DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and Alpk3

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_473426.2 Gene:Alpk3 / 116904 MGIID:2151224 Length:1680 Species:Mus musculus


Alignment Length:1999 Identity:370/1999 - (18%)
Similarity:620/1999 - (31%) Gaps:725/1999 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 GDSPKEG--WVP-----IDILEFNPTMSSSNGK----ESGDAEFRKLTILRELVETEEEFSRDLL 106
            |||..:|  |.|     ..:|...|..|.|:.:    .||.:.|  .:|:.:|.|..:.      
Mouse    21 GDSEDDGPVWTPGPASRSYLLSVRPEASLSSNRLSHPSSGRSTF--CSIIAQLTEETQP------ 77

  Fly   107 HVVEKYIKGIDKPVVPRSVRDNKDIIFCNFL------QIAEFHNNVLKE---GLKCY--SNQPNM 160
             :.|..:|.       |:|.::.|:.|...:      ::..:.:::..:   ||..|  ::|.| 
Mouse    78 -LFETTLKS-------RAVSEDSDVRFTCIVTGYPEPEVTWYKDDIELDRYCGLPKYEITHQGN- 133

  Fly   161 VAKTFLRLERDFDKHVVYCQNEPLAQDYLGSSPDAKKYFQELSKQLGDDKSLAEHLK-------- 217
              :..|:|.|        ||.|           ||..|           ::.|.:.|        
Mouse   134 --RHTLQLYR--------CQEE-----------DAAIY-----------QASARNTKGIVSCSGV 166

  Fly   218 LPIQRINDYQLLFKDFIKYSLSLKENVKDLERALE-----------LMLSV-PSRAYDNRFLSSI 270
            |.:..:.:|::..:.|.|........::::|::.:           |:..: |.|....|.||.:
Mouse   167 LEVGTMTEYKIHQRWFAKLKRKAAAKMREIEQSWKHGKEASGEADTLLRKISPDRFQRKRRLSGV 231

  Fly   271 EGCRGNIYKLGRLLLHAWCNVVDKEGKAHDRYCFLFKSRILVTKVRKISENRSVFILQNIVKLPL 335
            |                                    ..:|.|.||::.|..|....:.      
Mouse   232 E------------------------------------EAVLSTPVREMEEGSSAAWQEG------ 254

  Fly   336 CNIELKADEKQIHLSLKAPEANSFLPIDIKPHGPEAH----------LTWFNEISSHINQDVTLQ 390
                  ..|...|..|..  .|||.|.:...:|..|.          ||:..|:.....|:...:
Mouse   255 ------ETESAQHPGLGL--INSFAPGEAPTNGEPAPENGEDEERGLLTYICEVMELGPQNSPPK 311

  Fly   391 EHNADDLKVDASQIASESELILHLPQRAEAHDPNLSVRPSDVAENYFLSKETKERLQHEQQELLK 455
            |..|...:.|......|.:|.|...:.::....|: |..:|...:....|.|..:....|.....
Mouse   312 ESGAKKKRKDEESKPGEQKLELEKAEGSQCSSENV-VPSTDKPNSSRREKSTDTQPAQTQPRGRV 375

  Fly   456 LEQEAIELYKKQQSSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQVKEVTPVKVVSSPP 520
            .....||..:|..|...:..|.:.|                  |.|.|              :|.
Mouse   376 ARGPGIESTRKTASVLGIQDKVQDV------------------PAPAP--------------APV 408

  Fly   521 PPKEITPAKVATPPPQP-------QVV--------------TSPVKEVAPPPQPRA--------- 555
            |...:.||.|..|.|.|       ||.              .|..:|..|||..|.         
Mouse   409 PAPALAPAPVPVPAPTPVPSRSSEQVYFSLKDMFMETTRAGRSQEEEKPPPPSTRVAGESPPGKT 473

  Fly   556 -VASPAKEVTPSQSEPVKA--PSPIKEV-RKEVPPSASHSKEVEALVATEIRESLTETRSTVVES 616
             |.|..::|....|:|..:  |.|||.: ||...|..|..:.....::::..||:.::....:.|
Mouse   474 PVKSRLEKVPMVSSQPTSSMVPPPIKPLNRKRFAPPKSKVESTTTSLSSQTSESMAQSLGKALPS 538

