DRSC/TRiP Functional Genomics Resources

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Protein Alignment Obsc and mylkl

DIOPT Version :10

Sequence 1:NP_001097440.1 Gene:Obsc / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_002935598.3 Gene:mylkl / 100489678 XenbaseID:XB-GENE-923293 Length:855 Species:Xenopus tropicalis


Alignment Length:909 Identity:200/909 - (22%)
Similarity:327/909 - (35%) Gaps:256/909 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  2896 NLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVP-DPPKTYTYLPPGTDFRPETS----PYFP 2955
            |..|.|:....|      |.::|.|.:.|    .|| :...|....||.....|.||    |..|
 Frog   135 NKTPMREESTHV------GKTNPMPLSAT----TVPKESSSTQPSAPPSRFESPSTSITHGPVSP 189

  Fly  2956 KDFDIERPPH---------DGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDM 3011
            |     |.|:         ||:.|          |...|.| ..||...:.|......|:..:..
 Frog   190 K-----RKPNKTGDSLKIVDGVDQ----------IKARVGD-KVELHCGIQGTTPIAATWLRNKK 238

  Fly  3012 LIESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDET 3076
            .:..|.|. ..:|.:.::.|.|:::.:.|.|.|.....:..|..:....|.:.|||         
 Frog   239 QVTEGPRI-SVHTSDMESRLVIDQVCEDDSGCYTLYVQDRTGNVQHHTSLTVVEHP--------- 293

  Fly  3077 FIMARKNGRIEAKLVGIPLPE------------------VHWFK---------DWKPIVDSSRIK 3114
               :..:|:   .||....|.                  .:|.:         .||.:.||  ..
 Frog   294 ---SPPSGK---PLVSATQPSSLTLSWSGPCYDGGSAVVSYWIEMKCTKKEEDGWKLLTDS--CV 350

  Fly  3115 ISSYDPDIYVLSIHDSIIKDGGLYS--ISARNIAG--------SISTSVTVHIEENEDQYIYKTY 3169
            .:||       .:.:. ::.||.|.  :.|.|..|        .|...:....||.|.:      
 Frog   351 NTSY-------RVEEG-LQPGGQYQFRVRAANAHGVSEPGEESDIVAMLCAGDEETEGE------ 401

  Fly  3170 GRHPYVR---SKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGR--PELRPFMLN 3229
            |.:.|..   :....:.|.|...::||.|..|..|...|||:|...|.|....|  .|::...: 
 Frog   402 GSNGYTNVSVNTTEHFNDFYIQLEKLGMGKFGQVYKLKERSTGKICAGKFFKARTQKEIQGARV- 465

  Fly  3230 ELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDY-YTERDIAHYIRQTLWG 3293
            |:|:||..:|..|:|...|:.....|.:::|..|||||. :.::..|: :||.....||.|.|.|
 Frog   466 EVELMNKLHHPQLVRCLSAFQEPGRVVMVLEYIAGGELF-ERIVADDFEHTEVMCVEYICQILNG 529

  Fly  3294 LEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEG 3358
            :.:||...:.|:.|..::::......:.:|:.||||:|:::.|....:..|..|||:|||:..|.
 Frog   530 VAYMHHQSIVHLDLKPENIICLNTVSNQVKIIDFGLARELDPHVPMKVLQGTAEFVAPEVIAFEP 594

  Fly  3359 VNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLY 3423
            |.|:.|||::|:|.|:||.|.:||.|.:|.||:..|....|||.||....:|:..:||:.|||..
 Frog   595 VGFTTDMWSLGVICYILLSGDSPFQGNNDMETMQNITSACWDFDDETNALLSETAKDFVKRLLQK 659

  Fly  3424 SPEERMDVKTALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKNYFRRRRLSGCF 3488
            :...|:....||.|||                                                .
 Frog   660 NMRSRLTAVQALDHPW------------------------------------------------V 676

  Fly  3489 QHPSKMVYPPGHVYTPENTPEPLPEPRIRAKREEVVSKYLHPDYELGLIQSESHYQYGPDTYLLQ 3553
            ||  |.|                  .:.:...:|.:.|:|          :...:|         
 Frog   677 QH--KCV------------------SKTKTLSKERIKKFL----------ARQKWQ--------- 702

