DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and trio

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_012819807.1 Gene:trio / 100170157 XenbaseID:XB-GENE-922516 Length:3085 Species:Xenopus tropicalis


Alignment Length:2151 Identity:413/2151 - (19%)
Similarity:720/2151 - (33%) Gaps:730/2151 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IVFVSRDYQAQSLATDEISVSRGDLVELISSKASEKSRCFVRMFDSGDSPKEGWVPIDILEFNPT 71
            :..|.:.|:..||..::...|....:.:.|...|.||                 :.:||:   |.
 Frog  1216 VTAVDKRYRDFSLRMEKYRTSLEKALGISSDSKSSKS-----------------LQLDII---PA 1260

  Fly    72 MSSSNGKESGDAEF-----------RKLTILRELVETEEEFSRDLLHVVEKYI----KGIDKPVV 121
            .:..:..:..||..           ||..|:.||::||:.:.|||...::.|:    .|:::  :
 Frog  1261 TAPGSEVKLRDATHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE--I 1323

  Fly   122 PRSVRDNKDIIFCNFLQIAEFHNNVLKEGLKCYSNQPNMVAKTFLRLERDFDKHVVYCQNEPLAQ 186
            |..:.:.:.|||.|..:|.|||||:..:.|:.|...|..|...|:.....|..:|.||:|:|.:.
 Frog  1324 PPGIVNKEHIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVSYCKNKPDST 1388

  Fly   187 DYLGSSPDAKKYFQELSKQLGDDKSLAEHLKLPIQRINDYQLLFKDFIKYSLSLKENVKDLERAL 251
            ..:  ...|..||.|:.::.....|::.:|..|:|||..||||.|:.:......|..:||   .|
 Frog  1389 QLI--LEQAGTYFDEIQQRHELVNSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD---GL 1448

  Fly   252 ELMLSVPSRAYDNRFLSSIEGCRGNIYKLGRLLLHAWCNVVDKE---GKAHDRYCFLFKSRILVT 313
            |:|||||.||.|...||.:||...||...|.|:|.....|.|.:   .|..:|:.|||:..::.:
 Frog  1449 EVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFS 1513

  Fly   314 KVRKISENRSVFILQNIVKLPLCNIELKADEKQIHLS----------LKAPEANSFLPIDIKPHG 368
            |..|.|..||.:    |.|..|...||...|   |:.          .:.|.:::  .|.:|...
 Frog  1514 KEVKDSSGRSKY----IYKSKLFTSELGVTE---HVEGDPCKFALWVGRTPTSDN--KIVLKGSS 1569

  Fly   369 PEAHLTWFNEISSHINQDVTLQEHNADDLKVDASQIASESELILHLPQRAEAHDPNLSVRPSDVA 433
            .|....|...|...| ||.|:  |....||..           :|:|:.|.|             
 Frog  1570 IENKQDWIKHIREVI-QDRTI--HLRGALKEP-----------IHIPKTAAA------------- 1607

  Fly   434 ENYFLSKETKERLQHEQQELLKLEQEAIELYKKQQSSKSVSSKTESVEITSSQVKSSSEVRKVV- 497
                    ||::......|.|..:.:.    ..|..:.|::|:|....:.|.::....|:..|: 
 Frog  1608 --------TKQKPAKRDGEDLDSQGDG----SSQPDTISIASRTSQNTLDSDKLSGGCELTVVIH 1660

  Fly   498 -------SPPPPPQAQVKEVTP----------VKVVSSPPPPKEITPAKV--------------- 530
                   :.....:.|..||..          |:.....|..:.:.|:..               
 Frog  1661 DFTACNSNELTIKRGQTVEVLERHHDRPDWCLVRTTDRSPAAEGLVPSSSLCIAHSRSSMEMEGI 1725

  Fly   531 -------------ATPPP-----QPQVV---TSPVKEVAPPPQP-----RAVASPAKEVTPSQSE 569
                         |:||.     ||.::   :||     .|.:|     :.:.||.:.::..   
 Frog  1726 FNHKDSLSVSSNDASPPASVISLQPHMIGAQSSP-----GPKRPGNTLRKWLTSPVRRLSSG--- 1782

  Fly   570 PVKAPSPIKEVRKEVPPSASHSKEVEALVATEIRESLTETRSTVVESGQSSEIREEIVVTEESSL 634
              ||...:|::      :..|.|      :.|:|::        .:||...:..:.....::.::
 Frog  1783 --KADGHVKKL------AHKHKK------SREVRKN--------TDSGSQKDSDDSAATPQDETI 1825

  Fly   635 EGKQVVALEREPSPCSIPKIQVYRPVECENPVVTKHKPIELKDIVGYSESLRDGDTAPAGGSPGR 699
            |       ||.                                   .:|.|..| |.....|.|.
 Frog  1826 E-------ERV-----------------------------------RNEGLSSG-TLSKSSSSGM 1847