  Fly   617 GQSSEI------REEIVVTEESSLEGKQV-----VALEREPSPCSIPKIQVYRPVECEN----PV 666
            . |:::      |..  .|.:|.|:|:..     .|||   ||.::      .|.:..|    .|
Mouse   539 A-STQVPTPPARRRH--GTRDSPLQGQTSHKTPGEALE---SPATV------APTKSANSSSDTV 591

  Fly   667 VTKH---------KPIELKDIVGYSESLRDGDTAPAG--GS------------PGRQQGYSANIT 708
            ...|         :|::       :|:..||.|...|  ||            .||.||..|...
Mouse   592 SVDHDSSGNQGATEPMD-------TETQEDGRTLVDGRTGSRKKTHTDGKLQVDGRTQGDGAQDR 649

  Fly   709 DHAS------------------------LTIWNN----RLANIAGDRSGANQHLQQSGPPPPPIP 745
            .|||                        .:.|.|    |..::...:..|.:..||. |....|.
Mouse   650 AHASPRTQAGEKAPTDVVTQGSERPQSDRSSWKNLVTQRRVDMQVGQMQAGERWQQD-PGDARIQ 713

  Fly   746 PNFTRMPGFFQPLPLIAYETTIEILIVKARPPSP-----PPPPPPTIKRVLVHTESLEQKTQNFF 805
            ............:| :|:||..|.|.:.:....|     .|...|...:.:   |..|:.|    
Mouse   714 EEEKETQSAAGSIP-VAFETQSEQLSMASLSSLPGALKGSPSGCPRESQAI---ECFEKST---- 770

  Fly   806 EGIYDAASSDTSLRNAKQKIRSIKSTVL--------------KSKDSTNYAQDTVQKAKARDFLH 856
            |.......||..||:.:...||.:..:|              ....|.:....|.|:::..|.|.
Mouse   771 EAPCVQERSDLMLRSEEAAFRSHEDGLLGPPSGNRTYPTQLPPEGHSEHLGGQTHQRSEQEDSLS 835

  Fly   857 IFTPPVKKRPIYEIVEEPVNIFELEGDYTESIA-------------------------------- 889
              ..|.|::|     :||::: .|.|.::..::                                
Mouse   836 --QCPKKEQP-----QEPLHV-GLSGGHSTGLSQEVPAMPSLPGTGLTSSLQEELPGTAASLHTN 892

  Fly   890 ---------DDF--------------------------------REPSADFEARGQSVG------ 907
                     .||                                :||:.|    |:|.|      
Mouse   893 TDVPLPSRDQDFPSSAPTLQLGPGSPTQSHPPEAMATSSEGACAKEPNVD----GRSSGTRSCDP 953

  Fly   908 GMDDYYSGY-------SRASTRRYETKTRDY-DRG--TSYDSTVERSQY-GISSRRDRSSVDKVE 961
            |:.|....|       |...|.....::::. |.|  ||..:.|...:. |:|.|..|..:::||
Mouse   954 GLIDSLKNYLLLLLKLSSPETSEARAESQEVADTGGLTSSSTLVPTMEVAGLSPRTSRRILERVE 1018

  Fly   962 -------ARSSLLA-------TGRTESRAASRAESRAESRASYSVA-------------ESRAGI 999
                   |::.||:       ||..:....:..::.|.::.|....             |..||.
Mouse  1019 NNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGQQALAAAQCSRGPCPTPLTIPAIVVGEEGSAGE 1083

  Fly  1000 RSSSRLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPG-LVTWLKDNKPLE------ 1057
            .|..|..::...:.:...|....::|...||       .|.:..|| .:|.|....|.|      
Mouse  1084 DSEERTSQESDKKGLLGEVEGHTVESRTQEP-------CQEEAMPGEALTGLPAATPEELALGAR 1141

  Fly  1058 ------------DRLADRITQTAAPMNSYRLDIKNCSETDAGTYTIRAQSASETTTVSAQLAVGQ 1110
                        |..|::..:..:|..|.|...|..:....||.....:|.::....|    :.:
Mouse  1142 RKRFLPKVRAGSDGEANKAEERESPTVSPRGPRKGLTPGSPGTPGRERRSPTQARKAS----MLE 1202