  Fly  3554 LRDVNFPVRLREYMKVAHRRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDERTRSRISMYAA 3618
                    :..:.:...:|.:...|.:|:               :......|......::||:  
 Frog   703 --------KTGKAVLALNRMALLSAKSDN---------------NTTSTHTDGSHDCQQVSMH-- 742

  Fly  3619 NESYSIRRLRTELGPRLDEYTEADAMIETQREGYPPFFREKPQTIAITENQPSHIHCFAVGDPKP 3683
                            |.|..:|..:..|       ..:::.:.:..|    :...|...|.|.|
 Frog   743 ----------------LQEQLQAAPVFST-------LLKDQVEVVGST----ARFQCHIEGFPDP 780

  Fly  3684 CVQWFKNDMVLTESKRIKISVDEDGRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVATL 3747
            .|.||.....:.|.:|::|..::.|...|.....|..|.|||...|.|..|:..:..::.|.:|
 Frog   781 EVLWFHAGSPVQECRRLQIEYEDTGSCALIISDVLLTDSGVYTCRASNTQGEIESSAKLTVHSL 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ObscNP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Not5 <477..>652 CDD:444384
Ig 1017..1108 CDD:472250
Ig strand B 1034..1038 CDD:409353
Ig strand C 1046..1050 CDD:409353
Ig strand E 1074..1078 CDD:409353
Ig strand F 1088..1093 CDD:409353
Ig strand G 1101..1104 CDD:409353
I-set 1123..1212 CDD:400151
Ig strand B 1140..1144 CDD:409353
Ig strand C 1153..1157 CDD:409353
Ig strand E 1182..1186 CDD:409353
Ig strand F 1196..1201 CDD:409353
Ig strand G 1209..1212 CDD:409353
Ig <1236..1299 CDD:472250
Ig strand C 1238..1242 CDD:409353
Ig strand E 1259..1269 CDD:409353
Ig strand F 1279..1284 CDD:409353
Ig strand G 1292..1295 CDD:409353
I-set 1313..1403 CDD:400151
Ig strand B 1330..1334 CDD:409353
Ig strand C 1343..1347 CDD:409353
Ig strand E 1369..1373 CDD:409353
Ig strand F 1383..1388 CDD:409353
Ig strand G 1396..1399 CDD:409353
Ig_3 1406..1487 CDD:464046
I-set 1499..1595 CDD:400151
Ig strand B 1522..1526 CDD:409353
Ig strand C 1535..1539 CDD:409353
Ig strand E 1561..1565 CDD:409353
Ig strand F 1575..1580 CDD:409353
Ig strand G 1588..1591 CDD:409353
Ig 1599..1690 CDD:472250
Ig strand B 1617..1621 CDD:409353
Ig strand C 1630..1634 CDD:409353
Ig strand E 1656..1660 CDD:409353
Ig strand F 1670..1675 CDD:409353
Ig strand G 1683..1686 CDD:409353
I-set 1694..1786 CDD:400151
Ig strand B 1711..1715 CDD:409353
Ig strand C 1724..1728 CDD:409353
Ig strand E 1752..1756 CDD:409353
Ig strand F 1766..1771 CDD:409353
Ig strand G 1779..1782 CDD:409353
Ig <1836..1903 CDD:472250
Ig strand C 1846..1850 CDD:409353
Ig strand E 1871..1875 CDD:409353
Ig strand F 1885..1890 CDD:409353
Ig 1922..2005 CDD:472250
Ig strand B 1933..1937 CDD:409353
Ig strand C 1946..1950 CDD:409353
Ig strand E 1971..1984 CDD:409353
Ig strand F 1994..1999 CDD:409353
Ig 2018..2108 CDD:472250
Ig strand B 2034..2038 CDD:409353
Ig strand C 2047..2051 CDD:409353
Ig strand E 2074..2078 CDD:409353
Ig strand F 2088..2093 CDD:409353
Ig strand G 2101..2104 CDD:409353
Ig 2113..2214 CDD:472250
