DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and camk1da

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001116532.1	Gene:	camk1da / 100144566	ZFINID:	ZDB-GENE-080402-7	Length:	433	Species:	Danio rerio

Alignment Length:	353	Identity:	99/353 - (28%)
Similarity:	174/353 - (49%)	Gaps:	29/353 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  3186 YDIGDELGRGTQGITYHAVERSSGDNYAA-----KIMYGRPELRPFMLNELEMMNTFNHKNLIRP 3245
            ::..:.||.|.......|.|||:|..||.     |.:.|:   ...:.||:.::....|:|::..
Zfish    25 FEFKEVLGTGAFSEVVLAEERSTGKMYAVKCIPKKALKGK---ESSIENEIAVLRKIKHENIVAL 86

  Fly  3246 YDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIK 3310
            .|.|::...:.|||:|.:||||. |.::.:.:|||:|.:..|||.|..:.::|.||:.|..|..:
Zfish    87 EDIYESSDHLYLIMQLVSGGELF-DRIVEKGFYTEKDASTLIRQVLDAVNYLHTMGIVHRDLKPE 150

  Fly  3311 DLL-ISVVGGDIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYV 3374
            :|| .:...|..|.:||||||:.....::.:...|.|.:|:|||:.::..:.:.|.|::|:|.|:
Zfish   151 NLLYFNPQDGSKIMISDFGLSKMEGTGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYI 215

  Fly  3375 LLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPW 3439
            ||.|:.||...:|.:...:|.:..::|....|..|||..:||||.|:...|.:|...:.||:|||
Zfish   216 LLCGYPPFYDENDSKLFEQILKADYEFDAPYWDDISDSAKDFISCLMEKDPSKRNTCEQALRHPW 280

  Fly  3440 FFMLDRPVYDHDYQIGTDRLRNYY--DHFRDWYANASCKNYFRRRRLSGCF-----------QHP 3491
             ...|..:..:.::..:.::|..:  ..:|..:...:...:.||.:|....           |:.
Zfish   281 -IAGDTALCKNIHESVSRQMRKNFAKSKWRQAFNATAVVRHMRRLQLGSSMGSSMDQSNTANQNR 344

  Fly  3492 SKMVYPPGHVYTPENTP-----EPLPEP 3514
            .....||.:..|....|     :|.|.|
Zfish   345 ILNANPPLNTTTNSTAPLTQNQKPAPNP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011	84/259 (32%)
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
camk1da	NP_001116532.1	STKc_CaMKI_delta	14..314	CDD:271070	88/293 (30%)
camk1da	NP_001116532.1	S_TKc	25..281	CDD:214567	85/260 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810