DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and unc-89

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001020985.1	Gene:	unc-89 / 171990	WormBaseID:	WBGene00006820	Length:	8081	Species:	Caenorhabditis elegans

Alignment Length:	5292	Identity:	1194/5292 - (22%)
Similarity:	1933/5292 - (36%)	Gaps:	1521/5292 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DIVFVSRDYQAQSLATDEISVSRG-----DLVE-------LISSKASEKSRCFVRMFDSGDSPKE 58
            |||    .|:|  :||:.|..:..     ..||       |..:...||....:.:...|.:|..
Worm  3161 DIV----SYKA--IATNSIGTATSTSKITTKVEAPVFEQGLKKTSVKEKEEIKMEVKVGGSAPDV 3219

  Fly    59 GWVPID---------ILEFNP--------------------TMSSSN----GKESGDAE----FR 86
            .|...|         .::.||                    |..:||    .:.|.:||    ..
Worm  3220 EWFKDDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLE 3284

  Fly    87 KLTILRELVETEEEFSRDLLHVVEKYIKGIDKPVVPRSVRDNKDIIFCNFLQIAEFHNNVLKEGL 151
            |.|.:||||.||.:.:...  .:...:||:..|.| ..::|.:.:      |....|.....||.
Worm  3285 KPTFVRELVTTEVKINETA--TLSVTVKGVPDPSV-EWLKDGQPV------QTDSSHVIAKVEGS 3340

  Fly   152 KCYSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSPDAKKYFQELSKQLGDDK-----S 211
            ..||     :.....|||                        |:.||....:...|:.|     :
Worm  3341 GSYS-----ITIKDARLE------------------------DSGKYACRATNPAGEAKTEANFA 3376

  Fly   212 LAEHLKLP--IQRINDYQLLFKDFIKYSLSLKENVKDLERALELMLSVPSRAYDNRFLSSIEGCR 274
            :.::|..|  :::::..::..|:  ..:||:|. |...|.::|........:.||..:...:...
Worm  3377 VVKNLVPPEFVEKLSPLEVKEKE--STTLSVKV-VGTPEPSVEWFKDDTPISIDNVHVIQKQTAV 3438

  Fly   275 G------NIYKLGRLLLHAWCNVVDKEGKAHDRYCF-LFKSRI---LVTKVR--KISENRSVFIL 327
            |      |..:.|.:.::: |...::.|:|.....| :.:..|   ...|:|  ::.|..::.:.
Worm  3439 GSFSLTINDARQGDVGIYS-CRARNEAGEALTTANFGIIRDSIPPEFTQKLRPLEVREQETLDLK 3502

  Fly   328 QNIVKLPLCNIELKADEKQIH-----------------LSLK-----------------APEANS 358
            ..::..|:.|:|...|:|.|:                 |::|                 |.||.:
Worm  3503 VTVIGTPVPNVEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEAKT 3567

  Fly   359 F----------LPI---DIKPH----------------GPEAHLTWFNE------ISSHI----- 383
            .          .|:   .:||:                .||..:.||.:      .:.|:
Worm  3568 TANMAVQEEIEAPLFVQGLKPYEVEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIEKKG 3632

  Fly   384 -NQDVTL---QEHNADDLK--VDASQIASESELI--LHLP------QRAEAHDPNLSVRP----- 429
             |...||   ..:|||..|  ..|:..|.:.|.:  |.:|      |.||...| |.:.|
Worm  3633 ENGSHTLVIKDTNNADFGKYTCQATNKAGKDETVGELKIPKYSFEKQTAEEVKP-LFIEPLKETF 3696

  Fly   430 ----------------SDVAENYFLSKETKERLQHEQQELLKLEQEAIELYKKQQSSKSVSS-KT 477
                            |.....:|.:.:..|..||.|.|:  ||...|:|..:....:.|.: :.
Worm  3697 AVEGDTVVLECKVNKESHPQIKFFKNDQPVEIGQHMQLEV--LEDGNIKLTIQNAKKEDVGAYRC 3759

  Fly   478 ESVEITSSQVKSSSEVR-----KVVSPPPPPQAQVKEVTPVKVVSSPPPPKEITPAKVATPPPQP 537
            |:|.: :.:..::::::     ||.........|::|:...:.|.      :...:|..|....|
Worm  3760 EAVNV-AGKANTNADLKIQFAAKVEEHVTDESGQLEEIGQFETVG------DTASSKTDTGRGAP 3817

  Fly   538 QVVTSPVKEVAPPPQPRAVASPAKEVTPSQSEPVKAPSPIK-EVRKEVPPS---ASHSKEVE--A 596
            :.|                     |:..|.:...|..:.:| :|:.|..|.   ....||||  |
Worm  3818 EFV---------------------ELLRSCTVTEKQQAILKCKVKGEPRPKIKWTKEGKEVEMSA 3861

