Protein Alignment Vmat and slc18a3

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001072859.1
• Gene: slc18a3 / 780320
• XenbaseID: XB-GENE-965085
• Length: 524
• Species: Xenopus tropicalis
• Alignment Length: 460
• Identity: 173/460 - (37%)
• Similarity: 275/460 - (59%)
• Gaps: 44/460 - (9%)

  Fly   139 RLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTPLTSNVPPPPTPCPCNKDGS 203
            |::|:||.:||.|||||...:|||||:::.::|                            .|..
 Frog    40 RIILIIVCVALFLDNMLYMVIVPIIPDYIQNLR----------------------------ADRE 76

  Fly   204 EAAPLEISTISPEENETY-YRELEERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYS 267
            .|.  .|::.|...|::: .|......|    |.:::|:||||||.:|||:||:.|....|:||.
 Frog    77 HAK--SINSSSQYRNKSFAIRPQYPAEN----EDMQIGVLFASKAILQLLINPLSGTFIDRVGYD 135

  Fly   268 IPMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIA 332
            ||:..|.|::|.||:||||..:|..|||||:|||:||:.:..||:.|:||.:|::.||..|:|||
 Frog   136 IPLLIGLVVLFFSTVIFAFAENYATLFVARSLQGLGSAFADTSGIAMIADTYTEEAERSKALGIA 200

  Fly   333 LGGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPP---SLKS 394
            |..::.|.|:.|||||::|:||||..|||:||::||.||:|.|.:::|...:.....|   .:..
 Frog   201 LAFISFGSLVAPPFGGILYQFVGKRMPFLVLASIALIDGVLLLLVIKPFTNRTRANMPIGTPIHR 265

  Fly   395 LISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPL- 458
            |:.||||.:.|||:|..|:.:|.|||::..||...|.|:.|:.|:.:|||...:::|..:...|
 Frog   266 LMIDPYIAVVAGALTTCNIPLAFLEPTIANWMKTTMDASEWQMGLTWLPAFFPHVLGVYITVKLA 330

  Fly   459 -GHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHS 522
             .:...:||...:|::|||.....:|...:...||:|..|:.|.|.:||::::|.|..|||:||.
 Frog   331 ANYPHYQWFYGAIGMVIIGASSCTVPACKNFWELIVPLCGICFGIALVDTALLPTLALLVDVRHV 395

  Fly   523 AVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFEWMLFGIAILCFMYAPLLTLLKN----PPTS 583
            :|||||||:.|:::||.:|:||.::..:|.:.||..:..|:.:...:|||.|..|:|    .|:.
 Frog   396 SVYGSVYAIADISYCVAYALGPVVASQIVHTTGFTQLNLGMGLANVLYAPALLFLRNVCQMKPSH 460

  Fly   584 DEKKV 588
            .|:.:
 Frog   461 SERNI 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	168/442 (38%)
slc18a3	NP_001072859.1	MFS_SLC18A3_VAChT	43..451	CDD:340941	168/441 (38%)