DRSC/TRiP Functional Genomics Resources

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Protein Alignment Obsc and dapk-1

DIOPT Version :10

Sequence 1:NP_001097440.1 Gene:Obsc / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_490840.2 Gene:dapk-1 / 187322 WormBaseID:WBGene00003400 Length:1425 Species:Caenorhabditis elegans


Alignment Length:1120 Identity:240/1120 - (21%)
Similarity:390/1120 - (34%) Gaps:354/1120 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3144 NIAGSISTSVTVHIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSS 3208
            |.:.:.::|.|||.::..                    ::|.|:|..|||.|...:.....:|.:
 Worm     6 NSSATSTSSSTVHFDDTP--------------------FEDVYEIETELGSGQFAVVRRVRDRKT 50

  Fly  3209 GDNYAAKIM----YG---RPELRPFMLNELEMMNTF-NHKNLIRPYDAYDTDRSVTLIMELAAGG 3265
            |:.||||.:    |.   |...|..:..|:.::... .:.|::..:..|:|...|.:::||.:||
 Worm    51 GEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGG 115

  Fly  3266 ELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLS 3330
            ||. |::..::...|.:.|.:|:|.|..:.|:|.:.:.|:.:..:::::...|...||:.|||||
 Worm   116 ELF-DHVCAKECLDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLS 179

  Fly  3331 RKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIR 3395
            |:|....:.....|.||||:|||||.|.::.:.|||.||::||:||.|.:||||.:..||.:.|.
 Worm   180 REIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILLSGGSPFLGDNRDETFSNIT 244

  Fly  3396 EGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLR 3460
            ..|:.|.|..:.:.|...:|||.||.:...::|..|:..|:|||....:....|           
 Worm   245 RVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWIRGPEGNAID----------- 298

  Fly  3461 NYYDHFRDWYANASC------KNYFRRRRLSGCFQ------HPSKMVYPPG-------------- 3499
                     ...|||      :::..|:|...|.:      ..||.....|              
 Worm   299 ---------IRKASCITISHIQSFKTRQRWKRCVELVMVLLKASKSSRRIGDGRFDEEDMVASCT 354

  Fly  3500 ------------------HVYTPENTPEPL----PEPRIRAKREEVVSKYLHPDYELGLIQSESH 3542
                              |...|..|.:.|    .||. .|......:||.|.:     :.:..|
 Worm   355 LICAEEGNLRALHKLSALHKLLPNATRKSLKSSFSEPN-GATAMHCAAKYGHAE-----VFNYFH 413

  Fly  3543 YQYGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDE 3607
            .:.|.    :..||.|....|....:.|......:..|:.:|                   :|..
 Worm   414 MKGGN----ICARDDNGDTPLHVACRFAQHTVAGYVANEKID-------------------VDSI 455

  Fly  3608 RTRSRISMYAANESYSIR--RLRTELGPRLD-EYTEADAMIETQREGYPPFFREKPQTIA----- 3664
            ......:::.|.||...|  ||..:|.|||| .....|.::....:...|  |..|..:.     
 Worm   456 NKTGETALHCAVESADTRVVRLLLQLRPRLDLPNASGDTVLHLAADSINP--RIVPLLVCLAPPL 518

  Fly  3665 ----ITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKISVDEDGRSIL------------- 3712
                |.|..|  :|..|......|||      .|.::.....:|::||::.|             
 Worm   519 HLRNIREETP--LHVAAARGHVDCVQ------ALLDANSPIDAVEQDGKTALIIALENGNVDIAS 575

  Fly  3713 --------------RFEPALHF--DVGVYKVVARNKVGQTVARCRIVVATLPDAPDSPEISANSG 3761
                          ..:.|||.  ..|:.:.|      ||:..|.:.|       ||  ::||..
 Worm   576 ILITNGCDINHADHHGDTALHIASKHGLLQAV------QTLCHCAVTV-------DS--VNANKK 625

  Fly  3762 T----------------------EILLRWKQPRDDGHSTVLCYSLQYKLSNCDAWTTVADNIDHE 3804
            |                      ::.||    .|||.:..|......:|........|......|
 Worm   626 TALHLAAHYGHVDIIRVLLLARADVTLR----GDDGLTAELVAVAAERLEAHSLLKMVKSQEIRE 686

