DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and Mybpc2

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_038960733.1 Gene:Mybpc2 / 292879 RGDID:1311596 Length:1153 Species:Rattus norvegicus


Alignment Length:1525 Identity:307/1525 - (20%)
Similarity:514/1525 - (33%) Gaps:512/1525 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1210 CEAIATTVE--DKNPFG------ALSGQILPAGEKPVFQWKRNGEEFDPEERFKVLFGEDEDSLA 1266
            |..:.:.||  .|.|.|      |.:.:..|..|.|        :|..||::...:  |:...|.
  Rat    13 CLGVGSGVEAAKKAPKGKDAPKEAPAAKQTPPAEPP--------KEAPPEDQSPTV--EEPTGLF 67

  Fly  1267 LVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAI 1331
            |    .||:...:                             |..|.|:::      |.:.|   
  Rat    68 L----KKPDSVSV-----------------------------ETGKDTVIL------AKVNG--- 90

  Fly  1332 LELQCKGFP-KPAVQW-KHDGEVIQVDDRHKFMY-EDEESMSLVIKNVDTV----------DAGV 1383
                 |..| ||:::| |...:.:......:|.: |..:|.|    ||.||          |.|.
  Rat    91 -----KELPGKPSIKWFKGKWQELGSKSGARFTFKESHDSAS----NVYTVELHIGKVVLGDRGD 146

  Fly  1384 YTIEAINELGQDESSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTA 1448
            |.:|...:...|....|:.|:||.:        .|:|:::      |.|.:     :.:||   :
  Rat   147 YRLEVKAKDVCDSCPFNVDVEAPRQ--------DSSGQSL------ESFKR-----SGDGK---S 189

  Fly  1449 ESNVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYW----------------- 1496
            |...::..|.:.|..| ||.|.|:.|         |..:||....|.|                 
  Rat   190 EDAGELDFSGLLKKRE-VVEEEKKKK---------KDDDDLGIPPEIWELLKGAKKSEYEKIAFQ 244

  Fly  1497 ----------------SCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLTWYHDETEI 1545
                            ...||......|..:..|.......:::.|.| :.|:..|.|:.:..||
  Rat   245 YGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLVVEI-SDPDLPLKWFKNGQEI 308

  Fly  1546 KITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPE-FTHKLKNIT 1609
            | ..|||...:.|....|.|...|..|...|.|...:|    ...|:|.:|..|. ....|::..
  Rat   309 K-PSSKYVFENVGKKRILTINKCTLADDAAYEVAVKDE----KCFTELFVKEPPVLIVTPLEDQQ 368

  Fly  1610 VAEGDSNVELVVGVDAYPRPHAKWYIDGIEI---DEKRNDFRHVEEGNDFKLIMNQVATNMQGNY 1671
            |..|| .||:.|.| :.......|..||:|:   |..:..:|..::|....||.:.||....|.|
  Rat   369 VFVGD-RVEMSVEV-SEEGAQVMWMKDGVEMTREDSYKARYRFKKDGKRHILIYSDVAQEDGGRY 431

  Fly  1672 TCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYE 1736
              :::.:.|:.|...:|... :.:|.:.:.::.|:..:....:.|| |:.:...||:|:|.|:..
  Rat   432 --QVITNGGQCEAELIVEEK-QLEVLQDIADLTVKASEQAVFKCEV-SDEKVTGKWYKNGVEVRP 492

  Fly  1737 DARIKISRDTQRIENYY-LTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTK 1800
            ..||.||    .:..:: |.::..|.||.|.|......:                ||||...:..
  Rat   493 SKRITIS----HVGRFHKLVIDDVRPEDEGDYTFVPDGY----------------ALSLSAKLNF 537

  Fly  1801 TLIATTEEPEEGAVPEIVHVDVFQQHSYESV------PLKYEVIATGIPKPEAIWYHDGKPITPD 1859
            ..|.....|::  .|..:|:|...:.|..|:      .|:.:|..||.|.|.|.|.         
  Rat   538 LEIKVEYVPKQ--EPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGEPPPTATWL--------- 591

  Fly  1860 KHTAITVDGDHYKLEVQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKD 1924
                                                                             
