DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and Sestd1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_780674.1	Gene:	Sestd1 / 228071	MGIID:	1916262	Length:	696	Species:	Mus musculus

Alignment Length:	835	Identity:	150/835 - (17%)
Similarity:	265/835 - (31%)	Gaps:	292/835 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 ISSRRDRSSVDKVEARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSSRLQEDRPLR 1012
            :|..:||        ||.|:.|........|..|.........|:...:...|..:.:.:.|..:
Mouse    17 LSGGKDR--------RSGLILTIPLCLEQTSMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQ 73

  Fly  1013 -SVDKPVVVKMLKSV---------QVEPGE-----TAHFEIQFKDQPGLVTWLKDNKPLEDRLAD 1062
             :|.|.||: ||::|         .|:|.|     ..||          ..|.:     :|||..
Mouse    74 WNVVKTVVL-MLQNVVPAEVSLVCVVKPDEFWDKKVTHF----------CFWKE-----KDRLGF 122

  Fly  1063 RITQTAAPMNSYRLDIKNCSETD--AGTYT-----------IRAQSASETTTVSAQLAV---GQA 1111
            .:...:|  |.....|:.|..|:  .|:.|           :..:...|:|::..:||:   |..
Mouse   123 EVILVSA--NKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSD 185

  Fly  1112 PGHDETK-TNTEPAFLVSLKDAEMIENT----LFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQ 1171
            .|:::.| .:.:..||.|: |.|.:..|    |.....:........|.:...:.|:|.....::
Mouse   186 KGNEQEKERSVDLNFLPSV-DPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMK 249

  Fly  1172 IIRD--KDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQILPAG 1234
            ::..  :.|..:.|:              |:..:|  ....|.|...|  ......|.|   |..
Mouse   250 LLDSLREQYTRYQEV--------------CRQRSK--RTQLEEIQQKV--MQVVNWLEG---PGS 293

  Fly  1235 EKPVFQW------------KRNGEEFDPE--ERFKVLF------------GEDEDSLALVFQHVK 1273
            |:...||            ::..||.:.:  |.|.|..            |::||.:.|.....:
Mouse   294 EQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQ 358

  Fly  1274 PEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKG 1338
            ..|. .|...:|.........|.|...|..|.|:::.:                  .:|.:.|..
Mouse   359 LSDV-CYRQASQLEFRQNLLQAALEFHGVAQDLSQQLD------------------GLLGMLCVD 404

  Fly  1339 FPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESSINLVV 1403
            . .||     ||..||            :::.|:.:.:.:||.|   ::.:.|.||.
Mouse   405 V-APA-----DGASIQ------------QTLKLLEEKLKSVDVG---LQGLREKGQG-------- 440

  Fly  1404 KAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNN-----GKDVTAESNVKI-------SS 1456
                    :.|                       |::|.     |||||.|:...:       ..
Mouse   441 --------LLD-----------------------QISNQASWAYGKDVTIENKENVDHIQGVMED 474

  Fly  1457 SSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTV---------------KSKPVI 1506
            ..:.|...:.:|:|:.:|:.|.... .|...|.||..|:.|..:               ::|.::
Mouse   475 MQLRKQRCEDMVDVRRLKMLQMVQL-FKCEEDASQAVEWLSELLDALLKTHIRLGDDAQETKVLL 538

  Fly  1507 VKN------FESEYIHGEKENVQMTVRI------------DAYPEAKLTWYHDETEIKITDSKYT 1553
            .|:      .:|.|.:| ::.:|.||.:            |..|.....|           .::|
Mouse   539 EKHRKFVDVAQSTYDYG-RQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW-----------KQFT 591

  Fly  1554 VSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVE 1618
            |:|:...:.|::..|...:|.|.......|..:.....|.         .:::.|    |.|.::
Mouse   592 VASEERVHRLEMAIAFHSNAEKILQDCPEEPEAMNDEEQF---------EEIEAI----GKSLLD 643

  Fly  1619 LVVGVDAYPRPHAKWYIDGIE----------------------IDEKRNDFRHVE 1651
            .:.....||        ||.|                      :..||...||.|
Mouse   644 RLTIPVVYP--------DGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPE 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254	24/117 (21%)
		I-set	1123..1212	CDD:254352	14/94 (15%)
		I-set	<1236..1299	CDD:333254	16/88 (18%)
		I-set	1313..1403	CDD:254352	15/89 (17%)
		Ig_3	1406..1487	CDD:316449	15/92 (16%)
		I-set	1499..1595	CDD:254352	20/128 (16%)
		I-set	1599..1690	CDD:333254	13/75 (17%)
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Sestd1	NP_780674.1	CRAL_TRIO_2	33..153	CDD:404584	28/137 (20%)
		SPEC	273..478	CDD:413338	50/288 (17%)
		Spectrin 1	275..378		21/108 (19%)
		Spectrin 2	381..494		32/190 (17%)
		SPEC	413..605	CDD:413338	44/258 (17%)
		Spectrin 3	500..602		20/113 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900