  Fly   597 LVATEIRE--SLTETRSTVVESGQSSEIREEIVVTEESS--LEGKQVVALEREP----------S 647
            .|..|.::  :||.|...|.:: .:.|.|.| ...|..|  .||..:|.||..|          .
Worm  3862 RVRAEHKDDGTLTLTFDNVTQA-DAGEYRCE-AENEYGSAWTEGPIIVTLEGAPKIDGEAPDFLQ 3924

  Fly   648 PCSIPKIQVYRPVECENPVVTKHKPIELKDIVGY--SESLRDGDTAPAGGSPGRQQGYSANITDH 710
            |.....:.|......|..:..|.||    .:..|  .|.|:..|....           .|:.|.
Worm  3925 PVKPAVVTVGETAVLEGKISGKPKP----SVKWYKNGEELKPSDRVKI-----------ENLDDG 3974

  Fly   711 AS-LTIWNNRLANIAGDRSGANQH-------LQQSGPPPPPIPPNFTRMPGFFQPLPLIAYETT- 766
            .. ||:.|.:|.::...|..|:..       :..:...|..:      .||||:.|..|..:.|
Worm  3975 TQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLTVKEPAQV------APGFFKELSAIQVKETE 4033

  Fly   767 ---IEILIVKARPP---SPPPPPPPTIKRVLVHTESLEQKTQNFF--------EGIYD-AASSDT 816
               .|..:...:|.   .....|....||  ||.||.:..||...        :|.|. ..|:|.
Worm  4034 TAKFECKVSGTKPDVKWFKDGTPLKEDKR--VHFESTDDGTQRLVIEDSKTDDQGNYRIEVSNDA 4096

  Fly   817 SLRNAKQKIRSIKSTVLKSK---DSTNYAQDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVNIF 878
            .:.|:|..:..:.|..||.|   ...|..|.|      :..|.:
Worm  4097 GVANSKVPLTVVPSETLKIKKGLTDVNVTQGT------KILLSV--------------------- 4134

  Fly   879 ELEGDYTESIADDFREPSADFEARGQSVGGMDDYYSGYSRASTRRYETKTRDYDRGTSYDSTVER 943
            |:||                                          :.||..:.:||   .||..
Worm  4135 EVEG------------------------------------------KPKTVKWYKGT---ETVTS 4154

  Fly   944 SQYGISSRRDRSSVDKVEARSSLLATGRTESRAASRAESRAES-RASYSVAES--RAGIRSSSRL 1005
            ||        .:.:.:|           |||......||...| ..:|.|..|  ...:.||:.:
Worm  4155 SQ--------TTKIVQV-----------TESEYKLEIESAEMSDTGAYRVVLSTDSFSVESSATV 4200

  Fly  1006 QEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAP 1070
            ...:....:..|...|.|....|..|.....|::.:.:|..|.|.|:...::|...:.:..
Worm  4201 TVTKAAEKISLPSFKKGLADQSVPKGTPLVLEVEIEGKPKDVKWYKNGDEIKDGKVEDLGN---- 4261

  Fly  1071 MNSYRLDIKNCSETDAGTYTIRAQSASETTTVSAQLAVGQAPGHDETKTNTEPAFLVSLKDAEMI 1135
             ..|||.|.:..|.|.|.|::.|  |:|         .|:.....:...:.:|..:..|....:.
Worm  4262 -GKYRLTIPDFQEKDVGEYSVTA--ANE---------AGEIESKAKVNVSAKPEIVSGLVPTTVK 4314

  Fly  1136 ENTLFRFMVKIIGDPKPRVKFYKDEKEI--LETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYS 1198
            :.....|.||:.| |...||:||:.|||  .:|.|...        |.|.|.|.:.|..||..|.
Worm  4315 QGETATFNVKVKG-PVKGVKWYKNGKEIPDAKTKDNGD--------GSYSLEIPNAQVEDAADYK 4370

  Fly  1199 CKATNKHGEANCEAIATTV------EDKNPFGALSGQI---LPAGEKPVF-----------QWKR 1243
            ...:|..|:|:..| |.||      :||.....:||.|   :..||...|           :|.:
Worm  4371 VVVSNDAGDADSSA-ALTVKLADDGKDKVKPEIVSGLIPTTVKQGETATFNVKVKGPVKQVKWYK 4434

  Fly  1244 NGEEFDPEERFKVLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNR 1308
            ||:|. |..:.|   ...:.|.:|...:.:.:|...|..|.....|:...||.|:|
Worm  4435 NGKEI-PNAKAK---DNGDGSYSLEIPNAQLDDTADYKVVVSNDAGDADSSAALTV--------- 4486

  Fly  1309 EPEKPTLVIEH--REANASIGGSAILELQCKGFPKPAVQWKHDGEVIQVDDRHKFMYEDEESMSL 1371
              :.|.:.|..  .:|....|..|:|:::....|| .::|..:|:.|...|:.:...:.:....|
Worm  4487 --KLPGIAIVKGLEDAEVPKGKKAVLQVETNKKPK-EIKWYKNGKEITPSDKAQPGSDGDNKPQL 4548