  Rat   592 ----------------------------------------------------------------- 591

  Fly  1925 IKVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILE-AE 1988
                |||:     |||         :.:|:..:|        .:.|         |:..::| ||
  Rat   592 ----KGDE-----VFT---------VSEGRTRIE--------QRPD---------CSSFVIESAE 621

  Fly  1989 IKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTRG 2053
            ..|.|||.:||.|..||.|.|.::.|:..|:          |.:.:                   
  Rat   622 RSDEGRYTIKVTNPAGEDVASIFLRVVDVPD----------PPEAV------------------- 657

  Fly  2054 NENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQ 2118
                       .:..|..|...||::  .|..||...:|.                     ::::
  Rat   658 -----------RVTSVGEDWAILVWE--PPKYDGGQPVTG---------------------YLME 688

  Fly  2119 PESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVL 2183
            .:.:..|                   .|.|    :|:|...          :.|.:.|..||.||
  Rat   689 RKKKGSH-------------------RWMK----LNFEVFT----------DTTYESTKMIEGVL 720

  Fly  2184 -DIKSFRENDVGAYTCVATNEIGVTK-----APFKLAMLSLAPSF--VKKLDNALDVLQGEP--- 2237
             :::.|           |.|.|||::     .||.....:.||..  |:.:.:....|:..|   
  Rat   721 YEMRVF-----------AVNAIGVSQPSMNTKPFMPIAPTSAPQHLTVEDVTDTTTTLKWRPPDR 774

  Fly  2238 --------LVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKL 2294
                    .::|.|::||.    :|:....|........:...|.|...|            :::
  Rat   775 IGAGGIDGYLVEYCLEGSE----EWVSANKEPVERCGFTVKDLPTGARIL------------FRV 823

  Fly  2295 IISNPHG--------EKVALCAVAVKPEEMQPKFLKPITSQTVV--VGEPLKLEAQVTGFPAPEV 2349
            :..|..|        :.|.:..:..:|:...|:.|:    ||.:  |||.|.|.....|.|.|:|
  Rat   824 VGVNIAGRSEPATLLQPVTIREIVEQPKIRLPRHLR----QTYIRKVGEALNLVIPFQGKPRPQV 884

  Fly  2350 KWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPK--E 2412
            .|.|.|..|..| .:|...|....:..:..||:. |:|.|:..:..:..:.....::.:|.|  .
  Rat   885 VWTKGGAPLDTS-RVNVRTSDFDTVFFVRQAARS-DSGEYELSVQIENMKDTATIRIRVVEKAGP 947

  Fly  2413 SKPVFVAELQDASS-IEGFPVKMDIKVVGN-----------PKPKLQWF----HNGHEIKPDASH 2461
            ::.|.|.|:...:: :|..|.|.|    ||           .|..::||    ||.|        
  Rat   948 AENVMVKEVWGTNALVEWQPPKDD----GNSEITGYFVQKADKKTMEWFNVYEHNRH-------- 1000

  Fly  2462 IAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEG---------STASKAKLYVAPKADETATEE 2517
                      :|..:.....|:...:.|.::|..|         :||...|..:..|..|....:
  Rat  1001 ----------TSCTVSDLIVGNEYYFRVFSENICGLSDSPGVSKNTARILKTGITLKPMEYKEHD 1055

  Fly  2518 ---APQFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIK 2579
               ||:|::.|.|.....|....|:.....:|.|:|:|.|:.:.:..:.:.|:|.....:.|.|:
  Rat  1056 FRTAPKFLTPLMDRVVVAGYAAALNCAVRGHPKPKVVWMKNKMEIHEDPKFLITNYQGILTLNIR 1120

  Fly  2580 PAEAADSGNYTCLLANPLGEDSSACNANVR 2609
            .....|:|.|:|...|.|||..:.|..:||
  Rat  1121 RPSPFDAGTYSCRAFNELGEALAECKLDVR 1150

