATVVRV----------GKYSM---EC 1042

  Fly  2097 EGRAAVD-----FNLAVLVEKPTFIVQPESQ------------SIHDYRPVSTKVLV-HGVPLPT 2143
            :.|.|||     |...|....|    |.|.:            .:.:.:..:.|::. |...|.:
  Rat  1043 QTREAVDILHRQFQKFVTPSVP----QQEERIQEVVSLAQRLYGLEEGQKYAEKIVTRHKEILES 1103

  Fly  2144 I------------EWFKDDKP-IN----------YEAINKPGKDKLYA-KEDTKKGTDQIESVLD 2184
            |            :..:.|.| :|          .:.:.:||:|:... .|:..:|..|...|..
  Rat  1104 ITELCGSLVELKEKLMQGDVPKVNSNLEDFHGNSIDLLKEPGRDEQTTFSEERSEGQAQGADVSA 1168

  Fly  2185 IKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKKLDNAL------DVLQGEPLVLECC 2243
            |...||:.:                     .:.|..||.|: |:|.      |.|.||.  .||.
  Rat  1169 INGTREDGL---------------------PVGLRQSFDKE-DSAQGLTLPEDTLSGED--SECI 1209

  Fly  2244 ----VDGSPLPTVQWL----KDGDEVKPSES---------IKISTNPDGLVKLEINSCQPNDS-- 2289
                :...|||.....    .|.:..:|:.|         .::.|...||.|...:...|..:  
  Rat  1210 SSDDISLPPLPVTPESPLAPSDMEVEEPASSSALALHISGYRMRTGTGGLGKAPESVLPPPTAFT 1274

  Fly  2290 ---------------------GAYKLIISNPHGEKVALCAVAVK-----PEEMQPKFLKPIT-SQ 2327
                                 .|..|:.|...||......|.||     |.|:..|.|.|.: :|
  Rat  1275 DGYHNKKDTFTSHFERPYPQFKAEPLLTSRGSGEMSTKLHVNVKCPARMPREVHDKALPPSSQAQ 1339

  Fly  2328 TVVVG--EPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYK 2390
            .:.:|  |.:..::.||          |....|..:.::    ||    ||   ::|...:..::
  Rat  1340 EISLGTQEKVHADSNVT----------KTQDRLHAALDV----SP----GL---SSQSDTSRSHQ 1383

  Fly  2391 CLIANKGGEIEGVSKVEIVPKESK-PVFVAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGHE 2454
            ..:..:|......::..:|....: |.|...|.:.:..||.||.::::|.|.|:|.|.||..|.:
  Rat  1384 RQVGPQGDRKNSSAEKSVVSLAGQAPHFSRLLSNVTVTEGSPVTLEVEVTGFPEPTLTWFKKGQK 1448

  Fly  2455 IKPDASHIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYV 2506
            :..| .|:.:: :.|...|:.|.|....|:|||...|||..|:.:|||.|:|
  Rat  1449 LCAD-GHLQVL-HKDTKHSVFIPKVCEADAGLYVAQAQNSSGTLSSKAILHV 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254 17/90 (19%)
I-set 1123..1212 CDD:254352 13/90 (14%)
I-set <1236..1299 CDD:333254 14/64 (22%)
I-set 1313..1403 CDD:254352 20/89 (22%)
Ig_3 1406..1487 CDD:316449 11/82 (13%)
I-set 1499..1595 CDD:254352 16/98 (16%)
I-set 1599..1690 CDD:333254 17/99 (17%)
I-set 1694..1786 CDD:254352 18/102 (18%)
I-set <1836..1903 CDD:333254 12/70 (17%)
I-set 1922..2005 CDD:333254 15/84 (18%)
I-set 2018..2108 CDD:333254 22/106 (21%)
I-set 2113..2214 CDD:333254 20/137 (15%)
I-set 2220..2302 CDD:254352 25/127 (20%)
I-set 2318..2408 CDD:254352 16/92 (17%)
I-set 2415..2506 CDD:254352 33/90 (37%)
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Ccdc141XP_003749542.2 SPEC 132..356 CDD:238103 47/299 (16%)
SbcC <219..804 CDD:223496 125/732 (17%)
SPEC 260..458 CDD:295325 50/283 (18%)
I-set 1409..1498 CDD:254352 33/90 (37%)
Ig 1425..1499 CDD:299845 29/76 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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