  Fly  3805 FYLLHDLQPNTNYQFRLASKNRIGWSEMGIPVSASTVGGDAPKIHITKAM-KHLQQLTENGHQVV 3868
            .| :..|.| .:...|......:|.|:.|......|       :|.::.: ..|:.:|       
 Worm   687 EY-ISQLYP-LDTSLRRIKLKLLGHSQSGKTRLVQT-------LHSSRGISSFLESVT------- 735

  Fly  3869 PEEERVHTDYHCEREPPNWVTDSSV-SDKYSFISE----------IARGE-----FSTIVKGIQK 3917
               .|:...|    .|.:.:.|..: |...||:||          .|.|.     .|...:||..
 Worm   736 ---RRISDHY----SPSSSMKDDGIHSTNGSFVSESNNNSSFDLAAAAGSKYAPPHSQYTRGIDV 793

  Fly  3918 STDTVVVAKILEVTDENEDNVVAEFDNFKTLRHERIPALFSAYKPLNVPIAIFVMEKLQGAD--- 3979
            .|..:              |...||..::          |..|:|::.....||    ..||   
 Worm   794 QTVNI--------------NGCGEFSVWE----------FGGYEPMHTCYDHFV----GNADCIH 830

  Fly  3980 VLTYFSS---RHEYSEQMVATVVTQLLDALQYLHWRGYCHLNIQPDNVV----MASVRSIQVKLV 4037
            ::.|.:|   ..:|.               |.|:|..:....:.|...:    .:|.||      
 Worm   831 LILYRTSDPTEVQYK---------------QILYWMNFLKGRVTPFEPIGHCGFSSRRS------ 874

  Fly  4038 DFGSAKKVNKLGMKVTPCGSLDFQPPEMINDEPIFPQSDIWSLGALTYLLLSGCSPFRGADEYET 4102
                  ||..:|...|  .||.   |:| |.|..:..|||.::                      
 Worm   875 ------KVIIVGTHAT--SSLF---PQM-NQEGEYVSSDIEAM---------------------- 905

