DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and ttn-1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001346715.1	Gene:	ttn-1 / 266969	WormBaseID:	WBGene00006436	Length:	15188	Species:	Caenorhabditis elegans

Alignment Length:	4824	Identity:	962/4824 - (19%)
Similarity:	1667/4824 - (34%)	Gaps:	1440/4824 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ATDEISVSRGDLVELISSKASEKSRCFVRMFDSGDSPKEGWVPIDILEFNPTMSSSNGKESG--- 81
            :|:|.|.:.....:..|.|::||.....:...:| .|.|...|::  :.......|:.|||.
Worm  9267 STEEKSTTEKPTNDKTSKKSAEKKTVKPKKEVTG-KPLEAKKPVE--DKKDASQPSSSKESSPPT 9328

  Fly    82 DAEFRKLTILRELVETEEEFSR----DLLHV---VEKYIKG----------IDKPV---VPRSVR 126
            |.: :|..|.:.|...:|..||    ..:|.   :...|:|          :.:|:   |...|.
Worm  9329 DGK-KKKQIPKALFIPDEISSRFGDPSTMHSETNITTTIRGREGSADAKTPLVEPLSASVSMKVE 9392

  Fly   127 DNKDIIFCNFLQIAEFHNNV--LKEGLKCYSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQDYL 189
            ..|:....:|.:.:|..::.  .||||........   |..:..|:...:.::..:.:.:.:
Worm  9393 SAKEKAEFSFKRRSETPDDKSRKKEGLPPAKKSEK---KDEVTAEKQSTEALIESKKKEVDE--- 9451

  Fly   190 GSSPDAKKYFQELSKQLGDDKSLAEHLKLPIQRINDYQLLFKDFIKYSLSLKENVKDLERALELM 254
                      .::|:|...||:.:|.:.:|.:....             ..|::|.::|
Worm  9452 ----------SKISEQQPSDKNKSEVVGVPEKAAGP-------------ETKKDVSEIE------ 9487

  Fly   255 LSVPSRAYDNRFLSSIEGCRGNIYKLGRLLLHAWCNVVDKEGKAHDRYCFLFKSRILVTKVRKIS 319
             .||.:   .......|....:|.:...:|..|    .|.:.|:.|          :..|.:|.:
Worm  9488 -EVPKK---KTIKKKTEKSDSSISQKSNVLKPA----DDDKSKSDD----------VTDKSKKTT 9534

  Fly   320 ENRSVFILQNIVKLPLCNIELKAD-EKQIH-------------LSLKAPEANSFL------PIDI 364
            |:::.....:       .:|..|| .|||.             |..|..:::||:      |..:
Worm  9535 EDQTKVATDS-------KLEKAADTTKQIETETVVDDKSKKKVLKKKTEKSDSFISQKSETPPVV 9592

  Fly   365 KPHGP-EAHLTWFNEISSHINQDVTLQEHNADDLK----VDASQIASES---ELILHLPQRAEAH 421
            :|..| |:......|::.     ...|:...|:||    |.|.:||.|.   |...::.:.||..
Worm  9593 EPTKPAESEAQKIAEVNK-----AKKQKEVDDNLKREAEVAAKKIADEKLKIEAEANIKKTAEVE 9652

  Fly   422 --------DPNLSVRPSDVAENYFLSKETKERLQHEQQELLKLEQEAIELYKKQQ---------- 468
                    |..|.:....|::     |...|:|:.|:|..:|...|| :..|||:
Worm  9653 AAKKQKEKDEQLKLETEVVSK-----KSAAEKLELEKQAQIKKAAEA-DAVKKQKELNEKNKLEA 9711

  Fly   469 SSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQVKEVTPVKVVSSPPPPKEITPAKVATP 533
            :.||.:.|.:..|.::::.|..||  :.|......:.:..|.| |:|.|.|...|.|....|...
Worm  9712 AKKSAADKLKLEEESAAKSKKVSE--ESVKFGEEKKTKAGEKT-VQVESEPTSKKTIDTKDVGAT 9773

  Fly   534 PPQPQVVTSPVKEVAPPPQPRAVAS-PAKEVTPS--------QSEPVKAPSPIKEVRKEVPPSAS 589
            .|..:   :|.|::......::.:| ..|..|.|        |.||.|......::..|...|..
Worm  9774 EPADE---TPKKKIIKKKTEKSDSSISQKSATDSEKVSKQKEQDEPTKPAVSETQMVTEADKSKK 9835