  Fly   700 QQGYSANITDHASLTIWNNRLANIAGDRSGANQHLQQSGPPPPPIPPNFTRMPGFFQPLPLIAYE 764
            |.                      .|:..|      :.||...|:||     |...|...|:..:
 Frog  1848 QS----------------------CGEEEG------EEGPDAVPLPP-----PMAIQQHSLLQPD 1879

  Fly   765 -----TTIEILIVKARPPSPPPPPP----PTIKRVLVHTESLEQKTQNFFEGIYDAAS-----SD 815
                 |:..:|:   ||.|...|..    ..|:.::....:||.:..:......|::|     ||
 Frog  1880 SQDDKTSSRLLV---RPTSSETPSAAELVSAIEELVKSKMALEDRPSSLQVDQGDSSSPSFNPSD 1941

  Fly   816 TSLRNAKQKIRSI---KSTVLKSKDSTNYA-QDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVN 876
            |||.::...|..:   ||:.||.:   :|. |:.|:  ..||::         |.:..:||..:.
 Frog  1942 TSLLSSSSPIDEMEEKKSSSLKRR---HYVLQELVE--TERDYV---------RDLGYVVEGYMA 1992

  Fly   877 IFELEGDYTESIADDFREPSADFEARGQS---VGGMDDYYSGYSRASTRRYETKTRDYDRGTSYD 938
            :.:.:|     :.||.         :|:.   .|.:...|..:            ||:..|    
 Frog  1993 LMKEDG-----VPDDM---------KGKDKIVFGNLHQIYEWH------------RDFFLG---- 2027

  Fly   939 STVERSQYGISSRRDRSSVDKVEARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSS 1003
             .:||            .:|:.|..:||..          :.|.|......|.            
 Frog  2028 -ELER------------CLDEPERLASLFV----------KHERRLHMYIVYC------------ 2057

  Fly  1004 RLQEDRPLRSVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQT- 1067
               :::|                     ::.|...::.|     |:.:|   |:.||..|:..| 
 Frog  2058 ---QNKP---------------------KSEHIVSEYID-----TYFED---LKQRLGHRLQLTD 2090

  Fly  1068 --AAPMN---SYRLDIKNCSETDAGTYTIRA-------QSASETTTV-----SAQLAVGQAPGHD 1115
              ..|:.   .|:|.:|     |...|:.:|       :.|.|...:     :..:.||:..|.|
 Frog  2091 LLIKPIQRIMKYQLLLK-----DFLKYSKKACIDVAELERAVEVMCIVPKRCNDMMNVGRLQGFD 2150

  Fly  1116 -----ETKTNTEPAFLVSLKDAEMI----ENTLFRF-MVKIIGDPKPRVKFYKDEKEILETNDRI 1170
                 :.|...:..|||:.:||.::    |..:|.| .:.|..:|..:.|.|.....:.:.|.::
 Frog  2151 GKIVAQGKLLLQDTFLVTEQDAGLLPRCKERRVFLFEQIVIFSEPLDKKKGYSTPGFLFKNNIKV 2215

  Fly  1171 QII-----------------RDKDYL----------GFYELVIADVQKT---------------- 1192
            ..:                 |..|..          |..:|.|.::.:.                
 Frog  2216 SCLSLEECVDSDPCKFALLSRSADSTEMFVLHSSSPGVRQLWIHEINQILENQRNFLNALTSPIE 2280

  Fly  1193 -----DAGTYSCKATNKHGEANCEA-----------IATTVEDKNPF---GALSGQI-------L 1231
                 ..|:.|...|.....:||..           |...|...:|.   .|.|.|.       :
 Frog  2281 YHRNHTGGSSSGNVTFTSSPSNCSGLGGSSRSRPSRIPQPVRHHSPVLVSSAASAQSEADKMSGM 2345

  Fly  1232 PAGEKPVFQWKRNGEEFDPEERFKVLF-----GEDEDSLAL----VFQHVKPEDAGIYTCV--AQ 1285
            .|...||.....:.:. :|.::.:|..     |.|::|.::    :....:...:||.|..  ||
 Frog  2346 SARRAPVVPLNLSLDN-NPSQKGRVTAAPETGGRDKESNSVPKMKMLDGPRKSASGIPTLADGAQ 2409

  Fly  1286 TS-TGNISCSAELSVQGAIQ----------------TLN------REPEKPTLVIEHREANASIG 1327
            .. .|:...|...|..|.:.                |:|      :|...|:..::.....:||.
 Frog  2410 KELRGSTEDSRIRSTMGTLTLGKPRNGSASPLNSPVTINFPSSFGKESGPPSSPLQKGSFWSSIP 2474

  Fly  1328 GSAILELQCKGFPKPAVQWKHDGEVIQVD-DRHKFMYEDEESMSLV------------------- 1372
            ||.........||       .|.:.:|.. .||....:|.:.||..                   
 Frog  2475 GSPASRPGSFTFP-------GDSDSLQRQVHRHSTHSKDTDRMSTCSSTSEQSVHSTQSNGVRTE 2532