  Fly  4103 KQNISFVRYRFENLF 4117
               ::.||.|||..|
 Worm   906 ---LNTVRLRFETHF 917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ObscNP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Not5 <477..>652 CDD:444384
Ig 1017..1108 CDD:472250
Ig strand B 1034..1038 CDD:409353
Ig strand C 1046..1050 CDD:409353
Ig strand E 1074..1078 CDD:409353
Ig strand F 1088..1093 CDD:409353
Ig strand G 1101..1104 CDD:409353
I-set 1123..1212 CDD:400151
Ig strand B 1140..1144 CDD:409353
Ig strand C 1153..1157 CDD:409353
Ig strand E 1182..1186 CDD:409353
Ig strand F 1196..1201 CDD:409353
Ig strand G 1209..1212 CDD:409353
Ig <1236..1299 CDD:472250
Ig strand C 1238..1242 CDD:409353
Ig strand E 1259..1269 CDD:409353
Ig strand F 1279..1284 CDD:409353
Ig strand G 1292..1295 CDD:409353
I-set 1313..1403 CDD:400151
Ig strand B 1330..1334 CDD:409353
Ig strand C 1343..1347 CDD:409353
Ig strand E 1369..1373 CDD:409353
Ig strand F 1383..1388 CDD:409353
Ig strand G 1396..1399 CDD:409353
Ig_3 1406..1487 CDD:464046
I-set 1499..1595 CDD:400151
Ig strand B 1522..1526 CDD:409353
Ig strand C 1535..1539 CDD:409353
Ig strand E 1561..1565 CDD:409353
Ig strand F 1575..1580 CDD:409353
Ig strand G 1588..1591 CDD:409353
Ig 1599..1690 CDD:472250
Ig strand B 1617..1621 CDD:409353
Ig strand C 1630..1634 CDD:409353
Ig strand E 1656..1660 CDD:409353
Ig strand F 1670..1675 CDD:409353
Ig strand G 1683..1686 CDD:409353
I-set 1694..1786 CDD:400151
Ig strand B 1711..1715 CDD:409353
Ig strand C 1724..1728 CDD:409353
Ig strand E 1752..1756 CDD:409353
Ig strand F 1766..1771 CDD:409353
Ig strand G 1779..1782 CDD:409353
Ig <1836..1903 CDD:472250
Ig strand C 1846..1850 CDD:409353
Ig strand E 1871..1875 CDD:409353
Ig strand F 1885..1890 CDD:409353
Ig 1922..2005 CDD:472250
Ig strand B 1933..1937 CDD:409353
Ig strand C 1946..1950 CDD:409353
Ig strand E 1971..1984 CDD:409353
Ig strand F 1994..1999 CDD:409353
Ig 2018..2108 CDD:472250
Ig strand B 2034..2038 CDD:409353
Ig strand C 2047..2051 CDD:409353
Ig strand E 2074..2078 CDD:409353
Ig strand F 2088..2093 CDD:409353
Ig strand G 2101..2104 CDD:409353
Ig 2113..2214 CDD:472250
Ig strand B 2130..2134 CDD:409353
Ig strand C 2143..2147 CDD:409353
Ig strand E 2176..2185 CDD:409353
Ig strand F 2195..2200 CDD:409353
I-set 2220..2302 CDD:400151
Ig strand B 2238..2242 CDD:409353
Ig strand C 2251..2255 CDD:409353
Ig strand E 2277..2281 CDD:409353
Ig strand F 2291..2296 CDD:409353
Ig strand G 2304..2307 CDD:409353
I-set 2318..2408 CDD:400151
Ig strand B 2335..2339 CDD:409353
Ig strand C 2348..2352 CDD:409353
Ig strand E 2374..2378 CDD:409353
Ig strand F 2388..2393 CDD:409353
Ig 2415..2506 CDD:472250
Ig strand B 2432..2436 CDD:409353
Ig strand C 2445..2449 CDD:409353
Ig strand E 2472..2476 CDD:409353
Ig strand F 2486..2491 CDD:409353
Ig strand G 2499..2502 CDD:409353
I-set 2519..2608 CDD:400151
Ig strand B 2536..2540 CDD:409353
Ig strand C 2549..2553 CDD:409353
Ig strand E 2574..2578 CDD:409353
Ig strand F 2588..2593 CDD:409353
I-set 2615..2696 CDD:400151
Ig strand B 2632..2636 CDD:409353
Ig strand C 2645..2649 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2717..2805 CDD:400151
Ig strand B 2734..2738 CDD:409353
Ig strand C 2747..2751 CDD:409353
Ig strand E 2773..2777 CDD:409353
Ig strand F 2787..2792 CDD:409353
Ig strand G 2800..2803 CDD:409353
FN3 2834..2925 CDD:238020
Ig <2996..3063 CDD:472250
Ig strand C 3003..3007 CDD:409353
Ig strand E 3029..3033 CDD:409353
Ig strand F 3043..3048 CDD:409353
Ig strand G 3056..3059 CDD:409353
Ig 3067..3157 CDD:472250 4/12 (33%)
Ig strand B 3085..3088 CDD:409353
Ig strand C 3097..3101 CDD:409353
Ig strand E 3123..3127 CDD:409353
Ig strand F 3137..3142 CDD:409353
Ig strand G 3150..3153 CDD:409353 0/2 (0%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 88/265 (33%)
Ig 3654..3744 CDD:472250 24/127 (19%)
Ig strand B 3671..3675 CDD:409353 0/3 (0%)
Ig strand C 3684..3688 CDD:409353 3/3 (100%)
Ig strand E 3710..3714 CDD:409353 1/30 (3%)
Ig strand F 3724..3729 CDD:409353 0/4 (0%)
Ig strand G 3737..3740 CDD:409353 0/2 (0%)
FN3 3748..3840 CDD:238020 21/113 (19%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014 50/251 (20%)
dapk-1NP_490840.2 Protein Kinases, catalytic domain 25..289 CDD:473864 88/264 (33%)
ANK repeat 392..423 CDD:293786 6/40 (15%)
Ank_2 397..>469 CDD:463710 14/99 (14%)
ANK repeat 425..456 CDD:293786 6/49 (12%)
ANKYR 441..677 CDD:440430 52/283 (18%)
ANK repeat 491..522 CDD:293786 4/32 (13%)
ANK repeat 524..555 CDD:293786 8/38 (21%)
ANK repeat 557..588 CDD:293786 3/30 (10%)
ANK repeat 590..653 CDD:293786 14/77 (18%)
P-loop containing Nucleoside Triphosphate Hydrolases 777..>895 CDD:476819 34/178 (19%)
Death_DAPK1 1304..1386 CDD:260052
Blue background indicates that the domain is not in the aligned region.

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