  Fly   590 HSK-----EVEALVATEIRESLTETRSTVVESGQSSEIREEIVVTEESSLEGKQVVALEREPSPC 649
            ..:     :::|.:|.:.::...| :|.:....:..::.|:....:|..|..|..:..|......
Worm  9836 QKETDEKLKLDAEIAAKTKQEADE-KSKLDAQEKIKKVSEDDAARKEKELNDKLKLESEIATKKA 9899

  Fly   650 SIPKI------QVYRPVECENPVVTKHKPIELK-DIVGYS--------ESLRDGDTAPAGGSPGR 699
            |..|:      |..:..|.|.....|.|..:|| |....|        |..:......|.|:..
Worm  9900 SADKLKLEEQAQAKKAAEVEAAKKQKEKDEQLKLDTEAASKKAAAEKLELEKQAQIKKAAGADA- 9963

  Fly   700 QQGYSANITDHASLTIWNNRLAN---IAG-----DRSGA--NQHLQQSGPPPPPIPPNFTRMPGF 754
                   :.....|...|...||   .||     :.|.|  .|.:::...............
Worm  9964 -------VKKQKELDEKNKLEANKKSAAGKLKIEEESAAKSKQTVEEQAKLDAQTKAKTAEK--- 10018

Fly 755 FQPLPLIAYETTIEILIVKARPPSPPPPPPPTI-----KRVLVHTESLEQKTQNFFEGIYDAASS 814
:|.:| |....:.......|: |:| |::||: .|
Worm 10019 ---------QTKLE----KDEKSTKESESKETVDEKPKKKV------LKKKTE----------KS 10054

Fly 815 DTSLRNAKQKIRSIKSTVLKSKDSTNYAQDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVNIFE 879
|:|:....:..:::..:...|:..|....|..:|.|..| :|: :
Worm 10055 DSSISQKSETSKTVVESAGPSESETQKVADAARKQKETD---------EKQ-------------K 10097

Fly 880 LEGDYTESIADDFREPSADFEARGQSVGGMDDYYSGYSRASTRRYETKTRDYDRGTSYD------ 938
||.:.| .:.|||.:::.:: .|...:|:......|.::.|.....|
Worm 10098 LEAEIT-------AKKSADEKSKLEA-------ESKLKKAAEVEAAKKQKEKDEQLKLDTEAASK 10148

Fly 939 -STVERSQYGISSR-RDRSSVDKVEARSSLLATGRTESRAASR---------------------- 979
:..|:.:....|. :..:.||.|:.:..|....|.||.||::
Worm 10149 KAAAEKLELEKQSHIKKAAEVDAVKKQKELEEKQRLESEAATKKADAEKLKLEEQKKKAAEIALI 10213

Fly 980 -----------AESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGET 1033
.:||.|..|..|..:.:....:.|:..|:.|..|||:....|:||. :.|..::
Worm 10214 EIQKEQEKLAQEQSRLEDEAKKSAEKQKLESETKSKQTEEAPKESVDEKPKKKVLKK-KTEKSDS 10277

Fly 1034 AHFEIQFKDQPGLV----TWLKDNKPLEDRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQ 1094
: ...:.|.....| |...|...:|.:...::.| |..::.:.||:..
Worm 10278 S-ISQKSKSAKSTVDAAETLESDFNLVEKKTVQKVEQ---------------SPDESTSATIKRD 10326

Fly 1095 SASETTTVSAQLAVGQAPGHDETKTNTE------------PAFLVSLK----------DAEMIEN 1137
.|.:|..:|.| ...||.||.|: |...|..| ||.:.:
Worm 10327 PAQKTEEISKQ------DDGDEKKTTTDGKPPKPEDSEATPKKRVVKKKTQKSDSVASDASLAD- 10384

Fly 1138 TLFRFMVKIIGD----PKPRVKFYKDEKE---ILETN-------DRIQIIRDKDYLGFYELVIAD 1188
:.|:..| ||.:|...|.||. |.||: :.::|..:| ..::::.:
Worm 10385 -----VSKLSDDVEEKPKKKVLKKKTEKSDSVISETSSVDTIKPESVEIPTEK----AEQMILHN 10440