  Fly  1372 VIKNVDTVDAGVYTIEAINELGQD-ESSINLVVKAPPK----IKKITDITCSAGETIKMEIEVEG 1431
            ||.:....||..|.:...:|.|.. :||..|.||.|.|    ||.:.|...|.|..||:|||..|
Worm  4549 VIPDAGDDDAAEYKVVLTDEDGNTADSSCALTVKLPAKEPKIIKGLEDQVVSIGSPIKLEIETSG 4613

  Fly  1432 FPQPTVQVTNNGKDVTAESNVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYW 1496
            .|: ||:...|||::...:...|....|..:  |.|:|:....:...|:|.::..|:....:...
Worm  4614 SPK-TVKWYKNGKELPGAAAKTIKIQKIDDN--KYVLEIPSSVVEDTGDYKVEVANEAGSANSSG 4675

  Fly  1497 SCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLTWYHDETEIKITDSKYTVSSDGNA- 1560
            ..||:.|...:|..:.:.| .|.||.:.:|..:..|.. :.||.:..||| .:|::.:....:.
Worm  4676 KITVEPKITFLKPLKDQSI-TEGENAEFSVETNTKPRI-VKWYKNGQEIK-PNSRFIIEQKTDTK 4737

  Fly  1561 YTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAP----EFTHKLKNITVAEGDSNVELVV 1621
            |.|.|..|.|.||..|.:...|..|.|.||.||.:|.|.    :....|::..||:|   .::|.
Worm  4738 YQLVIKNAVRDDADTYKIVLENTAGEAESSAQLTVKKAKAGLCKIVKGLEDQVVAKG---AKMVF 4799

  Fly  1622 GVDAYPRPH-AKWYIDGIEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDN 1685
            .|.....|. .:|..|...|....|......:...::||:........|.||.:::|:.||.:.:
Worm  4800 EVKIQGEPEDVRWLRDANVISAGANAIIEKIDDTTYRLIIPSADLKDAGEYTVEVINESGKAKSD 4864

  Fly  1686 CVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDARIKISRDTQRI- 1749
            ....|:.||::.|||:|:|:.||.....:||| |.|..::||:|:..||..::.:    :.::|
Worm  4865 AKGEVDEKPEIVRGLENIEIPEGDDDVFKVEV-SAPVRQVKWYKNDQEIKPNSHL----EAKKIG 4924

  Fly  1750 -ENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGA 1813
             :.|.|.:|.|:.:|...|::..:|..|:..|:..:.|:....|.:
Worm  4925 PKKYELAINRAQLDDGADYKVVLSNAAGDCDSSAALTVVKPNVLKI------------------- 4970

  Fly  1814 VPEIVHVDVFQQHSYESVPLKYEVIATGIPKPEAIWYHDGKPITPDKHTAITVDG---------D 1869
            |..:..|||     .|..|::.:|...|||| ...||.:|:.:.||      .||         .
Worm  4971 VDGLKDVDV-----EEPQPVELKVKVEGIPK-VIKWYKNGQELKPD------ADGFKFEEKPESG 5023

  Fly  1870 HYKLEVQSLDLVDAGEYKVVVQNKVGE---------KSHQGELSLSGIAEYRKPILTQGPGLKDI 1925
            .:.|.:.|....|.|.|:||:.|..||         ||.:.....|| |.:..|       |||.
Worm  5024 EFSLTIPSSKKSDGGAYRVVLGNDKGEVYSGSVVHVKSAKSSEPTSG-ANFLSP-------LKDT 5080

  Fly  1926 KVNKGDKVCEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILEAEIK 1990
            :|.:||.:........:|.||::..|||..:.:.:.:.::|    |.:|    |.||.|..|:..
Worm  5081 EVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDRITMRV----ALDG----TATLRIRSAKKS 5137

  Fly  1991 DSGRYELKVKNKYGELVTSGWIDVL------AKPE-ISGLNDTKCLPGDTICFEALVQANPKPKV 2048
            |.|:|.:..||:.|...:...:.|.      :||: :..|.....||||...|...|:..|||.:
Worm  5138 DIGQYRVTAKNEAGSATSDCKVTVTEQGEQPSKPKFVIPLKTGAALPGDKKEFNVKVRGLPKPTL 5202

  Fly  2049 SWTRGN-----------ENLCNHENCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAV 2102
            .|....           :::.:...|..|.||..:.:. ..:.::..|:|.........:|....
Worm  5203 QWFLNGIPIKFDDRITLDDMADGNYCLTIRDVREEDFG-TLKCIAKNENGTDETVCEFQQGAGHD 5266

  Fly  2103 DFNLAVLVEKPTFIVQPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLY 2167
            |.:...|...|.|.|....:.|....|:..:..|...|...:|||||.|.|.:.|..:
Worm  5267 DGSRDDLRYPPRFNVPLWDRRIPVGDPMFIECHVDANPTAEVEWFKDGKKIEHTAHTE------- 5324

