DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and OBSL1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_011509159.1 Gene:OBSL1 / 23363 HGNCID:29092 Length:1918 Species:Homo sapiens


Alignment Length:1897 Identity:420/1897 - (22%)
Similarity:698/1897 - (36%) Gaps:433/1897 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1123 PAFLVSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDKDYLGFYELVIA 1187
            |.||...:...::..........::|:|.|.|.:.|..:: |..::|:....|....|   |::.
Human    12 PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHG---LLLT 72

  Fly  1188 DVQKTDAGTYSCKATNKHGEANCEAIATTVED----------KNPF--------------GALSG 1228
            ....||||.|.|:|.|..|||...|..|.:|.          :.|.              |..|.
Human    73 AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137

  Fly  1229 QILPAGE-----------KPVFQWKRNGEEFD---PEERFKVLFGEDED----SLALVFQHVKPE 1275
            .:|...|           :|...|:::|...|   ....|.:..|..||    ||||.....:..
Human   138 WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202

  Fly  1276 DAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREP-EKPTLVIEHREAN-----ASIGGSAILEL 1334
            |:|:|.|.|:.:.|:....|.|.|....::...:| |.|..|:|..:..     .:.|..|....
Human   203 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRC 267

  Fly  1335 QCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNV--DTVDAGVYTIEAINELGQDES 1397
            ...|.|:|.::|..:|..: :.||.:.||.|.:. ..|:|.:  ...|.|:|...|.|..||..|
Human   268 YVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDG-GFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330

  Fly  1398 SINLVVKAPPK--IKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAESNVKISSSSIG 1460
            ::.|.||.|..  .:.:.|:.........:|.:|.....||.....:.:.:......:|...::.
Human   331 AVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVR 395

  Fly  1461 KSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEKENVQMT 1525
            :.:      :..:|....|.|..:....:...:   :.|||..  |:|....:....|.||..:.
Human   396 RLI------IHRLKADDDGIYLCEMRGRVRTVA---NVTVKGP--ILKRLPRKLDVLEGENAVLL 449

  Fly  1526 VR-IDAYPEAKLTWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATS 1589
            |. ::|..|.:  |..|..|:.:    ...||.|:.:.|.:.|.||.|||:.|...    |::.:
Human   450 VETLEAGVEGR--WSRDGEELPV----ICQSSSGHMHALVLPGVTREDAGEVTFSL----GNSRT 504

  Fly  1590 STQLLIKC-------------------------------APE--FTHKLKNITV----------- 1610
            :|.|.:||                               |||  |.::|:...|           
Human   505 TTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSI 569

  Fly  1611 --------------AEGD--------------------------SNVELVVG---VDAYPRPHA- 1631
                          :|||                          ....||.|   |..|....| 
Human   570 EKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAV 634

  Fly  1632 -----------KWYIDGIEIDEKRND-----------FRHVEEGNDFKLIMNQVATNMQG---NY 1671
                       .|:::|.|:  |.|:           :|..::|...:||::.|.....|   .:
Human   635 FSLDLSTIIQGTWFLNGEEL--KSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGF 697

  Fly  1672 TCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEGKSFT--------LEVEVYSEPEAKIKWF 1728
            :|.      .::|:..:|:...|     :..:..|:..|.|        |..|: |..:....|:
Human   698 SCP------GVQDSAALTIQESP-----VHILSPQDRVSLTFTTSERVVLTCEL-SRVDFPATWY 750

  Fly  1729 KDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTYEMK---ATNFIGETTSTCKVAVLTSE 1790
            |||.::.|...:.:..|.::   :.|.|..|:.:|:|.:|.:   .:.|.|.|.....|.::   
Human   751 KDGQKVEESELLVVKMDGRK---HRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIV--- 809

  Fly  1791 ALSLEQTVTKTLIATTEEPEEGAVPEIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKP 1855
                             :|.|       ||.|....| |.|.|..||.....|   ..||.||:.
Human   810 -----------------DPRE-------HVFVHAITS-ECVMLACEVDREDAP---VRWYKDGQE 846