Fly 1189 VQKTDAGTYSCKATNKHGE----------ANCEAIATTVEDKNPFG------------------- 1224
...||:...| :..|.|.: ...::.|...:|:....
Worm 10441 RFSTDSAVES-EPKNAHKDDTEKTTDDMMTRRKSSAIFSDDEQSISSKTSSEGRRRRRRTGFASK 10504

Fly 1225 ------ALSG-------QILPAGEKPVFQWKRNGEEFDPEER--------FKVLFGEDEDSLALV 1268
||.| ::| .|.....||.||::.|...| |: .|:
Worm 10505 FASDTLALRGDNVEIEAELL--AEDDTVTWKVNGKDADLNSRCHEMSHTFFR----------TLI 10557

Fly 1269 FQHVKPEDAGI---YTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSA 1330
...|:|.|:|: .||..::.| .|....||.|. .::.|.|: |...|.:|...|:..:.
Worm 10558 IDEVEPTDSGMEITATCGTESHT-TILKVEELPVD-FVKYLPRK----TSGKEGQEVTISVTLNH 10616

Fly 1331 ILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEE--SMSLVIKNVDTVDAGVYTI--EAINE 1391
.:::. .|.|..||:.::::..:.. |.. |:||.::.....|:|.|.: :.:
Worm 10617 PIDIS-------KVVWLKDGKPLEINKDYSI---DTVGCSVSLTLRRAKYEDSGKYKVVCDGV-- 10669

Fly 1392 LGQDESSINLVVKAPPKIKKITD----ITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAESNV 1452
:.|.:|.::..|.:|.::: ||....:...:.:..:..|:.:..:|.:|||:..:...
Worm 10670 ----DCSTHLSIQGKPVLKNVSETKPVITVDKDDQFSLLVAYDSNPEASFSMTVDGKDLEFDGRS 10730

Fly 1453 KISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTVKSKP-----VIVKNFES 1512
:|.....|..|.| :.:..:.||.|.:|..|:..:.::.:...|...| |.|...||
Worm 10731 RIDVVDDGLKLTK-----RGVSKTDAGEYEVKLKNEFGEVAQKFDVKVNDTPSAPGDVSVVKAES 10790

Fly 1513 EYIH------GEKENVQMTVRIDAYPEAKLTWYHDETEIKITDSKYTVS--SDGNAYTLKITGAT 1569
:.:| .|....::|..:....|:....:|....:....:.|.|. .....|.::|....
Worm 10791 DCLHIEWTAPTEDNGAEVTSYVIEKKESGRRKFHKVATVNGKKTSYVVDDLEIETPYIVRIAAVN 10855

Fly 1570 RVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNIT-----------VAEGDSNVELVVGV 1623
:...|::......:.||......: ||...:.|:| :.:|.|. |.|.
Worm 10856 KFGTGEFIETKPVQTGSPFQVPTV------EFPPTIDNVTSTSCSLSWPKPIEDGGSP---VYGY 10911

Fly 1624 DAYPRPH-AKWY-IDGIEI--DEKRNDFRHVEEGNDFKL---IMNQVATNMQGNYTCKIMNDYG- 1680
|.|.|.: .:|. ::|.|: .|..| .|.:..|.:::. ..|:.......|...|.:...|
Worm 10912 DVYKRENEGEWQKMNGEELVFTESFN-VRALSSGKEYEFKIEACNEAGLRSNSNVVSKKLTVEGL 10975

Fly 1681 -----------KLEDNCVVTVNCKPKVKRGLKNVEVQ---EGKSFTLEVEV---YSEPEAKIKWF 1728
|:.||..|.|..| ..|.|...|| :|.|....|:: .||..|..|..
Worm 10976 VPEIILDMPMVKVLDNDKVEVTWK---SDGEKEFVVQYKSDGSSIWASVDIGGPRSESAATSKCI 11037

Fly 1729 KDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALS 1793
.||.. |.......:|.....||.|. :..|..|.||..:|..
Worm 11038 IDGLR----------------EGIPYVFRVAARNQHGTGEF--------SEPTIPVVVLADDAPR 11078