  Fly  2168 AKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEIG--VTKAPFKLAML---------SLAPS 2221
             ..:|..|..:|:    |..|.|:|:|.|.|||.||:|  .|:|.:::.:|         ..||.
Worm  5325 -IRNTVDGACRIK----IIPFEESDIGVYMCVAVNELGQAETQATYQVEILEHVEEEKRREYAPK 5384

  Fly  2222 FVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQP 2286
            ....|::. .|..|:|:.|.|.||..|..:|.|.|||..::......|....||...|.||....
Worm  5385 INPPLEDK-TVNGGQPIRLSCKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTE 5448

  Fly  2287 NDSGAYKLIISNPHGEKVALCAV-------AVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGF 2344
            .|.|||:.:.:|.||.....|:|       .||.|..:|.|.|.:.......|:...|:..|||.
Worm  5449 EDIGAYRCVATNAHGTINTSCSVNVKVPKQEVKKEGEEPFFTKGLVDLWADRGDSFTLKCAVTGD 5513

  Fly  2345 PAPEVKWYKDGMLLRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEIE-------- 2401
            |.||:|||::|.|||..|......||:|...|.::.:...|.|:|:|...|..|:.:
Worm  5514 PFPEIKWYRNGQLLRNGPRTVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQ 5578

  Fly  2402 -GVSKVEIVPK--ESK-PVFVAELQDAS------------------------------------- 2425
             .:.|.| .||  |.| |.|:.||.|.|
Worm  5579 MALGKTE-KPKMDEGKPPKFILELSDMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFE 5642

  Fly  2426 ----------------------------------------------------------------- 2425

Worm  5643 WSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSATTKSFVRMDDGLGSGVVTASQPPRFTLKM 5707

  Fly  2426 ----SIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLIIEKTAPGDSGL 2486
                :.||.|:|::.||..:|.|::.|:.:|..:.| :..|.|..:||..::|:|......|.|:
Worm  5708 GDVRTTEGQPLKLECKVDASPLPEMVWYKDGAIVTP-SDRIQISLSPDGVATLLIPSCVYDDDGI 5771

  Fly  2487 YEVIAQNPEGS-----TASKAKLYVAPK-------ADETA--TEEAPQFVSALRDVNADEGQELV 2537
            |.|||.||.|:     ||:..||   |:       ||...  ..:||:.:..|.::...|.|...
Worm  5772 YRVIATNPSGTAQDKGTATVKKL---PRDSGARRSADRDVFDANKAPKLMEPLENIRIPEKQSFR 5833

  Fly  2538 LSAPFISNPMPEVIWSKDGVTLTPNERLLM------TCDGKHIGLTIKPAEAADSGNYTCLLANP 2596
            |...|..:|.|.:.|.|||..:.|..||.:      .|:     |.:..|...|:|.|.|:..|.
Worm  5834 LRCKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCE-----LVVDSATRQDAGGYRCVAENT 5893

  Fly  2597 LGEDSSACNANV----RKVY---------KPPVFTQKIS-------------------------- 2622
            .|...::|:.||    ||..         |.|.||..::
Worm  5894 YGSARTSCDVNVIRGDRKPRDIDSSIREGKAPGFTTPLTIRRAKPGDSVTFECLPFGNPFPSIKW 5958

  Fly  2623 --DQQQVF--------------------------------------------------------- 2628
              |..::|
Worm  5959 LKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRCVATNEHGTASTKAELVIEGDRTIGS 6023

  Fly  2629 ----------------------------GNNAKIPVTVSGVPYPDLEWYFQDKPI----PKSEKY 2661
                                        ||..::.|..:|:|.|.::||...:.|    |..::.
Worm  6024 RPLPEVNGEPEECKPRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKDGQEIVGDGPDGKRV 6088

  Fly  2662 SIKND-GDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSE------PPVF 2719
            ...:: |.||::|| |....|:|.|...|:|:.|...|:|.|:|:.........|      ||.|
Worm  6089 IFTDERGIHHLVIV-NASPDDEGEYSLEATNKLGSAKTEGSLNIIRPRHIADADERGGMPFPPGF 6152

  Fly  2720 LKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYD 2784
            ::::.:..::..|...|.....|:|.||||||.|.:|:.|..|..|.....|...|.|.:.|..|
Worm  6153 VRQLKNKHVFNHMPTIFDCLVVGHPAPEVEWFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLED 6217

  Fly  2785 VGRYSCRIFNPYGDDICHAEL-----FYDSL----DSQQKP-LEDQYTDFKKYKKSGAPPPLSEG 2839
            .|.|.....|.:|.....|.|     |.||:    :....| |.::| .|||...:..|.|...|
Worm  6218 AGEYVATAKNSHGSASSSAVLDVTVPFLDSIKFNGEIDVTPYLTEEY-GFKKLNTASLPTPPDRG 6281

