Protein Alignment Vmat and TPO2

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_011654.1
• Gene: TPO2 / 853039
• SGDID: S000003370
• Length: 614
• Species: Saccharomyces cerevisiae
• Alignment Length: 665
• Identity: 125/665 - (18%)
• Similarity: 217/665 - (32%)
• Gaps: 240/665 - (36%)

  Fly     5 TDAGNGGPRKHTQSTAPQKQSEISETTSFTVNANTTTNSQQQQIPGGPASNTPSKNPFKQQLDSN 69
            |...|..|.::|..| |.....::...|....|:..:.::.:|: ...|:|:.|..  |::::..
Yeast    70 TAKNNIFPEEYTMET-PSGLVPVATLQSMGRTASALSRTRTKQL-NRTATNSSSTG--KEEMEEE 130

  Fly    70 Q------QNGNMEPDCGIMGVGKEPPVPPPPTYQSQTYAGRQAPPPADQYREEDPRAAGSWAAAK 128
            :      |:|..|.|               |..:..|:.            ..||....:|   .
Yeast   131 ETEEREDQSGENELD---------------PEIEFVTFV------------TGDPENPHNW---P 165

  Fly   129 SWMVSWRGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTPLTSNVPPPP 193
            || |.|..:..|.::::.:|.
Yeast   166 SW-VRWSYTVLLSILVICVAY-------------------------------------------- 185

  Fly   194 TPCPCNKDGSEAAPLEISTISPEENETYYRELEERHNELVGETVEVGLLFASKAFVQLLVNPIV- 257
                    ||......:.|:            |::::  ||  :|..:|..|...:...:.|::
Yeast   186 --------GSACISGGLGTV------------EKKYH--VG--MEAAILSCSLMVIGFSLGPLIW 226

  Fly   258 GPLTHRIGYSIPMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGM----GMLADR 318
            .|::...|..:..|....:..:..|..|...:...|...|.|.|:.||    ||:    |.:||.
Yeast   227 SPVSDLYGRRVAYFVSMGLYVIFNIPCALAPNLGCLLACRFLCGVWSS----SGLCLVGGSIADM 287

  Fly   319 FTDDKERGNAMGIALGGLALGVLIGP---------------------PFGGVMYEFVGKS----- 357
            |..: .||.|:........:|.::||                     .|.|||: .:..:
Yeast   288 FPSE-TRGKAIAFFAFAPYVGPVVGPLVNGFISVSTGRMDLIFWVNMAFAGVMW-IISSAIPETY 350

  Fly   358 APFLI---LAALALGDG-----------------LLQLFMLQPSIQKAETEPPSLKS------LI 396
            ||.::   .|.|....|                 :::..:|:| :..|.|||..:.:      :.
Yeast   351 APVILKRKAARLRKETGNPKIMTEQEAQGVSMSEMMRACLLRP-LYFAVTEPVLVATCFYVCLIY 414

  Fly   397 SDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYL--IGTNLFGP-- 457
            |..|....|..:.|..:          ....||:      .|:.|:|..|..|  :.|..:..
Yeast   415 SLLYAFFFAFPVIFGEL----------YGYKDNL------VGLMFIPIVIGALWALATTFYCENK 463

  Fly   458 ----------------LGHKIGRWFAACLGLIIIGGCLIFIPMATSITHLI---IPNAGLGFAIG 503
                            ||.|||..||| :.|.|:|        ||:..|:|   ..:|||.|..|
Yeast   464 YLQIVKQRKPTPEDRLLGAKIGAPFAA-IALWILG--------ATAYKHIIWVGPASAGLAFGFG 519

  Fly   504 MVDSSMMPEL-GYLVD----IRHSAVYGSVY--ALGDVAFCVGFAVGPALSGSLVKSIGFEWMLF 561
            ||  .:...| .|::|    ...||:...|:  :.|..||       |..:..:...:...|
Yeast   520 MV--LIYYSLNNYIIDCYVQYASSALATKVFLRSAGGAAF-------PLFTIQMYHKLNLHW--- 572

  Fly   562 GIAILCFMYAPLLTL 576
            |..:|.|:...::.|
Yeast   573 GSWLLAFISTAMIAL 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	98/523 (19%)
TPO2	NP_011654.1	MFS_Tpo1_MDR_like	173..599	CDD:340881	99/527 (19%)