Fly 1794 LEQTVTKTLIATTEEPEEGAVPEIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITP 1858
:.:.:....| |::| .|:.|..|.|.|.||.|||.|||.|.|
Worm 11079 VLKAIKPVKI-----PKKG-------------------ELRLECHAAGHPAPEYIWYKDGKEIIP 11119

Fly 1859 -DKHTAITVDGDHYKLEVQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGL 1922
|::|.|..:|....|.:..|...|.|.|||:|:|..|....:.|: |:
Worm 11120 TDENTEIVNEGSMSALIIHELAGEDVGLYKVLVENIHGTAESEAEV-----------------GI 11167

Fly 1923 KDIKVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILEA 1987
.|::.:..... .|:..:::|.. ::.||
Worm 11168 SDVRAHFNSSF-----------SELTEIEEGHD--------------------IELTC------- 11194

Fly 1988 EIKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTR 2052
|:.| |..|.|.|.: ..|.:..|.:.|.|:.:
Worm 11195 EVSD----EEAVVNWYKD-------------------GKKLVASDRVQFYAMAR----------- 11225

Fly 2053 GNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIV 2117
.....:....||| ..|..|| .::||:..:..:.|..::|..:|
Worm 11226 -------KRTLRIKGSTDAD------SGVYKCE---------TTDGRSRTEGEVIVNEQEPHILV 11268

Fly 2118 QPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESV 2182
.|:...:.|:............|:..::|||:...| .|..:|...:.|.|:.|
Worm 11269 GPQDAIVKDFGETMVLFCETSKPVRKVKWFKNGVEI------WPQMNKAIMENDGKRAT------ 11321

Fly 2183 LDIKSFRENDVGAYTC-VATNEIGVTKAPFKLAMLSLAPSFV--KKLDNALDVLQGEPLVLECCV 2244
|:||:|.::|:||||. |:..| |.||.|| :..:||:.: .::.:.:.|..|.........
Worm 11322 LEIKNFDKHDIGAYTASVSEKE---TSAPAKL-VFEVAPNLIIPTEIRDGVTVHAGNEFDFAVEF 11382

Fly 2245 DGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIISNPHGEKVALCAV 2309
.|.|:||:....:| .|.::|.:.|..|..|.:.:.....::||..::|..:|.|:.:....:
Worm 11383 SGFPIPTIHLTNNG---TPLKAIAVVTEYDDSVSVRMKDVTLDNSGTVRVIAESPLGQCIKEIPL 11444

Fly 2310 AV--KPEEMQPKFLKPITSQTVVVGEPLKLE---AQVTGF-------------PAPEVKWYK--- 2353
.: ||........|.:|..:|.:.....|| |.:||: |..:||..|
Worm 11445 KIIDKPSAPCDLQFKEVTEDSVFLSWQPPLETNGAPLTGYVIERKAVDNNRWRPCGQVKPTKLTF 11509

Fly 2354 ------------------------------DGMLLRPS-----------PEINFINSPNGQIGLI 2377
|.:.|..| |:|..:.:| |:.:.
Worm 11510 VAEDLFCNQVYGFRILAVNEVGESEPCDTVDVLTLESSEPVSESSELFVPKIAILRTP--QVTVA 11572

Fly 2378 IDAAQPL-------DAGVYK-----------CLIAN------------KGGE------IEGVSKV 2406
:|..:.. :..:|| ..||| :.|| ..|:..|
Worm 11573 VDETKVTLRWEECPETSLYKVERKKVGDSDWLEIANTDRNKFKDRSLTESGEYVYQVTATGIHAV 11637

Fly 2407 EIVPKESKPV--------------------------------FVAELQ------DASSIEGFPVK 2433
....:|:.|| .|||.| ..|:.|....|
Worm 11638 SSPSEETNPVKILVPGSEMPASKTEKKTDAAKSESEQKSAEEIVAEKQVDQSQASESTTEAVEEK 11702

Fly 2434 MDIKVVGNP-------------KPKLQWFHNGHEIKPDASHIAIVENPDNSS-SLIIEKTAPGDS 2484
...|||... |.||:......:::.::...::..:.||.| :...||.:..:
Worm 11703 KTKKVVKKKVAENKGEETLQEVKEKLKKGKAVEKVQDESRRGSLQASSDNESVTTTSEKRSEAE- 11766