  Fly  2840 PIISRMTDRGLLLSWNPSVPLTPRYP-ITYQIEMMDLPEGDWRTLRTGVRSCACDIRNLEPFRDY 2903
            |.|..:|...|.|||.|:....|||| :||.||:.:|||..|..|...:....|.:||||..:.|
Worm  6282 PFIKEVTGHYLTLSWIPTKRAPPRYPQVTYVIEIRELPEKQWSLLEYNIPEPVCKVRNLELGKSY 6346

  Fly  2904 RFRVRVENKFGVSDPSPYTQTYRQKLVPDP---PKTYTYLPPGTDFRPETSPYFPKDFDIERPPH 2965
            :||||.||.:|:|||||.:...|....|.|   .:|...:       |...||..|..|:..  .
Worm  6347 QFRVRAENIYGISDPSPASPPSRLMAPPQPVFDRRTNKVI-------PLLDPYAEKALDMRY--S 6402

  Fly  2966 DGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQS--YTRNG- 3027
            :..|.||.|.....:..|..::....::..|.|:|.|.:.:.|....|::.....:.  ||..|
Worm  6403 EQYACAPWFSPGVVEKRYCAENDTLTIVLNVSGFPDPDIKWKFRGWDIDTSSPTSKCKVYTYGGS 6467

  Fly  3028 QATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRP--DETFIMARKNGRIEAKL 3090
            :.||.|......:||.|:..|.|::|:|:|.:.:::|..|.|: :|  ::||..|:.. |::.::
Worm  6468 ETTLAITGFSKENVGQYQCFAKNDYGDAQQNIMVDLATRPNFI-QPLVNKTFSSAQPM-RMDVRV 6530

  Fly  3091 VGIPLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNIAGSISTSVTV 3155
            .|.|.||:.|.|:|:|||:|||||.....|.:..|.|:|.:.:|.|:||..|.|.||..:||.||
Worm  6531 DGEPFPELKWMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTSCTV 6595

  Fly  3156 HIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGR-GTQGITYHAVERSSGDNYAAKIMYG 3219
            .:|...|....:...|...:.|:::|  :.|:|.::..: ..:|..:...|:::|..:.|
Worm  6596 TVEAEGDYNDVELPRRRVTIESRRVR--ELYEISEKDEKLAAEGAPFRVKEKATGREFLA----- 6653

  Fly  3220 RPELRPF---MLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELA------------AGGELVR 3269
              :|||.   ::..:::.|:.:|..:::.:.....::...::.:.|            .|.|:..
Worm  6654 --QLRPIDDALMRHVDIHNSLDHPGIVQMHRVLRDEKLALVVFDNANSTIDGLSSLAHPGVEIAE 6716

  Fly  3270 DNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKIN 3334
            ...:.|    |..:..::||.|..|:|||::.:.|:.|..:.:|:.   .|.:|::|||.:|::.
Worm  6717 PKGVNR----ETCVRVFVRQLLLALKHMHDLRIAHLDLRPETILLQ---DDKLKLADFGQARRLL 6774

  Fly  3335 RHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRW 3399
            |..::....|.|||||||:|....:..:.|||:.|::|||||.|.:||.|.:|.|||..:...::
Worm  6775 RGLITGEIKGSPEFVSPEIVRSYPLTLATDMWSTGVLTYVLLTGLSPFHGDNDNETLANVDSCQF 6839

  Fly  3400 DFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWF------------------------ 3440
            |  .....:.|.|..||:.:||...|..|:.|..||.|||.
Worm  6840 D--SSPLGNFSYDAGDFVKKLLTEIPVSRLTVDEALDHPWINDEKLKTEPLSADTLREFKYQHKW 6902

  Fly  3441 -----FMLDRP-------------------------------VYDH------------DY----- 3452
                 |:...|                               :||:            :|
Worm  6903 LERRVFVQQTPSEQILEAILGPATAQAQQNAPVAPEGRRPAEIYDYLRIQPKKPPPTVEYVPQPR 6967

  Fly  3453 ---------------------------------------------QIGTDRLRN----------- 3461
                                                         |...|..|:
Worm  6968 KEHPPFIDEFGQLIDGDAFDRPEGTGFEGPHRQPPQIPPQPQRPNQAAHDSRRHEQQPQHQGQPQ 7032

  Fly  3462 --------------------------------YYD------HFRDWYANASCKNYFRRRRL---- 3484
                                            |.|      || |.|..........:|:|
Worm  7033 RIPVDQYGRPLVDPRYLNDPSHRPSSLDDAPFYVDKYGNPVHF-DKYGRPMAPQNLEKRKLIPQD 7096

  Fly  3485 ---------SGCFQHP--SKMVYPPG--------------------------------------- 3499
                     ....|||  :.::..||
Worm  7097 KGETPSHSKKEKTQHPVATPILASPGGDQQQQKIPMRMIRGERREIEEEIANRILSDISEEGSIA 7161

