DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and mylk5

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_005164113.1 Gene:mylk5 / 100003770 ZFINID:ZDB-GENE-050309-74 Length:856 Species:Danio rerio


Alignment Length:1329 Identity:239/1329 - (17%)
Similarity:416/1329 - (31%) Gaps:532/1329 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  2451 NGHEIKPDASHIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPKADETAT 2515
            ||...:|      :::.|:::||.:        :|.|                       :.|..
Zfish    24 NGQGSRP------VIKKPEDTSSAV--------NGNY-----------------------NHTRQ 51

  Fly  2516 EEAPQFVSALRDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIKP 2580
            .:.|.|...|.|...|||.::.|:.....:....:.|..:|.|:...:..|:   |:.:.|.::.
Zfish    52 LDPPLFTKPLEDCIVDEGNDITLNGSITGSQPISISWLHNGETVRFGKSSLV---GEKVTLVVRE 113

  Fly  2581 AEAADSGNYTCLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQQVFGNNAKIPVTVSGVPYPD 2645
            ....|:|.|||:..|..|:.||:....||             |.:.:...|..|           
Zfish   114 CLPEDAGAYTCMAENIAGKTSSSAAVCVR-------------DYESIVRVNNNI----------- 154

  Fly  2646 LEWYFQDKPIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKK 2710
                     |.||..:      .|...::|...: |..|.|...|.:.|..:|..          
Zfish   155 ---------INKSHAH------PHTPDLLNGTSE-DTSVCKGPESPQTGSPVTNS---------- 193

  Fly  2711 HSRSEPPVFLKKIGDCDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRL 2775
                  ||..:::        .|.:.::...|:..|.:::      :.|.||..:.:.....|..
Zfish   194 ------PVLKREV--------HVKRRSSSGAGFTAPPLQF------VDPLDRLEVQVGETARLEC 238

  Fly  2776 TIKNVTEYDVGRYSCRIFNPYGDDICHAELFY-DSLD-------SQQKPLED--QYTDFKKYKKS 2830
            ..|..:..    .||.:||.  .::..:..|: :|.|       |:..| ||  :||.|.:.:||
Zfish   239 FFKGSSPV----ASCWVFNK--KEVEESSRFHLESCDENSSLVISEALP-EDSGRYTIFVRDRKS 296

  Fly  2831 GA-----------PPPLSEGPIISRMTDRGLLLSWNPSVPLTPRY----PIT-YQIEMMDLPEGD 2879
            .|           |.|.:..|:...::...|:|||:     .|.|    .:| |.:|:.:.....
Zfish   297 SAQHTVTLNVIDLPQPPASCPVARVLSPHSLVLSWS-----GPSYDGGSAVTGYVVEVCEKESEQ 356

  Fly  2880 WRTLRTGVRSCACDIRN-LEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPG 2943
            |:.|....:|.:..:.: |:|...|.||:|..|..|||:||..:||                   
Zfish   357 WKELTAQCKSTSLRVTSGLQPQGQYCFRIRACNTVGVSEPSQESQT------------------- 402

  Fly  2944 TDFRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYF 3008
                                                                             
Zfish   403 ----------------------------------------------------------------- 402

  Fly  3009 DDMLIESGGRFDQSYTRNGQATLFINKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRP 3073
                                                  |..:..|::|:.               
Zfish   403 --------------------------------------VTMDNPGDSREE--------------- 414

  Fly  3074 DETFIMARKNGRIEAKLVGIPLPEVHWFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLY 3138
                                           ||:.              ||              
Zfish   415 -------------------------------KPVE--------------YV-------------- 420

  Fly  3139 SISARNIAGSISTSVTVHIEENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHA 3203
                         :||:                     ..|.:..|.|::.::||.|..|..:..
Zfish   421 -------------NVTI---------------------DTQHKLTDHYNVLEKLGVGKFGQVFRM 451

