DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and ncam-1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_741709.1 Gene:ncam-1 / 180418 WormBaseID:WBGene00017184 Length:955 Species:Caenorhabditis elegans


Alignment Length:1104 Identity:214/1104 - (19%)
Similarity:384/1104 - (34%) Gaps:312/1104 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1153 RVKFYKDEKEILETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCEAIATTV 1217
            ::::|:|.|.|......:.|  ::.|..  :|:|...:.:|.|.|:|| |...||.  :.::..:
 Worm    84 KIEWYRDGKLIPRFGSTMTI--ERTYSN--QLMINRPKISDGGKYTCK-TEIQGEQ--QEVSAEI 141

  Fly  1218 ------------EDKNPFGALSGQIL----PAGEKPVFQWKRNGEEFDPEERFKVLFGEDEDSLA 1266
                        |.::|......:|:    ...:..|| |:.||...|...:....|.|:...|.
 Worm   142 SFVDPPKFLNVQESQHPEEGTRAEIVCEVEGTDQLEVF-WQFNGVTLDETSQRGYEFSENNQILY 205

  Fly  1267 LVFQHVKPEDAGIYTCVA------QTSTGNISCSAELSVQGAIQTLNREPEKPTL-VIEHREANA 1324
            :.....|.:| |||.|.|      :|.:.|::..|                :||: |.:....|.
 Worm   206 IPHFTAKKDD-GIYNCNAAQYSSFETLSVNVTGYA----------------RPTITVFDVPNGNR 253

  Fly  1325 SIGGSAILELQC--KGFPKPAVQWKHDGEVIQV--DDRHKFMYEDEESMSLVIKNVDTVDAGVYT 1385
            .|.|..| ||:|  .|.|||..:|..:.:.:.:  .|:|..    ||.: |:|:::::.|||.|.
 Worm   254 GIEGHTI-ELKCGAVGKPKPTYKWFFEDDEVPIARSDKHNV----EEGL-LIIESLNSEDAGTYK 312

  Fly  1386 IEAINELGQDESSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNNGKDVTAES 1450
            ..|.|.:|.:|.:.:|.|...||:....:.....|:.:::.....|....|.:..:.    .:|.
 Worm   313 CVANNTVGSNERTFDLAVFLKPKVDLKHEYVVKEGDDVELVCSYHGEGHVTAKFVSG----HSEF 373

  Fly  1451 NVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLS-QTSEYWSCTVKSKPVIVKNFESEY 1514
            .|:..:.|.|.|        :||:.....:..:..|::.| :||......:||...:  |.|.::
 Worm   374 AVRNEAVSAGNS--------EEIRPESNESEEVTTTSENSEETSTQDEVELKSAENV--NDEEDH 428

  Fly  1515 IHGEKENVQMTVRIDAYPEAKLTW--YHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYT 1577
            ...:.:..|     |...|:| .|  :.|:    :.:.:.:|.::.|...|.|...:..||..||
 Worm   429 TSQQDDGEQ-----DEQEESK-KWKRFADD----VNNQRISVRAEENKLILTIKSISLEDAADYT 483

  Fly  1578 VKATNEHGSATSSTQLLIKCAPEFTHKL-KNITVAEGDSNVELVVGVDAYPRPHAKWYIDGIEID 1641
            ...:|:.|:....||:.|...|...|.. .:|...:|:: |.:...|.|.|.|...|:.:|.|::
 Worm   484 CAVSNDAGTVNKVTQVGIIHPPTLRHYTGPHIRSFDGNT-VSVYCDVSAVPSPKWHWFKNGKEVE 547

  Fly  1642 EKRNDFRHVEEGNDFKLIM-NQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGL---KN 1702
            ......:...:|:..||.: |...::..|.|||:..|..|:||....|.....|....|:   |.
 Worm   548 ANGVSIQIFTQGSSTKLTLENFDGSDNFGVYTCRADNGVGQLEKQIDVIKVVSPATPSGMNCKKM 612

