DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and MCF2L2

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_055893.4	Gene:	MCF2L2 / 23101	HGNCID:	30319	Length:	1114	Species:	Homo sapiens

Alignment Length:	535	Identity:	127/535 - (23%)
Similarity:	216/535 - (40%)	Gaps:	113/535 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ISSKASEKSRC--FVRMFDSGDSPKEGWVPIDILEFNPTMSSSNGKESGDAEFR----------- 86
            :|||.|:.|..  ..|...:.:.|           :..|..:|.|||..:.:|.
Human   548 VSSKTSQPSTSVPLARPLRTSEEP-----------YTETELNSRGKEDDETKFEVKSEEIFESHH 601

  Fly    87 ------------------KLTILRELVETEEEFSRDLLHVVEKYIKGID----KPVVPRSVRDNK 129
                              :..|:|:|:||||.:.:::..:::.||..:|    |.::|..:::||
Human   602 ERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNK 666

  Fly   130 DIIFCNFLQIAEFHNNV-LKEGLKCYSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSP 193
            |.:|.|..::.||||.. |||..||..| |.::|..||:.:.|...:..|.:|.|.|:.......
Human   667 DFLFGNIRELYEFHNRTFLKELEKCAEN-PELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQ 730

  Fly   194 DAKKYFQELSKQLGDDKSLAEHLKLPIQRINDYQLLFKDFIKYSLSLKENVKDLE-RALELMLSV 257
            |. .||....:||..:..|.::||.|.||:..||:|.|..:.:     |:.:|:| ...||..|.
Human   731 DC-AYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDF-----ESPEDMEIDPGELGGSA 789

  Fly   258 ---PSRAYDNRF-----------------------LSSIEGCRGNIYKLGRLLLH----AWCNVV 292
               |.|..|:.|                       |:::..|..:|.|||:||||    .|....
Human   790 KDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHK 854

  Fly   293 DK-------EGKAHDRYCFLFKSRILVTKVRKISENRSVFILQNIVK-LPLCNIELKADEKQIHL 349
            |:       ..|...|..:||:..|:..|:|....::.:....:..| :.|..:.::...:..|.
Human   855 DRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHR 919

  Fly   350 SLKAPEANSFLPIDIKPHGPEAHLTWFNEISSHINQDVTLQEHNADD-------LKVDASQIASE 407
            ..:....|......::....|....||:|||..:.:    |::|..|       :.......|..
Human   920 KFEIASRNGLEKYILQAASKEIRDCWFSEISKLLME----QQNNIKDQGNPQFEMSTSKGSGAGS 980

  Fly   408 SELILHLPQRA--EAHDPNLSVRP-SDVAENYFLSKETKERLQHEQQELLKLEQEAIE---LYKK 466
            ...|.:: :||  ...||..|... ...:...|.|.:|.|  ..|..|.::.|..|:.   |::.
Human   981 GPWIKNM-ERATTSKEDPASSTGGIKGCSSREFSSMDTFE--DCEGAEDMEKESSALSLAGLFQS 1042

  Fly   467 QQSSKSVSSKTESVE 481
            ..|.::.|||:..:|
Human  1043 DDSHETCSSKSAFLE 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091	58/178 (33%)
		PH_unc89	275..388	CDD:270134	27/124 (22%)
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
MCF2L2	NP_055893.4	SEC14	52..190	CDD:214706
		SPEC	321..523	CDD:238103
		Spectrin	323..428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..614		13/76 (17%)
		RhoGEF	623..820	CDD:214619	61/203 (30%)
		PH-like	827..956	CDD:418428	28/132 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1114		22/99 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810