DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and Vwa7

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_038954602.1	Gene:	Vwa7 / 309611	RGDID:	1303137	Length:	920	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	130/716 - (18%)
Similarity:	220/716 - (30%)	Gaps:	255/716 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 PPPTIKRVLVHTESLEQKTQNFFEGIYDAASSDTSLRNAKQKIRSIKSTVLKSKDSTNYAQDTVQ 847
            ||..:.::|:      ..|..||..|:...::..|:.:                      ||..:
  Rat    13 PPVLLLQLLL------PPTSAFFPNIWSLLAAPGSITH----------------------QDLTE 49

  Fly   848 KAKARDFLHIF--TPPVKKRPIYEIVEEPVNIFELEGDYTESIADDFREPSADFEARGQSVGGMD 910
            :|.....|.:|  .||..:..::           || ||                 ||:::.. |
  Rat    50 EAALNVTLELFLEQPPPGRPHLH-----------LE-DY-----------------RGRTLLA-D 84

  Fly   911 DYYSGY--SRASTRRYETKTRDYDRGTSYDSTVERSQYGISSRRDRSSVDKVEARSSLLATGRTE 973
            |.::.|  |..|:||:.....:..|..:....:..|         :|:.| :...:..|..|||.
  Rat    85 DIFAAYFGSGFSSRRFRAALGEVSRANAAQDFLPAS---------KSNPD-LHFDAERLVQGRTR 139

  Fly   974 SRAASRAESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSVQ--------VEP 1030
            ...|.|....|.....|::|..|.|                      ..|.::|        ||.
  Rat   140 LEGALRETLVAARALEYTLARQRLG----------------------AALHALQDFYSHSNWVEL 182

  Fly  1031 GETAHFEIQFKDQPGLVTW----LKDNKPLEDRLADRITQTAAPMNSYRLDI------------- 1078
            ||.       :..|.|: |    |.....:.|.........:.|.|...|.:
  Rat   183 GER-------QPHPHLL-WPRRELWSLAQVGDPTCSDCEGLSCPGNMMNLTMLTSGYFGTNPPKP 239

  Fly  1079 -KNCSETDAGTYTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDAEMIENTLFRF 1142
             ..||.  .|.:.   ||:|            |.|.....|.:|.|:|
  Rat   240 PGKCSH--GGRFD---QSSS------------QPPRGGINKDSTSPSF----------------- 270

  Fly  1143 MVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDK-DYLGFYELVIADVQKTDAGTYSCKATNKHG 1206
                  .|..|:.....|..:|.:.:.:.::|.: ...||..|:  |:....:.::....|...|
  Rat   271 ------SPHHRLHLQAAEVALLASIEALSLLRSRLGTRGFSRLL--DITPASSLSFVLDTTGSMG 327

  Fly  1207 E----ANCEAIATTVEDK--NPFGALSGQILP---AGEKPVFQWKRNGEEFDPEE------RFKV 1256
            |    |..:| ...||.:  :|...:|..::|   .|..|||...      ||:.      ....
  Rat   328 EEINAAKIQA-RRIVEQRQGSPMEPVSYILVPFHDPGFGPVFTTS------DPDSFWQKLTEIHA 385

  Fly  1257 LFGEDE-----DSLALVFQHVKP-EDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPE-KPT 1314
            |.|.||     .:|.|...|..| .|..::|..:         ..:..:...:::|.||.. :.|
  Rat   386 LGGGDEPEMCLSALELALLHTPPLSDIFVFTDAS---------PKDAFLTNRVESLTRERRCRVT 441

  Fly  1315 LVIEHREANASIGGSAILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNVDTV 1379
            .::....:.|...|........:..|..|:.....||||...|:|             |::|..|
  Rat   442 FLVTEDPSRAQGRGRREALSPSRFEPYEAIALASGGEVIFTKDQH-------------IRDVAAV 493

  Fly  1380 DAGVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAGE-------------TIKMEIEVEG 1431
                        :|:..:.:..:...||        ..:.||             |::|..::.|
  Rat   494 ------------VGESMAGLVTLPLEPP--------IFTPGEPCVFAVDSLLSKVTVRMHGDISG 538

  Fly  1432 F 1432
            |
  Rat   539 F 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254	20/116 (17%)
		I-set	1123..1212	CDD:254352	15/93 (16%)
		I-set	<1236..1299	CDD:333254	15/74 (20%)
		I-set	1313..1403	CDD:254352	15/89 (17%)
		Ig_3	1406..1487	CDD:316449	8/40 (20%)
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Vwa7	XP_038954602.1	Het-C	<163..>190	CDD:399889	7/55 (13%)
Vwa7	XP_038954602.1	vWFA	316..>422	CDD:412136	26/121 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900