  Fly  1373 -----IKNVDTV------------DAGVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAG 1420
                 ..|:.|:            :..||..|.:..|..::.::.||.:|      .|| .|.| 
 Frog  2533 SESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRA------ATD-ECPA- 2589

  Fly  1421 ETIKMEIEVEGFPQPTVQVTNNGKDVTAESNVKISSSSIGKSLEKVVVEVKEIKLSQAGNYSIKA 1485
                    .||: .|:..:.:....:|..::..:..||...:..:  :..|..|..:.|:...|.
 Frog  2590 --------AEGW-IPSYVLGHTSAIITDMTDATMKKSSSWHTALR--IRKKSEKREKDGSRDTKL 2643

  Fly  1486 TNDLSQTSEYWSCTVKSKPVIVKNFESEYIHGEK---------------ENVQMTVRIDAYPEAK 1535
            .|...::.|     ..:..|.||.....||:...               |.|.:..::...|:|.
 Frog  2644 ENGYRKSRE-----GLANKVSVKLLNPNYIYDAPPEFIVPLNEVTCDTGETVIIRCKVCGRPKAS 2703

  Fly  1536 LTWYHDETEIKITDSKYTVS-SDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLI---- 1595
            :||...:......|..|::| ||....||||.|.|..|.|.||..|||:.||.::|:.|.:    
 Frog  2704 ITWKGPDHNTLSNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIATNDLGSVSASSNLRVLGSW 2768

  Fly  1596 -------------------------------KCAPEFTHKL-----------------KNITVAE 1612
                                           ||....|.::                 ..:.:.:
 Frog  2769 SDGLRVIWKENFDIAYSEVAELGRGRFSVVKKCEQRVTRRIVATKFVNKKLMKRDQVTHELGILQ 2833

  Fly  1613 GDSNVELVVGVDAYPRPHAKWYIDGIEIDEKRNDFRHVEE-GN--DFKL--IMNQVATNMQGNYT 1672
            ...:.:|:..:|.:..|.:  |:..:||.::.....:|.: ||  :.|:  .|.:|...:|..:.
 Frog  2834 SLQHPQLISLLDTFETPAS--YVLVLEIADQGCLLEYVVQWGNLTEEKITSYMREVLEALQYLHN 2896

  Fly  1673 CKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYED 1737
            |:|.:            ::.||      :|:.|.:.         .::|..|:..|.|.      
 Frog  2897 CRIAH------------LDLKP------ENILVDQS---------LTKPTIKLSDFGDA------ 2928

  Fly  1738 ARIKISRDTQRIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALS-----LEQT 1797
                    .|....||:...|...|.|.. |:...|.:..|:....:.|||...||     |:::
 Frog  2929 --------VQLNTTYYIHQLLGSAEFAAP-EIILGNPVSLTSDIWSIGVLTYVLLSGVSPFLDES 2984

  Fly  1798 VTKTLI 1803
            |.:|.:
 Frog  2985 VEETCL 2990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091 57/173 (33%)
PH_unc89 275..388 CDD:270134 33/125 (26%)
Atrophin-1 <493..690 CDD:331285 33/255 (13%)
TonB_N 502..>596 CDD:318287 22/144 (15%)
I-set 1017..1108 CDD:333254 18/108 (17%)
I-set 1123..1212 CDD:254352 23/141 (16%)
I-set <1236..1299 CDD:333254 14/74 (19%)
I-set 1313..1403 CDD:254352 21/126 (17%)
Ig_3 1406..1487 CDD:316449 14/80 (18%)
I-set 1499..1595 CDD:254352 33/111 (30%)
I-set 1599..1690 CDD:333254 16/112 (14%)
I-set 1694..1786 CDD:254352 16/91 (18%)
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
trioXP_012819807.1 SEC14 64..199 CDD:214706
SPEC 215..440 CDD:238103
SPEC 336..561 CDD:238103
SPEC 562..778 CDD:238103
SPEC 782..1009 CDD:238103
SPEC 903..1132 CDD:238103
SPEC 1138..1238 CDD:197544 5/21 (24%)
RhoGEF 1289..1459 CDD:238091 58/176 (33%)
PH1_Kalirin_Trio_like 1466..1588 CDD:270060 35/131 (27%)
SH3_Kalirin_1 1654..1713 CDD:212786 8/58 (14%)
SH3-RhoG_link 1710..1967 CDD:293215 61/368 (17%)
RhoGEF 1965..2138 CDD:238091 45/288 (16%)
PH2_Kalirin_Trio_p63RhoGEF 2143..2281 CDD:270061 23/137 (17%)
SH3_Kalirin_2 2543..2601 CDD:212787 15/74 (20%)
I-set 2673..2764 CDD:254352 28/90 (31%)
Ig 2687..2764 CDD:299845 28/76 (37%)
STKc_Trio_C 2776..3038 CDD:271015 43/259 (17%)
S_TKc 2784..3038 CDD:214567 43/251 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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