Protein Alignment Vmat and VAChT

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_477138.1
• Gene: VAChT / 42795
• FlyBaseID: FBgn0270928
• Length: 578
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 184/465 - (39%)
• Similarity: 274/465 - (58%)
• Gaps: 49/465 - (10%)

  Fly   139 RLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTPLTSNVPPPPTPCPCNKDGS 203
            ||:||||:|||||||||...:|||||::|.:|       .||...|     .|||.     :|..
  Fly    32 RLILVIVSIALLLDNMLYMVIVPIIPDYLREI-------GSFDDGP-----TPPPL-----RDNI 79

  Fly   204 EAAPLEISTISPEENETYYRELEERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSI 268
            ....:.:                  |::..|:....|:||||||.|||:|||..|.|..:|||.:
  Fly    80 TGKIIPV------------------HHDHHGQDSATGILFASKAIVQLMVNPFSGGLIDKIGYDL 126

  Fly   269 PMFAGFVIMFLSTIIFAFGRSYLVLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIAL 333
            ||..|..|||.||.:||.|.||.|||.||:|||.||:.:..:|:.|:|||||::.||..|:||||
  Fly   127 PMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIAL 191

  Fly   334 GGLALGVLIGPPFGGVMYEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPPSLKS---- 394
            ..::.|.|:.|||||.:|:|.||..||||||.:.|.|||:.|.:::| :::|..:...::.
  Fly   192 AFISFGCLVAPPFGGALYQFAGKEVPFLILALVCLLDGLMLLLVMKP-VKEAMKQSKDVQDQVIP 255

  Fly   395 ---LISDPYILIAAGAITFANMGIAMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFG 456
               |:.||||.:.|||:|.:|:.:|.|||::.|||.|||....|:.|:.:|||...:::|..:..
  Fly   256 IWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGVVITV 320

  Fly   457 PLGHKI--GRWFAACLGLIIIGGCLIFIPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDI 519
            .:..|.  .:|..|..||.:.|.....||..:....|::|...:.|.|.::|::::|.||||||:
  Fly   321 KMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDV 385

  Fly   520 RHSAVYGSVYALGDVAFCVGFAVGPALSGSLVKSIGFEWMLFGIAILCFMYAPLLTLLKN----P 580
            |:.:||||:||:.|:::.:.:||||.::|.:|::|||..:.|.||.....|.|:|..|:|    .
  Fly   386 RYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFK 450

  Fly   581 PTSDEKKVRM 590
            |..:|..:.|
  Fly   451 PFENEANILM 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	177/445 (40%)
VAChT	NP_477138.1	MFS_SLC18A3_VAChT	35..444	CDD:340941	177/444 (40%)