  Fly  3500 --------------------HVYTPENTPE--------------------PLPEPR--------- 3515
                                ...||..|||                    |:|:|:
Worm  7162 GSLASLEDFEIPKDFQVEASEPSTPTLTPEVTIRETIPKPTPSPTSPQKSPVPQPQGLLIPAKVT 7226

  Fly  3516 ----------------------------------------------------------------- 3515

Worm  7227 YSDSILAGLPAADKKVLEDAENDPSIPVGAPLFLEGLHGSDLTIDTTSASGLIKVTSPAINLSPN 7291

  Fly  3516 ----------------------------IRAKR------------EEV----------------- 3523
                                        |..||            |::
Worm  7292 PKSPRRSTPGTKSPVVLSPRQEHSMEVLIATKRGKPGFLPPGELAEDIDDEDAFMDDRKKQVKPK 7356

  Fly  3524 ----------------------------VSKYL------------HPDYELGLIQSESHYQYGPD 3548
                                        :.||.            ||.|::.....:||||.|||
Worm  7357 DHDGENDFKDEKERLEKDKNRRTVNLDDLDKYRPSAFYKDDSDFGHPGYDIDATPWDSHYQIGPD 7421

  Fly  3549 TYLLQLRDVNFPVRLREYMKVAHRRSPSFAL-------------NDSVDWSLPVIRERRRFTDIM 3600
            |||:..|...|..|:|.|      |...|.:             |..:     .:|||||:|||:
Worm  7422 TYLMAARGAAFNSRVRNY------REELFGMGAPTVKQGFLGVRNRDI-----TVRERRRYTDIL 7475

  Fly  3601 DEEID----DERTRSRISMYAANESYSIRRLRTELGPRLDEYTEADAMIETQREGYPPFFREKPQ 3661
            .|...    ....:|...:..|..:.:|.|::.::     |.....|..:.....:.|.|..:.:
Worm  7476 RETTQGLEPKSHEQSTALLQKAPSATAIERIKADI-----EKVTPCATKKNDDGTFAPIFTARLR 7535

  Fly  3662 TIAITENQPSHIHCFAVGDPKPCVQWFKNDMVLTESKRIKISVDED-GRSILRFEPALHFDVGVY 3725
            .:.:.:|||:...|.....|.|.|.|.....:|..:.|:.|..|.: .|.||..  |..:|:|.|
Worm  7536 DVYLRKNQPAIFECAVSASPAPKVTWDFQGKILESNDRVTIEQDNNVARLILNH--AAPYDLGEY 7598

  Fly  3726 KVVARNKVGQTVARCRIVVATLPDAPDSPEISANSGTEILLRWKQPRDDGHSTVLCYSLQYKLS- 3789
            ...|.|:.|...:.||::....|..|..||...:|.|||.::|:.|....:...:.|.|:|:::
Worm  7599 VCTAINEYGTDKSSCRLISGETPSRPGRPEAELSSDTEIFIQWEAPEGPTYLEGITYRLEYRVAG 7663

  Fly  3790 ---NCDAWTTVADNIDHEFYLLHDLQPNTNYQFRLASKNRIGWSEMGIPVSAS----TVGGDAPK 3847
               :.|.|.||::.||.|..::..|.|...||||:.::|..|   :|:|..:|    |.|..|||
Worm  7664 PNDHGDPWITVSEKIDDESVIVKHLSPLGIYQFRVTAQNGFG---LGLPSLSSRIVQTHGKGAPK 7725

  Fly  3848 IHI------------------TKAMKHLQQLTENGHQVVPEEERVHTDYHCEREPPNWVTDSSVS 3894
            :.|                  |..:..:.:.:|...:.....|.:.::...:.:.|        :
Worm  7726 LQIDVLKSEIRLNVVSMPQKSTNQLGGISEESEEDSEARTANEDMKSNLQLQTDDP--------T 7782

  Fly  3895 DKYSFISEIARGEFSTIVKGIQKSTD--TVVVAKILEVTDENEDNVVAEFDNFKTLRHERIPALF 3957
            .::.......:|.||.|...:..:|:  .....||...:.|    .::|:::.:..:||.:..|.
Worm  7783 GRFQIGGLKFKGRFSVIRDAVDSTTEGHAHCAVKIRHPSSE----AISEYESLRDGQHENVQRLI 7843

  Fly  3958 SAYKPLNVPIAIFVMEKLQGADVLTYFSSRHEYSEQMVATVVTQLLDALQYLHWRGYCHLNIQPD 4022
            :|:...|.   ::::.:....||.:.|.....|:|:.||..:.|:..||.:||::|..||::.|.
Worm  7844 AAFNNSNF---LYLLSERLYEDVFSRFVFNDYYTEEQVALTMRQVTSALHFLHFKGIAHLDVNPH 7905

  Fly  4023 NVVMASVRSIQVKLVDFGSAKKVNKLGMKV---TPCGSLDFQPPEMINDEPIFPQSDIWSLGALT 4084
            |::..|.||..|||||||.|:||:.....|   |...|.:|..||    .|:..|||:|.:|.:|
Worm  7906 NIMFQSKRSWVVKLVDFGRAQKVSGAVKPVDFDTKWASPEFHIPE----TPVTVQSDMWGMGVVT 7966