Fly 2485 GLYEVIAQNPEGSTASK---AKLYVAPKAD----ET---ATEEAPQFVSALRD---VNADE---- 2532
:.:|.|.|...| |.|..|.||: || .||:..:.|..:.. |.||:
Worm 11767 -----LEKNSEKSAEKKSTSADLEAADKAETEKSETGKETTEKKKKVVKKVAKKGLVKADKSKIE 11826

Fly 2533 ---GQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLA 2594
|:|..:||. ::.....|.|.|||..| :....:|..|....:.|...:...||.:||.:.
Worm 11827 LTAGKEGEISAQ-VAETGVSVEWKKDGKAL--DASYTVTSTGGVSTVKIPIVDVNTSGVFTCKVK 11888

Fly 2595 NPLGEDSSACNANVRKVYKPPVFTQKISDQQQV----FGNNAKIPVTVSGVPYPDLEWYFQDKPI 2655
:..|::.....|...|:.:.| |:..:|.: .|:.||:...:| .|...:.|...||||
Worm 11889 SSEGDEEEVSIAVTVKLPEVP----KVEAEQSIVEVKVGDVAKLSAKIS-EPASSVNWTKDDKPI 11948

Fly 2656 PK--SEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEPPV 2718
.: :.|..:..||. ..|.::..:....|:||....|..|| |:::|...||..::..|.:
Worm 11949 KEDGNVKAQLSPDGT-AQLTISKTDSAHSGIYKLNVENDAGK----GKVEIALRIKGAAKGAPGI 12008

Fly 2719 FLKKIGDCDIYEGMVAKFT--------AC-ATGYPEPEVE-----W---FKNDQKLFPSDRFLID 2766
....|...|:.|.. |:|: .| .|||.....| | .|..:..|.:|
Worm 12009 PTGPIVFDDVTESS-AEFSWKAPENNGGCEITGYNVERKESKNKGWKQCGKTKELKFKAD----- 12067

Fly 2767 IEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDFKKYKKSG 2831
|| :..|:||| .....|..|.. ..||.:.|..||.:::|
Worm 12068 ----GL-----EEGTDYDV---KVSAVNTMGTG---------------SALEGKITTLKKKEETG 12105

Fly 2832 --------APPPLSEGPIISRM-----------TDRGLLLSWNPSVPLTPRYPITYQIEMMDL-P 2876
:....||...:|.: |...:.|.|. :....:||.::|.:. .
Worm 12106 KQKSEKSESDEKKSESDKVSELKQIGKPEYVSSTATSIALKWT-----SDNDEVTYTVQMKEANS 12165

Fly 2877 EGDWRTLRTGVRSCACDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLP 2941
:..|..:...:..|:..|..|:....|.|||..:||.|.:..|..:::...|...:..|
Worm 12166 KRPWAVVAKEISECSATIAQLKEGTSYLFRVIAQNKTGQTVTSEQSESIECKDTTESKK------ 12224

Fly 2942 PGTDFRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTY 3006
|.|.....|:: .||:..|::.....|:|.|::.:
Worm 12225 ------------------------------PAFTNAPTDLT-AVKNGKTKITAEFTGHPAPEIHW 12258

Fly 3007 YFDDMLIESGGRFDQSYTRN--GQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRF 3069
:.:...|.||.| .:..| |..:|.|.:|.:.|.|.|:.|..|..|......:|.:.:.|.
Worm 12259 FKNKKEIFSGKR---QWIENIAGATSLTIGEMREDDEGEYKIVVKNTAGSVEHSCKLTMDQLPE- 12319

Fly 3070 LKRPD---ETFIMAR-KNGRIEAKLVGIPLPEVHWF-KDWKPIVDSSRIKISSYDPDIYVLSIHD 3129
:.|.| .|.:..: :..::.....|.|.|||.|. .:.|.|.:|.::||.....:. ||:|:.
Worm 12320 INRVDRYASTLVFDKGETVKLRLSFSGRPQPEVIWIDNNGKVIEESRKMKIEKTVLNT-VLTINS 12383

Fly 3130 SIIKDGGLYSISARNIAGSISTSVTVHIEEN---------EDQYI-------------------- 3165
...:|.|.:::..:|..|....::.:.:.:. |||.:
Worm 12384 IDSQDQGEFALKIKNRCGEDKYAIGIQVTDRPAAPGKPAVEDQNVDSVRLRWAAPTNDGGSPVRN 12448

