Protein Alignment Vmat and slc18a1

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_012814578.1
• Gene: slc18a1 / 594935
• XenbaseID: XB-GENE-5738585
• Length: 494
• Species: Xenopus tropicalis
• Alignment Length: 487
• Identity: 201/487 - (41%)
• Similarity: 297/487 - (60%)
• Gaps: 39/487 - (8%)

  Fly   130 WMVSWRGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLYDI--------------RHPDAPLDS- 179
            |:.....|...:|::||:.:.:|.:|.|.:.||.|..||.|              ::|.:..||
 Frog    10 WLKKTWESRAPILLVVAVVMFVDCILFTIIAPIAPALLYHIEYGRGNRTFKNSSGQYPVSNYDSI 74

  Fly   180 FPRTPLTSNVPPPPTPCPCNKDGSEAAPLEISTI----SPEENETYYRELEERHNELVGETVEVG 240
            |..:.|               :.|...|.....|    ||.:.:..| |.::..||   |.|.||
 Frog    75 FNLSHL---------------EDSRKGPYHDQIINITESPGDKKNCY-EGKDFLNE---ENVRVG 120

  Fly   241 LLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSS 305
            ||.|.|||:|||.|||||.|..||||..|||.||||:.:||::|||..||.:|.|||..||||||
 Frog   121 LLLAIKAFLQLLFNPIVGKLVTRIGYDAPMFFGFVIVVVSTLLFAFANSYALLCVARGFQGIGSS 185

  Fly   306 CSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGD 370
            .:.|..:|.||..|.||.|||.|||:|:.|:|:|||.|||||..||||||||:|||::|||||.|
 Frog   186 FTMVPALGTLAQVFPDDVERGKAMGLAMSGVAIGVLAGPPFGSAMYEFVGKSSPFLVIAALALLD 250

  Fly   371 GLLQLFMLQPSIQKAETEPPS-LKSLISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATR 434
            |.||..:|:|:.....:.|.: .:.|::||||::||..:...|....::||::|:.|::.|.:..
 Frog   251 GALQCCVLKPTKFSPLSVPETPYRVLLTDPYIVVAAVGLCICNFSFGIMEPTIPIRMMETMCSPP 315

  Fly   435 WEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLG 499
            ::.|:||||..::|.|..|||....||||||....:|::.:|..::.:|:|.:|..||.|.||:|
 Frog   316 YQLGLAFLPCMLAYFICLNLFAGFAHKIGRWLCIMIGMMALGISVLCLPLARNIFGLIAPQAGVG 380

  Fly   500 FAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFEWMLFGIA 564
            ...|:.::||.|.:.:||||||::.||::||:.|:|.|:|:|:||:..|::.|:|||.|::..:.
 Frog   381 IGFGLFETSMFPMMAHLVDIRHTSNYGAIYAISDIALCIGYALGPSCGGAIAKAIGFTWLMVILG 445

  Fly   565 ILCFMYAPLLTLLKNPPTSDEKKVRMAREAAE 596
            |:..:||||..||:|||..:|....:::|..:
 Frog   446 IINLVYAPLFILLRNPPGKEETMPVLSQEETQ 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	193/456 (42%)
slc18a1	XP_012814578.1	MFS_SLC18A1_2_VAT1_2	21..459	CDD:340942	193/456 (42%)