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352 1/1 (100%)
I-set <1236..1299 CDD:333254 9/62 (15%)
I-set 1313..1403 CDD:254352 23/102 (23%)
Ig_3 1406..1487 CDD:316449 17/80 (21%)
I-set 1499..1595 CDD:254352 25/95 (26%)
I-set 1599..1690 CDD:333254 25/94 (27%)
I-set 1694..1786 CDD:254352 20/92 (22%)
I-set <1836..1903 CDD:333254 7/66 (11%)
I-set 1922..2005 CDD:333254 20/83 (24%)
I-set 2018..2108 CDD:333254 10/89 (11%)
I-set 2113..2214 CDD:333254 19/106 (18%)
I-set 2220..2302 CDD:254352 15/102 (15%)
I-set 2318..2408 CDD:254352 25/91 (27%)
I-set 2415..2506 CDD:254352 23/115 (20%)
I-set 2519..2608 CDD:254352 24/88 (27%)
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Mybpc2XP_038960733.1 Ig 66..166 CDD:416386 29/150 (19%)
Ig strand A 67..70 CDD:409353 1/6 (17%)
Ig strand A' 73..76 CDD:409353 0/2 (0%)
Ig strand B 81..88 CDD:409353 2/12 (17%)
Ig strand C 97..102 CDD:409353 1/4 (25%)
Ig strand C' 107..109 CDD:409353 0/1 (0%)
Ig strand D 117..125 CDD:409353 2/7 (29%)
Ig strand E 132..136 CDD:409353 1/3 (33%)
Ig strand F 146..153 CDD:409353 2/6 (33%)
Ig strand G 157..166 CDD:409353 2/8 (25%)
THB 225..258 CDD:408162 2/32 (6%)
Ig 272..353 CDD:416386 23/86 (27%)
Ig strand A 272..274 CDD:409353 1/1 (100%)
Ig strand A' 277..281 CDD:409353 1/3 (33%)
Ig strand B 285..291 CDD:409353 0/5 (0%)
Ig strand C 298..303 CDD:409353 2/4 (50%)
Ig strand C' 306..309 CDD:409353 1/2 (50%)
Ig strand D 314..319 CDD:409353 1/4 (25%)
Ig strand E 322..327 CDD:409353 1/4 (25%)
Ig strand F 336..342 CDD:409353 2/5 (40%)
Ig strand G 345..353 CDD:409353 3/11 (27%)
Ig 360..446 CDD:416386 23/89 (26%)
Ig strand B 374..380 CDD:409353 2/5 (40%)
Ig strand C 387..392 CDD:409353 1/4 (25%)
Ig strand C' 395..402 CDD:409353 1/6 (17%)
Ig strand D 407..412 CDD:409353 1/4 (25%)
Ig strand E 415..420 CDD:409353 1/4 (25%)
Ig strand F 429..435 CDD:409353 2/7 (29%)
Ig strand G 438..446 CDD:409353 2/7 (29%)
IG_like 459..>521 CDD:214653 18/66 (27%)
Ig strand B 468..472 CDD:409353 0/3 (0%)
Ig strand C 480..484 CDD:409353 1/3 (33%)
Ig strand E 505..509 CDD:409353 1/3 (33%)
Ig_C5_MyBP-C 562..647 CDD:409475 34/193 (18%)
Ig strand B 574..578 CDD:409475 1/3 (33%)
Ig strand C 587..591 CDD:409475 1/3 (33%)
Ig strand E 613..617 CDD:409475 0/3 (0%)
Ig strand F 627..632 CDD:409475 2/4 (50%)
Ig strand G 640..643 CDD:409475 1/2 (50%)
FN3 651..737 CDD:238020 27/192 (14%)
FN3 750..842 CDD:238020 16/107 (15%)
Ig_Titin_like 861..941 CDD:409406 22/81 (27%)
Ig strand B 870..874 CDD:409406 2/3 (67%)
Ig strand C 883..887 CDD:409406 1/3 (33%)
Ig strand E 907..911 CDD:409406 0/3 (0%)
Ig strand F 921..926 CDD:409406 1/4 (25%)
Ig strand G 934..937 CDD:409406 0/2 (0%)
FN3 946..1028 CDD:238020 20/103 (19%)
I-set 1060..1149 CDD:400151 24/88 (27%)
Ig strand A' 1068..1071 CDD:409353 1/2 (50%)
Ig strand B 1075..1084 CDD:409353 1/8 (13%)
Ig strand C 1089..1095 CDD:409353 3/5 (60%)
Ig strand C' 1098..1100 CDD:409353 0/1 (0%)
Ig strand D 1106..1110 CDD:409353 1/3 (33%)
Ig strand E 1113..1121 CDD:409353 2/7 (29%)
Ig strand F 1129..1136 CDD:409353 2/6 (33%)
Ig strand G 1139..1149 CDD:409353 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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