back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and Siglec1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	XP_036015809.1	Gene:	Siglec1 / 20612	MGIID:	99668	Length:	1719	Species:	Mus musculus

Alignment Length:	1889	Identity:	397/1889 - (21%)
Similarity:	650/1889 - (34%)	Gaps:	521/1889 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1017 PVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAPMNSY-----RL 1076
            |.:......|.|..|.||.:...:..:..:|....|.|.::.|...|    |..|.:.     .|
Mouse    46 PCIFSYPADVPVSNGITAIWYYDYSGKRQVVIHSGDPKLVDKRFRGR----AELMGNMDHKVCNL 106

  Fly  1077 DIKNCSETDAGTY--------------------TIRAQSASETTTVSAQLAV------------- 1108
            .:|:....|:|||                    |:....:..|.|:..:|..
Mouse   107 LLKDLKPEDSGTYNFRFEISDSNRWLDVKGTTVTVTTDPSPPTITIPEELREGMERNFNCSTPYL 171

  Fly  1109 ------------GQAPGHDETKT--NTEPAFL-------VSLKDAEMIENTLFRFMVKIIGDPKP 1152
                        ||.|.|..|.:  :.||..:       ::|...:.....|.:|.   :|....
Mouse   172 CLQEKQVSLQWRGQDPTHSVTSSFQSLEPTGVYHQTTLHMALSWQDHGRTLLCQFS---LGAHSS 233

  Fly  1153 RVKFY-------KDEKEILETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYSCKATNKHGEANC 1210
            |.:.|       |..:.:|.::.|                  ::...|..|.:|:..:.:
Mouse   234 RKEVYLQVPHAPKGVEILLSSSGR------------------NILPGDPVTLTCRVNSSY----- 275

  Fly  1211 EAIATTVEDKNPFGALSGQILPAGEKPVFQWKRNGEEFDPEERFKVLFGEDEDSLALVFQHVKPE 1275
                                 ||  ....||.|:|...........||     |.|.       .
Mouse   276 ---------------------PA--VSAVQWARDGVNLGVTGHVLRLF-----SAAW-------N 305

  Fly  1276 DAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKGFP 1340
            |:|.|||.|....|:: .|:.||:...:..:...|..|.|..|            .:.|.| ..|
Mouse   306 DSGAYTCQATNDMGSL-VSSPLSLHVFMAEVKMNPAGPVLENE------------TVTLLC-STP 356

  Fly  1341 KPAVQ-----WKHDGEVIQVDDRHKFMYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESS-I 1399
            |.|.|     |.          ::..:.||..:.:|.:..|...|.|.|..|..|..|.:.|| :
Mouse   357 KEAPQELRYSWY----------KNHILLEDAHASTLHLPAVTRADTGFYFCEVQNAQGSERSSPL 411

  Fly  1400 NLVVKAPPKIKKITD-ITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAES-----NVKISSSS 1458
            ::||:.||....:|. :...||....:...|...|..||.:::.|..:.:.|     |.:...||
Mouse   412 SVVVRYPPLTPDLTTFLETQAGLVGILHCSVVSEPLATVVLSHGGLTLASNSGENDFNPRFRISS 476

  Fly  1459 IGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTS---EYWSCTVKSKPVIVKNFESEYIHGEKE 1520
            ...||.   :|:::::.:.:|.|:..|.|.|..::   ::::...:    ::.|..:|.:.|:..
Mouse   477 APNSLR---LEIRDLQPADSGEYTCLAVNSLGNSTSSLDFYANVAR----LLINPSAEVVEGQAV 534

  Fly  1521 NVQMTVRIDAYPEAKLTWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKY---TVKATN 1582
            .:.....:...|:.:.:||.:.          .:..:|::.:|.:..|:..|||.|   |....|
Mouse   535 TLSCRSGLSPAPDTRFSWYLNG----------ALLLEGSSSSLLLPAASSTDAGSYYCRTQAGPN 589

  Fly  1583 EHGSA--TSSTQLLIKCAPEFTHKLKNITVAEGDSNVE-LVVGVDAYPRPHAKWYIDG------- 1637
            ..|.:  |..|.......|.||.:|...|...||.... |:..||:.|....:....|
Mouse   590 TSGPSLPTVLTVFYPPRKPTFTARLDLDTSGVGDGRRGILLCHVDSDPPAQLRLLHKGHVVATSL 654

  Fly  1638 ----------IEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNC 1692
                      .::....|.. |||       |...|..: :|.|.|:..|..|  ..:...:.|.
Mouse   655 PSRCGSCSQRTKVSRTSNSL-HVE-------IQKPVLED-EGVYLCEASNTLG--NSSAAASFNA 708

  Fly  1693 KPKVKRGLKNVEVQEGKSFTLEVEVYSE---PEAKIKWFKDGHEIYEDARIKISRDTQRIENYYL 1754
            |..|.....:..::||....|...|..|   ..|...||::| .::...    |.:|.|::
Mouse   709 KATVLVITPSNTLREGTEANLTCNVNQEVAVSPANFSWFRNG-VLWTQG----SLETVRLQ---- 764

  Fly  1755 TLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVH 1819
              .:||| ||..|             .|:  :||.:...|...|..:::...:.|:..|:
Mouse   765 --PVART-DAAVY-------------ACR--LLTEDGAQLSAPVVLSVLYAPDPPKLSAL----- 806

  Fly  1820 VDVFQQH------SYESVPLKY-------EVIATGIPKPEAIWYHDGKPITPD------KHTAIT 1865
            :||.|.|      :.:|.||.:       .::||.:           :|..|.      |.||
Mouse   807 LDVGQGHMAVFICTVDSYPLAHLSLFRGDHLLATNL-----------EPQRPSHGRIQAKATA-- 858