Ig strand B 2130..2134 CDD:409353
Ig strand C 2143..2147 CDD:409353
Ig strand E 2176..2185 CDD:409353
Ig strand F 2195..2200 CDD:409353
I-set 2220..2302 CDD:400151
Ig strand B 2238..2242 CDD:409353
Ig strand C 2251..2255 CDD:409353
Ig strand E 2277..2281 CDD:409353
Ig strand F 2291..2296 CDD:409353
Ig strand G 2304..2307 CDD:409353
I-set 2318..2408 CDD:400151
Ig strand B 2335..2339 CDD:409353
Ig strand C 2348..2352 CDD:409353
Ig strand E 2374..2378 CDD:409353
Ig strand F 2388..2393 CDD:409353
Ig 2415..2506 CDD:472250
Ig strand B 2432..2436 CDD:409353
Ig strand C 2445..2449 CDD:409353
Ig strand E 2472..2476 CDD:409353
Ig strand F 2486..2491 CDD:409353
Ig strand G 2499..2502 CDD:409353
I-set 2519..2608 CDD:400151
Ig strand B 2536..2540 CDD:409353
Ig strand C 2549..2553 CDD:409353
Ig strand E 2574..2578 CDD:409353
Ig strand F 2588..2593 CDD:409353
I-set 2615..2696 CDD:400151
Ig strand B 2632..2636 CDD:409353
Ig strand C 2645..2649 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2717..2805 CDD:400151
Ig strand B 2734..2738 CDD:409353
Ig strand C 2747..2751 CDD:409353
Ig strand E 2773..2777 CDD:409353
Ig strand F 2787..2792 CDD:409353
Ig strand G 2800..2803 CDD:409353
FN3 2834..2925 CDD:238020 7/28 (25%)
Ig <2996..3063 CDD:472250 12/66 (18%)
Ig strand C 3003..3007 CDD:409353 1/3 (33%)
Ig strand E 3029..3033 CDD:409353 1/3 (33%)
Ig strand F 3043..3048 CDD:409353 1/4 (25%)
Ig strand G 3056..3059 CDD:409353 0/2 (0%)
Ig 3067..3157 CDD:472250 19/126 (15%)
Ig strand B 3085..3088 CDD:409353 0/2 (0%)
Ig strand C 3097..3101 CDD:409353 0/21 (0%)
Ig strand E 3123..3127 CDD:409353 0/3 (0%)
Ig strand F 3137..3142 CDD:409353 1/6 (17%)
Ig strand G 3150..3153 CDD:409353 0/2 (0%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 91/260 (35%)
Ig 3654..3744 CDD:472250 21/89 (24%)
Ig strand B 3671..3675 CDD:409353 0/3 (0%)
Ig strand C 3684..3688 CDD:409353 1/3 (33%)
Ig strand E 3710..3714 CDD:409353 1/3 (33%)
Ig strand F 3724..3729 CDD:409353 2/4 (50%)
Ig strand G 3737..3740 CDD:409353 0/2 (0%)
FN3 3748..3840 CDD:238020 200/909 (22%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014
mylklXP_002935598.3 Ig 207..297 CDD:472250 21/113 (19%)
Ig strand B 217..221 CDD:409419 2/3 (67%)
Ig strand C 230..234 CDD:409419 1/3 (33%)
Ig strand E 255..259 CDD:409419 1/3 (33%)
Ig strand F 269..274 CDD:409419 1/4 (25%)
Ig strand G 282..285 CDD:409419 0/2 (0%)
FN3 293..388 CDD:238020 18/119 (15%)
Protein Kinases, catalytic domain 427..675 CDD:473864 88/249 (35%)
Ig 757..841 CDD:472250 21/87 (24%)
Ig strand B 768..772 CDD:409353 0/3 (0%)
Ig strand C 781..785 CDD:409353 1/3 (33%)
Ig strand E 807..811 CDD:409353 1/3 (33%)
Ig strand F 821..826 CDD:409353 2/4 (50%)
Ig strand G 834..837 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

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