  Fly  4085 YLLLSGCSPFRGADEY----ETKQNISFVRYRFENLFKEVTPEATRFIMLLFKRHPTKRPYTEDC 4145
            :.||:|..||  ..||    |.|:|:..|:.....:....:.|...|.....|:.|.:|..|::.
Worm  7967 FCLLAGFHPF--TSEYDREEEIKENVINVKCDPNLIPVNASQECLSFATWALKKSPVRRMRTDEA 8029

  Fly  4146 LEHRWLMSSDYMVRKRERAIFLGSRLK 4172
            |.|::|.|...|||:||...:..|||:
Worm  8030 LSHKFLSSDPSMVRRRESIKYSASRLR 8056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091	34/176 (19%)
		PH_unc89	275..388	CDD:270134	31/199 (16%)
		Atrophin-1	<493..690	CDD:331285	47/223 (21%)
		TonB_N	502..>596	CDD:318287	18/99 (18%)
		I-set	1017..1108	CDD:333254	22/90 (24%)
		I-set	1123..1212	CDD:254352	27/90 (30%)
		I-set	<1236..1299	CDD:333254	16/73 (22%)
		I-set	1313..1403	CDD:254352	23/92 (25%)
		Ig_3	1406..1487	CDD:316449	26/84 (31%)
		I-set	1499..1595	CDD:254352	31/96 (32%)
		I-set	1599..1690	CDD:333254	19/95 (20%)
		I-set	1694..1786	CDD:254352	28/93 (30%)
		I-set	<1836..1903	CDD:333254	24/84 (29%)
		I-set	1922..2005	CDD:333254	25/82 (30%)
		I-set	2018..2108	CDD:333254	20/101 (20%)
		I-set	2113..2214	CDD:333254	32/102 (31%)
		I-set	2220..2302	CDD:254352	27/81 (33%)
		I-set	2318..2408	CDD:254352	30/98 (31%)
		I-set	2415..2506	CDD:254352	36/201 (18%)
		I-set	2519..2608	CDD:254352	25/94 (27%)
		I-set	2615..2696	CDD:254352	27/198 (14%)
		I-set	2717..2805	CDD:254352	27/87 (31%)
		FN3	2834..2925	CDD:238020	41/91 (45%)
		I-set	<2996..3063	CDD:333254	20/69 (29%)
		I-set	3067..3157	CDD:333254	38/91 (42%)
		PK_Unc-89_rpt1	3182..3440	CDD:271011	73/273 (27%)
		I-set	3654..3744	CDD:333254	26/90 (29%)
		FN3	3748..3840	CDD:238020	31/99 (31%)
		STKc_Unc-89_rpt2	3893..4151	CDD:271014	76/266 (29%)
unc-89	NP_001020985.1	SH3	65..124	CDD:302595
		RhoGEF	153..328	CDD:238091
		PH_unc89	341..455	CDD:270134
		Ig	568..634	CDD:143165
		I-set	<570..638	CDD:254352
		I-set	648..737	CDD:254352
		Ig	661..728	CDD:299845
		I-set	748..837	CDD:254352
		IGc2	761..827	CDD:197706
		I-set	844..935	CDD:254352
		I-set	946..1034	CDD:254352
		Ig	954..1034	CDD:299845
		I-set	1044..1133	CDD:254352
		Ig	<1060..1132	CDD:299845
		I-set	1140..1237	CDD:254352
		Ig	1146..1237	CDD:299845
		RCSD	1384..1491	CDD:282963
		RCSD	1481..1590	CDD:282963
		RCSD	1576..1678	CDD:282963
		RCSD	1735..1819	CDD:282963
		RCSD	1789..>1860	CDD:282963
		I-set	1982..2068	CDD:254352
		Ig	2009..2069	CDD:299845
		Ig_TrkABC_d4	2075..2164	CDD:143173
		I-set	2081..2164	CDD:254352
		I-set	2171..2262	CDD:254352
		Ig	<2198..2262	CDD:299845
		I-set	2269..2360	CDD:254352
		Ig	2270..2360	CDD:299845
		I-set	2367..2456	CDD:254352
		IGc2	2380..2446	CDD:197706
		I-set	2463..2554	CDD:254352
		Ig	2490..2554	CDD:299845
		I-set	2563..2652	CDD:254352
		Ig	2579..2647	CDD:143165
		I-set	2659..2747	CDD:254352
		Ig	2667..2747	CDD:299845
		I-set	2754..2843	CDD:254352
		Ig	2777..2841	CDD:143165
		I-set	2887..2981	CDD:254352
		Ig	2904..2978	CDD:143165
		I-set	2994..3082	CDD:254352
		IGc2	3009..3072	CDD:197706
		I-set	3087..3183	CDD:254352	8/27 (30%)
		Ig	3101..3179	CDD:299845	8/23 (35%)
		I-set	3189..3279	CDD:254352	14/89 (16%)
		Ig	3206..3276	CDD:299845	10/69 (14%)
