DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and Plekhg1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_006512502.1	Gene:	Plekhg1 / 213783	MGIID:	2676551	Length:	1487	Species:	Mus musculus

Alignment Length:	1405	Identity:	250/1405 - (17%)
Similarity:	464/1405 - (33%)	Gaps:	458/1405 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ILRELVETEEEFSRDLLHVVEKYIKGI-DKPVVPRSVRDNKDIIFCNFLQIAEFHNNVLKEGLKC 153
            :::|::|||..:.:||..:||.|::.| |:..:| .|.:::..:|.|...|..|::.:|::...|
Mouse   213 VVQEILETERTYVQDLKSIVEGYLECIRDQTKLP-LVTEDRAALFGNIQDIYHFNSELLQDLENC 276

  Fly   154 YSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSPDAK---KYFQELSKQLGDDKSLAEH 215
             .|.|..:|:.|:....:|..:..||.|.|.:...|......|   |:|:|..:.|.....|..:
Mouse   277 -ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSY 340

  Fly   216 LKLPIQRINDYQLLFKDFIKYSLSLKENVKDLERALELMLSVPSRAYDNR--------------F 266
            |..|:|||..|.||..:...:.....|....:..|::.|..|.....|.:              .
Mouse   341 LLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSL 405

  Fly   267 LSSIEGCRGNIYKLGRLLLHAWCNVVDKEGKAHDRYCFLFKSRILVTKVR--------------- 316
            |::.||  .::...|.|:|..... :.|..|  :|..||....:|:||.|
Mouse   406 LTNWEG--PDLTSYGELVLEGTFR-IQKAKK--ERTLFLLDQLLLITKKRDDTFTYKAHILCGNL 465

  Fly   317 -----------------------------KISENRSVFILQNIVKLPLCN----IELKADEKQIH 348
                                         |..:::.:::| ::.:|.|.|    .::.|..||..
Mouse   466 MLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVL-HLKRLILENHAAAAKIPAKAKQAI 529

  Fly   349 LSLKA---------PEANSFLPIDIKPHGPEAHLTWFNEISSHINQDVTLQEHNADDLKVDASQI 404
            |.:.|         ||.....|....||    .|...:|.||..::.:...|.:.|..||...:.
Mouse   530 LEMDAIHYPGFCYSPEGEMKTPCGSAPH----RLRRKSEPSSRSHKVLKTSETSQDIQKVSREES 590

  Fly   405 ASE--------------SELIL----------------HLPQRAEAHDPNLSVRPSDVAENYFLS 439
            .|:              |..::                |:.||.:.|          :.:..|.|
Mouse   591 PSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHH----------IRQPLFPS 645

  Fly   440 KETKERLQHEQQE-------LLKLEQEAIELYKKQQSSKSVS---SKTESVEITSS------QVK 488
            :.:.:..:.:..:       ....:..:..|.::..||:..|   ...|..||:||      :..
Mouse   646 RRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRAS 710

  Fly   489 SSSEVRKVVSPPPPPQAQVK-----EVTPVKVVSSPPPP---KEITP------------------ 527
            |:.|     |...||:.:::     :..|.:.:.:.|.|   :.:||
Mouse   711 SAGE-----SNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDN 770

  Fly   528 -------AKVATPPPQPQVVTSPVKEVAPPPQPRAVASPAKEVTPSQSEPVKAPSPIKEVRKEVP 585
                   ..||.........:.|.::...|.....:|...::|:.|.|.        ...|||..
Mouse   771 ISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSS--------LHSRKEAG 827

  Fly   586 PSASHSKEVEALVATEIRESLTET------------RSTVVESGQSSEIREEI----------VV 628
            .....:.........|:.|::.:|            .|::.:..:|:.:..|.          .|
Mouse   828 LGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFV 892

  Fly   629 TEESSLEGKQVVALEREPSPCSIPKIQVYRPVECENPVVTKHKPIEL--------KDIVGYSESL 685
            :::|....:..::..:.||......: :|....|..|:..|....:|        .|:..|.:..
Mouse   893 SQDSLQFSEDDISYHQGPSDTEYLSL-LYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKN 956

  Fly   686 RD-------------GDTAP------AGGSPGRQQGYSANI-------------------TDHAS 712
            .|             .|.||      :....||..|::.::                   ...|:
Mouse   957 EDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRAN 1021

  Fly   713 LTIWNNRLANIAGDRSGANQHLQQSGPPPPPIPPNFTRMPGFFQPLPLIAYETTIEILIVKARPP 777
            .:: :|.:.:..|.....||....|..||...|.:....                      :.|.
Mouse  1022 CSL-DNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANC----------------------SLPQ 1063

  Fly   778 SPPPPPPPTIKRVLVHTESLEQKTQNFFEGIYDAASSDTSLRNAKQKIRSIKSTVLKSKDSTNYA 842
            :.|..|.|.::        :..||::   .::..|      |...|||:.: :.:||.| |....
Mouse  1064 TDPENPDPGME--------VTDKTKS---RVFMMA------RQYSQKIKKV-NQILKVK-SPELE 1109

  Fly   843 QDTVQKAKARDFLHIFTPPVKKRPIYE----IVEEP--------VNIFELEGDYTESIADDFREP 895
            |               .|..:.||.::    |:||.        ..|.|....|.:.:   |||.
Mouse  1110 Q---------------PPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIV---FRET 1156

  Fly   896 SADFEARG----------------QSVGGMDD--YYSGYSRASTRRYETKTRDYDRGTSYDSTVE 942
            ....:..|                |:.|..:|  ::|.||......:..:| :.|..:.|..|:|
Mouse  1157 PLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQT-EQDSKSKYPITLE 1220

  Fly   943 -------RSQYGISSRRDRSSVD----KVEARSSLLAT----------------GRTESRAASRA 980
                   |...|..|.......|    .|:.|.|::.:                ||....|..:.
Mouse  1221 STTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQP 1285

  Fly   981 ESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKP-------VVVKMLKSVQVEPGETAHFEI 1038
            .||.:|.:|..:.:|...|...|..:..:.|.|...|       :...:..|.|.:.|:.:...:
Mouse  1286 YSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTL 1350

  Fly  1039 QFKDQPGLVTWLKDNKPLEDRLA---------------DRITQTAAPMNSYRLDIK--------- 1079
            | ..|..||  :..|.||..::|               |...:..:..:..|||:.
Mouse  1351 Q-DSQKVLV--VNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDP 1412

  Fly  1080 -----NCSE---TDAGTYTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDAEMIE 1136
                 :||:   :.:..|:::       ..||.:|.:              |.:|.:.||::.:.
Mouse  1413 QTPDPDCSDSICSHSTPYSLK-------EPVSGRLGL--------------PPYLTACKDSDKLN 1456

  Fly  1137 NTLFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQIIRDK 1176
            :.|:|       .|.|      :::.|      :|.:|:|
Mouse  1457 DYLWR-------GPSP------NQQNI------VQSLREK 1477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091	47/173 (27%)
		PH_unc89	275..388	CDD:270134	31/169 (18%)
		Atrophin-1	<493..690	CDD:331285	37/272 (14%)
		TonB_N	502..>596	CDD:318287	18/126 (14%)
		I-set	1017..1108	CDD:333254	22/129 (17%)
		I-set	1123..1212	CDD:254352	12/54 (22%)
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Plekhg1	XP_006512502.1	RhoGEF	211..387	CDD:238091	47/175 (27%)
Plekhg1	XP_006512502.1	PH_PLEKHG1_G2_G3	369..514	CDD:270063	23/150 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910