  Fly  1856 ITPDKHTAITVDGDHYKLEVQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGP 1920
            :.......:..:|.|.:|.:.:....|.||::.|    .|::.....::::.::.:    :....
Human   847 VEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV----AGDECAYFTVTITDVSSW----IVYPS 903

  Fly  1921 GLKDIKVNKGDKVCEPVVFTAD---PAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTL 1982
            |    ||.......|.||.|.:   |..|:...|||:.|||  :..|.:.|:|....||      
Human   904 G----KVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVE--SPALLLQKEDTVRRLV------ 956

  Fly  1983 NILEAEIKDSGRYELKVKNKYGELVTSGWIDVLAKPEISGLNDTKCLPGDTICFEALV------- 2040
             :...:::|||.|..::.::     ::.:...:.:|.:..:     .|.|.:...|:.       
Human   957 -LPAVQLEDSGEYLCEIDDE-----SASFTVTVTEPPVRII-----YPRDEVTLIAVTLECVVLM 1010

  Fly  2041 --QANPKPKVSWTRGNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVD 2103
              .:.....|.|.:  :.|...|:..::.:.|..:.|||..:..|.:.|::...|.:...     
Human  1011 CELSREDAPVRWYK--DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA----- 1068

  Fly  2104 FNLAVLVEKPTFIVQPESQS--IHDYRPVSTKVLVHGVPLPT-IEWFKDDKPINYEAINKPGKDK 2165
            |....:...|..||.|.::|  :|...|...::.....|..: :.|:||...:.           
Human  1069 FFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVE----------- 1122

  Fly  2166 LYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNE-----IGVTKAPFKLAMLSLAPSFVKK 2225
              |.:..:.|.:.....|.:...:..|.|.|.|...:|     :.:.:.|.:...|...||    
Human  1123 --ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPS---- 1181

  Fly  2226 LDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSG 2290
               .|.|..|||:||.|.:..:..|.| |..:|..|:..|.:::.......| |.|.:..|..:|
Human  1182 ---PLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRV-LCIQAAGPAHAG 1241

  Fly  2291 AYKLIISNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEP---LKLEAQVTGFPAPEVKWY 2352
            .|........|  ....:..|:..|...:.:.|..:||.|...|   |:|...::| |...|:||
Human  1242 LYTCQSGAAPG--APSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWY 1303

  Fly  2353 KDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKC---------LIANKGGEIEGVSKVEI 2408
            |||..|.....:....:...|: |.:..|:..|||.|.|         |::     :|....|::
Human  1304 KDGERLASQGRVQLEQAGARQV-LRVQGARSGDAGEYLCDAPQDSRIFLVS-----VEEPLLVKL 1362

  Fly  2409 VPKESKPVFVAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSS 2473
            | .|..|:.|.|..||:    |..:     |..|...:.|..||..:.|...    ||...|.||
Human  1363 V-SELTPLTVHEGDDAT----FRCE-----VSPPDADVTWLRNGAVVTPGPQ----VEMAQNGSS 1413

  Fly  2474 --LIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPKADETATEEAPQFVSALRDVNADEGQEL 2536
              |.:.....||:|...:.|    ||||:.|:|:|        .|....|:..|:||.|:|||::
Human  1414 RILTLRGCQLGDAGTVTLRA----GSTATSARLHV--------RETELLFLRRLQDVRAEEGQDV 1466

  Fly  2537 VLSAPFISNPMPE---------VIWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCL 2592
            .|..        |         |.|.:.|..|..:.||.|..||....|.|.....||.|.|.| 
Human  1467 CLEV--------ETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC- 1522

  Fly  2593 LANPLGEDSSACNANVR----KVYKPPVFTQKISDQQQVFGNNAKIPVTVS--GVPYPDLEWYFQ 2651
               ....|.:....:||    :|.:|      :.|.....|.:|...:.:|  ||..   ||...
Human  1523 ---ESHHDRTLARLSVRPRQLRVLRP------LEDVTISEGGSATFQLELSQEGVTG---EWARG 1575