  Fly  1111 APGHDETKTNTEPAF--LVS-LKDAEMIENTLFRFMVKIIGDPKPRVKFYKDE--------KEIL 1164
            .||.:|     |||.  ||| .||:.:              |.:|.|...|.|        |::|
Mouse  1203 VPGAEE-----EPATGDLVSRSKDSGL--------------DSEPAVDEGKQEALAKQRKAKDLL 1248

  Fly  1165 ETNDRIQIIRDKDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQ 1229
            :....|:.||              |::....:.|.|...:......:::.|..:|::|.|.::..
Mouse  1249 KAPQVIRKIR--------------VEQFPDSSGSLKLWCQFFNIVSDSVLTWAKDQHPVGEVNRS 1299

  Fly  1230 ILPAGEKPVFQWKRNGEEFDPEERFKVLFGEDEDSLALVFQHVKPEDAGIYTCVAQTSTGNISCS 1294
               ||                          ||...||......|.|.|:|.|..|...|:.|..
Mouse  1300 ---AG--------------------------DEGPAALAIVQASPTDCGVYRCTIQNEHGSASTD 1335

  Fly  1295 AELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKG---FPK-PAVQWKHDGEVIQV 1355
            ..||.:.....::||..:   |.|..|....:....:.:..|.|   |.: .:.:.:..|..:|.
Mouse  1336 FCLSPEVLSGFISREEGE---VGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEELRGGGHGLQK 1397

  Fly  1356 DDRHKFMYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAG 1420
            ..|.|.                     :|.:|.|.|.|:                     ||   
Mouse  1398 ASRAKV---------------------IYGLEPIFESGR---------------------TC--- 1417

  Fly  1421 ETIKMEIEVEGFPQPTVQVTNNGKDVTAESNVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKA 1485
             .||:...:...|.....:.....|||.:          |..::.:..|..:|..::|     :|
Mouse  1418 -IIKVSSLLVFGPSSETSLLGRNYDVTIQ----------GCKIQNMSREYCKIFAAEA-----RA 1466

  Fly  1486 TNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAYPEAKLTWYHDETEIKITDS 1550
            .:...:.           |.|:..:   .|:....|:         |.|.|     |.::.....
Mouse  1467 ASGFGEV-----------PEIIPLY---LIYRPANNI---------PYATL-----EEDLGKPLQ 1503

  Fly  1551 KYTVSSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDS 1615
            .|.....|.|      ||.                :|.||::.|.|| ..|.|.|...|  .|..
Mouse  1504 TYCSRQWGCA------GAP----------------AAASSSEALQKC-QTFQHWLYQWT--NGSF 1543

  Fly  1616 NVELVVGVDAYPRPHAKWYIDGIEIDEKRNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYG 1680
            .|..:.|.|        |.:..::|..|...::.::| :.|..:::|.|::.|.|..|.::    
Mouse  1544 LVTDLTGAD--------WKMTDVQIATKLRGYQGLKE-SCFPALLDQFASSHQCNTYCDML---- 1595

  Fly  1681 KLEDNCVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFK 1729
                              |||.::..|.          :.|:||.|..|
Mouse  1596 ------------------GLKPLKGPEA----------AHPQAKAKGSK 1616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091 32/200 (16%)
PH_unc89 275..388 CDD:270134 19/122 (16%)
Atrophin-1 <493..690 CDD:331285 54/254 (21%)
TonB_N 502..>596 CDD:318287 30/127 (24%)
I-set 1017..1108 CDD:333254 21/109 (19%)
I-set 1123..1212 CDD:254352 20/99 (20%)
I-set <1236..1299 CDD:333254 13/62 (21%)
I-set 1313..1403 CDD:254352 15/93 (16%)
Ig_3 1406..1487 CDD:316449 13/80 (16%)
I-set 1499..1595 CDD:254352 16/95 (17%)
I-set 1599..1690 CDD:333254 18/90 (20%)
I-set 1694..1786 CDD:254352 9/36 (25%)
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Alpk3NP_473426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 6/15 (40%)
I-set 77..169 CDD:254352 23/138 (17%)
IGc2 90..159 CDD:197706 17/101 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..288 14/63 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 785..951 23/177 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1128 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1244 26/119 (22%)
Ig <1285..1330 CDD:299845 16/73 (22%)
Alpha_kinase 1372..1592 CDD:214828 61/342 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1603..1680 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7154
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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