  Fly  1703 VEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDARIKISRDTQRIENYYLTLNLARTEDAGTY 1767
            |....||. :.|.::|.:.|:|                                           
 Worm   613 VYPNYGKC-SFESDIYEKEESK------------------------------------------- 633

  Fly  1768 EMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVHVDVFQQHSYESVP 1832
                                       .||: :.|:|..||.|.               .|.   
 Worm   634 ---------------------------PQTM-ELLVAKLEEMES---------------DYN--- 652

  Fly  1833 LKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQSLDLVDAGEY--KVVVQNKVG 1895
                            |.| .:|::......:|:.           :|....:|  |....|:.|
 Worm   653 ----------------WSH-AQPVSVPFEDDLTIP-----------NLTSNTQYVIKARAVNEAG 689

  Fly  1896 EKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVVFTADPAPEIVLLKDGQPV---- 1956
            ...:..|:||    |...|...|.||...:|       |......:...|.    ..|.|:    
 Worm   690 SSEYSEEISL----ETTDPWAPQAPGSVAMK-------CSDYCTVSWDTPN----DHGSPLLKFK 739

  Fly  1957 VETNNVKLKVDKKDAE-------NGLVQYTCTLNILEAEIKDSGRYELKVKNKYGELVTSGWIDV 2014
            |....:|.|.|..:.|       |...:.|.|....:.:..::....:::|....|..|:     
 Worm   740 VTIQEMKYKTDDDEVEEKSDEKSNNNSEETETTTSDDNDETEASNESIEIKENSEEQETT----- 799

  Fly  2015 LAKPEISGLNDTKCLPGDTICFEALVQANPKPKVSWTRGNENLCNHENCEVIADVDADKYRLVFQ 2079
                 ::..:..:.||.|             |..|..|  :.:..:.:. ::.:||:::.::...
 Worm   800 -----LAHEDSAEILPTD-------------PSTSVER--DEMVPYGSL-LVLNVDSEENQVQLT 843

  Fly  2080 SVSPCEDGKYTITATNSEGR---AAVDFNLAVLVEKPTFIVQPESQSIHDYRPVSTKVLVHGVPL 2141
            ::......|.::.|.|.:|:   |.:||.                                    
 Worm   844 NIKQHSYYKISVAAENEKGQGEPAEIDFQ------------------------------------ 872

  Fly  2142 PTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIG 2205
                  .||.|..||    .|.|..:.......|...:..::|:..|..|..|..:|:..|..|
 Worm   873 ------TDDSPTKYE----EGIDSTHLIIAIAIGVLFLLLLVDLGCFITNKCGLISCICLNLCG 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352 16/58 (28%)
I-set <1236..1299 CDD:333254 19/68 (28%)
I-set 1313..1403 CDD:254352 30/94 (32%)
Ig_3 1406..1487 CDD:316449 12/80 (15%)
I-set 1499..1595 CDD:254352 22/97 (23%)
I-set 1599..1690 CDD:333254 25/92 (27%)
I-set 1694..1786 CDD:254352 10/94 (11%)
I-set <1836..1903 CDD:333254 9/68 (13%)
I-set 1922..2005 CDD:333254 14/93 (15%)
I-set 2018..2108 CDD:333254 15/92 (16%)
I-set 2113..2214 CDD:333254 15/93 (16%)
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
ncam-1NP_741709.1 IG 64..142 CDD:214652 16/64 (25%)
Ig 69..140 CDD:143165 16/62 (26%)
IG_like 153..236 CDD:214653 21/84 (25%)
Ig 160..222 CDD:299845 16/63 (25%)
IG_like 256..330 CDD:214653 25/79 (32%)
IGc2 256..320 CDD:197706 22/69 (32%)
IG_like <445..499 CDD:214653 13/57 (23%)
Ig <445..498 CDD:143165 12/56 (21%)
IG_like 520..596 CDD:214653 21/76 (28%)
IGc2 520..587 CDD:197706 18/67 (27%)
FN3 <652..701 CDD:238020 12/83 (14%)
FN3 <817..873 CDD:238020 10/100 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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