Fly 3166 ----------------------------------YK-------TYGR------------------ 3171
|: |:|:
Worm 12449 YTVEMCTEKGKTWTKAEVTKQAFITLFNLVPGESYRFRVRADNTFGQSEPSDESELVVVKNVSRV 12513

Fly 3172 --HPYVRSKQLRYQD------------------------------KYDIGDELGRGTQGITYHAV 3204
.|..:..:::.|: ||.|.:|||:|..|..|.|.
Worm 12514 VEEPKKKEVKVKEQESVDYERVAKDSEPSEYKTIDIHRLPNDLQAKYIIHEELGKGAYGTVYRAT 12578

Fly 3205 ERSSGDNYAAKIMYGRPEL-RPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELV 3268
|:::|..:|||::..||.: :..:::|:.|||..:|:.|:..::|:|....:.||.|..:||||.
Worm 12579 EKATGKTWAAKMVQVRPGVKKENVIHEISMMNQLHHEKLLNLHEAFDMGNEMWLIEEFVSGGELF 12643

Fly 3269 RDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKI 3333
...|......:|.::..|:.|.|.|:.|||:..:.|:.|..:::|:.....:.:|:.||||:||:
Worm 12644 EKILEDDSLMSEEEVRDYMHQILLGVSHMHKNQIVHLDLKPENILLKAKNSNELKIIDFGLARKL 12708

Fly 3334 NRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGR 3398
:......|.:|.|||.:|||||.:.|..|.||||||:|:||||.|.:||||..|.:||..:....
Worm 12709 DPKKSVKLLFGTPEFCAPEVVNYQPVGLSTDMWTVGVISYVLLSGLSPFLGDSDEDTLANVSASD 12773

Fly 3399 WDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWF------FMLDRPVYDHDYQIGTD 3457
|||.|..|..:||..:|||.||::....:||.|:.||:|||. ...|...|....|...|
Worm 12774 WDFDDPSWDDVSDLAKDFICRLMIKDKRKRMSVQDALRHPWITGPLLSAFNDLSEYVKKMQPKLD 12838

Fly 3458 R-------LRNYYDHFRDWYAN-------ASCKNYFRRRRLSGCFQH---------PS------K 3493
: .||:.. .:.|..: |.....|||..:.|.|:. || .
Worm 12839 KSGVPARQKRNFLS-LKRWSDDLLPIGRLAKRGAIFRRLTMDGVFERNIAFDTDAAPSVKKQLED 12902

Fly 3494 MVYPPGH-VYTPENTPEPLPEPRIRAKREE----VVSKYLHPDYELGLIQSESHYQYGPDTYLLQ 3553
:|...|. :.|.....:.:|.|:::..::: |.|......|..||.:.........|.....
Worm 12903 IVANVGDLIATLSCDVDGVPSPKVQWYKDDKELTVPSMKYDSFYNEGLAELTVKNIVESDAGKYT 12967

Fly 3554 LRDVN----------FPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRERR-RFTD---IMDEEI 3604
.|..| ..|:..|..|...:.||: ||.::: |.|. :::|.|
Worm 12968 CRATNDLGSIMTHAKLSVKADEKKKKKSKTSPA------------VIEKKKDRKTSKVVVIEEMI 13020

Fly 3605 D----------DERTR----------------SRISMYAANESYSIR---------RLRTELGPR 3634
| |:..: ..:..|...|..||. :.|.||...
Worm 13021 DMPPNFHHLLQDDEAKIGEPKILVVTNTTLPEPTVDWYHNGEHISINDSNYLRKHDKGRYELHIL 13085

Fly 3635 LDEYTE--------ADAMIETQREG----------YPPFFREKPQTIAITENQPSHIHCFAVGDP 3681
..:.|: .:|..|.:.|. |.|.|.::...:..:|:....:......:|
Worm 13086 SVDSTDEGKWKAVGKNAFGECESEAKLTVVIPDGQYAPSFGKQLSDVKCSESDILKLEVNIQANP 13150

Fly 3682 KPCVQWFKNDMVLTESKRIKISVDE-DGRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVA 3745
.|.:.||:|:..:..|:..::..|: .|...|....|...|.|.||.||:||:|:....|.:.:.
Worm 13151 APEINWFRNESEIEHSQHHRLQFDDGSGNYSLTIIDAYAEDSGEYKCVAKNKIGKAHTVCCVRIE 13215