  Fly  2652 DKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEP 2716
            ...:....|..|.:||..|.|::|.....|.|   |::...:..... .|| ||.|:       |
Human  1576 GVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFTADSLRCA-ARL-IVREV-------P 1628

  Fly  2717 PVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLR-LTIKNV 2780
            ...::...|.::.||..|.| .|.......:|.|.|:...|.||.|  :.::..|..| |.::..
Human  1629 VTIVRGPHDLEVTEGDTATF-ECELSQALADVTWEKDGNALTPSPR--LRLQALGTRRLLQLRRC 1690

  Fly  2781 TEYDVGRYSCRI 2792
            ...|.|.|||.:
Human  1691 GPSDAGTYSCAV 1702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352 24/88 (27%)
I-set <1236..1299 CDD:333254 20/69 (29%)
I-set 1313..1403 CDD:254352 26/96 (27%)
Ig_3 1406..1487 CDD:316449 10/82 (12%)
I-set 1499..1595 CDD:254352 28/96 (29%)
I-set 1599..1690 CDD:333254 27/172 (16%)
I-set 1694..1786 CDD:254352 23/102 (23%)
I-set <1836..1903 CDD:333254 15/66 (23%)
I-set 1922..2005 CDD:333254 23/85 (27%)
I-set 2018..2108 CDD:333254 16/98 (16%)
I-set 2113..2214 CDD:333254 20/108 (19%)
I-set 2220..2302 CDD:254352 22/81 (27%)
I-set 2318..2408 CDD:254352 27/101 (27%)
I-set 2415..2506 CDD:254352 28/92 (30%)
I-set 2519..2608 CDD:254352 27/97 (28%)
I-set 2615..2696 CDD:254352 18/82 (22%)
I-set 2717..2805 CDD:254352 21/77 (27%)
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
OBSL1XP_011509159.1 IG_like 18..101 CDD:214653 22/86 (26%)
IGc2 25..88 CDD:197706 17/66 (26%)
IG 134..226 CDD:214652 23/91 (25%)
IGc2 142..216 CDD:197706 18/73 (25%)
IG 252..336 CDD:214652 23/85 (27%)
Ig 252..336 CDD:299845 23/85 (27%)
I-set 342..426 CDD:254352 9/92 (10%)
Ig 358..421 CDD:143165 8/68 (12%)
IG_like 435..510 CDD:214653 23/84 (27%)
FN3 518..602 CDD:238020 9/83 (11%)
IG 725..802 CDD:214652 20/80 (25%)
Ig 734..802 CDD:143165 18/71 (25%)
Ig 825..893 CDD:143165 17/74 (23%)
Ig 916..984 CDD:143165 20/81 (25%)
IG 1005..1074 CDD:214652 12/75 (16%)
Ig 1007..1075 CDD:143165 12/74 (16%)
IG_like 1097..1154 CDD:214653 10/69 (14%)
IGc2 1099..1159 CDD:197706 11/72 (15%)
Ig_Semaphorin_C 1178..1267 CDD:143180 25/99 (25%)
IG 1180..1262 CDD:214652 24/92 (26%)
IG 1282..1343 CDD:214652 20/62 (32%)
IGc2 1283..1341 CDD:197706 19/59 (32%)
I-set 1361..1444 CDD:254352 30/100 (30%)
ig 1364..1430 CDD:278476 22/78 (28%)
IG_like 1456..1535 CDD:214653 25/90 (28%)
Ig 1481..1536 CDD:143165 17/58 (29%)
I-set 1541..1624 CDD:254352 22/96 (23%)
I-set 1631..1714 CDD:254352 21/75 (28%)
Ig 1635..1724 CDD:299845 21/71 (30%)
I-set 1725..1803 CDD:254352
Ig 1814..1893 CDD:299845
IG_like 1815..1893 CDD:214653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10356
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100287
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.