DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and Mylk4

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_006516731.1	Gene:	Mylk4 / 238564	MGIID:	3643758	Length:	656	Species:	Mus musculus

Alignment Length:	272	Identity:	104/272 - (38%)
Similarity:	163/272 - (59%)	Gaps:	5/272 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  3172 HPYVRSKQLRYQDKYDI--GDELGRGTQGITYHAVERSSGDNYAAKIMYGR-PELRPFMLNELEM 3233
            |..|.:|.....:.|.:  .:.||.|..|..:...|:::|...||||:..| .:.:..:.||:.:
Mouse   360 HRMVMAKHASVDNLYTVSKSEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGAKDKEDVKNEISV 424

  Fly  3234 MNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRD-YYTERDIAHYIRQTLWGLEHM 3297
            ||..:|.|||:.|||:::...:.|:||...||||. |.::..: ..||.|...:::|...|:.:|
Mouse   425 MNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELF-DRIIDENCNLTELDTILFMKQICEGIRYM 488

  Fly  3298 HEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFS 3362
            |:|.:.|:.|..:::|........||:.||||:|:........:::|.|||::|||||.:.|:||
Mouse   489 HQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFS 553

  Fly  3363 HDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEE 3427
            .|||:||:|||:||.|.:||||.:|.||||.|...|||.:||.:..||::.::|||:||:.....
Mouse   554 TDMWSVGVITYMLLSGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSW 618

  Fly  3428 RMDVKTALKHPW 3439
            |:....||||||
Mouse   619 RISASEALKHPW 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011	101/262 (39%)
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Mylk4	XP_006516731.1	STKc_MLCK4	371..631	CDD:271095	101/261 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910