Fly 3746 TLPDAPDSPEISANSGTEILLRWKQPRD---DGHSTVLCYSLQYKLSNCDAWTTVADNIDHEFYL 3807
.|. :..|.:|..:......::...||: ....|::| :|:..
Worm 13216 ELL-SKRSKKIDGSKAPRFRMQLPTPREVPQGADLTLVC--------------SVSGT------- 13258

Fly 3808 LHDLQPNTNYQFRLASKNRIGWSEMGIPVSASTVGGDAPKIHITKAMKHLQQLTENG----HQVV 3868
|:.| |.|::...|:..| .|.::| ||| | ::
Worm 13259 -----PHPN----------IKWTKDDKPIDMS-----------NKQVRH-----ENGVCTLH-II 13291

Fly 3869 PEEERVHTDYHCEREPPNWVTDSSVSDKYSFISEIARGEFSTIVKGIQKSTDTVVVAKILEVTDE 3933
...:.....|.||.|..:.|..| || |.:|.|..|
Worm 13292 GARDDDQGRYVCEAENIHGVAQS----------------FS--------------VVEIKEAVD- 13325

Fly 3934 NEDNVVAEF----DNFKTLR-HERIPALFSAYKPLNVPIAIFVMEKLQGADVLTYFSSRHEYSEQ 3993
:|:|..:| .|..|.. :|.:.......||: ..:|: |.:.
Worm 13326 -KDHVRPKFLEPLVNCSTCEGNEMVLECCVTGKPI---------------PTITW------YKDG 13368

Fly 3994 MVATVVTQLLDALQYLHWRGYCHLNIQPDNVVM--------ASVRSI-------QVKLVDFGSAK 4043
:...:..:: |||...:|...|||. |||| .:|.|: .||:||.|.:|
Worm 13369 LKLIIENRM---LQYTDRKGVSRLNIM--NVVMNDDGEYTCEAVNSLGKDFTHCTVKVVDMGLSK 13428

