DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and mlck-1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_509689.1 Gene:mlck-1 / 181217 WormBaseID:WBGene00013869 Length:1211 Species:Caenorhabditis elegans


Alignment Length:1116 Identity:227/1116 - (20%)
Similarity:418/1116 - (37%) Gaps:310/1116 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  3180 LRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGRPEL-RPFMLNELEMMNTFNHKNLI 3243
            :::...|.:...||.|..|..|..:|:.:|..:|||.:..|.|. |..:..|:.::....|..:.
 Worm    39 VKFDTLYQVTKLLGDGKFGKVYCVIEKETGKEFAAKFIKIRKEADRAEVEREVSILTQLRHPRIA 103

  Fly  3244 RPYDA-YDTDRSVTLIMELAAGGELVRDNLLRRDY-YTERDIAHYIRQTLWGLEHMHEMGVGHMG 3306
            :.||| |.|...|.||||:..||||. |.:....| .:|..:...|.|....::::|:..:.|:.
 Worm   104 QIYDAFYTTTNDVVLIMEIVRGGELF-DRVAEESYVLSELAVVMIICQLCEAIDYIHKQNILHLD 167

  Fly  3307 LTIKDLLISVVGGDIIKVSDFGLSRKINRHNLSTLDY--GMPEFVSPEVVNKEGVNFSHDMWTVG 3369
            :..::::...:.|:.||:.||||:|..:  ....|.|  |.|||.:|||:..|.:::..|||::|
 Worm   168 VKPENIMCVSLTGNRIKLIDFGLARHYD--GTQELKYMAGTPEFAAPEVIKFEKLDYHTDMWSIG 230

  Fly  3370 LITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTA 3434
            :|||:||.|::||||.:..||...:.:|.|:|.:|..| ::::.:||:::||:|...:||.....
 Worm   231 VITYILLSGYSPFLGDNLGETYCNVEKGVWEFTEEFDT-VTEEAKDFVTKLLVYDQSKRMLPHEC 294

  Fly  3435 LKHPWFFM--------------LDRPVYDH-------------------DYQIGTDRLRNYYDHF 3466
            |:|||...              |:.|..|:                   .:.|..:||||     
 Worm   295 LQHPWIAKHRQKAACNTILEKPLNAPTLDNKQIMRYNARRKFRRMIIYVKFLIEMNRLRN----- 354

  Fly  3467 RDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKYLH-- 3529
                   |.|.     |:|.           .||.:.     :||  .::..|:|:.:|..:.  
 Worm   355 -------SLKT-----RMSA-----------NGHKFF-----DPL--LKMAEKKEQKISNAIGTA 389

  Fly  3530 --PDYELGLIQS---ESHYQYG--PDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSL 3587
              |...||.:..   :|..:.|  |.|     :|.|......:..|...::..:...:...:.:.
 Worm   390 GCPASGLGSLVKMAVDSQKKNGDVPVT-----QDANMSTEPEKEEKKKKKKIANADGSTKTEKTS 449

  Fly  3588 PVIRERRRFTD----------IMD--------------------EEIDDERTRSRISMYAANESY 3622
            .|.:::...||          :|.                    |.:::..:..|.|:.:..|..
 Worm   450 SVKKKKLVETDGDAGLRPPPELMTKRASTGGESLLAAVKVLKNLEVVENGNSPKRKSLCSVKEEK 514

  Fly  3623 SIRRLRTELGPRLDEYTEADAMIETQREGYPPFFREKPQTIAITENQ---PSHIHCFAVGD---- 3680
            .|...:...|.:..|.||..   :.:|:..|    .|..|:...:|.   |..:.....|:    
 Worm   515 EIPAKKQTEGYKTLETTENG---DIRRKSAP----VKQDTLTCQDNSKVTPQLLETAPNGEIRRK 572

  Fly  3681 -----------PKPCVQWFKNDMVLTESKRIKISV-----------DEDGRSILRFE---PALHF 3720
                       |:..:: .|:...:.|:|.:::||           ||.|..:::.:   ..:..
 Worm   573 SASAKEEKSVKPEEVIR-KKSSASVKETKTVELSVVPVKLEKLASIDEKGEKLVKKKKKTTTVTA 636

  Fly  3721 DVGVYKVVARNKVGQTVARCRIVVAT---------------------------LPDAPDSPEI-- 3756
            ::...|.|..:|..:.|.:.:::..|                           ||....||:|  
 Worm   637 EIEKPKSVIESKEEKLVEKPKLLNGTLVSDALEKRRSLGSKRASETQDVGLRPLPVVDFSPKIVL 701

  Fly  3757 ------------SANSGTEILLRWKQPRDDGHSTVLCYSLQYKLSNCDAWTTVA----DNIDHEF 3805
                        .|....||:...|:|...|.......||...|:...:.||::    .::.|. 
 Worm   702 TDKKEPKESKTKPAEPLKEIVPETKKPARQGALRKRDKSLDDILNAAPSPTTLSKSTVTSVKHS- 765

  Fly  3806 YLLHDLQPNTNY--QFRLASKNRIGWSEMGI----PVSASTVGGDAPKIHI------TKAMKHLQ 3858
             ::..:.|:...  ..::.:|.:....:..|    ||.........||:..      :|.:|...
 Worm   766 -VVETIHPSGEIIKSEKVLTKKKSLKKDKSIDDRLPVKIIEDKASLPKLKTDVVTFESKPVKKTS 829

  Fly  3859 QLTENGHQVVPEEERVHTDYHCEREPPNWV------------TDSSV------SDKYSFISEIAR 3905
            ::.    :::||:..:..|   |::|...|            |.:||      |:|.  :...|.
 Worm   830 KIV----KLIPEDANLIKD---EKKPTKIVMTSEKQATTTVQTTTSVKRTTKSSEKK--VEHTAD 885

  Fly  3906 GEFSTIVKGIQKSTDTVVVAKILEVTDENED-------------NVV----------AEFDNFKT 3947
            |:   .|:..||........|:.:||.:.|:             |||          .|....:.
 Worm   886 GK---SVESSQKKNSQKDDVKVSQVTTKKEEDSTQPAPTLTVKKNVVKQTAEKSTSEKEHKTTEN 947

  Fly  3948 LRHERIPALFSAYKPLNV-PIAIFVMEKLQGADVLTYFSSRHEYSEQM-VATVVTQLLDALQYLH 4010
            ...|||....|..|..:| .:::....|:.|        .:|:.|:.: ..||:.:       |.
 Worm   948 KEQERIIKKSSTLKDKDVAQVSLQQSIKVNG--------EKHKESKVIGTKTVINK-------LE 997

  Fly  4011 WRGYCHLNIQPDNVVMASVRSIQVKLV-------------DFGSAKKVNKLGMKVTPCGSLDFQP 4062
            .:|...:|..|..   :|::....|:.             ..|..|..:...||::|..|.|...
 Worm   998 LKGEETINANPKK---SSLKKATAKVTGETTKHLEISTDGKLGVLKTKDTTSMKLSPDSSSDTSS 1059

  Fly  4063 PE----MINDE 4069
            .:    ::.||
 Worm  1060 SKNVRILLTDE 1070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011 86/262 (33%)
I-set 3654..3744 CDD:333254 18/121 (15%)
FN3 3748..3840 CDD:238020 21/115 (18%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014 43/225 (19%)
mlck-1NP_509689.1 PKc_like 51..300 CDD:389743 85/252 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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