  Fly  1866 VDGDHYKLEVQSLDLVDAGEYKVVVQNKVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKG 1930
               :..:|||:.|.|||:|.|.....|.:|..:......:.|..               ::|:
Mouse   859 ---NSLQLEVRELGLVDSGNYHCEATNILGSANSSLFFQVRGAW---------------VQVS-- 903

  Fly  1931 DKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDK-------KDAENGLVQYTCTLNILEAE 1988
                        |:||   |::||.||.:..|...|.:       :|........:.||.|....
Mouse   904 ------------PSPE---LREGQAVVLSCQVPTGVSEGTSYSWYQDGRPLQESTSSTLRIAAIS 953

  Fly  1989 IKDSGRYELKVK---NKYGELVTSGWIDVLAKPE---ISGLNDTKCLP---GDTICFEALVQANP 2044
            ::.:|.|..:.:   .....|.....:.|...|.   :|.|..|.  |   |..:|   .||::|
Mouse   954 LRQAGAYHCQAQAPDTAIASLAAPVSLHVSYTPRHVTLSALLSTD--PERLGHLVC---SVQSDP 1013

  Fly  2045 KPKV----------SWTRGNENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGR 2099
            ..::          |..:|.:.|.. .|..:...|..::.||........:||.||..|:|:.|:
Mouse  1014 PAQLQLFHRNRLVASTLQGADELAG-SNPRLHVTVLPNELRLQIHFPELEDDGTYTCEASNTLGQ 1077

  Fly  2100 --AAVDFNL-AVLVEK-PTFIVQPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINK 2160
              ||.||:. ||.|.. |...|| |.|.::               |..:.|......::| ...|
Mouse  1078 ASAAADFDAQAVRVTVWPNATVQ-EGQQVN---------------LTCLVWSTHQDSLSY-TWYK 1125

  Fly  2161 PGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIGVTKAPFKLAMLSLAPSFVKK 2225
            .|:..|.|:..|            :.|.:..|..:|.|      ||       .:...||...:.
Mouse  1126 GGQQLLGARSIT------------LPSVKVLDATSYRC------GV-------GLPGHAPHLSRP 1165

  Fly  2226 LDNALDVL--------------QGEPLVLE-CCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDG 2275
            :  .||||              ||..|.|. |.||..| |....|..||::..|.:   ..:...
Mouse  1166 V--TLDVLHAPRNLRLTYLLETQGRQLALVLCTVDSRP-PAQLTLSHGDQLVASST---EASVPN 1224

  Fly  2276 LVKLEINSCQPNDSGAYKLIISNPHGE-----KVALCAVAVKPEEMQPKFLKPITSQTVVVGEPL 2335
            .::||:...:|::.|.|.....:|.|:     ::.|..|.||   |.|       |.:|..|||:
Mouse  1225 TLRLELQDPRPSNEGLYSCSAHSPLGKANTSLELLLEGVRVK---MNP-------SGSVPEGEPV 1279

  Fly  2336 KLEAQ-VTGFPAPEVKWYKDGMLLR--PSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKG 2397
            .:..: .....:....|:.:|..|:  |:..:.|:.:....            ||.|.|.:.:..
Mouse  1280 TVTCEDPAALSSALYAWFHNGHWLQEGPASSLQFLVTTRAH------------AGAYFCQVHDTQ 1332

  Fly  2398 GEIEGVSKVEIVPKESKPVFVAELQ------DA------SSIEGFPVKMDIKVVGNPKPKLQWFH 2450
            |           .:.|:|   |.||      ||      .|.....|.:...|...|..::...|
Mouse  1333 G-----------TRSSRP---ASLQILYAPRDAVLSSFRDSRTRLMVVIQCTVDSEPPAEMVLSH 1383

  Fly  2451 NG------HEIKPDASHIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPK 2509
            ||      ||....||.|..::...|:..|.::....||...|...|||..||.::..:|..
Mouse  1384 NGKVLAASHERHSSASGIGHIQVARNALRLQVQDVTLGDGNTYVCTAQNTLGSISTTQRLLT--- 1445

  Fly  2510 ADETATEEAPQFVSALRDVNADEGQELVLSA--PFISNPMPEV----IWSKDGVTLTPNERLLMT 2568
                   |....|:|...::..||..|.||.  |..|.|....    .|::..:...|...|..|
Mouse  1446 -------ETDIRVTAEPGLDVPEGTALNLSCLLPGGSGPTGNSSFTWFWNRHRLHSAPVPTLSFT 1503

  Fly  2569 CDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQQVFGNNAK 2633
                       |...|.:|.|.|....|.|..:|| ...:|.:|.|...|..:..:.| .|:...
Mouse  1504 -----------PVVRAQAGLYHCRADLPTGATTSA-PVMLRVLYPPKTPTLIVFVEPQ-GGHQGI 1555

  Fly  2634 IPVTVSGVPYPDLEWYFQDKPIPKSE------KYSIKNDGDHHMLIVNNCEKG--DQGVYKCIAS 2690
            :...|...|...|..:...:.:..::      |..|:.....:.|.|:..|.|  :||.|.|.||
Mouse  1556 LDCRVDSEPLAILTLHRGSQLVASNQLHDAPTKPHIRVTAPPNALRVDIEELGPSNQGEYVCTAS 1620

  Fly  2691 NREG 2694
            |..|
Mouse  1621 NTLG 1624

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.