Fly 4044 KVNKLGMKVTPCGS 4057
.::||..|
Worm 13429 ------TRLTPVRS 13436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091	31/191 (16%)
		PH_unc89	275..388	CDD:270134	24/133 (18%)
		Atrophin-1	<493..690	CDD:331285	44/225 (20%)
		TonB_N	502..>596	CDD:318287	22/107 (21%)
		I-set	1017..1108	CDD:333254	17/94 (18%)
		I-set	1123..1212	CDD:254352	23/122 (19%)
		I-set	<1236..1299	CDD:333254	18/73 (25%)
		I-set	1313..1403	CDD:254352	17/93 (18%)
		Ig_3	1406..1487	CDD:316449	17/84 (20%)
		I-set	1499..1595	CDD:254352	18/108 (17%)
		I-set	1599..1690	CDD:333254	26/120 (22%)
		I-set	1694..1786	CDD:254352	20/97 (21%)
		I-set	<1836..1903	CDD:333254	28/67 (42%)
		I-set	1922..2005	CDD:333254	11/82 (13%)
		I-set	2018..2108	CDD:333254	12/89 (13%)
		I-set	2113..2214	CDD:333254	29/101 (29%)
		I-set	2220..2302	CDD:254352	17/83 (20%)
		I-set	2318..2408	CDD:254352	29/185 (16%)
		I-set	2415..2506	CDD:254352	26/145 (18%)
		I-set	2519..2608	CDD:254352	23/98 (23%)
		I-set	2615..2696	CDD:254352	22/86 (26%)
		I-set	2717..2805	CDD:254352	22/104 (21%)
		FN3	2834..2925	CDD:238020	21/102 (21%)
		I-set	<2996..3063	CDD:333254	19/68 (28%)
		I-set	3067..3157	CDD:333254	22/94 (23%)
		PK_Unc-89_rpt1	3182..3440	CDD:271011	102/288 (35%)
		I-set	3654..3744	CDD:333254	23/90 (26%)
		FN3	3748..3840	CDD:238020	12/94 (13%)
		STKc_Unc-89_rpt2	3893..4151	CDD:271014	38/185 (21%)
ttn-1	NP_001346715.1	IG	105..177	CDD:214652
		I-set	205..285	CDD:333254
		I-set	406..493	CDD:333254
		I-set	821..914	CDD:333254
		Ig	962..1032	CDD:319273
		I-set	1135..1215	CDD:333254
		I-set	1679..1767	CDD:254352
		Ig	1789..>1845	CDD:319273
		Atrophin-1	<1957..2285	CDD:331285
		I-set	2381..2468	CDD:333254
		I-set	2489..2578	CDD:333254
		I-set	2631..2717	CDD:333254
		I-set	2732..2815	CDD:333254
		Ig	2848..2909	CDD:319273
		I-set	2924..3007	CDD:333254
		RNase_E_G	<3161..3303	CDD:331378
		RNase_E_G	<3356..3556	CDD:331378
		RNase_E_G	<3506..3673	CDD:331378
		RNase_E_G	<3595..3803	CDD:331378
		RNase_E_G	<3722..3912	CDD:331378
		RNase_E_G	<3875..4073	CDD:331378
		FtsK	<4014..>4556	CDD:332908
		RNase_E_G	<4346..4567	CDD:331378
		RNase_E_G	<4525..4723	CDD:331378
		RNase_E_G	<4746..4936	CDD:331378
		RNase_E_G	<4858..5044	CDD:331378
		FtsK	<4960..>5541	CDD:332908
		Neuromodulin_N	<5525..6250	CDD:331332
		Neuromodulin_N	<6198..6681	CDD:331332
		V-ATPase_G_2	<6559..>6683	CDD:330366
		I-set	7448..7535	CDD:333254
		FN3	7540..7630	CDD:238020
		MDN1	<7687..8197	CDD:331582
		Neuromodulin_N	<7944..8780	CDD:331332
		Ig	8886..>8935	CDD:325142
		FN3	9052..9142	CDD:238020
		Neuromodulin_N	<9210..9875	CDD:331332	133/689 (19%)
		Neuromodulin_N	<9583..10392	CDD:331332	173/931 (19%)
		IG_like	10597..>10662	CDD:214653	15/78 (19%)
		Ig	10711..10773	CDD:325142	14/66 (21%)
		FN3	10777..10870	CDD:238020	15/92 (16%)
		FN3	10883..10958	CDD:238020	17/78 (22%)
		FN3	10984..11070	CDD:238020	25/112 (22%)
		I-set	11077..11165	CDD:333254	32/111 (29%)
		IG	11179..11259	CDD:214652	22/162 (14%)
		I-set	11264..11350	CDD:333254	28/100 (28%)
		I-set	11368..11446	CDD:333254	17/80 (21%)
		FN3	11450..11543	CDD:238020	14/92 (15%)
		FN3	11565..11645	CDD:238020	13/81 (16%)
		I-set	11823..11903	CDD:333254	19/82 (23%)
		I-set	11918..11996	CDD:333254	22/83 (27%)
		FN3	12006..12097	CDD:238020	25/123 (20%)
		FN3	12131..12217	CDD:238020	18/90 (20%)
		I-set	12225..12313	CDD:333254	24/91 (26%)
		Ig	12337..12411	CDD:325142	18/74 (24%)
		FN3	12415..12503	CDD:238020	6/87 (7%)
		PKc_like	12566..12815	CDD:328722	97/248 (39%)
		I-set	12894..12985	CDD:254352	15/90 (17%)
		I-set	13024..13114	CDD:333254	12/89 (13%)
		I-set	13123..13206	CDD:254352	22/82 (27%)
		Ig	13249..13314	CDD:319273	20/117 (17%)
		I-set	13331..13421	CDD:254352	22/115 (19%)
		I-set	13456..13545	CDD:254352
		I-set	13558..13650	CDD:254352
I-set	13663..13753	CDD:254352
FN3	13778..13864	CDD:238020
Ig	13893..13963	CDD:325142
I-set	13984..14074	CDD:333254
I-set	14083..14168	CDD:254352
Ig_3	14195..14275	CDD:316449
Ig_3	14302..14384	CDD:316449
I-set	14408..14498	CDD:333254
I-set	14634..14724	CDD:333254
IG_like	14754..14838	CDD:214653
I-set	14854..14943	CDD:333254
I-set	14969..15044	CDD:254352
Ig_3	15054..15132	CDD:316449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810