		I-set	3286..3377	CDD:254352	26/128 (20%)
		Ig	3303..3374	CDD:143165	19/108 (18%)
		I-set	3384..3472	CDD:254352	16/91 (18%)
		Ig	3402..3472	CDD:143165	14/71 (20%)
		I-set	3482..3573	CDD:254352	14/90 (16%)
		Ig	3501..3570	CDD:143165	11/68 (16%)
		I-set	3580..3671	CDD:254352	19/90 (21%)
		IGc2	3593..3661	CDD:197706	13/67 (19%)
		I-set	3686..3776	CDD:254352	17/93 (18%)
		IGc2	3699..3766	CDD:197706	14/69 (20%)
		I-set	3817..3902	CDD:254352	25/107 (23%)
		Ig	3834..3899	CDD:143165	19/66 (29%)
		I-set	3920..4010	CDD:254352	18/104 (17%)
		Ig	3921..4010	CDD:299845	18/103 (17%)
		I-set	4018..4107	CDD:254352	24/90 (27%)
		Ig	4046..4107	CDD:299845	16/62 (26%)
		Ig	4108..4201	CDD:299845	31/183 (17%)
I-set	4114..4202	CDD:254352	29/178 (16%)
I-set	4212..4298	CDD:254352	23/101 (23%)
IGc2	4226..4288	CDD:197706	18/77 (23%)
I-set	4302..4388	CDD:254352	29/95 (31%)
Ig	4319..4384	CDD:143165	25/73 (34%)
I-set	4400..4486	CDD:254352	21/89 (24%)
Ig	4417..4482	CDD:143165	13/68 (19%)
I-set	4493..4581	CDD:254352	22/88 (25%)
Ig	4518..>4566	CDD:299845	12/48 (25%)
I-set	4588..4679	CDD:254352	25/93 (27%)
Ig	4599..4679	CDD:299845	22/82 (27%)
I-set	4685..4772	CDD:254352	28/89 (31%)
Ig	<4713..4772	CDD:299845	21/59 (36%)
I-set	4781..4869	CDD:254352	19/90 (21%)
Ig	4790..4869	CDD:299845	18/81 (22%)
I-set	4873..4962	CDD:254352	28/93 (30%)
Ig	4891..4960	CDD:299845	20/73 (27%)
I-set	4969..5059	CDD:254352	28/120 (23%)
Ig	4985..5051	CDD:143165	21/72 (29%)
I-set	5073..5161	CDD:254352	27/102 (26%)
Ig	5094..5161	CDD:299845	20/74 (27%)
I-set	5171..5260	CDD:254352	18/89 (20%)
Ig	5189..5255	CDD:143165	12/66 (18%)
I-set	5277..5367	CDD:254352	32/101 (32%)
IGc2	5291..5357	CDD:197706	25/77 (32%)
I-set	5383..5473	CDD:254352	30/90 (33%)
IGc2	5397..5463	CDD:197706	23/65 (35%)
I-set	5487..5577	CDD:254352	29/89 (33%)
IGc2	5501..5567	CDD:197706	25/65 (38%)
I-set	5595..5684	CDD:254352	6/88 (7%)
Ig	5614..5681	CDD:143165	0/66 (0%)
I-set	5701..5791	CDD:254352	28/90 (31%)
IGc2	5714..5781	CDD:197706	25/67 (37%)
I-set	5815..5905	CDD:254352	25/94 (27%)
IGc2	5828..5895	CDD:197706	21/71 (30%)
I-set	5925..6015	CDD:254352	5/89 (6%)
Ig	5939..6015	CDD:299845	2/75 (3%)
I-set	6038..6131	CDD:254352	25/93 (27%)
Ig	6058..6126	CDD:143165	20/68 (29%)
I-set	6150..6240	CDD:254352	28/89 (31%)
Ig	6168..6237	CDD:143165	23/68 (34%)
FN3	6275..6358	CDD:214495	36/82 (44%)
IG_like	6413..6501	CDD:214653	21/87 (24%)
Ig	6427..6499	CDD:143165	20/71 (28%)
I-set	6507..6597	CDD:254352	38/91 (42%)
Ig	6529..6594	CDD:143165	29/64 (45%)
PK_Unc-89_rpt1	6620..6878	CDD:271011	74/275 (27%)
S_TKc	6640..6878	CDD:214567	70/253 (28%)
I-set	7528..7616	CDD:254352	26/89 (29%)
Ig	7546..7616	CDD:299845	21/71 (30%)
FN3	7621..7716	CDD:238020	31/97 (32%)
STKc_Unc-89_rpt2	7781..8035	CDD:271014	77/274 (28%)
S_TKc	7793..8035	CDD:214567	76/254 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I3751
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1142	1.000	Inparanoid score	I111
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016796
OrthoInspector	1	1.000	-	-		oto20629
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860