DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and MCF2L

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_011535788.2 Gene:MCF2L / 23263 HGNCID:14576 Length:1238 Species:Homo sapiens


Alignment Length:664 Identity:165/664 - (24%)
Similarity:248/664 - (37%) Gaps:165/664 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 SSNGKESGDAEFRKLTILR-----ELVETEEEFSRDLLHVVEKYIKGIDKPVVPR----SVRDNK 129
            |..|:.|...|...|.|||     ||::||..:..:||.|:|.|...:|.|::..    .:.:.|
Human   641 SRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK 705

  Fly   130 DIIFCNFLQIAEFHNNVLKEGLKCYSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSPD 194
            |::|.|..:|..|||.:....|:.|::.|.:|.:.||....||..:..||||:|.::.......|
Human   706 DVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD 770

  Fly   195 AKKYFQELSKQLGDDKSLAEHLKLPIQRINDYQLLFKDFIKYSLSLKENVKDLERALELMLSVPS 259
            . .:|||..::|....||..:|..|:|||..||||.|:.:|||.:. |..:||:.||..:|.:..
Human   771 C-PFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNC-EGAEDLQEALSSILGILK 833

  Fly   260 RAYDNRFLSSIEGCRGNIYKLGRLLLHAWCNVVDKEGKAH------------DRYCFLFKSRILV 312
            ...|:..|.:|.|..||:..||:||:....:|.....:.|            .|:.||.:..:|.
Human   834 AVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLF 898

  Fly   313 TKVRKISEN------------------RSVFILQNIVKLPLCNIELKADEKQIHLSLKAPEANSF 359
            .|.|:  ||                  .:|.|.:|:          |.|.|:..:...|.|....
Human   899 CKKRE--ENGEGYEKAPSYSYKQSLNMAAVGITENV----------KGDAKKFEIWYNAREEVYI 951

  Fly   360 LPIDIKPHGPEAHLTWFNEISSHINQDVTLQEHNADDLKVDASQIASESELILHLPQRAEAHDPN 424
                ::...||....|.|||.                 ||..||:.:..|...|   ||.....:
Human   952 ----VQAPTPEIKAAWVNEIR-----------------KVLTSQLQACREASQH---RALEQSQS 992

  Fly   425 LSV-RPSDVAENYFLSKETKERLQHEQQELLKLEQEAIELYKKQQSSKSVSSKTESVEITSSQVK 488
            |.: .|:..:.:...|:..|           |||:.                ||:.:.:..  ..
Human   993 LPLPAPTSTSPSRGNSRNIK-----------KLEER----------------KTDPLSLEG--YV 1028

  Fly   489 SSSEVRKVVSPPPPPQAQVKEVTPVKVVSSPPPPKEITPAKVATPPPQPQVVTSPVK-----EVA 548
            ||:.:.|     ||.:.:...||.....||....|..|....|....|....|||.|     ||.
Human  1029 SSAPLTK-----PPEKGKDDTVTSSASESSALSRKRFTLQGFANLKGQKASPTSPDKKAKRHEVK 1088

  Fly   549 PPPQPRAV-------------------ASPAKEVTPSQSEPVKAPSPIKEVRKEVPPSASHSK-- 592
            ..|.|..|                   :|..:::..|.:|......|.|.|..:....|.|.|  
Human  1089 SDPTPFGVRGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGG 1153

  Fly   593 ---------EVEALV------------ATEIRESLTETRSTVVESGQSSEIREEIVVTEESSLEG 636
                     :|..||            .|..:|......|..|..|.|..  .:.:.:.||| .|
Human  1154 PDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGS--AQCLSSSESS-PG 1215

  Fly   637 KQVVALEREPSPCS 650
            ..|::   ..|.||
Human  1216 SAVLS---NSSSCS 1226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091 61/178 (34%)
PH_unc89 275..388 CDD:270134 30/142 (21%)
Atrophin-1 <493..690 CDD:331285 46/205 (22%)
TonB_N 502..>596 CDD:318287 28/128 (22%)
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
MCF2LXP_011535788.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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