  Fly  3204 VERSSGDNYAAKIMYG-RPELRPFMLNELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGEL 3267
            ..:.:|...|.|.... |.:.|.....|:|:||..:|..|::...|||....:.::||..|||||
Zfish   452 THKVTGRECAGKFYKSRRAKDREAARKEIELMNFLHHPKLVQCLAAYDNKAEMVMVMEYVAGGEL 516

  Fly  3268 ----VRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFG 3328
                |.|:.    .:||.....|:||.|.|:::||:..:.|:.|..::::.....|..||:.|||
Zfish   517 FERIVDDSF----EHTEVSSVGYMRQILEGIKYMHQQNILHLDLKPENIVCVDRTGSQIKIIDFG 577

  Fly  3329 LSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTK 3393
            |:.|::.:....:..|.||||:|||:|.|.|..:.|||:||:|.|:||.|.:||.|..|.|||..
Zfish   578 LACKLDPNTPLKVMQGTPEFVAPEVINFEAVTLTTDMWSVGVICYILLSGESPFQGESDTETLAL 642

  Fly  3394 IREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPW--FFMLDRPVYDHDYQIGT 3456
            :...:|:|.:|.:..|:|..:.|||.||...|..|:..:.||.|.|  |..:|.. ......:..
Zfish   643 VTAAQWEFDEESFEEITDMAKGFISSLLNKDPRRRLSCEEALAHDWLGFLCVDNS-SSGGKNLSK 706

  Fly  3457 DRLRNYYDHFRDWYANASCKNYFRRRRLSGCFQHPSKMVYPPGHVYTPENTPEPLPEPRIRAKRE 3521
            |:::.:... :.|                                   :.|.:.|    :..||.
Zfish   707 DKMKKFLTR-QKW-----------------------------------KKTGKAL----LALKRM 731

  Fly  3522 EVVSKYLHPDYELGLIQSESHYQYGPDTYLLQLRDVNFPVRLREYMKVAHRRSPSFALNDSVDWS 3586
            .::||                                                            
Zfish   732 AILSK------------------------------------------------------------ 736

  Fly  3587 LPVIRERRRFTDIMDEEIDDERTRSRISMYAANESYSIRRLRTELGPRLDEYTEADAMIETQREG 3651
                               .|.:.|...::...::.....|:.:..|.                 
Zfish   737 -------------------PEASASTSPVHETEQALQSLELKLQCKPE----------------- 765

  Fly  3652 YPPFFREKPQTIAITENQPSHIHCFAVGDPKPCVQWFKN-DMVLTESKRIKISVDEDGRSILRFE 3715
                |.:.|..:::.:....|:.|...|.|.|.|.|.:: :::..:...:.:..:|||...|...
Zfish   766 ----FSKTPSDLSVPQGSSVHLSCLITGYPDPEVVWLRDGELLELQGGSVTVDYEEDGSCTLILN 826

  Fly  3716 PALHFDVGVYKVVARNKVGQTVARCRIVV 3744
            .......|:|...|.|.:|:.:....:.|
Zfish   827 NVSLNHSGLYSCKATNALGEALCSATLTV 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352 8/54 (15%)
I-set 2519..2608 CDD:254352 23/88 (26%)
I-set 2615..2696 CDD:254352 13/80 (16%)
I-set 2717..2805 CDD:254352 14/87 (16%)
FN3 2834..2925 CDD:238020 27/96 (28%)
I-set <2996..3063 CDD:333254 3/66 (5%)
I-set 3067..3157 CDD:333254 6/89 (7%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 92/264 (35%)
I-set 3654..3744 CDD:333254 18/90 (20%)
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
mylk5XP_005164113.1 I-set 55..141 CDD:254352 23/88 (26%)
Ig 72..137 CDD:143165 16/67 (24%)
Ig 217..314 CDD:299845 24/109 (22%)
I-set 218..306 CDD:254352 22/100 (22%)
FN3 310..404 CDD:238020 29/220 (13%)
S_TKc 434..689 CDD:214567 90/258 (35%)
STKc_MLCK 440..689 CDD:271005 89/252 (35%)
I-set 764..855 CDD:254352 19/111 (17%)
Ig 781..852 CDD:143165 16/70 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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