DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Unc-89 and D630003M21Rik

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_808325.2	Gene:	D630003M21Rik / 228846	MGIID:	3606579	Length:	1187	Species:	Mus musculus

Alignment Length:	961	Identity:	183/961 - (19%)
Similarity:	295/961 - (30%)	Gaps:	381/961 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  2108 VLVEKPTFIVQPES---QSIH--------DYRPVSTKVLVHGVPLP--------TIEWFKDDKPI 2153
            :|:.:..|.:|.||   ||:|        |.|.|..|      |:|        |.||.
Mouse    98 LLLRQGDFYLQVESWEEQSVHMTLKCLSSDLREVDKK------PIPESSYSLIFTPEWL------ 150

  Fly  2154 NYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGA---YTCVATNEIGVTKAPF-KLA 2214
              ||||                               ||...   :.|:..:|.|:|..|: |:.
Mouse   151 --EAIN-------------------------------NDFEGRPLHNCLVASENGITPVPWTKIT 182

  Fly  2215 MLSLAPSFVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESI------------ 2267
                :|.||.         ...|:|.....||...|    |:|....:|.|..
Mouse   183 ----SPEFVD---------DRPPIVKVPSSDGDSCP----LEDLHLSRPQEPYQAGDLGGKGSVA 230

  Fly  2268 --------KISTNP-DGLVKLE-----------INSCQPNDSGAYKLII--------SNPHGEKV 2304
                    |:|.:. .||:|:|           .:....:..|.|..::        ::|..|.|
Mouse   231 QIWDKGKGKLSGDKYPGLIKVEPARSGQLAFRTDSEASQSLEGDYVALLGFPQEYRGASPDSEVV 295

  Fly  2305 ALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPAPEVKWYKDGMLLRPSPEINFINS 2369
            .|.....|.:|.:|:     |....::|:.|.|                              :.
Mouse   296 TLSVDIQKSQETRPR-----TKGAPLLGKTLPL------------------------------SG 325

  Fly  2370 PNGQIGLIIDAAQPLDAGVYKCLIANKGGEIEGVSKVEIVPKESKPVFVAELQDASSIEGFPVKM 2434
            |.|        |.||  |.:.|......||              ||
Mouse   326 PAG--------APPL--GRWACERPAGSGE--------------KP------------------- 347

  Fly  2435 DIKVVGNPKPKLQWFHNGHEI--KPDASHIAIVEN-PDNSSSLIIE-KTAPGDSGLYEVIAQNPE 2495
               ..|..:.|.:...:||..  :|...|.::.|. ||.:|.|:.: :..|..|.:     |.|.
Mouse   348 ---CSGGSRRKARHKASGHTAVRQPQQPHTSVPEKLPDCTSGLVEDTEEEPAASEM-----QKPV 404

  Fly  2496 GSTASKAKLYVAPK---------------ADETATEEAPQFVSALRDVNADEGQE-LVLSAPFIS 2544
            |...:..:|...|:               |.||.|||     :.|....|.:.:: |..:|.|..
Mouse   405 GMPEAMVRLRPGPRQAFSPLLSSAGPGSPAAETKTEE-----TTLGHGRASKPEDCLNKNASFHG 464

  Fly  2545 NPMPEVIWS---KDGVT-LTPNERLLMTCDGKHIG--------LTIKPAEAADSGNYTCLL---- 2593
            :|.|.:.:|   :..|. :||.:.||     :|..        .:::|.||...|.....|
Mouse   465 SPAPGLQFSFLKEQRVPHVTPEKALL-----QHARPRKALCPLYSLQPCEAKAPGKDGTTLPTTS 524

  Fly  2594 -ANPL-GE------DSSA----------CNANVRKVYKPPVFTQKISDQQQ----VFGNNAKIPV 2636
             :.|| ||      ||:.          |:..     ||.:.|..:...|.    :.|...|:..
Mouse   525 GSGPLSGEPPGFRRDSAGPPGGGLRLEECSRT-----KPRIETLGVKLLQSGIACLPGGRDKVGR 584

  Fly  2637 TVSGVPYPDLEWYFQDKP----------------IPKSEKYSIKNDGDHHMLIVNNCEKGDQ--- 2682
            .:..|...:..|   :.|                :|:.|      |....:|:|.:..||.|
Mouse   585 PLLLVSTAEDAW---EAPWCTTSEVAELLSYLCSVPRLE------DKAKGLLVVIDARKGTQRPG 640

  Fly  2683 --------------GVYKCIASNREGK----DITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIY 2729
                          .|.|.:....:..    .:...:::::..:|.......|..|.     :..
Mouse   641 LVSALQGIQALAPASVSKVLLLGEKASIPQLSVLPAQVEVLTSLKALRNHVDPSQLP-----EAL 700

  Fly  2730 EGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDI-EPNGLLRLTIKNVTEYDVGRYSCRIF 2793
            ||          .:|....||.:..|||   |.||.|: :.:.||:.:|:   |::.|
Mouse   701 EG----------PFPYHHSEWVQFFQKL---DPFLTDLRQASSLLQASIQ---EFEKG------- 742

  Fly  2794 NPYGDDICHAELFYDSLDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSV 2858
            .|.|...........|.:..:..|.|  ......::.|       |..::.:......|:.||.|
Mouse   743 EPPGGVQEATRCLSKSKELMETVLRD--PGLLALQREG-------GTTLASLQQEASGLNANPDV 798

  Fly  2859 PLTPRYPITYQIEMMDLPEGDWRTLRTGVRSCACDIRNLEPFRDYRFRVRV 2909
                |..:|....:.:|.:|....|.|.....   :|.||      .|||:
Mouse   799 ----RSHLTEAAALYNLVDGQLHDLVTASNQL---LRRLE------LRVRL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254	183/961 (19%)
		I-set	2113..2214	CDD:333254	28/123 (23%)
		I-set	2220..2302	CDD:254352	21/121 (17%)
		I-set	2318..2408	CDD:254352	14/89 (16%)
		I-set	2415..2506	CDD:254352	18/94 (19%)
		I-set	2519..2608	CDD:254352	26/123 (21%)
		I-set	2615..2696	CDD:254352	17/121 (14%)
		I-set	2717..2805	CDD:254352	21/88 (24%)
		FN3	2834..2925	CDD:238020	17/76 (22%)
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
D630003M21Rik	NP_808325.2	PRK10475	<276..357	CDD:236698	24/161 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..405		33/188 (18%)
		PHA03247	<303..646	CDD:223021	85/452 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..451		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1148..1187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900